Kazuhiro Eto

Summary

Affiliation: Tokushima Bunri University
Country: Japan

Publications

  1. doi request reprint Citrin deficiency and current treatment concepts
    Takeyori Saheki
    Institute for Health Sciences, Tokushima Bunri University, Tokushima 770 8514, Japan
    Mol Genet Metab 100:S59-64. 2010
  2. doi request reprint Reduced carbohydrate intake in citrin-deficient subjects
    T Saheki
    Department of Molecular Metabolism and Biochemical Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Inherit Metab Dis 31:386-94. 2008
  3. ncbi request reprint Citrin/mitochondrial glycerol-3-phosphate dehydrogenase double knock-out mice recapitulate features of human citrin deficiency
    Takeyori Saheki
    Department of Molecular Metabolism and Biochemical Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890 8544, Japan
    J Biol Chem 282:25041-52. 2007
  4. doi request reprint Metabolomic analysis reveals hepatic metabolite perturbations in citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin deficiency
    Takeyori Saheki
    Institute for Health Sciences, Tokushima Bunri University, 180 Yamashiro cho, Tokushima, Japan
    Mol Genet Metab 104:492-500. 2011
  5. doi request reprint Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency
    Takeyori Saheki
    Institute of Resource Development and Analysis, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Mol Genet Metab 107:322-9. 2012
  6. ncbi request reprint Evidence for a compensated thermogenic defect in transgenic mice lacking the mitochondrial glycerol-3-phosphate dehydrogenase gene
    Rosangela A DosSantos
    Division of Endocrinology, Lady Davis Institute for Medical Research, Juwish General Hospital, McGill University, Montreal, Quebec, Canada H3T 1E2
    Endocrinology 144:5469-79. 2003
  7. ncbi request reprint Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c
    Tokuyuki Yamashita
    Department of Metabolic Diseases, University of Tokyo Graduate School of Medicine, Tokyo 113 8655, Japan
    Endocrinology 145:3566-77. 2004
  8. ncbi request reprint Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet
    Junji Matsui
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Diabetes 53:2844-54. 2004
  9. pmc Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance
    Yasuo Terauchi
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo, Japan
    J Clin Invest 117:246-57. 2007
  10. ncbi request reprint Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner
    Ryo Suzuki
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 278:43691-8. 2003

Collaborators

  • Keiko Kobayashi
  • Takashi Kadowaki
  • Akihiro Asakawa
  • Ken Ichi Yamamura
  • Y Yanagawa
  • T Hattori
  • T Ohura
  • A Inui
  • Naoko Tsunekawa
  • Guy A Rutter
  • Hideaki Kaneto
  • Takeyori Saheki
  • Yasuo Terauchi
  • Junji Matsui
  • Ryozo Nagai
  • Naoto Kubota
  • Toshimasa Yamauchi
  • Kajuro Komeda
  • Mitsuhiko Noda
  • Kanako Inoue
  • Sachiko Iseki
  • David S Sinasac
  • Ryo Suzuki
  • Tokuyuki Yamashita
  • Satoshi Kimura
  • Natsumi Katsura
  • Yukari Yoshidumi
  • Kazuyuki Tobe
  • Hiromi Ono
  • Mana Yokogawa
  • Anmi Tushima
  • Junji Kamon
  • Miharu Ushikai
  • T Saheki
  • Jamie L Volinic
  • Iseki Takamoto
  • Shinichi Aizawa
  • Toshiyuki Yoshida
  • Yoshiharu Tsubamoto
  • Masako Fujino
  • Shigeo Yamashita
  • Piyamas Sumrejkanchanakij
  • Rosangela A DosSantos
  • Philippe Froguel
  • Kyoko Nakano
  • Sumie Furuie
  • Eishi Kuroda
  • Tomiko Kuhara
  • Morimasa Ohse
  • Kozo Mutoh
  • H Fujimoto
  • Y Okano
  • K Mutoh
  • Z Kizaki
  • M Terashi
  • Yoko Yamada
  • Tsuyoshi Kobayashi
  • Masako Ishii-Suzuki
  • Atsushi Tajima
  • Akira Okano
  • Masahisa Horiuchi
  • Kunihiko Obata
  • Mihoko Tsuji
  • Akinobu Nakamura
  • Hiroyuki Aburatani
  • Mikio Iijima
  • Akemi Hara
  • Ichitomo Miwa
  • Xiao Jian Meng
  • Ituro Inoue
  • Yukiyasu Toyoda
  • Shinji Hashimoto
  • Meng Xian Li
  • Fumihiko Okumura
  • Shuichi Tsutsumi
  • Mitsuaki Moriyama
  • Lap Chee Tsui
  • Jee H Lee
  • Varinderpal Kaur
  • Melissa K Thomas
  • Isao Ishikawa
  • Leonidas A Phylactou
  • James B Uney
  • Nobuo Sekine
  • Shunbun Kita
  • Yukiko Okazaki
  • Takashi Taguchi
  • Gustav E Lienhard
  • Kousuke Azuma
  • Yuko Matsunaga

