T Fujita

Summary

Affiliation: Tokyo Metropolitan Institute of Gerontology
Country: Japan

Publications

  1. ncbi Expression and structure of senescence marker protein-30 (SMP30) and its biological significance
    T Fujita
    Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
    Mech Ageing Dev 107:271-80. 1999
  2. ncbi Hepatic and renal expression of senescence marker protein-30 and its biological significance
    T Fujita
    Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
    J Gastroenterol Hepatol 13:S124-31. 1998
  3. ncbi Gene regulation of senescence marker protein-30 (SMP30): coordinated up-regulation with tissue maturation and gradual down-regulation with aging
    T Fujita
    Department of Molecular Biology, Tokyo Metropolitan Institute of Gerontology, Japan
    Mech Ageing Dev 87:219-29. 1996
  4. ncbi Isolation and characterization of genomic and cDNA clones encoding mouse senescence marker protein-30 (SMP30)
    T Fujita
    Department of Molecular Biology, Tokyo Metropolitan Institute of Gerontology, Japan
    Biochim Biophys Acta 1308:49-57. 1996
  5. ncbi Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome
    T Fujita
    Department of Molecular Biology, Tokyo Metropolitan Institute of Gerontology, Japan
    Biochim Biophys Acta 1263:249-52. 1995
  6. ncbi Senescence marker protein-30 (SMP30) rescues cell death by enhancing plasma membrane Ca(2+)-pumping activity in Hep G2 cells
    T Fujita
    Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
    Biochem Biophys Res Commun 250:374-80. 1998
  7. ncbi Purification of senescence marker protein-30 (SMP30) and its androgen-independent decrease with age in the rat liver
    T Fujita
    Department of Molecular Biology, Tokyo Metropolitan Institute of Gerontology, Japan
    Biochim Biophys Acta 1116:122-8. 1992
  8. ncbi Regulatory effects of senescence marker protein 30 on the proliferation of hepatocytes
    T Ishigami
    Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Pathol Int 51:491-7. 2001
  9. ncbi Isolation of cDNA clone encoding rat senescence marker protein-30 (SMP30) and its tissue distribution
    T Fujita
    Department of Molecular Biology, Tokyo Metropolitan Institute of Gerontology, Japan
    Biochim Biophys Acta 1132:297-305. 1992
  10. ncbi PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor
    M Takahashi
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    EMBO J 15:4254-61. 1996

Collaborators

Detail Information

Publications60

  1. ncbi Expression and structure of senescence marker protein-30 (SMP30) and its biological significance
    T Fujita
    Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
    Mech Ageing Dev 107:271-80. 1999
    ..In this review, we present a overview of SMP30 in its structure, expression and possible physiological roles. We also discuss hypothetical role(s) of SMP30 in aging and Ca2+ homeostasis...
  2. ncbi Hepatic and renal expression of senescence marker protein-30 and its biological significance
    T Fujita
    Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
    J Gastroenterol Hepatol 13:S124-31. 1998
    ..This review gives an overview of SMP30 in its structure, expression and possible physiological function(s). A hypothetical role of SMP30 in ageing and calcium homeostasis is also discussed...
  3. ncbi Gene regulation of senescence marker protein-30 (SMP30): coordinated up-regulation with tissue maturation and gradual down-regulation with aging
    T Fujita
    Department of Molecular Biology, Tokyo Metropolitan Institute of Gerontology, Japan
    Mech Ageing Dev 87:219-29. 1996
    ..The high expression of SMP30 in the tissue-maturing process and adulthood suggests that SMP30 may be required for the maintenance of highly differentiated hepatic and renal functions...
  4. ncbi Isolation and characterization of genomic and cDNA clones encoding mouse senescence marker protein-30 (SMP30)
    T Fujita
    Department of Molecular Biology, Tokyo Metropolitan Institute of Gerontology, Japan
    Biochim Biophys Acta 1308:49-57. 1996
    ..These results provide important clues for understanding the regulatory mechanism of SMP30 gene expression and its relationship to aging...
