Research Topics
Genomes and Genes | Tetsuaki AraiSummaryAffiliation: Tokyo Institute of Psychiatry Country: Japan Publications
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Publications
Practical clinical use of therapeutic agents for Alzheimer's diseaseTetsuaki Arai
Nippon Yakurigaku Zasshi 130:494-8. 2007- TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosisTetsuaki Arai
Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Setagaya Ku, Tokyo 156 8585, Japan
Biochem Biophys Res Commun 351:602-11. 2006.... 
Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodiesTetsuaki Arai
Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
Acta Neuropathol 117:125-36. 2009..There may be genetic factors, such as mutations or genetic variants of PGRN underlying the co-occurrence of abnormal deposition of TDP-43, tau and alpha-synuclein...- Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62Tetsuaki Arai
Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Setagaya Ku, 156 8585, Tokyo, Japan
Neurosci Lett 342:41-4. 2003..These results suggest that the degenerative process involves p62 in FTD and that the process takes place not only in neurons but also in glial cells... - Different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from patients with Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degenerationTetsuaki Arai
Department of Psychogeriatrics, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, 156 8585 Tokyo, Japan
Acta Neuropathol 105:489-98. 2003..Advanced modification may expose the MBD in brain tissues of AD and PiD. It is suggested that the processing of abnormally accumulated tau characterizes the pathophysiology of each tauopathy... - A high incidence of apolipoprotein E epsilon4 allele in middle-aged non-demented subjects with cerebral amyloid beta protein depositsT Arai
Department of Neuropathology, Tokyo Institute of Psychiatry, Japan
Acta Neuropathol 97:82-4. 1999.... - Argyrophilic glial inclusions in the midbrain of patients with Parkinson's disease and diffuse Lewy body disease are immunopositive for NACP/alpha-synucleinT Arai
Department of Neuropathology, Institute of Psychiatry, Tokyo, Japan
Neurosci Lett 259:83-6. 1999.... - Immunohistochemical localization of amyloid beta-protein with amino-terminal aspartate in the cerebral cortex of patients with Alzheimer's diseaseT Arai
Department of Neuropathology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
Brain Res 823:202-6. 1999..Such regional as well as laminar differences in the distribution of Abeta beginning at N1[D] suggest that some local factors influence N-terminal processing of Abeta deposited in the brain... - Progressive nonfluent aphasia: a rare clinical subtype of FTLD-TDP in JapanNaoya Aoki
Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
Neuropathology 32:272-9. 2012..A few dystrophic neurites and neuronal intranuclear inclusions were also seen. FTLD-TDP showing PNFA seems to be rare but does exist in Japan, similar to that in other countries... - Identification of amino-terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degenerationTetsuaki Arai
Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Setagaya Ku, Tokyo, Japan
Ann Neurol 55:72-9. 2004..Such a biochemical divergence may be related to the neuropathological features of these diseases... - TDP-43 is deposited in the Guam parkinsonism-dementia complex brainsMasato Hasegawa
Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
Brain 130:1386-94. 2007..These results suggest that accumulation of TDP-43 is a common process in certain neurodegenerative disorders, including FTLD-U, ALS and G-PDC... - [Significance of the TDP-43 deposition in FTLD-U and ALS]Masato Hasegawa
Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research
Rinsho Shinkeigaku 48:994-7. 2008..These findings together with recent discovery of mutations in the TDP-43 gene in ALS strongly suggest that TDP-43 is the.. - Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain diseaseHiroshige Fujishiro
Department of Psychogeriatrics, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
Acta Neuropathol 117:151-8. 2009.... - Molecular dissection of TDP-43 proteinopathiesMasato Hasegawa
Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, 2 1 6 Kamikitazawa, Setagaya Ku, Tokyo, 156 8506, Japan
J Mol Neurosci 45:480-5. 2011.... - Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALSYuki Inukai
Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
FEBS Lett 582:2899-904. 2008..Analysis of postmortem changes of TDP-43 revealed that the amounts of Sarkosyl-insoluble, urea-soluble full-length TDP-43 and a 35kDa N-terminal fragment increased time-dependently... - Clinicopathological characterization of Pick's disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusionsOsamu Yokota
Department of Neuropathology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo, 156 8585, Japan
Acta Neuropathol 117:429-44. 2009.... 
Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosisMasato Hasegawa
Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, Kamikitazawa, Setagaya Ku, Tokyo, Japan
Ann Neurol 64:60-70. 2008..The aim of this study was to identify the phosphorylation sites and responsible kinases, and to clarify the pathological significance of phosphorylation of TDP-43...- [Frontotemporal dementia (FTD) and genetic mutations including progranulin gene]Tetsuaki Arai
Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research
Rinsho Shinkeigaku 48:990-3. 2008..Taken together, these results suggest that elucidating the mechanism of C-terminal fragment origination may shed light on the pathogenesis of several neurodegenerative disorders involving TDP-43 proteinopathy and tauopathy... - Identification of casein kinase-1 phosphorylation sites on TDP-43Fuyuki Kametani
Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan
Biochem Biophys Res Commun 382:405-9. 2009..Interestingly, 18 of them were located in the C-terminal glycine-rich region of TDP-43. Our results indicate that CK1-mediated phosphorylation may play a role in the pathogenesis of these diseases... - Clinicopathological characteristics of FTLD-TDP showing corticospinal tract degeneration but lacking lower motor neuron lossZen Kobayashi
Department of Psychogeriatrics, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
J Neurol Sci 298:70-7. 2010..This study clarified that FTLD-MND-P cases have characteristic clinicopathological features distinct from those of FTLD-MND-A... - Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathyTetsuaki Arai
Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan
Neuropathology 30:170-81. 2010..Understanding the mechanism of phosphorylation and truncation of TDP-43 and aggregate formation may be crucial for clarifying the pathogenesis of TDP-43 proteinopathy and for developing useful therapeutics... - Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular modelsMakiko Yamashita
Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Reearch, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
FEBS Lett 583:2419-24. 2009..These findings were confirmed by immunoblot analysis. The results indicate that MB and dimebon may be useful for the treatment of ALS, FTLD-U and other TDP-43 proteinopathies... - Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cellsTakashi Nonaka
Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, 2 1 8 Kamikitazawa, Setagaya ku 156 8585, Tokyo, Japan
FEBS Lett 583:394-400. 2009..Our results suggest that intracellular localization of TDP-43 and proteasomal function may be involved in inclusion formation and neurodegeneration in TDP-43 proteinopathies... - [Neurodegenerative disorders and TDP-43]Takashi Nonaka
Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
Brain Nerve 61:161-6. 2009..Elucidating the biochemical processes responsible for phosphorylation, fragmentation, and intracellular aggregation of TDP-43 may provide important insights into the pathogenesis of TDP-43 proteinopathy... - [Component of ubiquitin-positive inclusions in ALS]Masato Hasegawa
Department of Molecular Neur obiology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
Brain Nerve 59:1171-7. 2007..This article reviews the ubiquitin-positive inclusions in ALS and the recent discovery of TDP-43 in tau-negative inclusions in FTLD-U and ALS. We also discuss the biological implications of these findings for the pathogenesis of ALS... - Intractable hiccup caused by medulla oblongata lesions: a study of an autopsy patient with possible neuromyelitis opticaZen Kobayashi
Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, 113 8519, Japan
J Neurol Sci 285:241-5. 2009..Although animal experiments have shown that NTS is a critical structure in the hiccup reflex, we demonstrated for the first time the involvement of the NTS in an autopsy patient with intractable hiccup... - Microglial tau undergoes phosphorylation-independent modification after ischemiaToshiki Uchihara
Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashi dai, Fuchu, Tokyo 183 8526, Japan
Glia 45:180-7. 2004..Susceptibility of tau2 epitope to TX, seen in these microglia, is shared with glial cytoplasmic inclusions and will show its conformational state to be different from that in NFTs... - Occurrence of basophilic inclusions and FUS-immunoreactive neuronal and glial inclusions in a case of familial amyotrophic lateral sclerosisZen Kobayashi
Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Tokyo, Japan