Detail Information

Publications26

  1. doi request reprint Citrin deficiency and current treatment concepts
    Takeyori Saheki
    Institute for Health Sciences, Tokushima Bunri University, Tokushima 770 8514, Japan
    Mol Genet Metab 100:S59-64. 2010
    ..We also emphasize the importance of a citrin deficiency mouse model in elucidating the pathophysiology and developing novel therapeutics based on the pathophysiology, such as sodium pyruvate...
  2. doi request reprint Reduced carbohydrate intake in citrin-deficient subjects
    T Saheki
    Department of Molecular Metabolism and Biochemical Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Inherit Metab Dis 31:386-94. 2008
    ..These results strongly support an avoidance of carbohydrate-rich foods by citrin-deficient patients that may lead to worsening of symptoms...
  3. ncbi request reprint Citrin/mitochondrial glycerol-3-phosphate dehydrogenase double knock-out mice recapitulate features of human citrin deficiency
    Takeyori Saheki
    Department of Molecular Metabolism and Biochemical Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890 8544, Japan
    J Biol Chem 282:25041-52. 2007
    ....
  4. doi request reprint Metabolomic analysis reveals hepatic metabolite perturbations in citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin deficiency
    Takeyori Saheki
    Institute for Health Sciences, Tokushima Bunri University, 180 Yamashiro cho, Tokushima, Japan
    Mol Genet Metab 104:492-500. 2011
    ..Overall, we have identified additional metabolic disturbances in double-KO mice following oral sucrose administration, and provided further evidence for the therapeutic use of sodium pyruvate in our mouse model of citrin deficiency...
  5. doi request reprint Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency
    Takeyori Saheki
    Institute of Resource Development and Analysis, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Mol Genet Metab 107:322-9. 2012
    ....
  6. ncbi request reprint Evidence for a compensated thermogenic defect in transgenic mice lacking the mitochondrial glycerol-3-phosphate dehydrogenase gene
    Rosangela A DosSantos
    Division of Endocrinology, Lady Davis Institute for Medical Research, Juwish General Hospital, McGill University, Montreal, Quebec, Canada H3T 1E2
    Endocrinology 144:5469-79. 2003
    ..The results support a role for mGPD in thyroid hormone thermogenesis...
  7. ncbi request reprint Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c
    Tokuyuki Yamashita
    Department of Metabolic Diseases, University of Tokyo Graduate School of Medicine, Tokyo 113 8655, Japan
    Endocrinology 145:3566-77. 2004
    ..These results suggest that UCP-2 down-regulation and AMPK activation could be candidate targets for releasing beta-cells from lipotoxicity...
  8. ncbi request reprint Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet
    Junji Matsui
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Diabetes 53:2844-54. 2004
    ..Our results demonstrate that PPAR-gamma protects islets from lipotoxicity by regulating TG partitioning among tissues and that a PPAR-gamma agonist can restore impaired insulin secretion under conditions of islet fat accumulation...
  9. pmc Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance
    Yasuo Terauchi
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo, Japan
    J Clin Invest 117:246-57. 2007
    ..These results suggest that Gck and Irs2 are critical requirements for beta cell hyperplasia to occur in response to HF diet-induced insulin resistance...
  10. ncbi request reprint Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner
    Ryo Suzuki
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 278:43691-8. 2003
    ....
  11. ncbi request reprint Role of mitochondrial NADH shuttle system in acute amylase secretion by acetylcholine from mouse pancreatic acinar cells
    Kyoko Nakano
    Department of Medical Technology, Hirosaki University School of Health Sciences, Hirosaki 036 8564, Japan
    Tohoku J Exp Med 198:151-62. 2002
    ....
  12. ncbi request reprint Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice
    Yasuo Terauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Japan
    J Biol Chem 278:14284-90. 2003
    ....
  13. ncbi request reprint Disruption of adiponectin causes insulin resistance and neointimal formation
    Naoto Kubota
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 277:25863-6. 2002
    ..01). This study provides the first direct evidence that adiponectin plays a protective role against insulin resistance and atherosclerosis in vivo...
  14. ncbi request reprint Switch to anaerobic glucose metabolism with NADH accumulation in the beta-cell model of mitochondrial diabetes. Characteristics of betaHC9 cells deficient in mitochondrial DNA transcription
    Mitsuhiko Noda
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Japan
