Atsuhiro Ichihara

Summary

Affiliation: Tokyo Women's Medical University
Country: Japan

Publications

  1. ncbi request reprint (Pro)renin receptor and vacuolar H(+)-ATPase
    Atsuhiro Ichihara
    Department of Medicine II, Endocrinology and Hypertension, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Keio J Med 61:73-8. 2012
  2. doi request reprint Current knowledge of (pro)renin receptor as an accessory protein of vacuolar H+-ATPase
    Atsuhiro Ichihara
    Department of Medicine II, Institute of Endocrinology and Hypertension, Tokyo Women s Medical University, Japan
    J Renin Angiotensin Aldosterone Syst 12:638-40. 2011
  3. doi request reprint (Pro)renin receptor and autophagy in podocytes
    Atsuhiro Ichihara
    Department of Endocrinology and Hypertension, Tokyo Women s Medical University, Shinjuku, Tokyo, Japan
    Autophagy 8:271-2. 2012
  4. pmc (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Inaida Endowed Department of Anti Aging Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 173:1911-8. 2008
  5. pmc (Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetes 58:1625-33. 2009
  6. ncbi request reprint Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:422-9. 2007
  7. doi request reprint Add-on benefits of amlodipine and thiazide in nondiabetic chronic kidney disease stage 1/2 patients treated with valsartan
    Yuki Kaneshiro
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Kidney Blood Press Res 32:51-8. 2009
  8. ncbi request reprint Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage
    Atsuhiro Ichihara
    Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Am Soc Nephrol 17:2495-503. 2006
  9. ncbi request reprint (Pro)renin receptor-mediated activation of mitogen-activated protein kinases in human vascular smooth muscle cells
    Mariyo Sakoda
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 30:1139-46. 2007
  10. pmc Blood pressure-independent effect of candesartan on cardio-ankle vascular index in hypertensive patients with metabolic syndrome
    Kanako Bokuda
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Vasc Health Risk Manag 6:571-8. 2010

