Yasushi Kishimoto

Summary

Affiliation: Tokushima Bunri Univ
Location: Sanuki, Japan

Publications

  1. ncbi request reprint Conditioned eyeblink response is impaired in mutant mice lacking NMDA receptor subunit NR2A
    Y Kishimoto
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Japan
    Neuroreport 8:3717-21. 1997
  2. doi request reprint Early impairment in a water-finding test in a longitudinal study of the Tg2576 mouse model of Alzheimer's disease
    Yasushi Kishimoto
    Laboratory of Neurobiophysics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314 1 Shido, Sanuki, Kagawa, Japan
    Brain Res 1491:117-26. 2013
  3. doi request reprint Impaired long-trace eyeblink conditioning in a Tg2576 mouse model of Alzheimer's disease
    Yasushi Kishimoto
    Laboratory of Neurobiophysics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa 769 2193, Japan
    Neurosci Lett 506:155-9. 2012
  4. doi request reprint A role for myosin Va in cerebellar plasticity and motor learning: a possible mechanism underlying neurological disorder in myosin Va disease
    Mariko Miyata
    Department of Physiology, Tokyo Women s Medical University School of Medicine, Tokyo 162 8666, Japan
    J Neurosci 31:6067-78. 2011
  5. ncbi request reprint Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression
    Shin ichiro Kina
    Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, 108 8639, Japan
    Eur J Neurosci 26:2269-78. 2007
  6. pmc Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission
    Norio Wada
    Department of Systems Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 104:16690-5. 2007
  7. pmc Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity
    Sho Kakizawa
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    EMBO J 26:1924-33. 2007
  8. ncbi request reprint Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning
    Yasushi Kishimoto
    Department of Cellular Neuroscience, Graduate School of Medicine, Osaka University, Suita 565 0871, Japan
    J Neurosci 26:8829-37. 2006
  9. ncbi request reprint Hippocampal CA3 NMDA receptors are crucial for adaptive timing of trace eyeblink conditioned response
    Yasushi Kishimoto
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    J Neurosci 26:1562-70. 2006
  10. ncbi request reprint mGluR1 in cerebellar Purkinje cells is required for normal association of temporally contiguous stimuli in classical conditioning
    Yasushi Kishimoto
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, 13 1, Takaramachi, Kanazawa 920 8640, Japan
    Eur J Neurosci 16:2416-24. 2002

