Yuji Hirano

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. ncbi request reprint Modulation by dihydropyridines and protein kinases of the recombinant cardiac L-type Ca channel with multiple unitary current amplitudes
    Y Hirano
    Department of Cardiovascular Diseases, Tokyo Medical and Dental University, Japan
    Receptors Channels 4:93-104. 1996
  2. ncbi request reprint Prepulse-induced mode 2 gating behavior with and without beta-adrenergic stimulation in cardiac L-type Ca channels
    Y Hirano
    Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113, Japan
    Am J Physiol 276:C1338-45. 1999
  3. ncbi request reprint Effects of amlodipine on unitary non-L-type high voltage-activated Ca2+ channel currents in differentiated PC12 cells
    Y Hirano
    Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Japan
    Naunyn Schmiedebergs Arch Pharmacol 364:335-42. 2001
  4. ncbi request reprint Identical unitary current amplitude and Ca(2+) block of cardiac Na channel before and during beta-adrenergic stimulation
    Y Hirano
    Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, 113 8510 Japan
    Jpn J Physiol 51:679-85. 2001
  5. pmc Ca2+ entry-dependent inactivation of L-type Ca current: a novel formulation for cardiac action potential models
    Yuji Hirano
    Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Japan
    Biophys J 84:696-708. 2003
  6. doi request reprint Role of HCN4 channel in preventing ventricular arrhythmia
    Kazuo Ueda
    Department of Molecular Pathogenesis, Tokyo Medical and Dental University, Tokyo, Japan
    J Hum Genet 54:115-21. 2009
  7. ncbi request reprint Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K(+) current in guinea pig ventricular myocytes
    Ivan Kocic
    Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Pharmacol Sci 95:189-95. 2004
  8. ncbi request reprint Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2: additional amino acids generated by frameshift cause accelerated inactivation
    Tetsuo Sasano
    Department of Cardiovascular Disease, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    J Mol Cell Cardiol 37:1205-11. 2004
  9. ncbi request reprint Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect
    Yoshiyasu Aizawa
    Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    FEBS Lett 574:145-50. 2004
  10. ncbi request reprint Block of HERG current expressed in HEK293 cells by the Na+-channel blocker cibenzoline
    Mikio Hiramatsu
    Department of Cardiovascular Disease, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Heart Vessels 19:137-43. 2004

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Modulation by dihydropyridines and protein kinases of the recombinant cardiac L-type Ca channel with multiple unitary current amplitudes
    Y Hirano
    Department of Cardiovascular Diseases, Tokyo Medical and Dental University, Japan
    Receptors Channels 4:93-104. 1996
    ..We conclude that BHK cells provide a useful expression system where the modulations and biophysical aspects of Ca channels can be studied at the single channel level...
  2. ncbi request reprint Prepulse-induced mode 2 gating behavior with and without beta-adrenergic stimulation in cardiac L-type Ca channels
    Y Hirano
    Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113, Japan
    Am J Physiol 276:C1338-45. 1999
    ....
  3. ncbi request reprint Effects of amlodipine on unitary non-L-type high voltage-activated Ca2+ channel currents in differentiated PC12 cells
    Y Hirano
    Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Japan
    Naunyn Schmiedebergs Arch Pharmacol 364:335-42. 2001
    ..These results were consistent with the view that amlodipine prevented channel openings through the high-affinity binding to the inactivated state, as often observed when dihydropyridines block L-type Ca2+ channels...
  4. ncbi request reprint Identical unitary current amplitude and Ca(2+) block of cardiac Na channel before and during beta-adrenergic stimulation
    Y Hirano
    Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, 113 8510 Japan
    Jpn J Physiol 51:679-85. 2001
    ..They therefore argue against the "slip mode" concept of classical cardiac Na channel if a general concept of ion permeation through "multi-ion pores" is applicable to determine the ionic selectivity of Na channels...
  5. pmc Ca2+ entry-dependent inactivation of L-type Ca current: a novel formulation for cardiac action potential models
    Yuji Hirano
    Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Japan
    Biophys J 84:696-708. 2003
    ..Our study provides a basis for theoretical analysis of I(Ca,L) during action potentials, including the cases encountered in long QT syndromes...
  6. doi request reprint Role of HCN4 channel in preventing ventricular arrhythmia
    Kazuo Ueda
    Department of Molecular Pathogenesis, Tokyo Medical and Dental University, Tokyo, Japan
    J Hum Genet 54:115-21. 2009
    ..These observations suggested that the HCN4 channel played a preventive role in triggering bradycardia-induced ventricular arrhythmias...
