Toru Furukawa

Summary

Affiliation: Tokyo Women's Medical University
Country: Japan

Publications

  1. ncbi request reprint Clinical relevance of frozen diagnosis of ductal margins in surgery of bile duct cancer
    Toru Furukawa
    Institute of Integrated Medical Sciences, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, 162 8666, Japan
    J Hepatobiliary Pancreat Sci 21:459-62. 2014
  2. pmc A GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes
    Hirotake Komatsu
    Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Tokyo, Japan Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 9:e87875. 2014
  3. pmc Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas
    Toru Furukawa
    Institute for Integrated Medical Sciences, Institute of Gastroenterology, Deparment of Surgical Pathology, Tokyo Women s Medical University, Tokyo, Japan
    Sci Rep 1:161. 2011
  4. pmc Targeting of MAPK-associated molecules identifies SON as a prime target to attenuate the proliferation and tumorigenicity of pancreatic cancer cells
    Toru Furukawa
    Institute for Integrated Medical Sciences, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Mol Cancer 11:88. 2012
  5. ncbi request reprint The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer
    Masaharu Ishida
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Japan
    Dig Dis Sci 53:2576-82. 2008
  6. doi request reprint Association of epidermal growth factor receptor and mitogen-activated protein kinase with cystic neoplasms of the pancreas
    Yuko Kuboki
    International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Tokyo, Japan
    Mod Pathol 23:1127-35. 2010
  7. ncbi request reprint Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas
    Masaharu Ishida
    Department of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 35:348-52. 2007
  8. ncbi request reprint Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor-suppressor gene that suppresses angiogenesis
    Sumitaka Yamanaka
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Lab Invest 84:1339-51. 2004
  9. doi request reprint RNA interference targeting against S100A4 suppresses cell growth and motility and induces apoptosis in human pancreatic cancer cells
    Takahiro Tabata
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 390:475-80. 2009
  10. ncbi request reprint Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Mod Pathol 18:1034-42. 2005

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Clinical relevance of frozen diagnosis of ductal margins in surgery of bile duct cancer
    Toru Furukawa
    Institute of Integrated Medical Sciences, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, 162 8666, Japan
    J Hepatobiliary Pancreat Sci 21:459-62. 2014
    ....
  2. pmc A GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes
    Hirotake Komatsu
    Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Tokyo, Japan Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 9:e87875. 2014
    ..PK-8 cells expressing exogenous mutated GNAS may be an ideal in vitro model of IPMN. ..
  3. pmc Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas
    Toru Furukawa
    Institute for Integrated Medical Sciences, Institute of Gastroenterology, Deparment of Surgical Pathology, Tokyo Women s Medical University, Tokyo, Japan
    Sci Rep 1:161. 2011
    ..These results indicate that GNAS mutations are common and specific for IPMN, and activation of G-protein signaling appears to play a pivotal role in IPMN...
  4. pmc Targeting of MAPK-associated molecules identifies SON as a prime target to attenuate the proliferation and tumorigenicity of pancreatic cancer cells
    Toru Furukawa
    Institute for Integrated Medical Sciences, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Mol Cancer 11:88. 2012
    ..We hypothesized that knockdown of these MAPK-associated molecules could produce notable anticancer phenotypes...
  5. ncbi request reprint The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer
    Masaharu Ishida
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Japan
    Dig Dis Sci 53:2576-82. 2008
    ..These results suggest that PMAIP1 may play an important role in the progression of pancreatic cancer...
  6. doi request reprint Association of epidermal growth factor receptor and mitogen-activated protein kinase with cystic neoplasms of the pancreas
    Yuko Kuboki
    International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Tokyo, Japan
    Mod Pathol 23:1127-35. 2010
    ....
  7. ncbi request reprint Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas
    Masaharu Ishida
    Department of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 35:348-52. 2007
    ..The purpose of this study was to determine associations between the histological types and clinicopathological features in patients with IPMN...
