Tetsuaki Arai

Summary

Affiliation: Tokyo Institute of Psychiatry
Country: Japan

Publications

  1. ncbi A high incidence of apolipoprotein E epsilon4 allele in middle-aged non-demented subjects with cerebral amyloid beta protein deposits
    T Arai
    Department of Neuropathology, Tokyo Institute of Psychiatry, Japan
    Acta Neuropathol 97:82-4. 1999
  2. ncbi Practical clinical use of therapeutic agents for Alzheimer's disease
    Tetsuaki Arai
    Nihon Yakurigaku Zasshi 130:494-8. 2007
  3. doi Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies
    Tetsuaki Arai
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Acta Neuropathol 117:125-36. 2009
  4. ncbi TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Tetsuaki Arai
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Setagaya Ku, Tokyo 156 8585, Japan
    Biochem Biophys Res Commun 351:602-11. 2006
  5. ncbi Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62
    Tetsuaki Arai
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Setagaya Ku, 156 8585, Tokyo, Japan
    Neurosci Lett 342:41-4. 2003
  6. ncbi Different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from patients with Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration
    Tetsuaki Arai
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, 156 8585 Tokyo, Japan
    Acta Neuropathol 105:489-98. 2003
  7. ncbi Immunohistochemical localization of amyloid beta-protein with amino-terminal aspartate in the cerebral cortex of patients with Alzheimer's disease
    T Arai
    Department of Neuropathology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Brain Res 823:202-6. 1999
  8. ncbi Argyrophilic glial inclusions in the midbrain of patients with Parkinson's disease and diffuse Lewy body disease are immunopositive for NACP/alpha-synuclein
    T Arai
    Department of Neuropathology, Institute of Psychiatry, Tokyo, Japan
    Neurosci Lett 259:83-6. 1999
  9. doi Progressive nonfluent aphasia: a rare clinical subtype of FTLD-TDP in Japan
    Naoya Aoki
    Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    Neuropathology 32:272-9. 2012
  10. ncbi [Significance of the TDP-43 deposition in FTLD-U and ALS]
    Masato Hasegawa
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research
    Rinsho Shinkeigaku 48:994-7. 2008

Collaborators

Detail Information

Publications58

  1. ncbi A high incidence of apolipoprotein E epsilon4 allele in middle-aged non-demented subjects with cerebral amyloid beta protein deposits
    T Arai
    Department of Neuropathology, Tokyo Institute of Psychiatry, Japan
    Acta Neuropathol 97:82-4. 1999
    ....
  2. ncbi Practical clinical use of therapeutic agents for Alzheimer's disease
    Tetsuaki Arai
    Nihon Yakurigaku Zasshi 130:494-8. 2007
  3. doi Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies
    Tetsuaki Arai
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Acta Neuropathol 117:125-36. 2009
    ..There may be genetic factors, such as mutations or genetic variants of PGRN underlying the co-occurrence of abnormal deposition of TDP-43, tau and alpha-synuclein...
  4. ncbi TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Tetsuaki Arai
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Setagaya Ku, Tokyo 156 8585, Japan
    Biochem Biophys Res Commun 351:602-11. 2006
    ....
  5. ncbi Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62
    Tetsuaki Arai
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Setagaya Ku, 156 8585, Tokyo, Japan
    Neurosci Lett 342:41-4. 2003
    ..These results suggest that the degenerative process involves p62 in FTD and that the process takes place not only in neurons but also in glial cells...
  6. ncbi Different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from patients with Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration
    Tetsuaki Arai
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, 156 8585 Tokyo, Japan
    Acta Neuropathol 105:489-98. 2003
    ..Advanced modification may expose the MBD in brain tissues of AD and PiD. It is suggested that the processing of abnormally accumulated tau characterizes the pathophysiology of each tauopathy...
  7. ncbi Immunohistochemical localization of amyloid beta-protein with amino-terminal aspartate in the cerebral cortex of patients with Alzheimer's disease
    T Arai
    Department of Neuropathology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Brain Res 823:202-6. 1999
    ..Such regional as well as laminar differences in the distribution of Abeta beginning at N1[D] suggest that some local factors influence N-terminal processing of Abeta deposited in the brain...
  8. ncbi Argyrophilic glial inclusions in the midbrain of patients with Parkinson's disease and diffuse Lewy body disease are immunopositive for NACP/alpha-synuclein
    T Arai
    Department of Neuropathology, Institute of Psychiatry, Tokyo, Japan
    Neurosci Lett 259:83-6. 1999
    ....
