Teruo Amagasa

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. doi request reprint Oral premalignant lesions: from a clinical perspective
    Teruo Amagasa
    Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, Yushima 1 chome, 5 45, Bunkyo ku, Tokyo 113 8549, Japan
    Int J Clin Oncol 16:5-14. 2011
  2. doi request reprint Identification of PAK4 as a putative target gene for amplification within 19q13.12-q13.2 in oral squamous-cell carcinoma
    Asma Begum
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 100:1908-16. 2009
  3. doi request reprint Osteoblastic bone formation is induced by using nanogel-crosslinking hydrogel as novel scaffold for bone growth factor
    Chikako Hayashi
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Cell Physiol 220:1-7. 2009
  4. doi request reprint Dok-1 and Dok-2 deficiency induces osteopenia via activation of osteoclasts
    Aya Kawamata
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Cell Physiol 226:3087-93. 2011
  5. pmc Prognostic utility of chromosomal instability detected by fluorescence in situ hybridization in fine-needle aspirates from oral squamous cell carcinomas
    Hiroaki Sato
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    BMC Cancer 10:182. 2010
  6. doi request reprint EGFR gene copy number alteration is a better prognostic indicator than protein overexpression in oral tongue squamous cell carcinomas
    Yoshimi Nakata
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Cancer 47:2364-72. 2011
  7. doi request reprint Nanogel-based scaffold delivery of prostaglandin E(2) receptor-specific agonist in combination with a low dose of growth factor heals critical-size bone defects in mice
    Paksinee Kamolratanakul
    Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 63:1021-33. 2011
  8. ncbi request reprint Cyclin D1 gene numerical aberration is a predictive marker for occult cervical lymph node metastasis in TNM Stage I and II squamous cell carcinoma of the oral cavity
    Kunihiro Myo
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Japan
    Cancer 104:2709-16. 2005
  9. doi request reprint Potential of tumor-suppressive miR-596 targeting LGALS3BP as a therapeutic agent in oral cancer
    Hironori Endo
    Department of Molecular Cytogenetics, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo ku, Tokyo 113 8510, Japan
    Carcinogenesis 34:560-9. 2013
  10. pmc Profilin1 regulates sternum development and endochondral bone formation
    Daisuke Miyajima
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Biol Chem 287:33545-53. 2012

Detail Information

Publications66

  1. doi request reprint Oral premalignant lesions: from a clinical perspective
    Teruo Amagasa
    Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, Yushima 1 chome, 5 45, Bunkyo ku, Tokyo 113 8549, Japan
    Int J Clin Oncol 16:5-14. 2011
    ..Further research to clarify its role in malignant transformation is warranted...
  2. doi request reprint Identification of PAK4 as a putative target gene for amplification within 19q13.12-q13.2 in oral squamous-cell carcinoma
    Asma Begum
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 100:1908-16. 2009
    ..These findings reveal that the PAK4 overexpression through amplification or other mechanisms promotes the proliferation and/or survival of OSCC cells, and that PAK4 might be a good diagnostic and/or therapeutic target...
  3. doi request reprint Osteoblastic bone formation is induced by using nanogel-crosslinking hydrogel as novel scaffold for bone growth factor
    Chikako Hayashi
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Cell Physiol 220:1-7. 2009
    ..In conclusion, CHPA/hydrogel serves as an efficient and versatile scaffold for the stimulation of osteoblasts to form bone and to repair defects via delivery of BMP...
  4. doi request reprint Dok-1 and Dok-2 deficiency induces osteopenia via activation of osteoclasts
    Aya Kawamata
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Cell Physiol 226:3087-93. 2011
    ..These data revealed that Dok-1 and Dok-2 deficiency induces osteopenia by activation of osteoclasts...
  5. pmc Prognostic utility of chromosomal instability detected by fluorescence in situ hybridization in fine-needle aspirates from oral squamous cell carcinomas
    Hiroaki Sato
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    BMC Cancer 10:182. 2010
    ..In this study, we evaluated CIN in fine-needle aspiration (FNA) biopsied oral squamous cell carcinomas (SCCs) using fluorescence in situ hybridization (FISH) analysis, and investigated its prognostic significance...
  6. doi request reprint EGFR gene copy number alteration is a better prognostic indicator than protein overexpression in oral tongue squamous cell carcinomas
    Yoshimi Nakata
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Cancer 47:2364-72. 2011
    ..001). EGFR copy number status is a more reliable indicator than protein overexpression of the survival rate in OTSCCs. FISH analysis of the EGFR status is useful in predicting poor prognosis in OTSCCs...