    J Biol Chem 277:41817-26. 2002
    ..This is the first report to demonstrate the connection between metabolic alteration of electron transport system and that of tricarboxylic acid cycle and its impact on insulin secretion...
  15. ncbi request reprint [Role of NADH shuttle system in glucose-stimulated insulin secretion]
    Kazuhiro Eto
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo
    Nihon Rinsho 60:190-207. 2002
  16. ncbi request reprint Glucose metabolism and glutamate analog acutely alkalinize pH of insulin secretory vesicles of pancreatic beta-cells
    Kazuhiro Eto
    Dept of Metabolic Diseases, Graduate School of Medicine, Univ of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Physiol Endocrinol Metab 285:E262-71. 2003
    ..Moreover, glutamate derived from glucose may be one of the mediators of this alkalinizing effect of glucose, which may have potential relevance to the alteration of secretory function by glutamate...
  17. ncbi request reprint The role of PPARgamma in high-fat diet-induced obesity and insulin resistance
    Takashi Kadowaki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku 113 8655, Tokyo, Japan
    J Diabetes Complications 16:41-5. 2002
    ..These results revealed that both in mice and humans, PPARgamma is a thrifty gene mediating Type 2 diabetes...
  18. ncbi request reprint Experimental induction of palate shelf elevation in glutamate decarboxylase 67-deficient mice with cleft palate due to vertically oriented palatal shelf
    Sachiko Iseki
    Department of Molecular Craniofacial Embryology, Graduate School, Tokyo Medical and Dental University, Yushima, Tokyo 113 8549, Japan
    Birth Defects Res A Clin Mol Teratol 79:688-95. 2007
    ..In the present study, development of cleft palate was examined histologically and manipulated with culture of the maxilla and partial resection of fetal tongue...
  19. ncbi request reprint [Glucokinase]
    Kazuhiro Eto
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo
    Nihon Rinsho 60:523-34. 2002
  20. ncbi request reprint Overexpression of the coactivator bridge-1 results in insulin deficiency and diabetes
    Jamie L Volinic
    Laboratory of Molecular Endocrinology and Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Mol Endocrinol 20:167-82. 2006
    ..We propose that coactivator dysfunction in pancreatic beta-cells can limit insulin production and contribute to the pathogenesis of diabetes...
  21. pmc Twist is required for establishment of the mouse coronal suture
    Toshiyuki Yoshida
    Department of Molecular Craniofacial Embryology, Graduate School, Tokyo Medical and Dental University, Japan
    J Anat 206:437-44. 2005
    ..These results suggest that during establishment of the suture area, Twist is required for the regulation of sutural cell proliferation and osteoblast differentiation...
  22. ncbi request reprint Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis
    Toshimasa Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Japan
    J Biol Chem 278:2461-8. 2003
    ..In conclusion, replenishment of globular adiponectin may provide a novel treatment modality for both type 2 diabetes and atherosclerosis...
  23. ncbi request reprint Genetic manipulations of fatty acid metabolism in beta-cells are associated with dysregulated insulin secretion
    Kazuhiro Eto
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Diabetes 51:S414-20. 2002
    ..These results revealed some aspects about the mechanisms by which alterations of fatty acid metabolism affect beta-cell functions...
  24. ncbi request reprint Role of cyclin D1 cytoplasmic sequestration in the survival of postmitotic neurons
    Piyamas Sumrejkanchanakij
    Section of Molecular Embryology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Oncogene 22:8723-30. 2003
    ..These results indicate that nuclear accumulation of cyclin D1 is inhibited in postmitotic neurons and suggest a role of its subcellular localization in neuronal death and survival...
  25. ncbi request reprint Disappearance of epidermal growth factor receptor is essential in the fusion of the nasal epithelium
    Masako Fujino
    Section of Molecular Craniofacial Embryology, Graduate School, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Japan
    Anat Sci Int 78:25-35. 2003
    ..These results suggest that temporal disappearance of the EGF/EGF-R signaling from presumptive fusion of the nasal prominences is required for morphological change of the epithelial cells leading to the fusion of MNP and LNP...
  26. ncbi request reprint Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca(2+)] elevation signals
    Kazuhiro Eto
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Diabetes 51:87-97. 2002
    ..These results suggest that PI 3-kinase activity normally plays a crucial role in the suppression of glucose-stimulated insulin secretion...