  9. doi Progressive nonfluent aphasia: a rare clinical subtype of FTLD-TDP in Japan
    Naoya Aoki
    Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    Neuropathology 32:272-9. 2012
    ..A few dystrophic neurites and neuronal intranuclear inclusions were also seen. FTLD-TDP showing PNFA seems to be rare but does exist in Japan, similar to that in other countries...
  10. ncbi [Significance of the TDP-43 deposition in FTLD-U and ALS]
    Masato Hasegawa
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research
    Rinsho Shinkeigaku 48:994-7. 2008
    ..These findings together with recent discovery of mutations in the TDP-43 gene in ALS strongly suggest that TDP-43 is the..
  11. ncbi TDP-43 is deposited in the Guam parkinsonism-dementia complex brains
    Masato Hasegawa
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Brain 130:1386-94. 2007
    ..These results suggest that accumulation of TDP-43 is a common process in certain neurodegenerative disorders, including FTLD-U, ALS and G-PDC...
  12. ncbi Identification of amino-terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration
    Tetsuaki Arai
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Setagaya Ku, Tokyo, Japan
    Ann Neurol 55:72-9. 2004
    ..Such a biochemical divergence may be related to the neuropathological features of these diseases...
  13. doi Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease
    Hiroshige Fujishiro
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Acta Neuropathol 117:151-8. 2009
    ....
  14. doi Atypical FTLD-FUS associated with ALS-TDP: a case report
    Zen Kobayashi
    Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, 2 1 6 Kamikitazawa, Setagaya Ku, Tokyo 156 8506, Japan
    Neuropathology 33:83-6. 2013
    ..To our knowledge, this is the first report of a case in which FTLD-FUS pathology is of a dystrophic neurites-predominant type and FTLD-FUS is associated with ALS-TDP...
  15. doi Molecular dissection of TDP-43 proteinopathies
    Masato Hasegawa
    Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, 2 1 6 Kamikitazawa, Setagaya Ku, Tokyo, 156 8506, Japan
    J Mol Neurosci 45:480-5. 2011
    ....
  16. pmc Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Masato Hasegawa
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, Kamikitazawa, Setagaya Ku, Tokyo, Japan
    Ann Neurol 64:60-70. 2008
    ..The aim of this study was to identify the phosphorylation sites and responsible kinases, and to clarify the pathological significance of phosphorylation of TDP-43...
  17. doi Clinicopathological characterization of Pick's disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions
    Osamu Yokota
    Department of Neuropathology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo, 156 8585, Japan
    Acta Neuropathol 117:429-44. 2009
    ....
  18. doi Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS
    Yuki Inukai
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    FEBS Lett 582:2899-904. 2008
    ..Analysis of postmortem changes of TDP-43 revealed that the amounts of Sarkosyl-insoluble, urea-soluble full-length TDP-43 and a 35kDa N-terminal fragment increased time-dependently...
  19. doi Identification of casein kinase-1 phosphorylation sites on TDP-43
    Fuyuki Kametani
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan
    Biochem Biophys Res Commun 382:405-9. 2009
    ..Interestingly, 18 of them were located in the C-terminal glycine-rich region of TDP-43. Our results indicate that CK1-mediated phosphorylation may play a role in the pathogenesis of these diseases...
  20. ncbi [Frontotemporal dementia (FTD) and genetic mutations including progranulin gene]
    Tetsuaki Arai
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research
    Rinsho Shinkeigaku 48:990-3. 2008
    ..Taken together, these results suggest that elucidating the mechanism of C-terminal fragment origination may shed light on the pathogenesis of several neurodegenerative disorders involving TDP-43 proteinopathy and tauopathy...
  21. doi Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy
    Tetsuaki Arai
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan
    Neuropathology 30:170-81. 2010
    ..Understanding the mechanism of phosphorylation and truncation of TDP-43 and aggregate formation may be crucial for clarifying the pathogenesis of TDP-43 proteinopathy and for developing useful therapeutics...
  22. doi Clinicopathological characteristics of FTLD-TDP showing corticospinal tract degeneration but lacking lower motor neuron loss
    Zen Kobayashi
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    J Neurol Sci 298:70-7. 2010
    ..This study clarified that FTLD-MND-P cases have characteristic clinicopathological features distinct from those of FTLD-MND-A...