Collaborators

Detail Information

Publications45

  1. ncbi request reprint (Pro)renin receptor and vacuolar H(+)-ATPase
    Atsuhiro Ichihara
    Department of Medicine II, Endocrinology and Hypertension, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Keio J Med 61:73-8. 2012
    ..This review focuses on current insights into the possibility of (P)RR acting as a modulator of V-ATPase and future perspectives in translational research...
  2. doi request reprint Current knowledge of (pro)renin receptor as an accessory protein of vacuolar H+-ATPase
    Atsuhiro Ichihara
    Department of Medicine II, Institute of Endocrinology and Hypertension, Tokyo Women s Medical University, Japan
    J Renin Angiotensin Aldosterone Syst 12:638-40. 2011
    ..Thus, (P)RR is a multi-functional molecule with functions beyond renin and prorenin. This review focuses on the current knowledge and issues of (P)RR and V-ATPase...
  3. doi request reprint (Pro)renin receptor and autophagy in podocytes
    Atsuhiro Ichihara
    Department of Endocrinology and Hypertension, Tokyo Women s Medical University, Shinjuku, Tokyo, Japan
    Autophagy 8:271-2. 2012
    ..However, the physiological role of the (P)RR in podocytes has not yet been fully understood...
  4. pmc (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Inaida Endowed Department of Anti Aging Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 173:1911-8. 2008
    ..These results indicate the significant contribution of RAPS to CNV pathogenesis...
  5. pmc (Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetes 58:1625-33. 2009
    ..The aim of the present study was to define the association of the RAPS with diabetes-induced retinal inflammation...
  6. ncbi request reprint Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:422-9. 2007
    ..The purpose of the present study was to investigate whether nonproteolytically activated prorenin plays a role in ischemia-induced retinal neovascularization...
  7. doi request reprint Add-on benefits of amlodipine and thiazide in nondiabetic chronic kidney disease stage 1/2 patients treated with valsartan
    Yuki Kaneshiro
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Kidney Blood Press Res 32:51-8. 2009
    ..These results suggest that 12 months of add-on treatment with either amlodipine or hydrochlorothiazide could have beneficial effects in nondiabetic chronic kidney disease stage 1/2 patients already being treated with valsartan...
  8. ncbi request reprint Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage
    Atsuhiro Ichihara
    Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Am Soc Nephrol 17:2495-503. 2006
    ..These studies clearly demonstrated that nonproteolytic activation of prorenin in glomeruli is critically involved in renal tissue RAS activation, leading to renal damage in hypertensive animals...
  9. ncbi request reprint (Pro)renin receptor-mediated activation of mitogen-activated protein kinases in human vascular smooth muscle cells
    Mariyo Sakoda
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 30:1139-46. 2007
    ..The (pro)renin receptor-mediated ERK signal transduction is thus a possible new therapeutic target for preventing vascular complications...
  10. pmc Blood pressure-independent effect of candesartan on cardio-ankle vascular index in hypertensive patients with metabolic syndrome
    Kanako Bokuda
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Vasc Health Risk Manag 6:571-8. 2010
    ..Candesartan may be a better antihypertensive drug than CCBs to improve subclinical atherosclerosis of patients with MetS...
  11. doi request reprint Effects of telmisartan on arterial stiffness assessed by the cardio-ankle vascular index in hypertensive patients
    Kenichiro Kinouchi
    Department of Endocrinology, Metabolism, and Nephrology, Keio University School of Medicine, Tokyo, Japan
    Kidney Blood Press Res 33:304-12. 2010
    ..This study was conducted to determine the effect of telmisartan on the cardio-ankle vascular index (CAVI), a novel blood pressure (BP)-independent marker for arterial stiffness in hypertensive patients...
  12. doi request reprint Possible roles of human (pro)renin receptor suggested by recent clinical and experimental findings
    Atsuhiro Ichihara
    Department of Endocrinology and Anti Aging Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    Hypertens Res 33:177-80. 2010
    ....
  13. ncbi request reprint Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, 160 8582, Japan
    J Am Soc Nephrol 17:1950-61. 2006
    ..It is not only AngII but also intraglomerular activation of MAPK by the receptor-associated prorenin that plays a pivotal role in diabetic nephropathy...
  14. ncbi request reprint Add-on amlodipine improves arterial function and structure in hypertensive patients treated with an angiotensin receptor blocker
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Cardiovasc Pharmacol 49:161-6. 2007
    ..The antiatherogenic pleiotropic properties of amlodipine have a preventive effect on the progression of arterial stiffness in hypertensive patients treated with an ARB...
  15. doi request reprint Involvement of activated prorenin in the pathogenesis of slowly progressive nephropathy in the non-clipped kidney of two kidney, one-clip hypertension
    Masaki Ryuzaki
    Department of Endocrinology and Anti Aging Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 34:301-7. 2011
    ..These results suggest that the ((P)RR)-dependent activation of prorenin contributes to the pathogenesis of slowly progressive nephropathy in the intact kidney in a rat model of renovascular hypertension...
  16. doi request reprint Aliskiren inhibits intracellular angiotensin II levels without affecting (pro)renin receptor signals in human podocytes
    Mariyo Sakoda
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Hypertens 23:575-80. 2010
