Hirota Fujiki

Summary

Affiliation: Tokushima Bunri University
Country: Japan

Publications

  1. doi request reprint Carcinogenic aspects of protein phosphatase 1 and 2A inhibitors
    Hirota Fujiki
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
    Prog Mol Subcell Biol 46:221-54. 2009
  2. doi request reprint Green tea: an effective synergist with anticancer drugs for tertiary cancer prevention
    Hirota Fujiki
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770 8514, Japan
    Cancer Lett 324:119-25. 2012
  3. ncbi request reprint Green tea: cancer preventive beverage and/or drug
    Hirota Fujiki
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, 770 8514, Tokushima, Japan
    Cancer Lett 188:9-13. 2002
  4. ncbi request reprint Green tea: Health benefits as cancer preventive for humans
    Hirota Fujiki
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
    Chem Rec 5:119-32. 2005
  5. ncbi request reprint Carcinogenic potential of tobacco tar-resistant Staphylococcus aureus in buccal cavity
    H Fujiki
    Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima Japan
    J Cancer Res Clin Oncol 130:301-5. 2004
  6. ncbi request reprint New TNF-alpha releasing inhibitors as cancer preventive agents from traditional herbal medicine and combination cancer prevention study with EGCG and sulindac or tamoxifen
    Hirota Fujiki
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
    Mutat Res 523:119-25. 2003
  7. ncbi request reprint Involvement of TNF-alpha changes in human cancer development, prevention and palliative care
    Hirota Fujiki
    Saitama Cancer Center, Ina, Kitaadachi gun, Saitama 362 0806, Japan
    Mech Ageing Dev 123:1655-63. 2002
  8. ncbi request reprint Tumor promoters--microcystin-LR, nodularin and TNF-α and human cancer development
    Hirota Fujiki
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan
    Anticancer Agents Med Chem 11:4-18. 2011
  9. doi request reprint Nucleolin as cell surface receptor for tumor necrosis factor-alpha inducing protein: a carcinogenic factor of Helicobacter pylori
    Tatsuro Watanabe
    Saitama Cancer Center, Research Institute for Clinical Oncology, Kitaadachi gun, Saitama 362 0806, Japan
    J Cancer Res Clin Oncol 136:911-21. 2010
  10. doi request reprint TNF-alpha-inducing protein, a carcinogenic factor secreted from H. pylori, enters gastric cancer cells
    Masami Suganuma
    Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan
    Int J Cancer 123:117-22. 2008

Detail Information

Publications46

  1. doi request reprint Carcinogenic aspects of protein phosphatase 1 and 2A inhibitors
    Hirota Fujiki
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
    Prog Mol Subcell Biol 46:221-54. 2009
    ..The results indicate that inhibition of PP1 and PP2A is a general mechanism of tumor promotion applicable to various organs. This study supports the concept of endogenous tumor promoters in human cancer development...
  2. doi request reprint Green tea: an effective synergist with anticancer drugs for tertiary cancer prevention
    Hirota Fujiki
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770 8514, Japan
    Cancer Lett 324:119-25. 2012
    ..The combination of anticancer drugs with green tea could be a new cancer therapeutic strategy in humans...
  3. ncbi request reprint Green tea: cancer preventive beverage and/or drug
    Hirota Fujiki
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, 770 8514, Tokushima, Japan
    Cancer Lett 188:9-13. 2002
    ..An approach to develop green tea capsules as a cancer preventive drug in the US is discussed, aiming at taking full advantage of this cancer preventive beverage...
  4. ncbi request reprint Green tea: Health benefits as cancer preventive for humans
    Hirota Fujiki
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
    Chem Rec 5:119-32. 2005
    ..And finally, the stimulating comments of Prof. Jim Watson have encouraged green tea scientists...
