Daisuke Hayasaka

Summary

Affiliation: Tokyo Metropolitan Institute for Neuroscience
Country: Japan

Publications

  1. ncbi Pathogeneses of respiratory infections with virulent and attenuated vaccinia viruses
    Daisuke Hayasaka
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Virol J 4:22. 2007
  2. ncbi Increased permeability of human endothelial cell line EA.hy926 induced by hantavirus-specific cytotoxic T lymphocytes
    Daisuke Hayasaka
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Virus Res 123:120-7. 2007
  3. ncbi Recombinant adenovirus vector vaccine induces stronger cytotoxic T-cell responses than recombinant vaccinia virus vector, plasmid DNA, or a combination of these
    Ken Maeda
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Viral Immunol 18:657-67. 2005
  4. ncbi A BHK-21 cell culture-adapted tick-borne encephalitis virus mutant is attenuated for neuroinvasiveness
    Akiko Goto
    Laboratory of Public Health, Graduate School of Veterinary Medicine, Hokkaido University, Kita-18 Nishi-9, Kita-ku, Sapporo 060-0818, Japan
    Vaccine 21:4043-51. 2003
  5. ncbi Amino acid changes responsible for attenuation of virus neurovirulence in an infectious cDNA clone of the Oshima strain of tick-borne encephalitis virus
    Daisuke Hayasaka
    Department of Environmental Veterinary Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Gen Virol 85:1007-18. 2004
  6. ncbi [Phylogenetic analysis and pathogenicity of tick-borne encephalitis virus from Japan and far-east Russia]
    Ikuo Takashima
    Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Uirusu 55:35-44. 2005
  7. ncbi Immunopathogenesis of hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome: Do CD8+ T cells trigger capillary leakage in viral hemorrhagic fevers?
    Masanori Terajima
    Immunol Lett 113:117-20. 2007

Collaborators

Detail Information

Publications7

  1. ncbi Pathogeneses of respiratory infections with virulent and attenuated vaccinia viruses
    Daisuke Hayasaka
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Virol J 4:22. 2007
    ..In this study, we analyzed virus replication and host immune responses after intranasal infection with lethal and non-lethal doses of VV using the WR strain and the less virulent Wyeth strain...
  2. ncbi Increased permeability of human endothelial cell line EA.hy926 induced by hantavirus-specific cytotoxic T lymphocytes
    Daisuke Hayasaka
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Virus Res 123:120-7. 2007
    ..These results suggest that cytotoxic T lymphocyte activity contribute to capillary leakage observed in patients with hantavirus pulmonary syndrome or hemorrhagic fever with renal syndrome...
  3. ncbi Recombinant adenovirus vector vaccine induces stronger cytotoxic T-cell responses than recombinant vaccinia virus vector, plasmid DNA, or a combination of these
    Ken Maeda
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Viral Immunol 18:657-67. 2005
    ....
  4. ncbi A BHK-21 cell culture-adapted tick-borne encephalitis virus mutant is attenuated for neuroinvasiveness
    Akiko Goto
    Laboratory of Public Health, Graduate School of Veterinary Medicine, Hokkaido University, Kita-18 Nishi-9, Kita-ku, Sapporo 060-0818, Japan
    Vaccine 21:4043-51. 2003
    ..The attenuation process involved a single amino acid change in the E protein, which may have resulted in the rapid clearance of the virus due to its high affinity for negatively charged molecules in vivo...
  5. ncbi Amino acid changes responsible for attenuation of virus neurovirulence in an infectious cDNA clone of the Oshima strain of tick-borne encephalitis virus
    Daisuke Hayasaka
    Department of Environmental Veterinary Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Gen Virol 85:1007-18. 2004
    ..Comparative neurovirulence tests revealed how the accumulation of individual mutations (E-S(40)-->P, NS5-V(378)-->A and NS5-R(674)-->K) can result in the attenuation of a virus...
  6. ncbi [Phylogenetic analysis and pathogenicity of tick-borne encephalitis virus from Japan and far-east Russia]
    Ikuo Takashima
    Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Uirusu 55:35-44. 2005
    ..One amino acid change in envelope protein and 2 amino acid changes in Ns5 protein showed a synergistic effect on reduced neurovirulence in mice...
  7. ncbi Immunopathogenesis of hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome: Do CD8+ T cells trigger capillary leakage in viral hemorrhagic fevers?
    Masanori Terajima
    Immunol Lett 113:117-20. 2007
    ..CD8+ T cells may be a potential target for therapy of some viral hemorrhagic fevers...