H Hanyu

Summary

Affiliation: Tokyo Medical University
Country: Japan

Publications

  1. ncbi request reprint Differences in regional cerebral blood flow patterns in male versus female patients with Alzheimer disease
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    AJNR Am J Neuroradiol 25:1199-204. 2004
  2. ncbi request reprint [Awareness of memory deficits in patients with dementias: a study with the Everyday Memory Checklist]
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Nihon Ronen Igakkai Zasshi 44:463-9. 2007
  3. doi request reprint Prediction of response to donepezil in Alzheimer's disease: combined MRI analysis of the substantia innominata and SPECT measurement of cerebral perfusion
    Hidekazu Kanetaka
    Department of Geriatric Medicine, Tokyo Medical University, Japan
    Nucl Med Commun 29:568-73. 2008
  4. ncbi request reprint [Alzheimer's disease]
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University
    Nihon Rinsho 68:330-4. 2010
  5. doi request reprint Regional differences in cortical benzodiazepine receptors of Alzheimer, vascular, and mixed dementia patients
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    J Neurol Sci 323:71-6. 2012
  6. doi request reprint Voxel-based magnetic resonance imaging study of structural brain changes in patients with idiopathic REM sleep behavior disorder
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Parkinsonism Relat Disord 18:136-9. 2012
  7. doi request reprint Neuroanatomical correlates of unawareness of memory deficits in early Alzheimer's disease
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Dement Geriatr Cogn Disord 25:347-53. 2008
  8. doi request reprint The progression of cognitive deterioration and regional cerebral blood flow patterns in Alzheimer's disease: a longitudinal SPECT study
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    J Neurol Sci 290:96-101. 2010
  9. ncbi request reprint Comparative value of brain perfusion SPECT and [(123)I]MIBG myocardial scintigraphy in distinguishing between dementia with Lewy bodies and Alzheimer's disease
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku ku, Tokyo 160 0023, Japan
    Eur J Nucl Med Mol Imaging 33:248-53. 2006
  10. ncbi request reprint Favourable effects of nilvadipine on cognitive function and regional cerebral blood flow on SPECT in hypertensive patients with mild cognitive impairment
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Japan
    Nucl Med Commun 28:281-7. 2007

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Differences in regional cerebral blood flow patterns in male versus female patients with Alzheimer disease
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    AJNR Am J Neuroradiol 25:1199-204. 2004
    ..There may be some differences in the pathophysiology between men and women with Alzheimer disease (AD). This study was undertaken to explore the possible influence of sex on regional cerebral blood flow (rCBF) patterns in patients with AD...
  2. ncbi request reprint [Awareness of memory deficits in patients with dementias: a study with the Everyday Memory Checklist]
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Nihon Ronen Igakkai Zasshi 44:463-9. 2007
    ....
  3. doi request reprint Prediction of response to donepezil in Alzheimer's disease: combined MRI analysis of the substantia innominata and SPECT measurement of cerebral perfusion
    Hidekazu Kanetaka
    Department of Geriatric Medicine, Tokyo Medical University, Japan
    Nucl Med Commun 29:568-73. 2008
    ....
  4. ncbi request reprint [Alzheimer's disease]
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University
    Nihon Rinsho 68:330-4. 2010
    ..In addition, PPARgamma agonists have been shown to inhibit inflammatory gene expression, alter Abeta homeostasis and exhibit neuroprotective effects. PPARgamma agonists represent a new and potentially efficacious treatment of AD...
  5. doi request reprint Regional differences in cortical benzodiazepine receptors of Alzheimer, vascular, and mixed dementia patients
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    J Neurol Sci 323:71-6. 2012
    ....
  6. doi request reprint Voxel-based magnetic resonance imaging study of structural brain changes in patients with idiopathic REM sleep behavior disorder
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Parkinsonism Relat Disord 18:136-9. 2012
    ..In this study, we investigated structural brain changes using magnetic resonance imaging (MRI) in patients with idiopathic RBD (iRBD) to determine structural brain alterations associated with the disorder...
  7. doi request reprint Neuroanatomical correlates of unawareness of memory deficits in early Alzheimer's disease
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Dement Geriatr Cogn Disord 25:347-53. 2008
    ..To investigate neuroanatomical substrates of unawareness of memory deficits in patients with early Alzheimer's disease (AD)...
  8. doi request reprint The progression of cognitive deterioration and regional cerebral blood flow patterns in Alzheimer's disease: a longitudinal SPECT study
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    J Neurol Sci 290:96-101. 2010
    ..We examined the possible relationship between the rate of cognitive deterioration and regional cerebral blood flow (rCBF) patterns in patients with AD...