  5. ncbi Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome
    T Fujita
    Department of Molecular Biology, Tokyo Metropolitan Institute of Gerontology, Japan
    Biochim Biophys Acta 1263:249-52. 1995
    ..3-q11.2 segment of the X chromosome. This gene thus could be a candidate for one of the X-linked diseases mapped to this regions...
  6. ncbi Senescence marker protein-30 (SMP30) rescues cell death by enhancing plasma membrane Ca(2+)-pumping activity in Hep G2 cells
    T Fujita
    Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
    Biochem Biophys Res Commun 250:374-80. 1998
    ..These results suggest that SMP30 regulates [Ca2+]i by modulating plasma membrane Ca(2+)-pumping activity, and thus down-regulation of SMP30 during aging may contribute to deterioration of cellular functions...
  7. ncbi Purification of senescence marker protein-30 (SMP30) and its androgen-independent decrease with age in the rat liver
    T Fujita
    Department of Molecular Biology, Tokyo Metropolitan Institute of Gerontology, Japan
    Biochim Biophys Acta 1116:122-8. 1992
    ..Although the amount of SMP30 in the liver was relatively large and the tissue distribution was characteristic, no known protein corresponds to this protein...
  8. ncbi Regulatory effects of senescence marker protein 30 on the proliferation of hepatocytes
    T Ishigami
    Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Pathol Int 51:491-7. 2001
    ..Suppressive activity of SMP 30 cDNA was shown in cultured hepatoblastic cells. Our results suggest that SMP 30 performs a regulatory function in liver regeneration...
  9. ncbi Isolation of cDNA clone encoding rat senescence marker protein-30 (SMP30) and its tissue distribution
    T Fujita
    Department of Molecular Biology, Tokyo Metropolitan Institute of Gerontology, Japan
    Biochim Biophys Acta 1132:297-305. 1992
    ....
  10. ncbi PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor
    M Takahashi
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    EMBO J 15:4254-61. 1996
    ..This autosomal location would explain why PIG-B is not involved in the defective GPI anchor synthesis in paroxysmal nocturnal hemoglobinuria, which is always caused by a somatic mutation of the X-linked PIG-A gene...
  11. ncbi Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats
    T Ogihara
    Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan
    Diabetes 50:573-83. 2001
    ....
  12. ncbi Clusterin is up-regulated in glomerular mesangial cells in complement-mediated injury
    K Yamada
    Division of Nephrology and Endocrinology, Department of Internal Medicine, University of Tokyo School of Medicine, Tokyo, Japan
    Kidney Int 59:137-46. 2001
    ..CONCLUSION: Clusterin was induced in glomerular mesangial cells during the course of immune-mediated injuries. This up-regulation of clusterin may play a critical role in protecting mesangial cells from complement attack...
  13. ncbi Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress
    S F Yan
    Department of Surgery, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Nat Med 6:1355-61. 2000
    ..These studies define a central and unifying role for Egr-1 activation in the pathogenesis of ischemic tissue damage...
  14. ncbi Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines
    N Tanaka
    Department of Microbiology and Immunology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Biol Chem 274:19129-35. 1999
    ..These results suggest that AMSH plays a critical role in the cytokine-mediated intracellular signal transduction downstream of the Jak2/Jak3.STAM complex...
  15. ncbi Functional reconstitution of the angiotensin II type 2 receptor and G(i) activation
    J L Hansen
    Laboratory for Molecular Cardiology and the Department of Medicine B, University of Copenhagen, Denmark
    Circ Res 87:753-9. 2000
    ..In combination with previous observations, these results show that the AT(2) receptor is fully capable of activating G(i) and provides a new tool for exploring AT(2) receptor pharmacology and interactions with G-protein trimers...
  16. ncbi Complex formation between hepatitis C virus core protein and p21Waf1/Cip1/Sdi1
    F Wang
    Department of Microbiology, International Center for Medical Research, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Biochem Biophys Res Commun 273:479-84. 2000
    ..Due to the close vicinity of the binding sites, however, Core and PCNA competed with each other when interacting with p21. The distinct interaction between Core and p21 may provide a new aspect to the studies of HCV pathogenesis...