  8. ncbi request reprint Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor-suppressor gene that suppresses angiogenesis
    Sumitaka Yamanaka
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Lab Invest 84:1339-51. 2004
    ..In summary, this study provides the first functional evidence of the existence of an additional tumor-suppressor gene(s) on chromosome 12, whose absence is responsible for the pathogenesis in pancreatic ductal carcinogenesis...
  9. doi request reprint RNA interference targeting against S100A4 suppresses cell growth and motility and induces apoptosis in human pancreatic cancer cells
    Takahiro Tabata
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 390:475-80. 2009
    ..Our present results suggest the possibility that the inhibition of S100A4 can be utilized in antitumor applications for patients with pancreatic cancer...
  10. ncbi request reprint Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Mod Pathol 18:1034-42. 2005
    ....
  11. doi request reprint The discrete nature and distinguishing molecular features of pancreatic intraductal tubulopapillary neoplasms and intraductal papillary mucinous neoplasms of the gastric type, pyloric gland variant
    Hiroshi Yamaguchi
    Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Tokyo, Japan Department of Pathology, Saitama International Medical Center, Saitama Medical University, Hidaka, Japan
    J Pathol 231:335-41. 2013
    ..The term 'intraductal tubular adenoma' should be eliminated and replaced with IPMN-PG...
  12. ncbi request reprint Functional analysis of chromosome 18 in pancreatic cancer: strong evidence for new tumour suppressor genes
    Liviu P Lefter
    Departments of Gastrointestinal Surgery and Molecular Pathology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aoba ku, Sendai 980 8574, Japan
    Asian J Surg 27:85-92. 2004
    ..This study was intended to provide functional evidence for the existence of new tumour suppressor gene(s) located on chromosome 18...
  13. ncbi request reprint Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis
    Masaharu Ishida
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Sendai, Japan
    World J Gastroenterol 13:4593-7. 2007
    ....
  14. ncbi request reprint DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro
    Tatsuo Hata
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Int J Oncol 24:513-20. 2004
    ..These results indicate that DSCP1 is a stress-inducible gene in both a TP53 dependent and independent manner and that its protein product can inhibit cancer cell growth...
  15. ncbi request reprint Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreatoduodenectomy for cancer of Vater's papilla associated with intraductal papillary-mucinous adenoma
    Masaharu Ishida
    Department of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryocho, Aobaku, Sendai, 980 8574, Japan
    J Hepatobiliary Pancreat Surg 14:522-5. 2007
    ..These findings suggest that careful surveillance of the gastrointestinal tract and careful follow up are necessary for IPMN, because an IPMN could be associated with other gastrointestinal tract malignancies...
  16. doi request reprint Synchronous and metachronous extrapancreatic malignant neoplasms in patients with intraductal papillary-mucinous neoplasm of the pancreas
    Masaharu Ishida
    Department of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Pancreatology 8:577-82. 2008
    ..Recently there have been some reports on extrapancreatic malignant neoplasms (EPM) occurring in patients with IPMN. The purpose of this study was to discover the characteristic features of IPMN with EPM compared with IPMN without EPM...
  17. doi request reprint Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas
    Toru Furukawa
    Institute for Integrated Medical Sciences, Tokyo Women s Medical University 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Gut 60:509-16. 2011
    ..The clinicopathological significance of four morphological types of intraductal papillary mucinous neoplasms of the pancreas (IPMNs; gastric, intestinal, pancreatobiliary and oncocytic) was assessed...
  18. doi request reprint Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas
    Hiroshi Yamaguchi
    Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Tokyo, Japan
    Am J Surg Pathol 35:1812-7. 2011
    ..In contrast, the mutation in KRAS seems to play a major role in IPMNs but not in ITPNs. The activated phosphatidylinositol 3-kinase pathway may be a potential target for molecular diagnosis and therapy of ITPNs...
  19. doi request reprint Upregulation of IGF2 is associated with an acquired resistance for cis-diamminedichloroplatinum in human head and neck squamous cell carcinoma
    Takenori Ogawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi, 980 8575, Japan
    Eur Arch Otorhinolaryngol 267:1599-606. 2010
    ..These findings suggest the possibility for developing a new strategy for treating patients with HNSCC, particularly those with acquired CDDP resistance, by combining CDDP with inhibition of the IGF2 pathway...