    ..Because (P)RR is present in the podocytes, a central component of the glomerular filtration barrier, we hypothesized that aliskiren influences the (P)RR-induced two pathways in human podocytes...
  17. ncbi request reprint Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp
    Yasufumi Seki
    Department of Endocrinology and Anti Aging Medicine, Keio University School of Medicine, Tokyo, Japan
    Front Biosci (Elite Ed) 2:972-9. 2010
    ..Thus, (pro)renin receptor contributes to the accelerated pathogenesis in the heart and kidneys of diabetic SHRsp...
  18. ncbi request reprint Pathologic roles of prorenin and (pro)renin receptor in the eye
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Front Biosci 13:3884-95. 2008
    ..These findings demonstrate that nonproteolytically activated prorenin plays a significant role in the ocular inflammation and neovascularization...
  19. ncbi request reprint Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats
    Yuki Kaneshiro
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Am Soc Nephrol 18:1789-95. 2007
    ..This study clearly provided in vivo evidence for the AngII-independent MAPK activation by human (pro)renin receptor and induction of glomerulosclerosis with increased TGF-beta1 expression...
  20. doi request reprint Prediction of gestational diabetes mellitus by soluble (pro)renin receptor during the first trimester
    Noriyoshi Watanabe
    Department of Endocrinology and Hypertension, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku, Tokyo, 162 8666, Japan
    J Clin Endocrinol Metab 98:2528-35. 2013
    ..There are currently no factors that have been shown to predict gestational diabetes mellitus (GDM) during early pregnancy. The soluble (pro)renin receptor [s(P)RR] may contribute to the development of GDM...
  21. ncbi request reprint New approaches to blockade of the renin-angiotensin-aldosterone system: characteristics and usefulness of the direct renin inhibitor aliskiren
    Atsuhiro Ichihara
    Department of Anti Aging Medicine, Keio University School of Medicine, Tokyo, Japan
    J Pharmacol Sci 113:296-300. 2010
    ....
  22. ncbi request reprint The (pro)renin receptor and the kidney
    Atsuhiro Ichihara
    Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Semin Nephrol 27:524-8. 2007
    ....
  23. doi request reprint Soluble (pro)renin receptor and blood pressure during pregnancy: a prospective cohort study
    Noriyoshi Watanabe
    Department of Endocrinology and Hypertension, Tokyo Women s Medical University, Shinju, Tokyo 162 8666, Japan
    Hypertension 60:1250-6. 2012
    ..5 [95% CI, 1.8-279.9]). In conclusion, high circulating levels of s(P)RR at early pregnancy predicted a subsequent elevation in BP, and high concentrations at delivery were significantly associated with preeclampsia...
  24. ncbi request reprint Regression of nephropathy developed in diabetes by (Pro)renin receptor blockade
    Hidena Takahashi
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Tokyo, Japan
    J Am Soc Nephrol 18:2054-61. 2007
    ..These results suggest that (pro)renin receptor blockade does not only inhibit the progression of nephropathy but also reverses the glomerulosclerosis that has already developed in diabetic rats...
  25. pmc Involvement of (pro)renin receptor in the glomerular filtration barrier
    Atsuhiro Ichihara
    Departments of Anti Aging Medicine and Endocrinology and Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    J Mol Med (Berl) 86:629-35. 2008
    ..Thus, the (pro)renin receptor may be upregulated in podocytes under hypertensive conditions and may contribute to the breakdown of the glomerular filtration barrier...
  26. pmc Prorenin receptor is essential for normal podocyte structure and function
    Yoichi Oshima
    Department of Endocrinology and Anti Aging Medicine and Internal Medicine, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo, 160 8582, Japan
    J Am Soc Nephrol 22:2203-12. 2011
    ..In conclusion, the prorenin receptor is important for the maintenance of normal podocyte structure and function...
  27. doi request reprint The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes
    Kenichiro Kinouchi
    Department of Endocrinology, Metabolism, and Nephrology, Keio University School of Medicine, Tokyo, Japan
    Circ Res 107:30-4. 2010
    ..A truncated form of (P)RR, termed M8.9, was also found to be associated with the vacuolar H(+)-ATPase (V-ATPase), implicating a non-RAS-related function of ATP6AP2...
  28. pmc The Role of Individual Domains and the Significance of Shedding of ATP6AP2/(pro)renin Receptor in Vacuolar H(+)-ATPase Biogenesis
    Kenichiro Kinouchi
    Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e78603. 2013
    ..The V-ATPase assembly occurs prior to its delivery to the trans-Golgi network and hence shedding of ATP6AP2/PRR would not affect the biogenesis of active V-ATPase. ..
  29. doi request reprint Association of (pro)renin receptor mRNA expression with angiotensin-converting enzyme mRNA expression in human artery
    Tomoko Takemitsu
    Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Nephrol 30:361-70. 2009
    ..A significant role of (pro)renin receptor in the pathogenesis of end-organ damage has been suggested only in animal studies. This study was conducted to examine the mRNA expression of (pro)renin receptor in human artery...
  30. doi request reprint Cardio-ankle vascular index and ankle pulse wave velocity as a marker of arterial fibrosis in kidney failure treated by hemodialysis
    Atsuhiro Ichihara
    Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Kidney Dis 52:947-55. 2008
    ..This study sought to compare the strength of predictions of arterial fibrosis by using a new parameter, the cardio-ankle vascular index (CAVI), versus pulse wave velocity (PWV) in patients with kidney failure treated with hemodialysis...
  31. pmc Association between soluble (Pro)renin receptor concentration in cord blood and small for gestational age birth: a cross-sectional study