  17. ncbi Potentiation of endogenous fibrinolysis and rescue from lung ischemia/reperfusion injury in interleukin (IL)-10-reconstituted IL-10 null mice
    K Okada
    Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 275:21468-76. 2000
    ..Ischemia-driven IL-10 expression confers postischemic pulmonary protection by augmenting endogenous fibrinolytic mechanisms...
  18. ncbi PDZ domain-dependent suppression of NF-kappaB/p65-induced Abeta42 production by a neuron-specific X11-like protein
    S Tomita
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 275:13056-60. 2000
    ..Our finding indicates NF-kappaB and X11L may, in novel way, regulate Abeta production in neuronal cells. Targeting X11L by specific therapy may provide the possibility to control the progression of AD...
  19. ncbi Role of the renal kallikrein-kinin system in the development of salt-sensitive hypertension
    M Katori
    Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Biol Chem 382:61-4. 2001
    ..In conclusion, the renal kallikrein-kinin system works as a safety valve for excess sodium intake...
  20. ncbi PACT, a double-stranded RNA binding protein acts as a positive regulator for type I interferon gene induced by Newcastle disease virus
    T Iwamura
    Department of Tumor Cell Biology, Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8613, Japan
    Biochem Biophys Res Commun 282:515-23. 2001
    ..Thus the observed effect of PACT is novel and PACT is involved in the regulation of viral replication and results in a marked increase of cellular IFN-beta gene expression...
  21. ncbi Renal L-type fatty acid-binding protein mediates the bezafibrate reduction of cisplatin-induced acute kidney injury
    K Negishi
    Department of Nephrology and Endocrinology, Hemodialysis and Apheresis, University Hospital, University of Tokyo, Tokyo, Japan
    Kidney Int 73:1374-84. 2008
    ..Our study shows that the bezafibrate-mediated upregulation of proximal tubule L-FABP plays a pivotal role in the reduction of cisplatin-induced acute kidney injury...
  22. ncbi Carbohydrate-binding specificities of mouse ficolin A, a splicing variant of ficolin A and ficolin B and their complex formation with MASP-2 and sMAP
    Y Endo
    Department of Immunology, Fukushima Medical University School of Medicine, Japan
    Immunogenetics 57:837-44. 2005
    ..These results suggest that ficolin A and its variant function as recognition molecules of the lectin pathway, and ficolin B plays a distinct role through its unique carbohydrate-binding specificity...
  23. ncbi Involvement of retinoic acid-inducible gene-I in the IFN-{gamma}/STAT1 signalling pathway in BEAS-2B cells
    T Imaizumi
    Dept of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Eur Respir J 25:1077-83. 2005
    ..It is concluded that retinoic acid-inducible gene-I may play an important role in the regulation of immunological reactions in bronchial epithelial cells elicited by interferon-gamma...
  24. ncbi Severity dependent up-regulations of LOX-1 and MCP-1 in early sclerotic changes of common carotid arteries in spontaneously hypertensive rats
    Y Hamakawa
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Japan
    Neurol Res 26:767-73. 2004
    ..Activations of LOX-1 and MCP-1 are collectively involved in the early stage of atherosclerosis...
  25. ncbi Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth
    K Miyoshi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Japan
    Mol Psychiatry 8:685-94. 2003
    ..As there is a high level of DISC1 expression in developing rat brain, dysfunction of DISC1 may confer susceptibility to psychiatric illnesses through abnormal development of the nervous system...
  26. ncbi Down-regulation of Lsm1 is involved in human prostate cancer progression
    S Takahashi
    First Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Br J Cancer 86:940-6. 2002
    ..These results suggest that Lsm1 is deeply involved in prostate cancer progression through its down-regulation, independent of any gene mutation...