J Neurol Sci 293:6-11. 2010..These findings support the idea that both BIs and FUS-ir structures are pathological hallmarks of a subset of ALS cases... - Amyotrophic lateral sclerosis with dementia: an autopsy case showing many Bunina bodies, tau-positive neuronal and astrocytic plaque-like pathologies, and pallido-nigral degenerationOsamu Yokota
Department of Neuropathology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Tokyo, Japan
Acta Neuropathol 112:633-45. 2006..Although the pathophysiological relationship between tau pathology and the selective involvement of motor neurons, substantia nigra, and globus pallidus was unclear, we considered that it might be more than coincidental... - FALS with Gly72Ser mutation in SOD1 gene: report of a family including the first autopsy caseZen Kobayashi
Department of Psychogeriatrics, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo, 156 8585, Japan
J Neurol Sci 300:9-13. 2011..Involvement of Onuf's nucleus may be a characteristic pathological feature in FALS with Gly72Ser mutation in the SOD1 gene... - Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brainHaruhiko Akiyama
Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, 156 8585, Tokyo, Japan
Acta Neuropathol 107:53-8. 2004.... - Gray matter lesions in Nasu-Hakola disease: a report on three autopsy casesNaoya Aoki
Tokyo Institute of Psychiatry, Japan
Neuropathology 31:135-43. 2011..These gray matter pathologies are considered to be responsible for some of the clinical manifestations of the disease, including extrapyramidal symptoms... - [An autopsy case of argyrophilic grain dementia with abundant neurofibrillary tangles]Kenichi Oshima
Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Tokyo, Japan
No To Shinkei 55:133-8. 2003..Sarkosyl-insoluble tau extracted from the temporal lobe consisted predominantly of four-repeat tau isoforms. To our knowledge, this is the first report of argyrophilic grain dementia complicated with tangle only dementia... - Frontotemporal lobar degeneration with motor neuron disease showing severe and circumscribed atrophy of anterior temporal lobesHiroya Kuwahara
Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
J Neurol Sci 297:92-6. 2010..This case report showed typical features of FTLD-MND in clinical course and TDP-43 pathology with unusual severity and distribution of cerebral atrophy, suggesting a unique manifestation of FTLD-MND... - Morphometrical reappraisal of motor neuron system of Pick's disease and amyotrophic lateral sclerosis with dementiaKenji Ikeda
Tokyo Metropolitan Matsuzawa Hospital, 2 1 1 Kamikitazawa, Setagaya Ku, Japan
Acta Neuropathol 104:21-8. 2002..However, the border between the two group is not always clear and there are patients who can not be definitively classified... - Pick-body-like inclusions in corticobasal degeneration differ from Pick bodies in Pick's diseaseKenji Ikeda
Tokyo Metropolitan Matsuzawa Hospital, 2 1 1 Kamikitazawa, Setagaya Ku, Tokyo 156 0057, Japan
Acta Neuropathol 103:115-8. 2002..These results are useful for the argument of an overlap between PiD and CBD as well as discussion of the phenotypic resemblance of PB-like inclusions bearing types of FTDP-17 to Pick's disease... - Molecular analysis and biochemical classification of TDP-43 proteinopathyHiroshi Tsuji
Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156 8506, Japan
Brain 135:3380-91. 2012..These results suggest a new clinicopathological classification of TAR DNA-binding protein 43 proteinopathies based on their molecular properties... - Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43Takashi Nonaka
Department of Molecular Neurobiology, Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan
Hum Mol Genet 18:3353-64. 2009.... - Distribution of cerebral cortical lesions in diffuse neurofibrillary tangles with calcification: a clinicopathological study of four autopsy cases showing prominent parietal lobe involvementKuniaki Tsuchiya
Department of Laboratory Medicine and Pathology, Tokyo Metropolitan Matsuzawa Hospital, Kamikitazawa, Setagaya Ku, Japan
Acta Neuropathol 110:57-68. 2005.... - Clinicopathological study of early progressive multifocal leukoencephalopathy incidentally found in a schizophrenia patientKenichi Oshima
Department of Psychiatry, Tokyoo Metropolitan Matsuzawa Hospital, Tokyo, Japan
Neuropathology 29:684-8. 2009..PML could be considered a short-term disease preceding death, as "incidental PML" in this case. This is a rare autopsy case of early PML occurring in a schizophrenia patient with PML... - Metastatic CNS lymphoma presenting with periventricular dissemination - MRI and neuropathological findings in an autopsy caseZen Kobayashi
Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, 113 8519, Japan