  5. ncbi request reprint Carcinogenic potential of tobacco tar-resistant Staphylococcus aureus in buccal cavity
    H Fujiki
    Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima Japan
    J Cancer Res Clin Oncol 130:301-5. 2004
    ....
  6. ncbi request reprint New TNF-alpha releasing inhibitors as cancer preventive agents from traditional herbal medicine and combination cancer prevention study with EGCG and sulindac or tamoxifen
    Hirota Fujiki
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
    Mutat Res 523:119-25. 2003
    ..Overall, our results indicate that, with the continuing spread of cancer chemoprevention as a fundamental medical strategy, both clinicians and researchers should take a closer look at herbal medicine...
  7. ncbi request reprint Involvement of TNF-alpha changes in human cancer development, prevention and palliative care
    Hirota Fujiki
    Saitama Cancer Center, Ina, Kitaadachi gun, Saitama 362 0806, Japan
    Mech Ageing Dev 123:1655-63. 2002
    ....
  8. ncbi request reprint Tumor promoters--microcystin-LR, nodularin and TNF-α and human cancer development
    Hirota Fujiki
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan
    Anticancer Agents Med Chem 11:4-18. 2011
    ..The carcinogenic features of TNF-α are described in this review, and the TNF-α inducing protein (Tipα) of Helicobacter pylori genome is presented as an example of a tumor promoter of human stomach cancer development...
  9. doi request reprint Nucleolin as cell surface receptor for tumor necrosis factor-alpha inducing protein: a carcinogenic factor of Helicobacter pylori
    Tatsuro Watanabe
    Saitama Cancer Center, Research Institute for Clinical Oncology, Kitaadachi gun, Saitama 362 0806, Japan
    J Cancer Res Clin Oncol 136:911-21. 2010
    ..To elucidate mechanism of action of Tipalpha, we studied a binding protein of Tipalpha in gastric epithelial cells...
  10. doi request reprint TNF-alpha-inducing protein, a carcinogenic factor secreted from H. pylori, enters gastric cancer cells
    Masami Suganuma
    Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan
    Int J Cancer 123:117-22. 2008
    ..Tip alpha is thus a new carcinogenic factor of H. pylori that can enter the nucleus through a specific binding molecule, and its mechanism of action is completely different from that of CagA...
  11. doi request reprint New role of (-)-epicatechin in enhancing the induction of growth inhibition and apoptosis in human lung cancer cells by curcumin
    Achinto Saha
    Tokushima Bunri University, Japan
    Cancer Prev Res (Phila) 3:953-62. 2010
    ..This report is the first report on the enhancing effects of EC on curcumin, and the data suggest that EC plays a significant role in the enhancement of the cancer-preventive activity of curcumin in the diet...
  12. ncbi request reprint Apoptosis of human lung cancer cells by curcumin mediated through up-regulation of "growth arrest and DNA damage inducible genes 45 and 153"
    Achinto Saha
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan
    Biol Pharm Bull 33:1291-9. 2010
    ..All the results with PC-9 cells suggest that the up-regulation of GADD45 and 153 by curcumin is a prime mechanism in the anticancer activity of curcumin...
  13. ncbi request reprint Epithelial-mesenchymal transition in human gastric cancer cell lines induced by TNF-α-inducing protein of Helicobacter pylori
    Tatsuro Watanabe
    Research Institute for Clinical Oncology, Saitama Cancer Center, Kitaadachi gun, Saitama, Japan
    Int J Cancer 134:2373-82. 2014
    ..This is the first report that Tipα is a new inducer of EMT, probably associated with tumor progression in human gastric carcinogenesis. ..
  14. ncbi request reprint Green tea polyphenol stimulates cancer preventive effects of celecoxib in human lung cancer cells by upregulation of GADD153 gene
    Masami Suganuma
    Research Institute of Clinical Oncology, Saitama Cancer Center, Saitama, Japan
    Int J Cancer 119:33-40. 2006
    ..These findings indicate that high upregulation of GADD153 is a key requirement for cancer prevention in combination with EGCG...