  20. ncbi request reprint Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer
    Hidekazu Oishi
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 39:897-903. 2010
    ..In this study, we examined the effects of the DLL4-Notch signaling on tumor angiogenesis using the neutralizing monoclonal antibodies against DLL4...
  21. ncbi request reprint Molecular genetics of intraductal papillary-mucinous neoplasms of the pancreas
    Toru Furukawa
    International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Tokyo 162 8666, Japan
    J Hepatobiliary Pancreat Surg 14:233-7. 2007
    ..Alterations of KRAS, AKT/PKB, CDKN2A, TP53, SMAD4, STK11/LKB1, and DUSP6, and other molecular alterations, including global expression studies as well as their clinical implications, are discussed...
  22. doi request reprint Identification of commensal flora-associated antigen as a pathogenetic factor of autoimmune pancreatitis
    Naoko Yanagisawa
    Department of Microbiology and Immunology, Tokyo Women s Medical University, Japan
    Pancreatology 14:100-6. 2014
    ..The pathogenetic factors of AIP have not been fully elucidated. We previously established a mouse model of AIP using chronic exposure to a commensal bacteria, Escherichia coli...
  23. ncbi request reprint The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma
    Makoto Sunamura
    Department of Gastroenterological Surgery, Tohoku University School of Medicine, Sendai, Japan
    Pancreas 28:311-6. 2004
    ..It was revealed that there was increased expression of 4 genes relating to apoptosis in the 18 chromosome hybrids cells compared with the parental cells. We are now analyzing the function of these genes...
  24. doi request reprint Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-gamma and interleukin-10 production
    Yoshinori Sasaki
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int Arch Allergy Immunol 148:239-50. 2009
    ..A series of epidemiological and experimental studies have suggested that diesel exhaust particles (DEP) and formaldehyde (FA) may help trigger T helper type 2 (Th2)-mediated allergic responses...
  25. ncbi request reprint APAF-1-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line
    Takenori Ogawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 306:537-43. 2003
    ..These results indicate that APAF-1-ALT is a molecule that is deficient and impeded for mediating apoptosis and that it may contribute to the resistance to DNA damage-induced treatment observed in LNCaP...
  26. ncbi request reprint Molecular pathology of pancreatic cancer: in quest of tumor suppressor genes
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Pancreas 28:253-6. 2004
    ..We continue work to more completely understand the complex molecular mechanisms of pancreatic carcinogenesis and to apply the information gained to the clinical treatment of pancreatic cancer...
  27. ncbi request reprint A case of solid pseudopapillary neoplasm of the pancreas presenting with left-sided extrahepatic portal hypertension
    Shinichi Nakamura
    Institute of Gastroenterology, Tokyo Women s Medical University, Tokyo, Japan
    Intern Med 49:1749-53. 2010
    ..This is a rare case of SPN associated with splenic vein occlusion and left-sided extrahepatic portal hypertension...
  28. ncbi request reprint Clinical and pathological features of solid pseudopapillary neoplasms of the pancreas at a single institution
    Shuji Suzuki
    Department of Surgery, Institute of Gastroenterology, Tokyo Women s Medical University, Tokyo, Japan
    Dig Surg 31:143-50. 2014
    ..There were no significant differences between genders except for the cystic component on radiological imaging. © 2014 S. Karger AG, Basel. ..
  29. ncbi request reprint Prognostic relevance of ductal margins in operative resection of bile duct cancer
    Ryota Higuchi
    Department of Surgery, Institute of Gastroenterology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Surgery 148:7-14. 2010
    ..The purpose of this study was to assess the prognostic significance of ductal margins in patients with bile duct carcinoma...
  30. doi request reprint MicroRNAs associated with mitogen-activated protein kinase in human pancreatic cancer
    Yushi Ikeda
    International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Tokyo, Japan
    Mol Cancer Res 10:259-69. 2012
    ..These results indicate that activation of MAPK may play a significant role in aberrant expression of miRNAs and their associated phenotypes in pancreatic cancer...