  7. doi request reprint Nanogel-based scaffold delivery of prostaglandin E(2) receptor-specific agonist in combination with a low dose of growth factor heals critical-size bone defects in mice
    Paksinee Kamolratanakul
    Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 63:1021-33. 2011
    ..The aim of this study was to explore a new system for delivery of a selective EP4 receptor agonist (EP4A) in combination with low-dose bone morphogenetic protein 2 (BMP-2)...
  8. ncbi request reprint Cyclin D1 gene numerical aberration is a predictive marker for occult cervical lymph node metastasis in TNM Stage I and II squamous cell carcinoma of the oral cavity
    Kunihiro Myo
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Japan
    Cancer 104:2709-16. 2005
    ..The purpose of this study was to evaluate the value of cyclin D1 gene (CCND1) numerical aberrations in predicting the risk of late lymph node metastases...
  9. doi request reprint Potential of tumor-suppressive miR-596 targeting LGALS3BP as a therapeutic agent in oral cancer
    Hironori Endo
    Department of Molecular Cytogenetics, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo ku, Tokyo 113 8510, Japan
    Carcinogenesis 34:560-9. 2013
    ..Our findings define a central role for miR-596 in OSCC and suggest the potential of miR-596 as an anticancer agent for miRNA replacement therapy in OSCC...
  10. pmc Profilin1 regulates sternum development and endochondral bone formation
    Daisuke Miyajima
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Biol Chem 287:33545-53. 2012
    ..These observations revealed that Pfn1 is a critical molecule for the skeletal development, and this could be at least in part associated with the retardation of cell migration...
  11. doi request reprint CIZ/NMP4 is expressed in B16 melanoma and forms a positive feedback loop with RANKL to promote migration of the melanoma cells
    Tomomi Sakuma
    Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Cell Physiol 227:2807-12. 2012
    ..These observations indicate that CIZ/NMP4 is critical regulator of metastasis of melanoma cells...
  12. doi request reprint CXCL2 synthesized by oral squamous cell carcinoma is involved in cancer-associated bone destruction
    Erika Oue
    Section of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
    Biochem Biophys Res Commun 424:456-61. 2012
    ..These results indicate that CXCL2 is involved in bone destruction induced by oral cancer. This is the first report showing the role of CXCL2 in cancer-associated bone destruction...
  13. doi request reprint Clinical significance of lymphatic and blood vessel invasion in oral tongue squamous cell carcinomas
    Chieko Michikawa
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Oral Oncol 48:320-4. 2012
    ..Evaluation of VI status, as LVI and BVI status separately, using IHC with D2-40 and EVG staining may be useful in predicting lymph node metastasis and poor prognosis in OTSCCs...
  14. ncbi request reprint Prognostic significance of cyclin D1 amplification and overexpression in oral squamous cell carcinomas
    Ryozo Miyamoto
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Oral Oncol 39:610-8. 2003
    ..From the present study, CCND1 amplification is a more reliable prognostic indicator than CCND1 overexpression in OSCCs...
  15. doi request reprint LPS-induced inhibition of osteogenesis is TNF-alpha dependent in a murine tooth extraction model
    Nobuyoshi Tomomatsu
    Department of Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Bone Miner Res 24:1770-81. 2009
    ..In conclusion, TNF-alpha might play a major role in LPS-induced inhibition of osteogenesis under inflammatory conditions...
  16. doi request reprint Gene expression changes in initiation and progression of oral squamous cell carcinomas revealed by laser microdissection and oligonucleotide microarray analysis
    Jun Sumino
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Cancer 132:540-8. 2013
    ..One of these, ISG15, is likely to be associated with both dysgenesis and tumorigenesis and may be a potential prognostic marker for oral cancer...
  17. doi request reprint A structural modulator of tumor necrosis factor type 1 receptor promotes bone formation under lipopolysaccharide-induced inflammation in a murine tooth extraction model
    Hiroyuki Nakachi
    Department of Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8549, Japan
    Eur J Pharmacol 679:132-8. 2012
    ..We did not observe any significant differences among the PBS-injected groups. Taken together, TNF-α antagonist CIAM compound, was found to accelerate bone formation under LPS-induced inflammatory condition...
  18. doi request reprint Acerogenin A, a natural compound isolated from Acer nikoense Maxim, stimulates osteoblast differentiation through bone morphogenetic protein action
    Tasuku Kihara
    Section of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Biochem Biophys Res Commun 406:211-7. 2011
    ..These results indicated that acerogenin A stimulates osteoblast differentiation through BMP action, which is mediated by Runx2-dependent and Runx2-independent pathways...
