K Aoshiba

Summary

Affiliation: Tokyo Women's Medical University
Country: Japan

Publications

  1. ncbi Serine proteases increase oxidative stress in lung cells
    K Aoshiba
    First Department of Medicine, Tokyo Women s Medical University, Shinjuku ku, Tokyo 162 8666, Japan
    Am J Physiol Lung Cell Mol Physiol 281:L556-64. 2001
  2. pmc Oxidative stress, cell death, and other damage to alveolar epithelial cells induced by cigarette smoke
    K Aoshiba
    First Department of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Tob Induc Dis 1:219-26. 2003
  3. doi Therapeutic effects of erythropoietin in murine models of endotoxin shock
    Kazutetsu Aoshiba
    First Department of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Crit Care Med 37:889-98. 2009
  4. ncbi Chronic lung inflammation in aging mice
    Kazutetsu Aoshiba
    First Department of Medicine, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    FEBS Lett 581:3512-6. 2007
  5. ncbi [Role of alveolar cell apoptosis in COPD]
    Kazutetsu Aoshiba
    First Department of Medicine, Tokyo Women s Medical University
    Nihon Rinsho 65:629-32. 2007
  6. doi DNA damage as a molecular link in the pathogenesis of COPD in smokers
    Kazutetsu Aoshiba
    Pulmonary Division, Graduate School of Medical Science, First Dept of Medicine, Tokyo Women s Medical University, Tokyo 162 8666, Japan
    Eur Respir J 39:1368-76. 2012
  7. pmc Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury
    Fang Zhou
    Graduate School of Medical Science, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Respir Res 12:78. 2011
  8. ncbi Bleomycin induces cellular senescence in alveolar epithelial cells
    K Aoshiba
    First Department of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Eur Respir J 22:436-43. 2003
  9. ncbi Immunohistochemical evaluation of oxidative stress in murine lungs after cigarette smoke exposure
    Kazutetsu Aoshiba
    First Department of Medicine, TokyoWomen sMedical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Inhal Toxicol 15:1029-38. 2003
  10. ncbi Alveolar wall apoptosis causes lung destruction and emphysematous changes
    Kazutetsu Aoshiba
    First Department of Medicine, Tokyo Women s Medical University, Japan
    Am J Respir Cell Mol Biol 28:555-62. 2003

Collaborators

  • Atsushi Nagai
  • J Tamaoki
  • M Kondo
  • T Tsuji
  • Shigemitsu Onizawa
  • Naoko Yokohori
  • Fang Zhou
  • Osamitsu Yagi
  • Takaaki Ishikawa
  • Kimihiko Yasuda
  • Hiroko Suzuki
  • Atsushi Takahashi
  • K Nishimura
  • Yusei Miyamoto
  • Masashi Kajita
  • K Isono

