Affiliation: Tokyo Metropolitan Institute of Gerontology
Aida J, Kobayashi T, Saku T, Yamaguchi M, Shimomura N, Nakamura K, et al
. Short telomeres in an oral precancerous lesion: Q-FISH analysis of leukoplakia. J Oral Pathol Med. 2012;41:372-8 pubmed publisher
..Therefore, when this type of leukoplakia is recognized in the oral region, strict follow-up for oral squamous cell carcinoma is necessary, focusing not only on the areas of leukoplakia, but also the surrounding background. ..
Aida J, Yokoyama A, Shimomura N, Nakamura K, Ishikawa N, Terai M, et al
. Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history. PLoS ONE. 2013;8:e63860 pubmed publisher
..Telomere shortening may not generate cancer directly, but may create conditions under which SCC can develop more easily, depending on subsequent exposure to carcinogens...
Aida J, Yokoyama A, Izumiyama N, Nakamura K, Ishikawa N, Poon S, et al
. Alcoholics show reduced telomere length in the oesophagus. J Pathol. 2011;223:410-6 pubmed publisher
..Further studies to clarify the reason for the large annual loss of telomere length with rapid turnover or lower telomerase activity in the oesophageal epithelium of alcoholics will be necessary...