  15. doi request reprint Structural basis for the Helicobacter pylori-carcinogenic TNF-alpha-inducing protein
    Hideaki Tsuge
    Institute for Health Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
    Biochem Biophys Res Commun 388:193-8. 2009
    ..del-Tipalpha's unique mode of dimer formation provides important insight into protein-protein interactions and into the mechanism underlying the carcinogenicity of H. pylori infection...
  16. doi request reprint Human gastric cancer development with TNF-α-inducing protein secreted from Helicobacter pylori
    Masami Suganuma
    Research Institute for Clinical Oncology, Saitama Cancer Center, Japan
    Cancer Lett 322:133-8. 2012
    ..This paper discusses a new mechanism of gastric cancer development with H. pylori and provides a new preventive strategy...
  17. ncbi request reprint Carcinogenic role of tumor necrosis factor-alpha inducing protein of Helicobacter pylori in human stomach
    Masami Suganuma
    Saitama Cancer Center, Research Institute for Clinical Oncology, Saitama 362 0806, Japan
    J Biochem Mol Biol 39:1-8. 2006
    ..Our recent finding showing that penicillin-binding proteins of other bacteria are weak homologues of Tipalpha is also discussed...
  18. ncbi request reprint Synergistic effects of multiple treatments, and both DNA and RNA direct bindings on, green tea catechins
    Takashi Kuzuhara
    Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima, Japan
    Mol Carcinog 46:640-5. 2007
    ....
  19. ncbi request reprint Nucleolin on the cell surface as a new molecular target for gastric cancer treatment
    Tatsuro Watanabe
    Research Institute for Clinical Oncology, Saitama Cancer Center, Kitaadachigun, Saitama 362 0806, Japan
    Biol Pharm Bull 33:796-803. 2010
    ..All results indicate that nucleolin on the cell surface is a new and promising therapeutic target for treatment of gastric cancer...
  20. doi request reprint Challenging the effectiveness of green tea in primary and tertiary cancer prevention
    Hirota Fujiki
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770 8514, Japan
    J Cancer Res Clin Oncol 138:1259-70. 2012
    ..All results were significant, including human studies with informed consent...
  21. pmc Cell-surface nucleolin acts as a central mediator for carcinogenic, anti-carcinogenic, and disease-related ligands
    Hirota Fujiki
    Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, 362 0806, Japan
    J Cancer Res Clin Oncol 140:689-99. 2014
    ..Other ligands can be grouped among disease-related ligands, which is an important new topic for the prevention of various ailments...
  22. doi request reprint Tumor promoters: from chemicals to inflammatory proteins
    Hirota Fujiki
    Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, 362 0806, Japan
    J Cancer Res Clin Oncol 139:1603-14. 2013
    ....
  23. doi request reprint New cancer treatment strategy using combination of green tea catechins and anticancer drugs
    Masami Suganuma
    Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan
    Cancer Sci 102:317-23. 2011
    ..Based on the evidence, we present a new concept: green tea catechins as synergists with anticancer drugs...
  24. ncbi request reprint Helicobacter pylori-secreting protein Tipalpha is a potent inducer of chemokine gene expressions in stomach cancer cells
    Takashi Kuzuhara
    Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770 8514, Japan
    J Cancer Res Clin Oncol 133:287-96. 2007
    ..pylori acts as a tumor promoter in stomach cancer development, and thus started to investigate whether Tipalpha is involved in induction of chemokine genes...
  25. ncbi request reprint Mechanism-based inhibition of cancer metastasis with (-)-epigallocatechin gallate
    Atsushi Takahashi
    Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama 362 0806, Japan Graduate School of Science and Engineering, Saitama University, Saitama 338 8570, Japan Green Tea Laboratory, Saitama Prefectural Agriculture and Forestry Research Center, Saitama 358 0042, Japan
    Biochem Biophys Res Commun 443:1-6. 2014
    ..Methyl-β-cyclodextrin, a reagent to deplete cholesterol in plasma membrane, showed inhibition of EMT phenotypes similar that by EGCG, suggesting that EGCG induces inhibition of EMT phenotypes by alteration of membrane organization...