  9. ncbi request reprint Comparative value of brain perfusion SPECT and [(123)I]MIBG myocardial scintigraphy in distinguishing between dementia with Lewy bodies and Alzheimer's disease
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku ku, Tokyo 160 0023, Japan
    Eur J Nucl Med Mol Imaging 33:248-53. 2006
    ..The aim of this study was to compare the diagnostic value of these two methods for differentiation of DLB from Alzheimer's disease (AD)...
  10. ncbi request reprint Favourable effects of nilvadipine on cognitive function and regional cerebral blood flow on SPECT in hypertensive patients with mild cognitive impairment
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Japan
    Nucl Med Commun 28:281-7. 2007
    ..We compared the effects of nilvadipine and amlodipine on the cognitive function and regional cerebral blood flow (rCBF) in patients with mild cognitive impairment (MCI) and hypertension...
  11. doi request reprint Regional cerebral blood flow changes in patients with idiopathic REM sleep behavior disorder
    H Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Eur J Neurol 18:784-8. 2011
    ..Recent studies have shown an association between rapid eye movement sleep behavior disorder (RBD) and neurodegenerative disorders, especially alpha-synucleinopathies...
  12. ncbi request reprint MR features of the substantia innominata and therapeutic implications in dementias
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Nishishinjuku Shinjuku ku, Tokyo, Japan
    Neurobiol Aging 28:548-54. 2007
    ..Clinical response to cholinergic therapy may be partly attributable to damaged cholinergic neurons in AD and DLB, but not in VaD, suggesting differences in the therapeutic implication of cholinergic system degeneration...
  13. ncbi request reprint The role of 123I-metaiodobenzylguanidine myocardial scintigraphy in the diagnosis of Lewy body disease in patients with dementia in a memory clinic
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Dement Geriatr Cogn Disord 22:379-84. 2006
    ..The scintigraphy may provide a valuable and adjunctive method in the diagnosis of Lewy body disease and a differential diagnostic tool for patients with dementias...
  14. doi request reprint Japanese version of the Test Your Memory as a screening test in a Japanese memory clinic
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Psychiatry Res 190:145-8. 2011
    ..The TYM-J is useful for the diagnosis of AD and MCI, and can be applied as a screening test in a Japanese memory clinic...
  15. ncbi request reprint Differentiation of dementia with Lewy bodies from Alzheimer's disease using Mini-Mental State Examination and brain perfusion SPECT
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Neurol Sci 250:97-102. 2006
    ..Our findings will need to be substantiated in an independent and prospective study sample...
  16. ncbi request reprint Phenylephrine and pilocarpine eye drop test for dementia with Lewy bodies and Alzheimer's disease
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Neurosci Lett 414:174-7. 2007
    ..The pupil assay using combined phenylephrine and pilocarpine eye drop test may be useful in the detection of patients with DLB and AD and in distinguishing between them...
  17. doi request reprint Differences in clinical course between dementia with Lewy bodies and Alzheimer's disease
    H Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Eur J Neurol 16:212-7. 2009
    ..To investigate whether there may be differences in the clinical course and changes in cognitive progression between dementia with Lewy bodies (DLB) and Alzheimer's disease (AD)...
  18. doi request reprint The effect of education on rCBF changes in Alzheimer's disease: a longitudinal SPECT study
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Eur J Nucl Med Mol Imaging 35:2182-90. 2008
    ..To determine the relationship of differing levels of education on regional cerebral blood flow (rCBF) in patients with Alzheimer's disease (AD)...
  19. ncbi request reprint Are subjective memory complaints mandatory for the diagnosis of mild cognitive impairment?
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University
    Intern Med 46:791-2. 2007
  20. ncbi request reprint Magnetization transfer measurements of the hippocampus in the early diagnosis of Alzheimer's disease
    H Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, 160 0023, Tokyo, Japan
    J Neurol Sci 188:79-84. 2001
    ..MTR measurements may provide additional information in detecting structural damage of the hippocampus of AD and be helpful in providing improved diagnosis and early detection of AD...
  21. ncbi request reprint Magnetisation transfer measurements of the subcortical grey and white matter in Parkinson's disease with and without dementia and in progressive supranuclear palsy
    H Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Japan
    Neuroradiology 43:542-6. 2001
    ..This suggests that regional patterns of structural brain damage can be detected using the magnetisation transfer technique. Measurement of MTR in the subcortical grey and white matter may be useful in differential diagnosis...