  27. ncbi Hepatic parenchymal enhancement in the cirrhotic liver: evaluation by triple-phase dynamic MRI
    T Fujita
    Department of Radiology, Ube Industries Central Hospital, 750, Nishikiwa, Ube, Yamaguchi 7550151, Japan
    Abdom Imaging 27:29-33. 2002
    ..05). CONCLUSION: The enhancement of cirrhotic liver parenchyma is greater than that of the normal liver parenchyma at every phase of triple-phase dynamic MR imaging...
  28. ncbi Amino acid substitution analyses of the DNA contact region, two amphipathic alpha-helices and a recognition-helix-like helix outside the dimeric beta-barrel of Epstein-Barr virus nuclear antigen 1
    T Fujita
    Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan
    Intervirology 44:271-82. 2001
    ..Alpha-helix I477 is indispensable for oriP binding, and alpha-helix III568 contributes to the homodimeric structure of EBNA-1. Alpha-helix II514 contributes to oriP binding, perhaps changing its alignment with DNA...
  29. ncbi Cryoprecipitate of patients with cryoglobulinemic glomerulonephritis contains molecules of the lectin complement pathway
    I Ohsawa
    Internal Medicine II, Nihon University School of Medicine, Tokyo, Japan
    Clin Immunol 101:59-66. 2001
    ..The serum C4 level was significantly reduced. These results indicate that immune complex formation involves molecules of the lectin pathway and leads to organ damage in cryoglobulinemic glomerulonephritis...
  30. ncbi Transactivation of core binding factor alpha1 as a basic mechanism to trigger parathyroid hormone-induced osteogenesis
    T Fujita
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan
    Jpn J Pharmacol 86:405-16. 2001
    ..These results obtained by a concerted study in vitro and in vivo suggest that PTH triggers its osteogenic action via promotion of the transactivation of Cbfa1...
  31. ncbi Protective role of nitric oxide in a model of thrombotic microangiopathy in rats
    J Shao
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    J Am Soc Nephrol 12:2088-97. 2001
    ..The absence of effects with L-NIL treatment suggests a minor role for inducible NOS in this model. These results suggest that production of NO, most likely by endothelial cells, is an important protective mechanism in TMA...
  32. ncbi Augmentation of megakaryocytopoiesis within the hematopoietic microenvironment of human granulocyte colony-stimulating factor transgenic mice
    T Fujita
    Department of Pathology, Keio University School of Medicine, Tokyo, Japan
    Exp Hematol 29:1010-8. 2001
    ..We examined the characteristics of megakaryocytes and megakaryocyte progenitor cells in these mice...
  33. ncbi The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3
    C Stover
    Department of Microbiology and Immunology, University of Leicester, Leicester, UK
    Genes Immun 2:119-27. 2001
    ....
  34. ncbi Tissue-specific changes of type 1 angiotensin II receptor and angiotensin-converting enzyme mRNA in angiotensinogen gene-knockout mice
    K Tamura
    Department of Dermatology, Yokohama City University School of Medicine, Yokohama 236, Japan
    J Endocrinol 160:401-8. 1999
    ..Thus, expression of AT1 and ACE is regulated by salt loading in a tissue-specific manner that appears to be mediated, at least partly, by a mechanism other than changes in the circulating or tissue levels of angiotensin peptides...
  35. ncbi Genomic organization and regulation of expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene
    M Nagase
    Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Bunkyo ku, Tokyo 112 0015, Japan
    J Biol Chem 273:33702-7. 1998
    ..These data provide important information for elucidating the molecular mechanisms of LOX-1 gene regulation and suggest a role for LOX-1 in the pathophysiology of atherosclerotic cardiovascular disease...
  36. ncbi Molecular cloning and characterization of murine IL-12 genes
    T Yoshimoto
    Department of Allergology, University of Tokyo, Japan
    J Immunol 156:1082-8. 1996
    ..Thus, the characteristics of promoter regions of p40 and p35 genes are quite different, and this would account for the different regulations of p40 and p35 expression...