  7. ncbi request reprint Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K(+) current in guinea pig ventricular myocytes
    Ivan Kocic
    Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Pharmacol Sci 95:189-95. 2004
    ..We conclude that osmotic stress increases efficacy of rilmakalim to activate K(ATP) channels in guinea pig ventricular myocytes due to the specific interaction with actin filaments...
  8. ncbi request reprint Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2: additional amino acids generated by frameshift cause accelerated inactivation
    Tetsuo Sasano
    Department of Cardiovascular Disease, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    J Mol Cell Cardiol 37:1205-11. 2004
    ..To understand further the role of C-terminus region, we performed a functional analysis of a novel frameshift mutation (1122fs/147) identified in a Japanese long QT syndrome 2 (LQT2) patient who had recurrent episodes of syncope...
  9. ncbi request reprint Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect
    Yoshiyasu Aizawa
    Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    FEBS Lett 574:145-50. 2004
    ..Our findings suggest a novel mechanism for LQT1 that the truncated S1-S2 KCNQ1 mutant forms hetero-multimer and cause a dominant-negative effect due to trafficking defect...
  10. ncbi request reprint Block of HERG current expressed in HEK293 cells by the Na+-channel blocker cibenzoline
    Mikio Hiramatsu
    Department of Cardiovascular Disease, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Heart Vessels 19:137-43. 2004
    ..Cibenzoline has a preferential affinity, at least, to the open state of the HERG channel with a rapid access to the binding site...
  11. ncbi request reprint Regional and frequency-dependent changes in action potentials and transient outward K+ currents in ventricular myocytes from J-2-K cardiomyopathic hamsters
    Ivan Kocic
    Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8510 Tokyo, Japan
    Basic Res Cardiol 98:367-79. 2003
    ....
  12. ncbi request reprint The effects of K+ channels modulators terikalant and glibenclamide on membrane potential changes induced by hypotonic challenge of guinea pig ventricular myocytes
    Ivan Kocic
    Department of Cardiovascular Disease, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Pharmacol Sci 95:27-32. 2004
    ..Our results indicate that I(K1) and I(KATP) do not participate in membrane potential changes induced by hypotonic solution at least in the guinea pig ventricular myocytes with sufficient intracellular ATP...
  13. ncbi request reprint Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia
    Kazuo Ueda
    Department of Molecular Pathogenesis, Medical Research Institute and Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
    J Biol Chem 279:27194-8. 2004
    ....
  14. ncbi request reprint Early exposure to hypertonic solution strongly intensifies the effects of K+ channel opener, rilmakalim, in guinea pig ventricular myocytes
    Ivan Kocic
    Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Pol J Pharmacol 55:1159-62. 2003
    ..44 +/- 0.11 compared to pD2 = 6.49 +/- 0.18 in isotonic solution) without changing Emax, and observed effect was completely reversed by glibenclamide at 1 microM...
  15. ncbi request reprint Block of recombinant KCNQ1/KCNE1 K+ channels (IKs) by intracellular Na+ and its implications on action potential repolarization
    Minako Orikabe
    Department of Cardiovascular Medicine, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8510 Japan
    Jpn J Physiol 53:417-25. 2003
    ....
  16. ncbi request reprint Rate-dependent changes in action potential duration and membrane currents in hamster ventricular myocytes
    Ivan Kocic
    Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Pflugers Arch 443:353-61. 2002
    ..Recovery from inactivation for I(Ca,L) was rapid with t=20+/-4 ms ( n=6). Results suggest that the slow recovery from inactivation in Ito1 is the main reason for the rate-dependent prolongation of APD in hamster ventricular myocytes...
  17. ncbi request reprint Effects of Na+ channel blocker, pilsicainide, on HERG current expressed in HEK-293 cells
    Long Mei Wu
    Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Yushima, Japan
    J Cardiovasc Pharmacol 42:410-8. 2003
    ..We studied effects of pilsicainide on the K+ channel current of the human ether-a-go-go-related gene (HERG) in heterologous expression system...
  18. ncbi request reprint Modulation of ICa-L by alpha1-adrenergic stimulation in rat ventricular myocytes
    Shetuan Zhang
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre and Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada
    Can J Physiol Pharmacol 83:1015-24. 2005
    ....
  19. ncbi request reprint Hypotonic stress enhances slope conductivity of ATP-sensitive K+ channels activated pharmacologically
    Ivan Kocic
    Int J Cardiol 116:423-4. 2007
    ....