  19. doi request reprint Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma
    Erina Nakamura
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo ku, Tokyo 113 8510, Japan
    Cancer Sci 99:1390-400. 2008
    ....
  20. doi request reprint Increasing participation of sclerostin in postnatal bone development, revealed by three-dimensional immunofluorescence morphometry
    Takashi Watanabe
    Section of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
    Bone 51:447-58. 2012
    ....
  21. doi request reprint Cell-printing and transfer technology applications for bone defects in mice
    Junichi Tsugawa
    Department of Cellular Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Tissue Eng Regen Med 5:695-703. 2011
    ..Our findings support the development of a biologically stable and effective bone regeneration therapy...
  22. ncbi request reprint Serum osteopontin, an enhancer of tumor metastasis to bone, promotes B16 melanoma cell migration
    Chikako Hayashi
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Cell Biochem 101:979-86. 2007
    ....
  23. ncbi request reprint Fluorescence in situ hybridization for detecting genomic alterations of cyclin D1 and p16 in oral squamous cell carcinomas
    Narikazu Uzawa
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer 110:2230-9. 2007
    ..The objective of the current study was to determine whether CCND1 numerical aberrations and p16 deletions in oral SCCs detected by fluorescence in situ hybridization (FISH) have any impact on clinical outcome...
  24. doi request reprint JunD suppresses bone formation and contributes to low bone mass induced by estrogen depletion
    Aya Kawamata
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, 101 0062, Tokyo, Japan
    J Cell Biochem 103:1037-45. 2008
    ..Thus, JunD is involved in estrogen depletion-induced osteopenia via its action to suppress bone formation and to enhance bone resorption...
  25. doi request reprint Bone morphogenetic proteins are involved in the pathobiology of synovial chondromatosis
    Shoichi Nakanishi
    Section of Oral Pathology, Graduate School of Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Biochem Biophys Res Commun 379:914-9. 2009
    ..Further, it inhibited Osteocalcin expression in the synovial cells. These results suggest that BMPs are involved in the pathobiology of cartilaginous and osteogenic metaplasia observed in synovial chondromatosis...
  26. doi request reprint Comprehensive keratin profiling reveals different histopathogenesis of keratocystic odontogenic tumor and orthokeratinized odontogenic cyst
    Tadanobu Aragaki
    Section of Oral Pathology, Tokyo Medical and Dental University, Tokyo, Japan
    Hum Pathol 41:1718-25. 2010
    ....
  27. ncbi request reprint Neurosensory alteration in the lower lip and chin area after orthognathic surgery: bilateral sagittal split osteotomy versus inverted L ramus osteotomy
    Akiko Kobayashi
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Oral Maxillofac Surg 64:778-84. 2006
    ..This study investigated neurosensory disturbances in patients after orthognathic surgery in relation to differences in mandibular splitting methods and degree of surgical skill...
  28. ncbi request reprint Effective staining method with iodine for leukoplakia and lesions surrounding squamous cell carcinomas of the tongue assessed by colorimetric analysis
    Keiko Maeda
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Med Dent Sci 56:123-30. 2009
    ....
  29. doi request reprint Inhibitory effect of CT domain of CCN3/NOV on proliferation and differentiation of osteogenic mesenchymal stem cells, Kusa-A1
    Yuko Katsuki
    Maxillofacial Surgery, Graduate School of Tokyo Medical and Dental University, Tokyo, Japan
    Biochem Biophys Res Commun 368:808-14. 2008
    ..These results suggest that CCN3 employs Notch and BMP pathways in anti-osteogenic activity while it inhibits cell proliferation uniquely by Notch/p21 pathway...
  30. doi request reprint Hard tissue regeneration capacity of apical pulp derived cells (APDCs) from human tooth with immature apex
    Shigehiro Abe
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Biochem Biophys Res Commun 371:90-3. 2008
    ..This study suggests that the human tooth with an immature apex is an effective source of cells for hard tissue regeneration...
  31. ncbi request reprint Sarcomas of the oral and maxillofacial region: a review of 32 cases in 25 years
    Satoshi Yamaguchi
    Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyou ku, 113 8549 Tokyo, Japan
    Clin Oral Investig 8:52-5. 2004
    ..Adequate excision with safety surgical margin as the initial therapy is important for better survival. The value of radiation therapy and/or chemotherapy is uncertain. The 5-year survival rate of primary cases was 61%...