  22. ncbi request reprint Deep gray matter hyperperfusion with occipital hypoperfusion in dementia with Lewy bodies
    T Sato
    Department of Geriatric Medicine, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Eur J Neurol 14:1299-301. 2007
    ..Our results suggest that the addition of deep gray matter hyperperfusion to occipital hypoperfusion may be useful in the clinical differentiation of DLB and AD...
  23. doi request reprint Telomere length shortening in patients with dementia with Lewy bodies
    K Kume
    Department of Geriatric Medicine, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Eur J Neurol 19:905-10. 2012
    ..To elucidate these changes, we set out to determine telomere length in peripheral leukocytes as well as the level of urinary 8-hydroxy-deoxyguanosine (8-OHdG) as a marker of oxidative stress in DLB...
  24. ncbi request reprint Atrophy of the substantia innominata on magnetic resonance imaging and response to donepezil treatment in Alzheimer's disease
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo 160 0023, Japan
    Neurosci Lett 319:33-6. 2002
    ..MRI analysis of the substantia innominata may be a simple and practical method for the selection of possible treatment responders...
  25. ncbi request reprint Regional cerebral blood flow patterns and response to donepezil treatment in patients with Alzheimer's disease
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Dement Geriatr Cogn Disord 15:177-82. 2003
    ..These results suggest that frontal function, as assessed by SPECT, affects the patient's response to treatment with donepezil. Measuring rCBF may aid in the selection of possible treatment responders...
  26. doi request reprint Longitudinal patterns of unawareness of memory deficits in mild Alzheimer's disease
    Tomotaka Akai
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Geriatr Gerontol Int 9:16-20. 2009
    ..However, less is known about the longitudinal progression of this phenomenon. We examined the longitudinal evolution of unawareness in patients with mild AD to determine whether impaired awareness progresses with cognitive decline...
  27. ncbi request reprint Atrophy of the substantia innominata on magnetic resonance imaging predicts response to donepezil treatment in Alzheimer's disease patients
    Yuriko Tanaka
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Dement Geriatr Cogn Disord 16:119-25. 2003
    ..We conclude that atrophy of the substantia innominata on MRI helps to predict response to donepezil treatment in patients with AD...
  28. ncbi request reprint [Concept and clinical presentation of mild cognitive impairment]
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Brain Nerve 62:719-25. 2010
    ..In this review, I have discussed the most current aspects related to the concept and clinical presentation of MCI, with emphasis possible risk factors for conversion to dementia...
  29. ncbi request reprint MR analysis of the substantia innominata in normal aging, Alzheimer disease, and other types of dementia
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    AJNR Am J Neuroradiol 23:27-32. 2002
    ....
  30. ncbi request reprint [Diagnosis of Alzheimer's disease using brain SPECT with three-dimensional stereotactic surface projections]
    H Hanyu
    Department of Geriatric Medicine, Tokyo Medical University
    Rinsho Shinkeigaku 41:582-7. 2001
    ..These results suggest that SPECT with 3D-SSP provides an sensitive as well as accurate tool for the diagnosis of AD...
  31. ncbi request reprint [A patient with early Alzheimer's disease who showed improvement of cognitive function and cerebral perfusion by combined therapy of nilvadipine and PPAR gamma agonists]
    Tomohiko Sato
    Department of Geriatric Medicine, Tokyo Medical University
    Nihon Ronen Igakkai Zasshi 45:428-33. 2008
    ....
  32. ncbi request reprint Differentiation of dementia with Lewy bodies from Alzheimer's disease using brain SPECT
    Soichiro Shimizu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Dement Geriatr Cogn Disord 20:25-30. 2005
    ..Objective and quantitative CBF measurement in the medial occipital lobe may be useful in the clinical differentiation of DLB and AD...
  33. ncbi request reprint [Characteristics of MRI features in Alzheimer's disease patients predicting response to donepezil treatment]
    Yuriko Tanaka
    Department of Geriatric Medicine, Tokyo Medical University
    Nihon Ronen Igakkai Zasshi 40:261-6. 2003
    ..These results suggest that AD patients who show more severe cholinergic dysfunction and less severe structural damage of the hippocampus and parahippocampus as shown on MRI are likely to respond to donepezil treatment...
  34. ncbi request reprint SPECT follow-up study of cerebral blood flow changes during Donepezil therapy in patients with Alzheimer's disease
    Soichiro Shimizu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Neuroimaging 16:16-23. 2006
    ..We attempted to evaluate the possible correlation between regional cerebral blood flow (rCBF) differences in patients with AD and response to donepezil hydrochloride (Donepezil) therapy...