    Noriyoshi Watanabe
    Department of Endocrinology and Hypertension, Tokyo Women s Medical University, Shinjuku, Tokyo, Japan
    PLoS ONE 8:e60036. 2013
    ..The purpose of this study was to assess the association between plasma soluble (P)RR [s(P)RR] concentration in human cord blood (i.e., neonatal blood at birth) and small for gestational age (SGA) birth...
  32. doi request reprint Prediction of pregnancy-induced hypertension by a shift of blood pressure class according to the JSH 2009 guidelines
    Seung Chik Jwa
    Department of Maternal Fetal and Neonatal Medicine, National Center for Child Health and Development, Tokyo, Japan
    Hypertens Res 34:1203-8. 2011
    ..05). Within JSH 2009 Classes I, II and III, a shift in BP from a low to a high class between 16 and 20 weeks of gestation predicts the subsequent development of PIH...
  33. ncbi request reprint Drug discovery for overcoming chronic kidney disease (CKD): new therapy for CKD by a (pro)renin-receptor-blocking decoy peptide
    Atsuhiro Ichihara
    Department of Anti Aging Medicine and Endocrinology, Keio University School of Medicine, Tokyo, Japan
    J Pharmacol Sci 109:20-3. 2009
    ..Thus, (pro)renin-receptor blockade can be a useful therapy for chronic kidney disease with low renin levels in the plasma...
  34. doi request reprint Activated prorenin as a therapeutic target for diabetic nephropathy
    Atsuhiro Ichihara
    Anti Aging Medicine and Endocrinology and Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Diabetes Res Clin Pract 82:S63-6. 2008
    ..Receptor-bound prorenin may prove useful as an important therapeutic target for the prevention and regression of end-organ damage in patients with diabetes...
  35. ncbi request reprint Benefits of candesartan on arterial and renal damage of non-diabetic hypertensive patients treated with calcium channel blockers
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Nephrol 26:462-8. 2006
    ..The present study was conducted to examine add-on benefits of candesartan therapy on hypertensive patients treated with CCBs for at least 12 months...
  36. ncbi request reprint Effects of adding ezetimibe to fluvastatin on kidney function in patients with hypercholesterolemia: a randomized control trial
    Kenichiro Kinouchi
    Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 20:245-56. 2013
    ..Ezetimibe, a cholesterol-absorption inhibitor, also lowers LDL cholesterol levels when added to statins; however, the effect of add-on ezetimibe on kidney function has had conflicting results...
  37. ncbi request reprint Podocytes as a target of prorenin in diabetes
    Mariyo Sakoda
    Department of Internal Medicine, School of Medicine, Keio University of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Curr Diabetes Rev 7:17-21. 2011
    ..Further inquiry regarding podocyte (P)RR intracellular signal transduction will be needed to develop a new therapeutic approach targeting podocyte (P)RR in patients with diabetic nephropathy...
  38. doi request reprint Involvement of receptor-bound prorenin in development of nephropathy in diabetic db/db mice
    Atsuhiro Ichihara
    Deparment of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Am Soc Hypertens 2:332-40. 2008
    ..Thus prorenin also contributes to the development of nephropathy in type II diabetes, probably through a (pro)renin receptor-dependent mechanism...
  39. ncbi request reprint Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, and Department of Ophthalmology, Kobe City General Hospital, Japan
    Invest Ophthalmol Vis Sci 47:2686-92. 2006
    ..The purpose of the present study was to elucidate the role of the receptor-dependent nonproteolytic activation of prorenin in ocular inflammation in endotoxin-induced uveitis (EIU)...
  40. ncbi request reprint [Case of nephrotic syndrome due to AL-type primary amyloidosis associated with renal cell carcinoma]
    Morito Takano
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Nihon Jinzo Gakkai Shi 49:1014-9. 2007
    ....
  41. ncbi request reprint Functional characterization of (pro)renin receptor in association with V-ATPase
    Kenichiro Kinouchi
    Department of Endocrinology, Metabolism, and Nephrology, Keio University School of Medicine, Tokyo, 160 8582, Japan
    Front Biosci (Landmark Ed) 16:3216-23. 2011
    ..Thus, the (P)RR is a multi-functional molecule that shows the complex structure and behaviour. This review highlights the current insights and the future perspectives in research regarding the (P)RR and mammalian V-ATPase...
  42. ncbi request reprint [Regulatory mechanisms for the renin-angiotensin-aldosterone system]
    Atsuhiro Ichihara
    Department of Endocrinology and Hypertension, Tokyo Women s Medical University
    Nihon Rinsho 70:1477-81. 2012
    ..The purpose of this article is to review the recent advances in tissue RAAS research with a particular focus on the roles of (pro)renin receptor in the pathological conditions and its physiological function...
  43. ncbi request reprint Critical roles of (pro)renin receptor-bound prorenin in diabetes and hypertension: sallies into therapeutic approach
    Atsuhiro Ichihara
    Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Am Soc Hypertens 2:15-9. 2008
    ..The (pro)renin receptor may prove useful as an important therapeutic target for the prevention and regression of end-organ damage in diabetes and hypertension...
  44. doi request reprint Safety and benefits of a tablet combining losartan and hydrochlorothiazide in Japanese diabetic patients with hypertension
    Kenichiro Kinouchi
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 32:1143-7. 2009
    ..Thus, the L/HCTZ tablet could be a useful drug for Japanese diabetic patients with hypertension...
  45. ncbi request reprint Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertension 47:894-900. 2006
    ....