K Arima

Summary

Affiliation: Tokyo Institute of Psychiatry
Country: Japan

Publications

  1. ncbi Two brothers with frontotemporal dementia and parkinsonism with an N279K mutation of the tau gene
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Tokyo, Japan
    Neurology 54:1787-95. 2000
  2. ncbi Cellular co-localization of phosphorylated tau- and NACP/alpha-synuclein-epitopes in lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo, Japan
    Brain Res 843:53-61. 1999
  3. ncbi Immunohistochemical and ultrastructural characterization of neuritic clusters around ghost tangles in the hippocampal formation in progressive supranuclear palsy brains
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Japan
    Acta Neuropathol 97:565-76. 1999
  4. ncbi NACP/alpha-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Japan
    Acta Neuropathol 96:439-44. 1998
  5. ncbi Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Brain Res 808:93-100. 1998
  6. ncbi Immunohistochemical and ultrastructural characterization of ubiquitinated eosinophilic fibrillary neuronal inclusions in sporadic amyotrophic lateral sclerosis
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Japan
    Acta Neuropathol 96:75-85. 1998
  7. ncbi Argyrophilic tau-positive twisted and non-twisted tubules in astrocytic processes in brains of Alzheimer-type dementia: an electron microscopical study
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Japan
    Acta Neuropathol 95:28-39. 1998
  8. ncbi NACP/alpha-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: double-immunolabeling fluorescence and electron microscopic studies
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Japan
    Acta Neuropathol 100:115-21. 2000
  9. ncbi Ultrastructural characterization of the tau-immunoreactive tubules in the oligodendroglial perikarya and their inner loop processes in progressive supranuclear palsy
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Japan
    Acta Neuropathol 93:558-66. 1997
  10. ncbi Genetic analysis in patients with familial and sporadic frontotemporal dementia: two tau mutations in only familial cases and no association with apolipoprotein epsilon4
    A Kowalska
    Department of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Tokyo, Japan
    Dement Geriatr Cogn Disord 12:387-92. 2001