  32. ncbi request reprint Osteopontin-deficiency suppresses growth of B16 melanoma cells implanted in bone and osteoclastogenesis in co-cultures
    Yoshio Ohyama
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Bone Miner Res 19:1706-11. 2004
    ..Osteopontin deficiency decreased tumor invasion in bone based on knockout mouse study. In bone, osteopontin is a positive factor to increase tumor invasion...
  33. ncbi request reprint Poly(ethylene glycol) hydrogels cross-linked by hydrolyzable polyrotaxane containing hydroxyapatite particles as scaffolds for bone regeneration
    Mariko Fujimoto
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Biomater Sci Polym Ed 16:1611-21. 2005
    ..These images are similar to intramembranous ossification, and it is expected that bone regeneration occurs on the surface of the PRX-HAp. This study strongly suggests the great potential of the PRX-HAp as scaffolds for bone regeneration...
  34. pmc Characterization of the radioresponse of human apical papilla-derived cells
    Shigehiro Abe
    Oral Radiation Oncology, Department of Oral Restitution, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Stem Cell Res Ther 2:2. 2011
    ..The purpose of this study was to characterize the radiobiological properties of stem/progenitor cells derived from apical papilla-derived cells (APDCs) compared to bulk APDCs...
  35. doi request reprint Induction of IL-10- and IFN-gamma-producing T-cell responses by autoreactive T-cells expressing human T-cell leukemia virus type I Tax
    Natsuko Takatsuka
    Department of Immunotherapeutics, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Int Immunol 21:1089-100. 2009
    ..Our findings provide new insights into the complex immune conditions underlying HTLV-I-associated diseases...
  36. ncbi request reprint A comparison of the tube forming potentials of early and late endothelial progenitor cells
    Nana Mukai
    Department of Cellular Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Japan
    Exp Cell Res 314:430-40. 2008
    ..The phenomena were also observed in the in vivo model. These observations suggest that early EPCs cause the disorganization of pre-existing vessels, whereas late EPCs constitute and orchestrate vascular tube formation...
  37. ncbi request reprint Loss of cyclin E requirement in cell growth of an oral squamous cell carcinoma cell line implies deregulation of its downstream pathway
    Shumpei Yamada
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Cancer 111:17-22. 2004
    ..These results indicate that HSC-2 cells lost proper growth control specifically mediated by cyclin E and suggest that deregulation of its downstream pathway may contribute to tumorigenesis of oral SCC...
  38. ncbi request reprint A mutation in the common docking domain of ERK2 in a human cancer cell line, which was associated with its constitutive phosphorylation
    Ramanathan Arvind
    Department of Molecular Cellular Oncology and Microbiology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 113 8549 Tokyo, Japan
    Int J Oncol 27:1499-504. 2005
    ..The present study is the first to report ERK2 substitution mutation in a human cancer cell line which resulted in constitutive phosphorylation...
  39. ncbi request reprint Effects of autologous serum on osteoblastic differentiation in human bone marrow cells
    Noriyuki Yamamoto
    Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Med Dent Sci 50:63-9. 2003
    ..To overcome these problems, we examined whether a patient's autologous serum could support the growth and differentiation of his/her BMSCs...
  40. ncbi request reprint Relationship between oral sensory thresholds and depressive moods
    Yuko Watanabe
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduated School, Tokyo Medical and Dental University, Japan
    J Med Dent Sci 52:73-80. 2005
    ....
  41. ncbi request reprint Trimodal combination therapy for maxillary sinus carcinoma
    Ryo ichi Yoshimura
    Department of Radiology, Tokyo Medical and Dental University, 5 45 Yushima I chome, Bunkyo ku, Tokyo 113 8519, Japan
    Int J Radiat Oncol Biol Phys 53:656-63. 2002
    ..This study was conducted to evaluate the effectiveness of trimodal combination therapy (radiotherapy, intra-arterial chemotherapy, antrotomy) for the treatment of primary maxillary sinus carcinoma...
  42. ncbi request reprint Clinical and magnetic resonance imaging study of unilateral sideways disc displacements of the temporomandibular joint
    Shigeru Aoyama
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Med Dent Sci 49:89-94. 2002
    ..5865 for lateral disc displacement). This study suggested the wide opening of the mouth to become the predictor for the lateral disc displacement among the cases suspected to have disc displacement without reduction...
