N Honma

Summary

Affiliation: Tokyo Metropolitan Institute of Gerontology
Country: Japan

Publications

  1. ncbi request reprint Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast
    N Honma
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo, Japan
    Histopathology 47:195-201. 2005
  2. doi request reprint Association between estrogen receptor-β dinucleotide repeat polymorphism and incidence of femoral fracture
    Naoko Honma
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo, 173 0015, Japan
    J Bone Miner Metab 31:96-101. 2013
  3. doi request reprint Estrogen receptor-β gene polymorphism and colorectal cancer risk: effect modified by body mass index and isoflavone intake
    Naoko Honma
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Int J Cancer 132:951-8. 2013
  4. ncbi request reprint Comparative study of monoclonal antibody B72.3 and gross cystic disease fluid protein-15 as markers of apocrine carcinoma of the breast
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    APMIS 114:712-9. 2006
  5. ncbi request reprint Expression of oestrogen receptor-beta in apocrine carcinomas of the breast
    N Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Histopathology 50:425-33. 2007
  6. doi request reprint Clinical importance of estrogen receptor-beta evaluation in breast cancer patients treated with adjuvant tamoxifen therapy
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Clin Oncol 26:3727-34. 2008
  7. doi request reprint Oestrogen receptor-beta1 but not oestrogen receptor-betacx is of prognostic value in apocrine carcinoma of the breast
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    APMIS 116:923-30. 2008
  8. pmc Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    Breast Cancer Res 11:R48. 2009
  9. ncbi request reprint Breast carcinoma in women over the age of 85: distinct histological pattern and androgen, oestrogen, and progesterone receptor status
    N Honma
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Department of Breast Pathology, Cancer Institute, Tokyo, Japan
    Histopathology 42:120-7. 2003
  10. doi request reprint Oestrogen receptor-β CA repeat polymorphism is associated with incidence of colorectal cancer among females
    Naoko Honma
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
    Histopathology 59:216-24. 2011