  26. ncbi request reprint Translational research on TNF-alpha as an endogenous tumor promoter and green tea as cancer preventive in humans
    Hirota Fujiki
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 23:3-30. 2005
  27. ncbi request reprint Lung cancer prevention with (-)-epigallocatechin gallate using monitoring by heterogeneous nuclear ribonucleoprotein B1
    Nobukazu Fujimoto
    Saitama Cancer Center, Ina, Kitaadachi gun 362 0806, Japan
    Int J Oncol 20:1233-9. 2002
    ....
  28. ncbi request reprint Generation of mouse monoclonal antibody against (-)-epigallocatechin gallate
    Takashi Kuzuhara
    Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
    Biol Pharm Bull 31:816-9. 2008
    ..The TG38 antibody is the first monoclonal antibody against EGCG and catechins, since it bound to four green tea catechins with a galloyl group...
  29. ncbi request reprint New tumor necrosis factor-alpha-inducing protein released from Helicobacter pylori for gastric cancer progression
    Masami Suganuma
    Saitama Cancer Center, Ina Kitaadachi gun, 362 0806 Saitama, Japan
    J Cancer Res Clin Oncol 131:305-13. 2005
    ..To investigate the association between Helicobacter pylori infection and its inflammatory reaction in gastritis, gastric ulcer, and gastric cancer, a new tumor necrosis factor-alpha (TNF-alpha)-inducing protein of H. pylori was studied...
  30. ncbi request reprint Helicobacter pylori membrane protein 1: a new carcinogenic factor of Helicobacter pylori
    M Suganuma
    Saitama Cancer Center, Saitama 362-0806, Japan
    Cancer Res 61:6356-9. 2001
    ..Two Bhas/ure clones showed weak tumorigenicity; the other Bhas and BALB clones showed none. Results indicate strong carcinogenic activity of HP-MP1 in cooperation with viral Ras protein and weak activity of urease B...
  31. ncbi request reprint DNA and RNA as new binding targets of green tea catechins
    Takashi Kuzuhara
    Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
    J Biol Chem 281:17446-56. 2006
    ..These findings reveal for the first time the link between catechins and polynucleotides and will intensify our understanding of the effects of catechins on DNA in terms of cancer prevention...
  32. ncbi request reprint Green tea catechin as a chemical chaperone in cancer prevention
    Takashi Kuzuhara
    Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
    Cancer Lett 261:12-20. 2008
    ..Since these conformations result in interaction with various types of molecules, we think that green tea catechin induces cancer preventive activity mediated through a chaperone-like property...
  33. ncbi request reprint DNA-binding activity of TNF-alpha inducing protein from Helicobacter pylori
    T Kuzuhara
    Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
    Biochem Biophys Res Commun 362:805-10. 2007
    ..This suggests a strong correlation between DNA-binding activity and carcinogenic activity of Tipalpha. And the DNA-binding activity of Tipalpha was first demonstrated with a molecule secreted from H. pylori...
  34. ncbi request reprint Gist of Dr. Katsusaburo Yamagiwa's papers entitled "Experimental study on the pathogenesis of epithelial tumors" (I to VI reports)
    Hirota Fujiki
    Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan
    Cancer Sci 105:143-9. 2014
    ..Scientists' comments on Yamagiwa's contribution are attached by way of introduction. ..
  35. ncbi request reprint Presence of a motif conserved between Helicobacter pylori TNF-alpha inducing protein (Tipalpha) and penicillin-binding proteins
    Takashi Kuzuhara
    Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan
    Biol Pharm Bull 28:2133-7. 2005
    ..pylori. This finding suggests that Tipalpha and penicillin-binding proteins are derived from a common ancestral protein, and that Tipalpha gene may be transferred horizontally from Gram-positive bacteria to H. pylori...