  37. ncbi The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner
    G P Nolan
    Rockefeller University, New York, New York 10021
    Mol Cell Biol 13:3557-66. 1993
    ..Bcl-3 appears to be a nuclear, I kappa B-related molecule that regulates the activity of homodimeric nuclear p50 and its homolog p52...
  38. ncbi Characterization of the DNA binding domain of the mouse IRF-2 protein
    K Uegaki
    Institute for Protein Research, Osaka University, Japan
    Protein Eng 6:195-200. 1993
    ..These results showed that this peptide fragment, IRF-2(113), may be a good material for investigation of the DNA binding domain of IRF-2 and of the DNA-protein interaction...
  39. ncbi The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers
    T Fujita
    Rockefeller University, New York, New York 10021
    Genes Dev 7:1354-63. 1993
    ..These results strongly suggest that BCL-3 can act as a transcriptional coactivator, acting through DNA-bound p50 homodimers...
  40. ncbi The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms
    M L Scott
    Rockefeller University, New York, New York 10021
    Genes Dev 7:1266-76. 1993
    ..Thus, p65 and I kappa B are linked in an autoregulatory loop, ensuring that NF-kappa B is held in the cytoplasm until cells are specifically induced to translocate it to the nucleus...
  41. ncbi Organization and transcription of the gluconate operon, gnt, of Bacillus subtilis
    Y Fujita
    J Biol Chem 261:13744-53. 1986
    ..Besides the gnt promoter about 40 base pairs upstream of the gntR gene, we detected two overlapping internal promoters between the gntP and gntZ genes. The gnt transcripts terminate about 45 base pairs downstream of the gntZ gene...
  42. ncbi Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1
    T Fujita
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Nature 337:270-2. 1989
    ..This may be the first demonstration of the specific induction of silent chromosomal genes by transfection of a single transcription factor gene in mammalian cells...
  43. ncbi Immunohistochemistry of neuron-specific and glia-specific proteins
    T Iwanaga
    Department of Anatomy, Niigata University School of Medicine, Japan
    Arch Histol Cytol 52:13-24. 1989
    ..Although it is now widely accepted that S-100 protein is not "glia-specific" but contained in a variety of non-glial cells, its beta subunit protein is still a useful marker for a series of glial and sustentacular cells...
  44. ncbi Immunocytochemistry of neuron-specific proteins and neuropeptides in taste buds and associated nerves
    S Yoshie
    Department of Oral Anatomy, Nippon Dental University, Niigata, Japan
    Arch Histol Cytol 52:389-96. 1989
    ..The aminergic innervation was rather meager and appeared in the nerve fibers localized in the taste buds and connective tissue of the cat and mouse...
  45. ncbi Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes
    H Harada
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Cell 58:729-39. 1989
    ..Our results suggest that transcription of the IFN and IFN-inducible genes is regulated by two similar trans-acting factors that apparently compete for the same cis-acting recognition sequences, but which have opposite effects...
  46. ncbi Identification and nucleotide sequence of the promoter region of the Bacillus subtilis gluconate operon
    Y Fujita
    Nucleic Acids Res 14:1237-52. 1986
    ..The fragment on a high copy plasmid could titrate a regulator of the gnt operon so that the expression of the operon on the host chromosome also became derepressed...
  47. ncbi A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin
    M Matsushita
    Department of Biochemistry, Fukushima Medical College, Japan
    J Biol Chem 271:2448-54. 1996
    ..Therefore, P35 represents a new type of GlcNAc-binding lectin with structural and functional similarities to collectins involved in innate immunity...
  48. ncbi Characterization of a small-cell-lung-carcinoma cell line from a patient with cancer-associated retinopathy
    Y Yamaji
    First Department of Internal Medicine, Kagawa Medical School, Japan
    Int J Cancer 65:671-6. 1996
    ....