Collaborators

Detail Information

Publications23

  1. ncbi Two brothers with frontotemporal dementia and parkinsonism with an N279K mutation of the tau gene
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Tokyo, Japan
    Neurology 54:1787-95. 2000
    ....
  2. ncbi Cellular co-localization of phosphorylated tau- and NACP/alpha-synuclein-epitopes in lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo, Japan
    Brain Res 843:53-61. 1999
    ....
  3. ncbi Immunohistochemical and ultrastructural characterization of neuritic clusters around ghost tangles in the hippocampal formation in progressive supranuclear palsy brains
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Japan
    Acta Neuropathol 97:565-76. 1999
    ..TANCs may constitute a distinctive form of neuronal degeneration in PSP cortices. We hypothesize that axon terminal accumulation may occur in response to GT-formation...
  4. ncbi NACP/alpha-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Japan
    Acta Neuropathol 96:439-44. 1998
    ..The present study demonstrates that NACP is associated with cytoplasmic inclusions of MSA, and suggests a role of NACP in abnormal filament aggregation in neuronal degeneration...
  5. ncbi Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Brain Res 808:93-100. 1998
    ..The present study indicates that the entire molecule of NACP is involved in the neuronal filament-aggregating processes of LB disorders...
  6. ncbi Immunohistochemical and ultrastructural characterization of ubiquitinated eosinophilic fibrillary neuronal inclusions in sporadic amyotrophic lateral sclerosis
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Japan
    Acta Neuropathol 96:75-85. 1998
    ....
  7. ncbi Argyrophilic tau-positive twisted and non-twisted tubules in astrocytic processes in brains of Alzheimer-type dementia: an electron microscopical study
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Japan
    Acta Neuropathol 95:28-39. 1998
    ..As-TBs appear indistinguishable from dystrophic neurites under the light microscope. The present data suggest that they may be more widely distributed in the damaged cerebral neuropil than previously thought...
  8. ncbi NACP/alpha-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: double-immunolabeling fluorescence and electron microscopic studies
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Japan
    Acta Neuropathol 100:115-21. 2000
    ..We show that NACP and tau aggregate into different filamentous components even if both proteins are incorporated into the same inclusions...
  9. ncbi Ultrastructural characterization of the tau-immunoreactive tubules in the oligodendroglial perikarya and their inner loop processes in progressive supranuclear palsy
    K Arima
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Japan
    Acta Neuropathol 93:558-66. 1997
    ..Moreover, even though the white matter alterations of PSP resemble those of corticobasal degeneration, there are certain ultrastructural differences in the abnormal oligodendroglial tubules of the two diseases...
  10. ncbi Genetic analysis in patients with familial and sporadic frontotemporal dementia: two tau mutations in only familial cases and no association with apolipoprotein epsilon4
    A Kowalska
    Department of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Tokyo, Japan
    Dement Geriatr Cogn Disord 12:387-92. 2001
    ..Tau mutations were not found in subjects with a negative family history suggesting that tau mutations do not account for most sporadic cases of FTD. We also found no association of apolipoprotein E4 allele with FTD...
  11. doi Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains
    J Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Tokyo, Japan
    Neuropathol Appl Neurobiol 38:132-41. 2012
    ..Therefore, GSAP is an ideal target for designing γ-secretase modulators with least side effects in Alzheimer's disease (AD). However, at present, the precise distribution of GSAP in AD brains remains to be characterized...
  12. ncbi Fibroblast growth factor (FGF)-9 immunoreactivity in senile plaques
    S Nakamura
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya, Tokyo 156 8585, Japan
    Brain Res 814:222-5. 1998
    ..The amyloid core and neurofibrillary tangles lacked immunoreactivity. FGF-9 immunoreactive astrocytes were conspicuous in AD brains. FGF-9 may be involved in the neuropathology of AD...
  13. ncbi Detection of Borna disease virus genome in normal human brain tissue
    S Haga
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Tokyo, Japan
    Brain Res 770:307-9. 1997
    ..Our results suggest that BDV can infect human brain tissue latently, without causing an apparent neuropsychiatric disorder...
  14. ncbi Mutations of the notch3 gene in non-caucasian patients with suspected CADASIL syndrome
    S Kotorii
    Department of Demyelinating Disease and Aging, National Institute of Neuroscience, Tokyo, Japan
    Dement Geriatr Cogn Disord 12:185-93. 2001
    ..These data indicate that the CADASIL Notch3 mutations were found in approximately 35% of familial cases with leukoencephalopathy, suggesting genetic heterogeneity of the disease...
  15. doi Ubiquilin-1 immunoreactivity is concentrated on Hirano bodies and dystrophic neurites in Alzheimer's disease brains
    J Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Tokyo, Japan
    Neuropathol Appl Neurobiol 39:817-30. 2013
    ..Although previous studies suggested a key role of ubiquilin-1 in the pathogenesis of Alzheimer's disease (AD), a direct relationship between ubiquilin-1 and Hirano bodies in AD brains remains unknown...
  16. ncbi Accumulation of a repulsive axonal guidance molecule RGMa in amyloid plaques: a possible hallmark of regenerative failure in Alzheimer's disease brains
    J Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan, Department of Pathology and Laboratory Medicine, Kohnodai Hospital, NCGM, 1 7 1 Kohnodai, Ichikawa, Chiba 272 8516, Japan, Department of Laboratory Medicine, National Center Hospital, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan, and Department of Psychiatry, National Center Hospital, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neuropathol Appl Neurobiol . 2012
    ..2012 The Authors. Neuropathology and Applied Neurobiology © 2012 British Neuropathological Society...
  17. ncbi TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions
    J Satoh
    Department of Bioinformatics, Meiji Pharmaceutical University, Tokyo, Japan
    Neuropathol Appl Neurobiol 33:99-107. 2007
    ....
  18. ncbi Regression stage senile plaques in the natural course of Alzheimer's disease
    T Oide
    Department of Laboratory Medicine, Musashi Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Neuropathol Appl Neurobiol 32:539-56. 2006
    ..Astrocytes are actively engaged in the natural Abeta clearance mechanism in advanced stage AD brains, which may provide clues for developing new therapeutic strategies for AD...
  19. ncbi Clinical and genetic studies of families with the tau N279K mutation (FTDP-17)
    Y Tsuboi
    Mayo Clinic, Jacksonville, FL 32224, USA
    Neurology 59:1791-3. 2002
    ..A founder effect indicated by a shared disease haplotype was seen only in two Japanese families. The N279K mutation can develop independently in different parts of the world...
  20. ncbi Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease
    A M Shiarli
    Clinical Neuroscience Research Group, University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital, Salford, UK
    Neuropathol Appl Neurobiol 32:374-87. 2006
    ....
  21. ncbi Molecular cloning of murine sodium-phosphate cotransporter type IIb (Na/P(i)-IIb) gene promoter and characterization of gene structure
    K Arima
    Department of Pediatrics and Physiology, Steele Memorial Children s Research Center, University of Arizona Health Sciences Center, 1501 N Campbell Ave, Tucson, AZ, USA
    Biochim Biophys Acta 1494:149-54. 2000
    ..Three promoter/reporter gene constructs, -159/+73, -429/+73 and -954/+73, showed significant luciferase activity (22-82-fold over background) when transfected into in rat intestinal epithelial (RIE-1) cells...
  22. ncbi Genetic variants of IL-13 signalling and human asthma and atopy
    A Heinzmann
    University Children s Hospital, University of Freiburg, Freiburg, Germany
    Hum Mol Genet 9:549-59. 2000
    ..38 in males, 1.10 in females) rather than asthma. Thus, certain variants of IL-13 signalling are likely to be important promoters of human asthma; detailed functional analysis of their actions is needed...
  23. ncbi [A case report of atypical tuberculous spondylitis]
    M Uno
    Department of Internal Medicine, Kawasaki Municipal Hospital
    Kansenshogaku Zasshi 68:982-5. 1994
    ..This was a case of atypical tuberculous spondylitis. The main locus existed at the posterior elements of the vertebra and the distribution of vertebral lesions was multiple including cervical spine...