J Neurol Sci 277:109-13. 2009..We considered that the lymphoma cells entered the ventricular system through the choroid plexus of the lateral ventricle, followed by dissemination of the periventricular parenchyma... - Methylene blue reduced abnormal tau accumulation in P301L tau transgenic miceMasato Hosokawa
Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
PLoS ONE 7:e52389. 2012..Subsequent results of Western blotting analysis revealed that this agent reduced detergent-insoluble phospho-tau. Methylene blue may have potential as a drug candidate for the treatment of tauopathy... - [The molecular mechanisms of intracellular TDP-43 aggregates]Takashi Nonaka
Department of Molecular Neur obiology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
Brain Nerve 61:1292-300. 2009.... - Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathiesAasami Ishii
Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
FEBS Lett 581:4711-7. 2007..Taken together, these findings suggest that CK2 may be involved in the hyperphosphorylation of alpha-synuclein in alpha-synucleinopathies... - Pick's disease with Pick bodies: an unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke's column, and lower motor neuronTatsuro Oda
Department of Psychiatry, National Hospital Organization Shimofusa Psychiatric Medical Center, Chiba, Japan
Neuropathology 27:81-9. 2007..The atypical clinical symptoms and the widespread neuropathological abnormalities observed in this case seem to represent an extremely extended form of PDPB... - Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's diseaseJian Ping Guo
Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
Proc Natl Acad Sci U S A 103:1953-8. 2006..Blocking the sites where Abeta initially binds to tau might arrest the simultaneous formation of plaques and tangles in AD... - Thrombin and prothrombin are expressed by neurons and glial cells and accumulate in neurofibrillary tangles in Alzheimer disease brainTetsuaki Arai
Department of Psychiatry, Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC, Canada
J Neuropathol Exp Neurol 65:19-25. 2006..The accumulation of thrombin and prothrombin in NFTs supports the hypothesis that thrombin may be involved in tau proteolysis and that failure to metabolize tau may lead to its aggregation in neurodegenerative diseases... - Clinicopathological study of two subtypes of Pick's disease in JapanToshinari Odawara
Department of Psychiatry, Yokohama City University School of Medicine, Yokohama, Japan
Dement Geriatr Cogn Disord 15:19-25. 2003..These findings suggested that two subtypes of Pick's disease in Japan can be distinguished not only neuropathologically but also clinically based on differences in pathogenesis... - Proteolysis of non-phosphorylated and phosphorylated tau by thrombinTetsuaki Arai
Department of Psychiatry, Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
J Biol Chem 280:5145-53. 2005..They are consistent with the hypothesis that phosphorylation of tau inhibits proteolysis by thrombin or other endogenous proteases, leading to aggregation of tau into insoluble fibrils... - 4-repeat tauopathy sharing pathological and biochemical features of corticobasal degeneration and progressive supranuclear palsyOmi Katsuse
Department of Psychiatry, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, 236 0004 Yokohama, Japan
Acta Neuropathol 106:251-60. 2003..The present case shared tau-related pathological and biochemical features of CBD and PSP. These findings support that CBD and PSP are closely associated disorders having a pathogenesis common to 4R tauopathy... - Presenile dementia mimicking Pick's disease: an autopsy case of localized amygdala degeneration with character change and emotional disorderSumiko Shibuya-Tayoshi
Department of Psychiatry, Tokushima University Hospital, Tokushima, Japan
Neuropathology 25:235-40. 2005..This case indicates that localized amygdala degeneration can cause presenile dementia, and that character changes and emotional disorders are predominant over memory disturbance and/or disorientation... - Immunohistochemical study of the serotonergic neuronal system in an animal model of the mood disorderShuji Iritani
Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466 8550, Japan
Exp Neurol 201:60-5. 2006..These alterations may underlie the changes of serotonergic system observed in the brains of patients with the depressive disorder... - LRRK2 expression in normal and pathologic human brain and in human cell linesJudith Miklossy
Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC, Canada
J Neuropathol Exp Neurol 65:953-63. 2006..In summary, LRRK2 is constitutively expressed in neurons and also in glial cells of human brain. It strongly associates with pathological inclusions in several neurodegenerative disorders...