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Conditioned eyeblink response is impaired in mutant mice lacking NMDA receptor subunit NR2A
    Y Kishimoto
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Japan
    Neuroreport 8:3717-21. 1997
    ....
  2. doi request reprint Early impairment in a water-finding test in a longitudinal study of the Tg2576 mouse model of Alzheimer's disease
    Yasushi Kishimoto
    Laboratory of Neurobiophysics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314 1 Shido, Sanuki, Kagawa, Japan
    Brain Res 1491:117-26. 2013
    ..We therefore propose that the water-finding test is a rapid and sensitive method that can be used to assess cognitive and/or behavioral deficits in mouse models of Alzheimer's disease...
  3. doi request reprint Impaired long-trace eyeblink conditioning in a Tg2576 mouse model of Alzheimer's disease
    Yasushi Kishimoto
    Laboratory of Neurobiophysics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa 769 2193, Japan
    Neurosci Lett 506:155-9. 2012
    ..The long-trace eyeblink conditioning could be a potential tool for detecting early cognitive deficits in AD mouse model...
  4. doi request reprint A role for myosin Va in cerebellar plasticity and motor learning: a possible mechanism underlying neurological disorder in myosin Va disease
    Mariko Miyata
    Department of Physiology, Tokyo Women s Medical University School of Medicine, Tokyo 162 8666, Japan
    J Neurosci 31:6067-78. 2011
    ..Interestingly, d-n mice had defects of motor coordination from young to adult ages, suggesting that the role of myosin Va in PC spines is not sufficient for motor coordination...
  5. ncbi request reprint Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression
    Shin ichiro Kina
    Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, 108 8639, Japan
    Eur J Neurosci 26:2269-78. 2007
    ..These results suggest that tyrosine dephosphorylation events regulated by PTPMEG are important for both motor learning and cerebellar synaptic plasticity...
  6. pmc Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission
    Norio Wada
    Department of Systems Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 104:16690-5. 2007
    ..These results indicate that the convergent information at the interpositus nucleus is critical for acquisition and storage of learning in intimate association with the Purkinje cell circuit for expression of CRs in eyeblink conditioning...
  7. pmc Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity
    Sho Kakizawa
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    EMBO J 26:1924-33. 2007
    ..Therefore, JPs support the Ca(2+)-mediated communication between voltage-gated Ca(2+) channels, RyRs and SK channels, which modulates the excitability of PCs and is fundamental to cerebellar LTD and motor functions...
  8. ncbi request reprint Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning
    Yasushi Kishimoto
    Department of Cellular Neuroscience, Graduate School of Medicine, Osaka University, Suita 565 0871, Japan
    J Neurosci 26:8829-37. 2006
    ..These results indicate that endogenous cannabinoid signaling through CB1 is essential for cerebellum-dependent discrete motor learning, especially for its acquisition...
  9. ncbi request reprint Hippocampal CA3 NMDA receptors are crucial for adaptive timing of trace eyeblink conditioned response
    Yasushi Kishimoto
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    J Neurosci 26:1562-70. 2006
    ..These results indicate that CA3-NR1 KO mice are unable to rapidly retrieve adaptive CR timing, suggesting that CA3 NRs play a crucial role in the memory of adaptive CR timing in trace conditioning...
  10. ncbi request reprint mGluR1 in cerebellar Purkinje cells is required for normal association of temporally contiguous stimuli in classical conditioning
    Yasushi Kishimoto
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, 13 1, Takaramachi, Kanazawa 920 8640, Japan
    Eur J Neurosci 16:2416-24. 2002
    ..In contrast, mGluR1 in other cell types is required for associating discontiguous stimuli and long-term memory formation in nonspatial hippocampus-dependent learning...
  11. ncbi request reprint Impairment of eyeblink conditioning in GluRdelta2-mutant mice depends on the temporal overlap between conditioned and unconditioned stimuli
    Y Kishimoto
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    Eur J Neurosci 14:1515-21. 2001
    ....
  12. ncbi request reprint Age-dependent impairment of delay and trace eyeblink conditioning in mice
    Y Kishimoto
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan
    Neuroreport 12:3349-52. 2001
    ..These results indicate that trace eyeblink conditioning is more susceptible to age-related deterioration of memory in mice than delay eyeblink conditioning...
  13. ncbi request reprint Impaired delay but normal trace eyeblink conditioning in PLCbeta4 mutant mice
    Y Kishimoto
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Neuroreport 12:2919-22. 2001
    ..Rostral cerebellar LTD may be required as a neural substrate for delay conditioning, but is not required for trace conditioning...
  14. ncbi request reprint Effects of the noncompetitive NMDA receptor antagonist MK-801 on classical eyeblink conditioning in mice
    K Takatsuki
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, 113-0033, Tokyo, Japan
    Neuropharmacology 41:618-28. 2001
    ....
  15. ncbi request reprint Phospholipase Cbeta4 and protein kinase Calpha and/or protein kinase CbetaI are involved in the induction of long term depression in cerebellar Purkinje cells
    M Hirono
    Department of Molecular Neurobiology, Advanced Research Institute for Science and Engineering, Waseda University, 3 4 1 Okubo, Shinjuku ku, Tokyo, Japan
    J Biol Chem 276:45236-42. 2001
    ..Taken together, these results suggest that mGluR1-mediated activation of PLCbeta4 in rostral cerebellar Purkinje cells induced LTD via PKCalpha and/or PKCbetaI...
  16. ncbi request reprint Classical eyeblink conditioning in glutamate receptor subunit delta 2 mutant mice is impaired in the delay paradigm but not in the trace paradigm
    Y Kishimoto
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Eur J Neurosci 13:1249-53. 2001
    ..Thus, the present study has revealed a cerebellar LTD-independent learning in eyeblink conditioning...
  17. ncbi request reprint Long-trace interval eyeblink conditioning is impaired in mutant mice lacking the NMDA receptor subunit epsilon 1
    Y Kishimoto
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Eur J Neurosci 13:1221-7. 2001
    ....
  18. doi request reprint Presenilin 2 mutation accelerates the onset of impairment in trace eyeblink conditioning in a mouse model of Alzheimer's disease overexpressing human mutant amyloid precursor protein
    Yasushi Kishimoto
    Laboratory of Neurobiophysics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa 769 2193, Japan
    Neurosci Lett 538:15-9. 2013
    ..This cross-sectional study clearly indicates that PS2 mutation significantly accelerates the onset of cognitive impairment in associative trace eyeblink memory...