  36. ncbi request reprint Discrete roles of cytokines, TNF-alpha, IL-1, IL-6 in tumor promotion and cell transformation
    M Suganuma
    Saitama Cancer Center, Ina Kitaadachi gun, Saitama 362 0806, Japan
    Int J Oncol 20:131-6. 2002
    ..Considering all these results, we conclude that various cytokines have discrete roles in tumor promotion and cell transformation...
  37. ncbi request reprint New TNF-alpha releasing inhibitors, geraniin and corilagin, in leaves of Acer nikoense, Megusurino-ki
    S Okabe
    Saitama Cancer Center, Kitaadachi-gun, Japan
    Biol Pharm Bull 24:1145-8. 2001
    ....
  38. ncbi request reprint Anti-cancer effects of morphine through inhibition of tumour necrosis factor-alpha release and mRNA expression
    N Sueoka
    Saitama Cancer Center Research Institute, Ina, Kitaadachi gun, Japan
    Carcinogenesis 17:2337-41. 1996
    ..The high dosage of morphine required to induce anticarcinogenic effects is also discussed...
  39. ncbi request reprint Modulation of gene expression by (-)-epigallocatechin gallate in PC-9 cells using a cDNA expression array
    S Okabe
    Saitama Cancer Center, Japan
    Biol Pharm Bull 24:883-6. 2001
    ..Among them, we think down-regulation of NIK gene expression is significant for cancer prevention, based on evidence that inhibition of NF-kappaB activation is a result of inhibition of NIK/IKK signalling complex...
  40. ncbi request reprint Isolation and synthesis of TNF-alpha release inhibitors from Fijian kawa (Piper methysticum)
    T Hashimoto
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima, Japan
    Phytomedicine 10:309-17. 2003
    ..We synthesized 5,6-dehydrokawain (1) and yangonin (4) via three steps from the dianion of ethyl acetoacetate achieving a good yield and determined their conformations by high resolution NMR and x-ray crystallographic analysis...
  41. ncbi request reprint Mechanistic findings of green tea as cancer preventive for humans
    H Fujiki
    Saitama Cancer Center Research Institute, Ina, Kitaadachi gun, Saitama 362 0806, Japan
    Proc Soc Exp Biol Med 220:225-8. 1999
    ..These results provide new insights into our understanding of the mechanisms of action of tea polyphenols and green tea extract as a cancer preventive...
  42. pmc Analysis of the stimulative effect of thapsigargin, a non-TPA-type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages
    K Ohuchi
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University, Miyagi, Japan
    Br J Pharmacol 94:917-23. 1988
    ..6. These results suggest that thapsigargin stimulates arachidonic acid release by a mechanism different from that of TPA, viz by acting as a selective Ca2+ mobilizer, but not by activating protein kinase C as TPA does...
  43. ncbi request reprint Cancer prevention with green tea and monitoring by a new biomarker, hnRNP B1
    H Fujiki
    Saitama Cancer Center, Ina, Kitaadachi gun, Saitama 362 0806, Japan
    Mutat Res 480:299-304. 2001
    ....
  44. pmc A receptor model for tumor promoters: rational superposition of teleocidins and phorbol esters
    A Itai
    Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 85:3688-92. 1988
    ..Their mutual spatial arrangements are most important for biological activity...
  45. ncbi request reprint [Mechanisms of action of tipa (TNF-alpha inducing protein), a new carcinogenic factor, released from H. pylori]
    Masami Suganuma
    Saitama Cancer Center, Research Institute for Clinical Oncology
    Nihon Rinsho 63:80-3. 2005
  46. doi request reprint Friendship in research: the Japan-Korea Symposia on Cancer and Ageing
    Hirota Fujiki
    J Cancer Res Clin Oncol 134:813-7. 2008