  23. doi Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models
    Makiko Yamashita
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Reearch, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    FEBS Lett 583:2419-24. 2009
    ..These findings were confirmed by immunoblot analysis. The results indicate that MB and dimebon may be useful for the treatment of ALS, FTLD-U and other TDP-43 proteinopathies...
  24. ncbi [Neurodegenerative disorders and TDP-43]
    Takashi Nonaka
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Brain Nerve 61:161-6. 2009
    ..Elucidating the biochemical processes responsible for phosphorylation, fragmentation, and intracellular aggregation of TDP-43 may provide important insights into the pathogenesis of TDP-43 proteinopathy...
  25. doi Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells
    Takashi Nonaka
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, 2 1 8 Kamikitazawa, Setagaya ku 156 8585, Tokyo, Japan
    FEBS Lett 583:394-400. 2009
    ..Our results suggest that intracellular localization of TDP-43 and proteasomal function may be involved in inclusion formation and neurodegeneration in TDP-43 proteinopathies...
  26. ncbi Pathological features of FTLD-FUS in a Japanese population: analyses of nine cases
    Zen Kobayashi
    Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan Department of Neurology, JA Toride Medical Center, Toride, Ibaraki, Japan
    J Neurol Sci 335:89-95. 2013
    ..Redistribution of FUS from the nucleus to the cytoplasm could be associated with the formation of abnormal FUS aggregates in FTLD-FUS. ..
  27. ncbi [Component of ubiquitin-positive inclusions in ALS]
    Masato Hasegawa
    Department of Molecular Neur obiology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Brain Nerve 59:1171-7. 2007
    ..This article reviews the ubiquitin-positive inclusions in ALS and the recent discovery of TDP-43 in tau-negative inclusions in FTLD-U and ALS. We also discuss the biological implications of these findings for the pathogenesis of ALS...
  28. doi Prion-like properties of pathological TDP-43 aggregates from diseased brains
    Takashi Nonaka
    Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Setagaya Ku, Tokyo 156 8506, Japan
    Cell Rep 4:124-34. 2013
    ..These results indicate that insoluble TDP-43 has prion-like properties that may play a role in the progression of TDP-43 proteinopathy. ..
  29. pmc Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice
    Masato Hosokawa
    Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    PLoS ONE 7:e52389. 2012
    ..Subsequent results of Western blotting analysis revealed that this agent reduced detergent-insoluble phospho-tau. Methylene blue may have potential as a drug candidate for the treatment of tauopathy...
  30. ncbi Amyotrophic lateral sclerosis with dementia: an autopsy case showing many Bunina bodies, tau-positive neuronal and astrocytic plaque-like pathologies, and pallido-nigral degeneration
    Osamu Yokota
    Department of Neuropathology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Tokyo, Japan
    Acta Neuropathol 112:633-45. 2006
    ..Although the pathophysiological relationship between tau pathology and the selective involvement of motor neurons, substantia nigra, and globus pallidus was unclear, we considered that it might be more than coincidental...
  31. doi Intractable hiccup caused by medulla oblongata lesions: a study of an autopsy patient with possible neuromyelitis optica
    Zen Kobayashi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, 113 8519, Japan
    J Neurol Sci 285:241-5. 2009
    ..Although animal experiments have shown that NTS is a critical structure in the hiccup reflex, we demonstrated for the first time the involvement of the NTS in an autopsy patient with intractable hiccup...
  32. doi Occurrence of basophilic inclusions and FUS-immunoreactive neuronal and glial inclusions in a case of familial amyotrophic lateral sclerosis
    Zen Kobayashi
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Tokyo, Japan
    J Neurol Sci 293:6-11. 2010
    ..These findings support the idea that both BIs and FUS-ir structures are pathological hallmarks of a subset of ALS cases...
  33. doi FALS with Gly72Ser mutation in SOD1 gene: report of a family including the first autopsy case
    Zen Kobayashi
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo, 156 8585, Japan
    J Neurol Sci 300:9-13. 2011
    ..Involvement of Onuf's nucleus may be a characteristic pathological feature in FALS with Gly72Ser mutation in the SOD1 gene...
  34. ncbi Microglial tau undergoes phosphorylation-independent modification after ischemia
    Toshiki Uchihara
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashi dai, Fuchu, Tokyo 183 8526, Japan
    Glia 45:180-7. 2004
    ..Susceptibility of tau2 epitope to TX, seen in these microglia, is shared with glial cytoplasmic inclusions and will show its conformational state to be different from that in NFTs...