Detail Information

Publications31

  1. ncbi Serine proteases increase oxidative stress in lung cells
    K Aoshiba
    First Department of Medicine, Tokyo Women s Medical University, Shinjuku ku, Tokyo 162 8666, Japan
    Am J Physiol Lung Cell Mol Physiol 281:L556-64. 2001
    ..These results suggest that several proteases increase oxidative stress, indicating a direct interaction between proteases and ROS in mediating cytotoxicity...
  2. pmc Oxidative stress, cell death, and other damage to alveolar epithelial cells induced by cigarette smoke
    K Aoshiba
    First Department of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Tob Induc Dis 1:219-26. 2003
    ..This review will discuss oxidative stress, cell death, and other damage to alveolar epithelial cells induced by cigarette smoke...
  3. doi Therapeutic effects of erythropoietin in murine models of endotoxin shock
    Kazutetsu Aoshiba
    First Department of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Crit Care Med 37:889-98. 2009
    ..We investigated the therapeutic effects of erythropoietin in a murine model of endotoxin shock...
  4. ncbi Chronic lung inflammation in aging mice
    Kazutetsu Aoshiba
    First Department of Medicine, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    FEBS Lett 581:3512-6. 2007
    ..Immunohistochemistry showed that the lungs of the aged mice contained increased numbers of CD4 cells, CD8 cells, B cells and macrophages. These results suggest that a pro-inflammatory shift occurs in the lungs of mice with aging...
  5. ncbi [Role of alveolar cell apoptosis in COPD]
    Kazutetsu Aoshiba
    First Department of Medicine, Tokyo Women s Medical University
    Nihon Rinsho 65:629-32. 2007
    ..In this review, recent data on the role of apoptosis in emphysema from both animal models as well as from studies on human subjects will be discussed...
  6. doi DNA damage as a molecular link in the pathogenesis of COPD in smokers
    Kazutetsu Aoshiba
    Pulmonary Division, Graduate School of Medical Science, First Dept of Medicine, Tokyo Women s Medical University, Tokyo 162 8666, Japan
    Eur Respir J 39:1368-76. 2012
    ..In conclusion, DSBs, at least in part caused by oxidative stress, appear to contribute to the pathogenesis of COPD by inducing apoptosis, cell senescence and pro-inflammatory responses...
  7. pmc Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury
    Fang Zhou
    Graduate School of Medical Science, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Respir Res 12:78. 2011
    ..The present study was designed to test the hypothesis that premature senescence of airway epithelial cells (Clara cells) impairs repair processes and exacerbates inflammation after airway injury...
  8. ncbi Bleomycin induces cellular senescence in alveolar epithelial cells
    K Aoshiba
    First Department of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Eur Respir J 22:436-43. 2003
    ..The induction of epithelial senescence by bleomycin may contribute to the pathway of impaired re-epithelialisation leading to pulmonary fibrosis...
  9. ncbi Immunohistochemical evaluation of oxidative stress in murine lungs after cigarette smoke exposure
    Kazutetsu Aoshiba
    First Department of Medicine, TokyoWomen sMedical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Inhal Toxicol 15:1029-38. 2003
    ..These results suggest that acute CS exposure imposes oxidative stress predominantly on bronchiolar epithelial and alveolar type II cells, confirming that cigarette smoking causes oxidative damage to the respiratory epithelium...
  10. ncbi Alveolar wall apoptosis causes lung destruction and emphysematous changes
    Kazutetsu Aoshiba
    First Department of Medicine, Tokyo Women s Medical University, Japan
    Am J Respir Cell Mol Biol 28:555-62. 2003
    ..Furthermore, this simple technique for protein transfection of lung tissue can be used in a variety of future applications...
  11. doi Senescence hypothesis for the pathogenetic mechanism of chronic obstructive pulmonary disease
    Kazutetsu Aoshiba
    First Department of Medicine, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, Japan
    Proc Am Thorac Soc 6:596-601. 2009
    ..Thus, cellular senescence may be involved in arrested tissue repair, chronic inflammation, and increased susceptibility to infection, which are the typical features of COPD...
  12. ncbi Acute cigarette smoke exposure induces apoptosis of alveolar macrophages
    K Aoshiba
    First Department of Medicine, Tokyo Women s Medical University, Shinjuku ku, Tokyo 162 8666, Japan
    Am J Physiol Lung Cell Mol Physiol 281:L1392-401. 2001
    ..These results suggest that acute CS exposure is capable of inducing apoptosis of AMs...
  13. ncbi Differences in the distribution of CD4+ and CD8+ T cells in emphysematous lungs
    Kazutetsu Aoshiba
    First Department of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Respiration 71:184-90. 2004
    ..Recent studies have shown that T cells are the predominant cells infiltrating the alveolar wall of patients with emphysema. Since CD4+ and CD8+ cells have dissimilar function, they may have different distributions in emphysematous lungs...
  14. ncbi Macrolide antibiotics protect against immune complex-induced lung injury in rats: role of nitric oxide from alveolar macrophages
    J Tamaoki
    First Department of Medicine, Tokyo Women s Medical University School of Medicine, Japan
    J Immunol 163:2909-15. 1999
    ....
  15. ncbi Beta-adrenergic receptor-mediated growth of human airway epithelial cell lines
    K Nishimura