  49. ncbi Human erythrocyte bisphosphoglycerate mutase: inactivation by glycation in vivo and in vitro
    T Fujita
    Department of Biochemistry, Osaka University Medical School, Suita, Osaka, 565 0871, Japan
    J Biochem 124:1237-44. 1998
    ..From these results, the loss of enzymatic activity appears to be due to the glycation of Lys158 which may be located in the vicinity of the substrate binding site...
  50. ncbi Exon structure of the gene encoding the human mannose-binding protein-associated serine protease light chain: comparison with complement C1r and C1s genes
    Y Endo
    Department of Biochemistry, Fukushima Medical College, Japan
    Int Immunol 8:1355-8. 1996
    ....
  51. ncbi BRAM1, a BMP receptor-associated molecule involved in BMP signalling
    K Kurozumi
    Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Genes Cells 3:257-64. 1998
    ..One such molecule, the immunophilin FKBP12, has been reported to interact with TGF-beta family type I receptors. However, the identity of signalling specific molecules interacting with the receptor was unknown...
  52. ncbi Cloning and characterization of the mouse pituitary adenylate cyclase-activating polypeptide (PACAP) gene
    K Yamamoto
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Gene 211:63-9. 1998
    ..Promoter analysis of the 5'-flanking region of the PACAP gene using a luciferase gene reporter system revealed that the isolated 5'-flanking region has functional promoter activity and is responsible for inducible expression...
  53. ncbi Unique repetitive sequence and unexpected regulation of expression of rat endothelial receptor for oxidized low-density lipoprotein (LOX-1)
    M Nagase
    Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Bunkyo ku, Tokyo 112, Japan
    Biochem J 330:1417-22. 1998
    ....
  54. ncbi Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone
    T Yamauchi
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Nature 390:91-6. 1997
    ..This may represent a novel cross-talk pathway between the cytokine receptor superfamily and growth factor receptor...
  55. ncbi Differentiation and transforming growth factor-beta receptor down-regulation by collagen-alpha2beta1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells
    Y Takeuchi
    Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Tokyo 112, Japan
    J Biol Chem 272:29309-16. 1997
    ..These signaling pathways may play an important role in the sequential differentiation of osteoblasts during bone formation...
  56. ncbi A new protein containing an SH2 domain that inhibits JAK kinases
    T A Endo
    Institute of Life Science, Kurume University, Aikawamachi, Japan
    Nature 387:921-4. 1997
    ..JAB and CIS appear to function as negative regulators in the JAK signalling pathway...
  57. ncbi SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates
    H Maegawa
    Third Department of Medicine, Shiga University of Medical Science, Japan
    Biochem Biophys Res Commun 228:122-7. 1996
    ..Thus, SHPTP2 might serve as an adapter protein linking between JAK2 and IRS. These results suggest that JAK1 and JAK2 behave differently and they may constitute a new regulatory component in insulin signaling...
  58. ncbi Identification of a cDNA encoding a thiazide-sensitive sodium-chloride cotransporter from the human and its mRNA expression in various tissues
    H Chang
    Fourth Department of Internal Medicine, Faculty of Medicine, Universityof Tokyo, Japan
    Biochem Biophys Res Commun 223:324-8. 1996
    ..5 kb transcript and a minor 6.5 kb specifically in the kidney, but low level of expression was also observed in small intestine, placenta, prostate, colon, and spleen...
  59. ncbi The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium
    U Chung
    Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Bunkyo ku, Tokyo 112, Japan
    J Biol Chem 271:8593-8. 1996
    ..Here, we report that the specific binding of the Ku antigen to another protein, REF1, leads to DNA-protein complex formation with a novel sequence specificity and thereby regulates gene expression...
  60. ncbi Calcium treatment of essential hypertension in elderly patients evaluated by 24 H monitoring
    Y Takagi
    Department of Medicine, Kobe University School of Medicine, Japan
    Am J Hypertens 4:836-9. 1991
    ..05) and plasma parathyroid hormone was suppressed (12.2 +/- 2.3 pg/mL, P less than .005). These data suggest that supplementation of dietary calcium may contribute to a reduction of BP in elderly patients with essential hypertension...