  35. ncbi Differential diagnosis of amyotrophic lateral sclerosis from Guillain-Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid
    Masato Hosokawa
    1Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    Int J Neurosci 124:344-9. 2014
    ..4% and the specificity was 84.6%. Quantitative determination of TDP-43 concentrations in the CSF by sandwich ELISA is a potential laboratory test for differentiating ALS from peripheral motor neuropathies such as GBS. ..
  36. pmc Prion-like spreading of pathological α-synuclein in brain
    Masami Masuda-Suzukake
    Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, 2 1 6 Kamikitazawa, Setagaya Ku, Tokyo 156 8506, Japan
    Brain 136:1128-38. 2013
    ..This is a new mouse model of sporadic α-synucleinopathy and should be useful for elucidating progression mechanisms and evaluating disease-modifying therapy...
  37. ncbi Morphometrical reappraisal of motor neuron system of Pick's disease and amyotrophic lateral sclerosis with dementia
    Kenji Ikeda
    Tokyo Metropolitan Matsuzawa Hospital, 2 1 1 Kamikitazawa, Setagaya Ku, Japan
    Acta Neuropathol 104:21-8. 2002
    ..However, the border between the two group is not always clear and there are patients who can not be definitively classified...
  38. doi Frontotemporal lobar degeneration with motor neuron disease showing severe and circumscribed atrophy of anterior temporal lobes
    Hiroya Kuwahara
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Neurol Sci 297:92-6. 2010
    ..This case report showed typical features of FTLD-MND in clinical course and TDP-43 pathology with unusual severity and distribution of cerebral atrophy, suggesting a unique manifestation of FTLD-MND...
  39. doi Gray matter lesions in Nasu-Hakola disease: a report on three autopsy cases
    Naoya Aoki
    Tokyo Institute of Psychiatry, Japan
    Neuropathology 31:135-43. 2011
    ..These gray matter pathologies are considered to be responsible for some of the clinical manifestations of the disease, including extrapyramidal symptoms...
  40. ncbi [An autopsy case of argyrophilic grain dementia with abundant neurofibrillary tangles]
    Kenichi Oshima
    Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Tokyo, Japan
    No To Shinkei 55:133-8. 2003
    ..Sarkosyl-insoluble tau extracted from the temporal lobe consisted predominantly of four-repeat tau isoforms. To our knowledge, this is the first report of argyrophilic grain dementia complicated with tangle only dementia...
  41. ncbi Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain
    Haruhiko Akiyama
    Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, 156 8585, Tokyo, Japan
    Acta Neuropathol 107:53-8. 2004
    ....
  42. ncbi Pick-body-like inclusions in corticobasal degeneration differ from Pick bodies in Pick's disease
    Kenji Ikeda
    Tokyo Metropolitan Matsuzawa Hospital, 2 1 1 Kamikitazawa, Setagaya Ku, Tokyo 156 0057, Japan
    Acta Neuropathol 103:115-8. 2002
    ..These results are useful for the argument of an overlap between PiD and CBD as well as discussion of the phenotypic resemblance of PB-like inclusions bearing types of FTDP-17 to Pick's disease...
  43. doi Molecular analysis and biochemical classification of TDP-43 proteinopathy
    Hiroshi Tsuji
    Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156 8506, Japan
    Brain 135:3380-91. 2012
    ..These results suggest a new clinicopathological classification of TAR DNA-binding protein 43 proteinopathies based on their molecular properties...
  44. doi Metastatic CNS lymphoma presenting with periventricular dissemination - MRI and neuropathological findings in an autopsy case
    Zen Kobayashi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, 113 8519, Japan
    J Neurol Sci 277:109-13. 2009
    ..We considered that the lymphoma cells entered the ventricular system through the choroid plexus of the lateral ventricle, followed by dissemination of the periventricular parenchyma...
  45. doi Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43
    Takashi Nonaka
    Department of Molecular Neurobiology, Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan
    Hum Mol Genet 18:3353-64. 2009
    ....
  46. ncbi Distribution of cerebral cortical lesions in diffuse neurofibrillary tangles with calcification: a clinicopathological study of four autopsy cases showing prominent parietal lobe involvement
    Kuniaki Tsuchiya
    Department of Laboratory Medicine and Pathology, Tokyo Metropolitan Matsuzawa Hospital, Kamikitazawa, Setagaya Ku, Japan
    Acta Neuropathol 110:57-68. 2005
    ....