  43. doi request reprint Effects of embryonic hypoxia on lip formation
    Ryosuke Nagaoka
    Section of Molecular Craniofacial Embryology, Graduated School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
    Birth Defects Res A Clin Mol Teratol 94:215-22. 2012
    ....
  44. doi request reprint GITR ligand-costimulation activates effector and regulatory functions of CD4+ T cells
    Hanna Igarashi
    Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Biochem Biophys Res Commun 369:1134-8. 2008
    ..Our results suggest that highly activated and increased ratios of Treg reverse the immune-enhancing effects of GITRL-costimulation in Teff, which may be problematic for therapeutic applications using strong GITR agonists...
  45. ncbi request reprint Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis
    Yoshio Ohyama
    Department of Molecular Pharmacology, Tokyo Medical and Dental University, 3 10 Kanda Surugadai 2 Chome, Chiyoda ku, Tokyo, Japan
    Endocrinology 145:4685-92. 2004
    ..Thus, expression and regulation of SOST under the control of BMP were closely associated with those of Osx in vivo and in vitro...
  46. doi request reprint Synchronous Warthin tumors and lymphoepithelial cyst in the ipsilateral parotid gland
    Ken ichiro Takahashi
    Department of Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Oral Maxillofac Surg 66:1053-6. 2008
  47. ncbi request reprint Teeth contacting habit as a contributing factor to chronic pain in patients with temporomandibular disorders
    Fumiaki Sato
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Japan
    J Med Dent Sci 53:103-9. 2006
    ..944, p = 0.043). Other factors associated with TCH were as follows: unilateral chewing (OR = 2.802) and involvement in a precision job (OR = 2.195). [CONCLUSION] TCH can prolong TMD pain and is associated with other behavioral factors...
  48. ncbi request reprint Axillary nodal metastasis from oral and maxillofacial cancers: a report of 3 cases
    Aung Lwin Oo
    Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Oral Maxillofac Surg 62:1019-24. 2004
  49. doi request reprint Diagnostic accuracy of cone-beam CT in the assessment of mandibular invasion of lower gingival carcinoma: comparison with conventional panoramic radiography
    Mohammad A Momin
    Oral and Maxillofacial Radiology, Graduate School, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8549, Japan
    Eur J Radiol 72:75-81. 2009
    ..To evaluate the diagnostic accuracy of cone-beam CT in assessing mandibular invasion by lower gingival carcinoma and compare it with that of panoramic radiography...
  50. ncbi request reprint Noninvasive quantitative assessment of oral tongue cancer by intraoral ultrasonography
    Masashi Yamane
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Head Neck 29:307-14. 2007
    ....
  51. ncbi request reprint Expression of proteoglycan mRNA in human temporomandibular joint disks in temporomandibualr disorders
    Tomoaki Shibuya
    Dept of Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, PO BOX 113 8549 5 45 Yushima 1 chome Bunkyo ku, Tokyo, Japan
    J Med Dent Sci 49:85-8. 2002
    ..Calcification would be initiated in the part of the disk experiencing the increased compression...
  52. ncbi request reprint Novel targets for the 18p11.3 amplification frequently observed in esophageal squamous cell carcinomas
    Koichi Nakakuki
    Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Carcinogenesis 23:19-24. 2002
    ..Taken together, these results suggest that YES1, TYMS, HEC and TGIF are likely to be candidate targets for 18p11.3 amplification and be associated with esophageal tumorigenesis...
  53. pmc Identification of a novel human immunodeficiency virus type 1 integrase interactor, Gemin2, that facilitates efficient viral cDNA synthesis in vivo
    Seiji Hamamoto
    Department of Immunotherapeutics, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Virol 80:5670-7. 2006
    ..Thus, we provide the evidence for a novel host protein that binds to HIV-1 IN and facilitates viral cDNA synthesis and subsequent steps that precede integration in vivo...
  54. ncbi request reprint Regulation of the expression of pigment epithelium-derived factor, an anti-angiogenic factor in human oral squamous cell carcinoma cell lines
    Daisuke Miyagishi
    Department of Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8549, Japan
    Cancer Lett 196:77-85. 2003
    ..These data suggest that human oral squamous cell carcinoma cells produce VEGF, which in turn regulates PEDF production, and this balance may be contributing to neovascularization in tumors...
  55. ncbi request reprint [Treatment results of acupuncture in inferior alveolar and lingual nerves sensory paralysis after oral surgery]
    Lucy Ka
    Maxillofacial Surgery, Department of Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University
    Kokubyo Gakkai Zasshi 73:40-6. 2006
    ..In summary, the study indicated that acupuncture is useful in treating sensory paralysis...