  31. ncbi request reprint Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryomachi, Sendai, 980 8575, Japan
    Virchows Arch 447:794-9. 2005
    ..These definitions can be used for further analyses of the clinicopathological significance of the variations of IPMN...
  32. doi request reprint Feedback regulation of DUSP6 transcription responding to MAPK1 via ETS2 in human cells
    Toru Furukawa
    International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Tokyo, Japan
    Biochem Biophys Res Commun 377:317-20. 2008
    ..Because ETS2 is a direct target of MAPK, these results indicate that intron 1 of DUSP6 plays a crucial role in transcriptional regulation of DUSP6 in a feedback loop manner responding to MAPK1 via ETS2 in human cells...
  33. doi request reprint Duodenum-preserving total pancreatectomy for pancreatic neoplasms
    Takashi Hatori
    Department of Surgery, Institute of Gastroenterology, Tokyo Women s Medical University, 8 1 Shinjuku ku, Tokyo, 162 8666, Japan
    J Hepatobiliary Pancreat Sci 17:824-30. 2010
    ..Recently, we performed four duodenum-preserving TPs (DPTPs) on patients with low-grade malignant neoplasms of the entire pancreas and we introduce our operative technique and results herein...
  34. doi request reprint A mouse model of autoimmune pancreatitis with salivary gland involvement triggered by innate immunity via persistent exposure to avirulent bacteria
    Ikuko Haruta
    Department of Microbiology and Immunology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Lab Invest 90:1757-69. 2010
    ..These slowly progressive steps may lead to the establishment of AIP and associated extrapancreatic lesions. Our model might be useful for clarifying the pathogenesis of AIP...
  35. ncbi request reprint Cystic neoplasm of the pancreas: a Japanese multiinstitutional study of intraductal papillary mucinous tumor and mucinous cystic tumor
    Yutaka Suzuki
    Department of Surgery, Kyorin University School of Medicine, Tokyo, Japan
    Pancreas 28:241-6. 2004
    ..5% in invasive carcinoma cases. In conclusion, IPMT and MCT show distinct clinicopathologic and prognostic differences. The results from this study may contribute to the diagnosis and treatment of IPMT and MCT...
  36. ncbi request reprint Mutation of junctophilin type 2 associated with hypertrophic cardiomyopathy
    Yoshihisa Matsushita
    International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, 162 8666, and Department of Pediatrics, Kagoshima Seikyo General Hospital, Japan
    J Hum Genet 52:543-8. 2007
    ..022). This result was still significant after Bonferroni's correction for multiple comparisons (P=0.044). To the best of our knowledge, this is the first report on JPH2 mutation associated with HCM...
  37. doi request reprint Molecular targeting therapy for pancreatic cancer: current knowledge and perspectives from bench to bedside
    Toru Furukawa
    International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Tokyo, Japan
    J Gastroenterol 43:905-11. 2008
    ....
  38. doi request reprint Transrepression activity of T-box1 in a gene regulation network in mouse cells
    Karen K L Yee
    Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Tokyo 162 8666, Japan
    Gene 510:162-70. 2012
    ..Hence, the loss of TBX1 transrepression activity could be associated with the disease phenotypes of patients with DGS/CAFS...
  39. doi request reprint Molecular pathology of pancreatic cancer: implications for molecular targeting therapy
    Toru Furukawa
    International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Shinjuku, Tokyo, Japan
    Clin Gastroenterol Hepatol 7:S35-9. 2009
    ..Understanding the mechanisms of carcinogenesis could help researchers find the Achilles' heel of pancreatic cancer. Molecular targeting is a promising strategy for curing this devastating disease...
  40. pmc Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Am J Pathol 162:1807-15. 2003
    ..These results show that DUSP6 exerts apparent tumor-suppressive effects in vitro and suggest that DUSP6 is a strong candidate tumor suppressor gene at 12q22 locus...