Hiroshi Hasegawa


Affiliation: Tokyo University of Pharmacy and Life Science
Country: Japan


  1. request reprint
    Hasegawa H, Akira K, Shinohara Y, Kasuya Y, Hashimoto T. Kinetics of intramolecular acyl migration of 1beta-O-acyl glucuronides of (R)- and (S)-2-phenylpropionic acids. Biol Pharm Bull. 2001;24:852-5 pubmed
    ..The value of the free energy of activation at 310 K for (R)-1PG (99.67 kJ/mol) was smaller than that of (S)-IPG (101.60kJ/mol), suggesting that (R)-IPG showed thermodynamically higher reactivity in acyl migration than (S)-1PG. ..
  2. request reprint
    Hasegawa H, Matsukawa T, Shinohara Y, Konno R, Hashimoto T. Role of renal D-amino-acid oxidase in pharmacokinetics of D-leucine. Am J Physiol Endocrinol Metab. 2004;287:E160-5 pubmed
    ..77, whereas that in five-sixths-nephrectomized rats was 0.25. The elimination behavior of d-[(2)H(7)]leucine observed in rats suggested that kidney was the principal organ responsible for converting d-leucine to KIC. ..