    First Dept of Medicine, Tokyo Women s Medical University School of Medicine, Japan
    Eur Respir J 20:353-8. 2002
    ....
  16. doi Alveolar cell senescence exacerbates pulmonary inflammation in patients with chronic obstructive pulmonary disease
    Takao Tsuji
    First Department of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Respiration 80:59-70. 2010
    ..Alveolar cell senescence is accelerated in patients with chronic obstructive pulmonary disease (COPD)...
  17. doi Platinum nanoparticle antioxidants inhibit pulmonary inflammation in mice exposed to cigarette smoke
    Shigemitsu Onizawa
    First Department of Medicine, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, Japan
    Pulm Pharmacol Ther 22:340-9. 2009
    ..These results suggest that platinum nanoparticles act as antioxidants that inhibit pulmonary inflammation induced by acute cigarette smoking...
  18. doi A systemically administered EP2 receptor agonist stimulates pulmonary angiogenesis in a murine model of emphysema
    Takao Tsuji
    First Department of Medicine, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Prostaglandins Other Lipid Mediat 90:85-8. 2009
    ..These results suggest that systemically administered ONO-AE1-259 stimulates pulmonary angiogenesis in an elastase-induced murine model of emphysema...
  19. ncbi Macrophage colony-stimulating factor aggravates rather than regenerates emphysematous lungs in mice
    Takaaki Ishikawa
    First Department of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Respiration 73:538-45. 2006
    ..Lung regeneration is an innovative strategy that may cure pulmonary emphysema. The bone marrow (BM) harbors pulmonary stem cells. Hematopoietic cytokine-driven mobilization of BM cells may thus support lung regeneration...
  20. ncbi Activation of nuclear factor-kappaB in airway epithelial cells in patients with chronic obstructive pulmonary disease
    Osamitsu Yagi
    First Department of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Respiration 73:610-6. 2006
    ..Nuclear factor-kappaB (NF-kappaB) is a transcription factor that mediates proinflammatory gene expression. NF-kappaB is activated when its inhibitor, IkappaBalpha, is phosphorylated and degraded...
  21. ncbi Increased levels of cell death and proliferation in alveolar wall cells in patients with pulmonary emphysema
    Naoko Yokohori
    First Department of Medicine, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Chest 125:626-32. 2004
    ..However, alterations in the turnover of pulmonary cells are less well understood. This study was designed to examine whether the turnover of alveolar wall cells is altered in patients with emphysema...
  22. ncbi Validity and safety of sputum induction by inhaled uridine 5'-triphosphate
    J Tamaoki
    First Department of Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan
    Am J Respir Crit Care Med 164:378-81. 2001
    ..Keywords: uridine triphosphate; induced sputum; airway inflammation; bronchoconstriction; asthma..
  23. ncbi Alveolar cell senescence in patients with pulmonary emphysema
    Takao Tsuji
    First Department of Medicine, Tokyo Women s Medical University 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Am J Respir Crit Care Med 174:886-93. 2006
    ..In this study we investigated whether the senescence of alveolar epithelial and endothelial cells is accelerated in emphysematous lungs...
  24. ncbi Apoptosis of wound fibroblasts induced by oxidative stress
    Atsushi Takahashi
    First Department of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Exp Lung Res 28:275-84. 2002
    ..Fibroblast apoptosis induced by oxidative stress during wound repopulation may be relevant to intractable wound healing...
  25. ncbi Cigarette smoke induces senescence in alveolar epithelial cells
    Takao Tsuji
    First Department of Medicine, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Am J Respir Cell Mol Biol 31:643-9. 2004
    ..The induction of cellular senescence by CS may contribute to impaired re-epithelialization, leading to CS-related chronic lung diseases...
  26. ncbi Transforming growth factor-beta promotes fibroblast apoptosis induced by H2O2
    Kimihiko Yasuda
    First Department of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Exp Lung Res 29:123-34. 2003
    ..Thus, TGF-beta may promote the elimination of fibroblasts from wounds, particularly under conditions of exposure to enhanced oxidative stress in the lung...
  27. ncbi Differences in airway remodeling between asthma and chronic obstructive pulmonary disease
    Kazutetsu Aoshiba
    First Department of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Clin Rev Allergy Immunol 27:35-43. 2004
    ..The remodeling processes accompanied by chronic inflammatory infiltrates interact in a complex fashion and contribute to the development of airflow limitation in both asthma and COPD...
  28. ncbi Epidermal growth factor receptor tyrosine kinase inhibition augments a murine model of pulmonary fibrosis
    Hiroko Suzuki
    First Department of Medicine, Tokyo Women s Medical University, Tokyo 162 8666, Japan
    Cancer Res 63:5054-9. 2003
    ..Our data suggest that EGFR-TKIs should be used with caution in cancer patients with pulmonary fibrosis...
  29. ncbi [Aging lung and smoking]
    Kazutetsu Aoshiba
    Nihon Ronen Igakkai Zasshi 43:582-4. 2006
  30. ncbi [Progress in the field of pulmonary medicine in the last 100 years: Medical history of pulmonary emphysema and chronic obstructive pulmonary disease]
    Kazutetsu Aoshiba
    Nihon Naika Gakkai Zasshi 91:1747-52. 2002