  47. doi Clinicopathological study of early progressive multifocal leukoencephalopathy incidentally found in a schizophrenia patient
    Kenichi Oshima
    Department of Psychiatry, Tokyoo Metropolitan Matsuzawa Hospital, Tokyo, Japan
    Neuropathology 29:684-8. 2009
    ..PML could be considered a short-term disease preceding death, as "incidental PML" in this case. This is a rare autopsy case of early PML occurring in a schizophrenia patient with PML...
  48. ncbi [The molecular mechanisms of intracellular TDP-43 aggregates]
    Takashi Nonaka
    Department of Molecular Neur obiology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Brain Nerve 61:1292-300. 2009
    ....
  49. ncbi Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies
    Aasami Ishii
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    FEBS Lett 581:4711-7. 2007
    ..Taken together, these findings suggest that CK2 may be involved in the hyperphosphorylation of alpha-synuclein in alpha-synucleinopathies...
  50. pmc Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease
    Jian Ping Guo
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Proc Natl Acad Sci U S A 103:1953-8. 2006
    ..Blocking the sites where Abeta initially binds to tau might arrest the simultaneous formation of plaques and tangles in AD...
  51. ncbi Clinicopathological study of two subtypes of Pick's disease in Japan
    Toshinari Odawara
    Department of Psychiatry, Yokohama City University School of Medicine, Yokohama, Japan
    Dement Geriatr Cogn Disord 15:19-25. 2003
    ..These findings suggested that two subtypes of Pick's disease in Japan can be distinguished not only neuropathologically but also clinically based on differences in pathogenesis...
  52. ncbi Thrombin and prothrombin are expressed by neurons and glial cells and accumulate in neurofibrillary tangles in Alzheimer disease brain
    Tetsuaki Arai
    Department of Psychiatry, Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC, Canada
    J Neuropathol Exp Neurol 65:19-25. 2006
    ..The accumulation of thrombin and prothrombin in NFTs supports the hypothesis that thrombin may be involved in tau proteolysis and that failure to metabolize tau may lead to its aggregation in neurodegenerative diseases...
  53. ncbi 4-repeat tauopathy sharing pathological and biochemical features of corticobasal degeneration and progressive supranuclear palsy
    Omi Katsuse
    Department of Psychiatry, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, 236 0004 Yokohama, Japan
    Acta Neuropathol 106:251-60. 2003
    ..The present case shared tau-related pathological and biochemical features of CBD and PSP. These findings support that CBD and PSP are closely associated disorders having a pathogenesis common to 4R tauopathy...
  54. ncbi Pick's disease with Pick bodies: an unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke's column, and lower motor neuron
    Tatsuro Oda
    Department of Psychiatry, National Hospital Organization Shimofusa Psychiatric Medical Center, Chiba, Japan
    Neuropathology 27:81-9. 2007
    ..The atypical clinical symptoms and the widespread neuropathological abnormalities observed in this case seem to represent an extremely extended form of PDPB...
  55. ncbi Proteolysis of non-phosphorylated and phosphorylated tau by thrombin
    Tetsuaki Arai
    Department of Psychiatry, Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 280:5145-53. 2005
    ..They are consistent with the hypothesis that phosphorylation of tau inhibits proteolysis by thrombin or other endogenous proteases, leading to aggregation of tau into insoluble fibrils...
  56. ncbi Immunohistochemical study of the serotonergic neuronal system in an animal model of the mood disorder
    Shuji Iritani
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466 8550, Japan
    Exp Neurol 201:60-5. 2006
    ..These alterations may underlie the changes of serotonergic system observed in the brains of patients with the depressive disorder...
  57. ncbi Presenile dementia mimicking Pick's disease: an autopsy case of localized amygdala degeneration with character change and emotional disorder
    Sumiko Shibuya-Tayoshi
    Department of Psychiatry, Tokushima University Hospital, Tokushima, Japan
    Neuropathology 25:235-40. 2005
    ..This case indicates that localized amygdala degeneration can cause presenile dementia, and that character changes and emotional disorders are predominant over memory disturbance and/or disorientation...
  58. ncbi LRRK2 expression in normal and pathologic human brain and in human cell lines
    Judith Miklossy
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC, Canada
    J Neuropathol Exp Neurol 65:953-63. 2006
    ..In summary, LRRK2 is constitutively expressed in neurons and also in glial cells of human brain. It strongly associates with pathological inclusions in several neurodegenerative disorders...