  35. ncbi request reprint Cerebral blood flow patterns in Binswanger's disease: a SPECT study using three-dimensional stereotactic surface projections
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku, Tokyo 160 0023, Japan
    J Neurol Sci 220:79-84. 2004
    ..In the future, a longitudinal study including pathology will be needed to determine whether these patients have coexisting AD pathology...
  36. ncbi request reprint Differences in magnetization transfer ratios of the hippocampus between dementia with Lewy bodies and Alzheimer's disease
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku ku, Tokyo 160 0023, Japan
    Neurosci Lett 380:166-9. 2005
    ..These results may reflect underlying histopathological differences with less severe neuronal degeneration in the hippocampus of DLB. MTR measurement of the hippocampus may contribute to the clinical differentiation between DLB and AD...
  37. ncbi request reprint Effect of age on regional cerebral blood flow patterns in Alzheimer's disease patients
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishihsinjuku, Shinjuku, Tokyo, 160 0023, Japan
    J Neurol Sci 209:25-30. 2003
    ....
  38. ncbi request reprint [Regional cerebral blood flow patterns in extremely elderly patients with Alzheimer's disease]
    Kentaro Hirao
    Department of Geriatric Medicine, Tokyo Medical University
    Nihon Ronen Igakkai Zasshi 45:408-13. 2008
    ....
  39. ncbi request reprint [Prediction of the development of Alzheimer disease in patients with mild cognitive impairment]
    Kazumasa Kume
    Department of Geriatric Medicine, Tokyo Medical University
    Nihon Ronen Igakkai Zasshi 47:147-52. 2010
    ....
  40. ncbi request reprint Increased blood-brain barrier permeability in white matter lesions of Binswanger's disease evaluated by contrast-enhanced MRI
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Dement Geriatr Cogn Disord 14:1-6. 2002
    ..These results suggest that BBB permeability increases in areas of PVH in BD and that a BBB dysfunction is related to a progression of cognitive impairment...
  41. ncbi request reprint Cerebral microbleeds in Binswanger's disease: a gradient-echo T2*-weighted magnetic resonance imaging study
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo 160 0023, Japan
    Neurosci Lett 340:213-6. 2003
    ..Patients with BD exhibited a high frequency and number of MBs, indicating advanced bleeding-prone microangiopathy within the brain, which should be taken into account in treatment and management...
  42. ncbi request reprint [Elderly case of isolated ACTH deficiency presenting with depression and digestive symptoms]
    Kentaro Hirao
    Department of Geriatric Medicine, Tokyo Medical University
    Nihon Ronen Igakkai Zasshi 44:117-21. 2007
    ..In summary, we report an elderly case of isolated ACTH deficiency with nonspecific initial manifestations such as nausea, fatigue, and depression...
  43. ncbi request reprint Autoimmune hemolytic anemia in an elderly patient with primary Sjögren's syndrome
    Masayuki Kikawada
    Department of Geriatric Medicine, Tokyo Medical University, Japan
    Intern Med 44:1312-5. 2005
    ..Although the direct Coomb's test is often positive, the occurrence of autoimmune hemolytic anemia (AIHA) is rare. Here, we report an elderly patient with primary Sjögren's syndrome who developed AIHA during the clinical course...
  44. ncbi request reprint Differences in MR features of the substantia innominata between dementia with Lewy bodies and Alzheimer's disease
    Haruo Hanyu
    J Neurol 252:482-4. 2005
  45. ncbi request reprint Unawareness of memory deficits depending on cerebral perfusion pattern in mild cognitive impairment
    Haruo Hanyu
    J Am Geriatr Soc 55:470-1. 2007
  46. ncbi request reprint Difference in practice effects depending on cerebral perfusion pattern in mild cognitive impairment
    Haruo Hanyu
    Int J Geriatr Psychiatry 23:111-2. 2008
  47. ncbi request reprint Nilvadipine prevents cognitive decline of patients with mild cognitive impairment
    Haruo Hanyu
    Int J Geriatr Psychiatry 22:1264-6. 2007
  48. ncbi request reprint Cerebral microbleeds in Alzheimer's disease
    Haruo Hanyu
    J Neurol 250:1496-7. 2003
  49. ncbi request reprint Decreased cerebral blood flow and prognosis of Alzheimer's disease: a multicenter HMPAO-SPECT study
    Tsunehiko Nishimura
    Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji Sagaru, Kamigyo ku, Kyoto 602 8566, Japan
    Ann Nucl Med 21:15-23. 2007
    ..To determine the usefulness of brain perfusion SPECT for evaluating the severity and progression of Alzheimer's disease (AD)...