Detail Information

Publications30

  1. ncbi request reprint Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast
    N Honma
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo, Japan
    Histopathology 47:195-201. 2005
    ..Apocrine lesions reportedly exhibit an unusual immunohistochemical status, expressing androgen receptors (AR) instead of oestrogen receptors (ER), progesterone receptors (PR), or bcl-2. Their expression was also examined...
  2. doi request reprint Association between estrogen receptor-β dinucleotide repeat polymorphism and incidence of femoral fracture
    Naoko Honma
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo, 173 0015, Japan
    J Bone Miner Metab 31:96-101. 2013
    ..0133). Japanese subjects, especially women, bearing at least one allele of 20 CA repeats in the ESR2 may have a lower risk of femoral fracture than those without it, suggesting this polymorphism plays a role in bone metabolism...
  3. doi request reprint Estrogen receptor-β gene polymorphism and colorectal cancer risk: effect modified by body mass index and isoflavone intake
    Naoko Honma
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Int J Cancer 132:951-8. 2013
    ..Aging and estrogenic condition may be important in the colon cancer pathogenesis associated with ESR2 CA repeat polymorphism...
  4. ncbi request reprint Comparative study of monoclonal antibody B72.3 and gross cystic disease fluid protein-15 as markers of apocrine carcinoma of the breast
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    APMIS 114:712-9. 2006
    ..3 and GCDFP-15. Whether these two cases should be differentiated from ordinary apocrine carcinomas remains to be investigated...
  5. ncbi request reprint Expression of oestrogen receptor-beta in apocrine carcinomas of the breast
    N Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Histopathology 50:425-33. 2007
    ..The aim was to study ER-beta status in apocrine carcinoma...
  6. doi request reprint Clinical importance of estrogen receptor-beta evaluation in breast cancer patients treated with adjuvant tamoxifen therapy
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Clin Oncol 26:3727-34. 2008
    ..A large and systematic study is needed to address these important issues...
  7. doi request reprint Oestrogen receptor-beta1 but not oestrogen receptor-betacx is of prognostic value in apocrine carcinoma of the breast
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    APMIS 116:923-30. 2008
    ..ER-beta1 itself, independent of ER-alpha expression and tamoxifen treatment, seems to have a tumor-suppressive effect, at least in apocrine carcinomas. Further study of ER-beta1 is desired to optimize breast cancer treatment...
  8. pmc Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    Breast Cancer Res 11:R48. 2009
    ..The aim of the present study is to elucidate whether there are any specific patterns in use of multiple exons 1 in elderly breast tissue...
  9. ncbi request reprint Breast carcinoma in women over the age of 85: distinct histological pattern and androgen, oestrogen, and progesterone receptor status
    N Honma
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Department of Breast Pathology, Cancer Institute, Tokyo, Japan
    Histopathology 42:120-7. 2003
    ..In an effort to understand the pathogenesis of breast carcinoma in these women, this study was undertaken to compare the histological patterns and hormone receptor status of breast carcinomas arising in very elderly and younger women...
  10. doi request reprint Oestrogen receptor-β CA repeat polymorphism is associated with incidence of colorectal cancer among females
    Naoko Honma
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
    Histopathology 59:216-24. 2011
    ..The aim was to elucidate the association of the dinucleotide (CA) repeat polymorphism of the ER-β gene (ESR2) with colorectal cancer...
  11. doi request reprint Sex steroid hormones in pairs of tumor and serum from breast cancer patients and pathobiological role of androstene-3β, 17β-diol
    Naoko Honma
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Cancer Sci 102:1848-54. 2011
    ..The intratumoral increase of E2, but not E1, in hormone receptor-positive postmenopausal breast cancer tissue, as well as the proliferative role of Aenediol, was elucidated...
  12. ncbi request reprint Mucinous cystadenocarcinoma of the breast: a case report and review of the literature
    Naoko Honma
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Arch Pathol Lab Med 127:1031-3. 2003
    ..Because MCAs appear to have a distinct pathogenesis and biologic behavior, they should be distinguished from ordinary mucinous carcinomas, cystic hypersecretory carcinomas, and carcinomas of other histologic subtypes...
  13. ncbi request reprint Estrogen-metabolizing enzymes in breast cancers from women over the age of 80 years
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    J Clin Endocrinol Metab 91:607-13. 2006
    ..These estrogen-metabolizing enzymes (EMEs) are important in postmenopausal breast cancers, but have never been systematically examined in breast cancers of the elderly...
  14. ncbi request reprint Microsatellite-unstable mucinous colorectal carcinoma occurring in the elderly: comparison with medullary type poorly differentiated adenocarcinoma
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Sakaecho, Tokyo, Japan
    Pathol Int 57:205-12. 2007
    ....
  15. ncbi request reprint Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method
    Junko Aida
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Hum Pathol 38:1192-200. 2007
    ....
  16. ncbi request reprint Age-related alteration in the association of microsatellite instability with absent hMLH1 expression and histological types of colorectal carcinoma
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Pathol Int 56:597-603. 2006