  56. ncbi request reprint Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma
    Itaru Sonoda
    Department of Molecular Cytogenetics, Medical Research Institute, and Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Res 64:3741-7. 2004
    ..These results suggest that loss of LRP1B function in esophageal carcinogenesis most often occurs either by homozygous deletion or by transcriptional silencing through hypermethylation of its CpG island...
  57. ncbi request reprint Clinical evaluation of the temporomandibular joint following orthognathic surgery--multiple logistic regression analysis
    Shigeru Aoyama
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Japan
    J Med Dent Sci 52:109-14. 2005
    ..95 (95 percent confidence interval, from 1.06 to 45.42). We concluded that surgical correction in skeletal malocclusion may affect temporomandibular joint dysfunction symptoms...
  58. ncbi request reprint Effect of the reclining position in patients after oral tumor surgery
    Yoshiko Umeda
    Department of Gerodontology, Division of Gerontology and Gerodontology, Graduate School, Tokyo Medical and Dental University
    J Med Dent Sci 58:69-77. 2011
    ..This study investigated the effects of reclining position on swallowing functions in the patients who had undergone surgery for oral tumors...
  59. pmc Assessment of oral transmission using cell-free human immunodeficiency virus-1 in mice reconstituted with human peripheral blood leucocyte
    Ryoma Nakao
    Department of Maxillofacial Reconstruction and Function, Graduate School, Tokyo Medical and Dental University, Tokyo Japan
    Immunology 109:271-82. 2003
    ....
  60. ncbi request reprint Identification of a novel fusion gene in a pre-B acute lymphoblastic leukemia with t(1;19)(q23;p13)
    Yasuhiro Yuki
    Department of Molecular Cytogenetics, Medical Research Institute, Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8510, Japan
    Cancer Sci 95:503-7. 2004
    ..Given the frequency of t(1;19) without the E2A-PBX1 fusion in hematological malignancies, we suggest that MEF2D / DAZAP1 rearrangements might be involved in the pathogenesis of those diseases...
  61. ncbi request reprint Potential marker of oral squamous cell carcinoma aggressiveness detected by fluorescence in situ hybridization in fine-needle aspiration biopsies
    Ryozo Miyamoto
    Department of Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer 95:2152-9. 2002
    ..Amplification of chromosome 11q13 is a frequent event in carcinogenesis of the head and neck squamous cell carcinomas including oral carcinoma...
  62. ncbi request reprint A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti-tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis
    Hiroaki Saito
    Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 56:1164-74. 2007
    ..We undertook this study to compare the effects of the WP9QY peptide on collagen-induced arthritis (CIA) in mice with those of anti-TNFalpha monoclonal antibody...
  63. ncbi request reprint Effects of experimentally induced inflammation on temporomandibular joint nociceptors in rats
    Yoshinari Takeuchi
    Maxillofacial Surgery, Maxillofacial Reconstruction, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8549, Japan
    Neurosci Lett 354:172-4. 2004
    ..These results suggest that inflammation may sensitize nociceptors in the temporomandibular joint, and cause hyperalgesia and allodynia...
  64. ncbi request reprint Subcutaneous injections of a TNF-alpha antagonistic peptide inhibit both inflammation and bone resorption in collagen-induced murine arthritis
    Takefumi Kojima
    Maxillofacial Surgery, Department of Maxillofacial Reconstruction and Function, Graduate School, Tokyo Medical and Dental University, Japan
    J Med Dent Sci 52:91-9. 2005
    ..The WP9QY treatment prevented the inflammation as well as bone destruction of the joints in the CIA mice, suggesting that the administration of WP9QY peptide might be useful for developing a drug to prevent inflammatory bone destruction...
  65. ncbi request reprint Arthroscopic removal of nodules of synovial chondromatosis of the temporomandibular joint
    Tomoaki Shibuya
    Dept of Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, Japan
    Cranio 20:304-6. 2002
    ..Based on this experience, we suggest the use of ethmoid forceps should be considered as an alternative procedure when nodules are unable to pass through the cannula by lavage with sterile saline...
  66. ncbi request reprint Synovial chondromatosis of the temporomandibular joint: long-term postoperative follow-up of the residual calcification
    Junichi Ishii
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Japan
    J Med Dent Sci 50:133-7. 2003
    ..We report a case of extra-articular synovial condromatosis, for which we carried out a long-term follow-up of the postoperative course using diagnostic images...