    ..These results indicate that an age-related increase of medullary-type tumors in poorly differentiated adenocarcinoma may play an important role in the increase of absent hMLH1 expression and MSI in colorectal carcinoma...
  17. ncbi request reprint Telomere shortening with aging in the human pancreas
    Akio Ishii
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo 173 0015, Japan
    Exp Gerontol 41:882-6. 2006
    ..4 kilobase pairs (kbp) in 16 neonates, as opposed to 8.4 kbp in 2 centenarians. Mean telomere length (+/-SD) in four age groups, 0-24, 25-49, 50-74, and 75-100 yr, was 13.5+/-1.5, 12.3+/-0.7, 11.3+/-2.5, and 10.7+/-1.8, respectively...
  18. ncbi request reprint Expression of human telomerase reverse transcriptase gene and protein, and of estrogen and progesterone receptors, in breast tumors: preliminary data from neo-adjuvant chemotherapy
    Makoto Kammori
    Division of Breast and Endocrine Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Japan
    Int J Oncol 27:1257-63. 2005
    ..These results suggest that detection of hTERT protein by ICH can be used to distinguish breast cancers as a potential diagnostic and therapeutic marker...
  19. ncbi request reprint Oncocytic adenocarcinoma of the stomach: parietal cell carcinoma
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology and Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Am J Surg Pathol 26:458-65. 2002
    ..Previously reported cases of parietal cell carcinoma have been said to have a favorable prognosis, but it will be necessary to study a larger number of cases to determine the prognosis of oncocytic adenocarcinoma...
  20. ncbi request reprint Early pathogenesis of cardiac amyloid deposition in senile systemic amyloidosis: close relationship between amyloid deposits and the basement membranes of myocardial cells
    Motoji Sawabe
    Departments of Pathology and Cardiology, Tokyo Metropolitan Geriatric Hospital, 35 2 Sakae cho, Itabashi, 173 0015, Tokyo, Japan
    Virchows Arch 442:252-7. 2003
    ..Our results indicate that the basement membrane of myocardial cells is the initial site of amyloid deposition, providing a suitable place for concentration of TTR...
  21. ncbi request reprint Age-related mitochondrial DNA deletion in human heart: its relationship with cardiovascular diseases
    Tomio Arai
    Departments of Pathology, Tokyo Metropolitan Geriatric Medical Center, Tokyo, Japan
    Aging Clin Exp Res 15:1-5. 2003
    ..The aim of the present study was to clarify the relationship between aging, mtDNA deletion and cardiovascular (CV) diseases...
  22. ncbi request reprint Hypermethylation of the hMLH1 promoter with absent hMLH1 expression in medullary-type poorly differentiated colorectal adenocarcinoma in the elderly
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, Tokyo, Japan
    Mod Pathol 17:172-9. 2004
    ..These results indicated that hMLH1 hypermethylation, concurrent with a lack of its protein expression, may play an important role in the development of medullary-type poorly differentiated colorectal adenocarcinomas in the elderly...
  23. ncbi request reprint Pathologic characteristics of gastric cancer in the elderly: a retrospective study of 994 surgical patients
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, 35 2 Sakae cho, Itabashi ku, 173 0015 Tokyo, Japan
    Gastric Cancer 7:154-9. 2004
    ..The clinicopathologic features of gastric carcinoma in elderly people have been reported previously. The present study examined the patterns and distribution of gastric carcinomas in the elderly, especially in patients aged 85 and older...
  24. ncbi request reprint Ciliated surface in the esophagogastric junction zone: a precursor of Barrett's mucosa or ciliated pseudostratified metaplasia?
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Am J Surg Pathol 29:211-7. 2005
    ..These findings may suggest that squamous metaplasia-like change at the EGJ is not a precursor of Barrett's mucosa but rather is a form of pseudostratified metaplasia...
  25. ncbi request reprint Is there a set of histologic changes that are invariably reflux associated?
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Sakae cho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    Arch Pathol Lab Med 129:159-63. 2005
    ..To develop a set of characteristic reflux-associated features, endoscopists may perform targeted biopsies from several sites with various endoscopic features and at different stages of disease...
  26. ncbi request reprint Islands of squamous epithelium and their surrounding mucosa in columnar-lined esophagus: a pathognomonic feature of Barrett's esophagus?
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Japan
    Hum Pathol 36:269-74. 2005
    ..From a practical point of view, biopsy specimens from columnar-lined mucosa of the esophagus do not always show intestinal metaplasia (specialized intestinal metaplasia)...
  27. ncbi request reprint Detection of human papillomavirus infection of the cervix in very elderly women using PCR
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Clin Cancer Res 11:2919-23. 2005
    ....
  28. ncbi request reprint [Biopsy methods and pathology of Barrett's esophagus]
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology
    Nihon Rinsho 63:1429-33. 2005
    ....
  29. ncbi request reprint Telomere lengths are characteristic in each human individual
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, 173 0015, Japan
    Exp Gerontol 37:523-31. 2002
    ..However, there is no simple link between telomeres and tissue turnover. We recently proposed a hypothesis that telomere shortening with aging and telomere lengths in different organs are characteristic for human individuals...
  30. ncbi request reprint Granulomatous meningitis as a late complication of iodized oil myelography
    Nyoka N Ruberu
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Japan
    Neuropathology 24:144-8. 2004
    ..The pathology was identical to foreign-body granulomatous meningitis, caused by iodized oil myelography, and caused cognitive impairment in this patient...