Masahiko Watanabe

Summary

Affiliation: Tokai University
Country: Japan

Publications

  1. ncbi request reprint Analysis of predisposing factors in elderly people with type II odontoid fracture
    Masahiko Watanabe
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan Electronic address
    Spine J 14:861-6. 2014
  2. ncbi request reprint GRP78 suppresses lipid peroxidation and promotes cellular antioxidant levels in glial cells following hydrogen peroxide exposure
    Kaori Suyama
    Department of Anatomy and Cellular Biology, Basic Medical Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    PLoS ONE 9:e86951. 2014
  3. ncbi request reprint Cervical myelopathy with retroodontoid pseudotumor caused by atlantoaxial rotatory fixation and senile tremor
    Masahiko Watanabe
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    Tokai J Exp Clin Med 34:39-41. 2009
  4. ncbi request reprint Intramedullary spinal cord metastasis: a clinical and imaging study of seven patients
    Masahiko Watanabe
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Spinal Disord Tech 19:43-7. 2006
  5. doi request reprint Clinical features of the extension teardrop fracture of the axis: review of 13 cases
    Masahiko Watanabe
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Kanagawa, Japan
    J Neurosurg Spine 14:710-4. 2011
  6. ncbi request reprint Residual neck pain after traumatic spondylolisthesis of the axis
    Masahiko Watanabe
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Kanagawa, Japan
    J Spinal Disord Tech 18:148-51. 2005
  7. doi request reprint Risk factors for surgical site infection following spine surgery: efficacy of intraoperative saline irrigation
    Masahiko Watanabe
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Neurosurg Spine 12:540-6. 2010
  8. doi request reprint Laparoscopy-assisted pancreas- and spleen-preserving total gastrectomy for gastric cancer as compared with open total gastrectomy
    Shinichi Sakuramoto
    Department of Surgery, Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara, Kanagawa, 228 8520, Japan
    Surg Endosc 23:2416-23. 2009
  9. doi request reprint Efficacy of the coadministration of granulocyte colony-stimulating factor and stem cell factor in the activation of intrinsic cells after spinal cord injury in mice
    Takahiro Osada
    Department of Neurosurgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Neurosurg Spine 13:516-23. 2010
  10. ncbi request reprint Diminishing impact of preoperative carcinoembryonic antigen (CEA) in prognosis of Dukes' C colorectal cancer
    Hiroshi Katoh
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    Anticancer Res 28:1933-41. 2008

Detail Information

Publications134 found, 100 shown here

  1. ncbi request reprint Analysis of predisposing factors in elderly people with type II odontoid fracture
    Masahiko Watanabe
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan Electronic address
    Spine J 14:861-6. 2014
    ..However, to our knowledge, few reports have investigated statistically whether disproportionate degeneration between joints influences the susceptibility to fracture...
  2. ncbi request reprint GRP78 suppresses lipid peroxidation and promotes cellular antioxidant levels in glial cells following hydrogen peroxide exposure
    Kaori Suyama
    Department of Anatomy and Cellular Biology, Basic Medical Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    PLoS ONE 9:e86951. 2014
    ..the overexpression of GRP78 significantly protected cells from ROS-induced cell damage when compared to non-GRP78 overexpressing cells, which was most likely due to GRP78-overexpressing cells having higher levels of glutathione (GSH) and..
  3. ncbi request reprint Cervical myelopathy with retroodontoid pseudotumor caused by atlantoaxial rotatory fixation and senile tremor
    Masahiko Watanabe
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    Tokai J Exp Clin Med 34:39-41. 2009
    ..A rare case of retroodontoid pseudotumor caused by the combination of atlantoaxial rotatory fixation and senile tremor is reported...
  4. ncbi request reprint Intramedullary spinal cord metastasis: a clinical and imaging study of seven patients
    Masahiko Watanabe
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Spinal Disord Tech 19:43-7. 2006
    ..To investigate the clinical and imaging characteristics of ISCM, seven cases of ISCM of a nonneurogenic origin were examined retrospectively...
  5. doi request reprint Clinical features of the extension teardrop fracture of the axis: review of 13 cases
    Masahiko Watanabe
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Kanagawa, Japan
    J Neurosurg Spine 14:710-4. 2011
    ..The purpose of the present study was to clarify the clinical features of extension teardrop fracture of the axis...
  6. ncbi request reprint Residual neck pain after traumatic spondylolisthesis of the axis
    Masahiko Watanabe
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Kanagawa, Japan
    J Spinal Disord Tech 18:148-51. 2005
    ..To clarify the factor that plays a major role in residual neck pain after this fracture, we reviewed nine patients who underwent conservative treatment...
  7. doi request reprint Risk factors for surgical site infection following spine surgery: efficacy of intraoperative saline irrigation
    Masahiko Watanabe
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Neurosurg Spine 12:540-6. 2010
    ..The purpose of this study was to identify risk factors for surgical site infection after spine surgery, noting the amount of saline used for intraoperative irrigation to minimize wound contamination...
  8. doi request reprint Laparoscopy-assisted pancreas- and spleen-preserving total gastrectomy for gastric cancer as compared with open total gastrectomy
    Shinichi Sakuramoto
    Department of Surgery, Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara, Kanagawa, 228 8520, Japan
    Surg Endosc 23:2416-23. 2009
    ..To assess the safety and usefulness of LATG, we compared the outcomes of LATG with those of open total gastrectomy (OTG)...
  9. doi request reprint Efficacy of the coadministration of granulocyte colony-stimulating factor and stem cell factor in the activation of intrinsic cells after spinal cord injury in mice
    Takahiro Osada
    Department of Neurosurgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Neurosurg Spine 13:516-23. 2010
    ..The object of this study was to investigate the effects of these cytokines on BM stem cells, intrinsic cells, and motor function recovery in spinal cord-injured mice...
  10. ncbi request reprint Diminishing impact of preoperative carcinoembryonic antigen (CEA) in prognosis of Dukes' C colorectal cancer
    Hiroshi Katoh
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    Anticancer Res 28:1933-41. 2008
    ..However, data remains insufficient to support its clinical use. The aim of the current study was to validate the prognostic impact of preCEA in Dukes' C CRC...
  11. doi request reprint A Phase II trial of neoadjuvant preoperative chemoradiotherapy with S-1 plus irinotecan and radiation in patients with locally advanced rectal cancer: clinical feasibility and response rate
    Takeo Sato
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Int J Radiat Oncol Biol Phys 79:677-83. 2011
    ..We aimed to validate our hypothesis that a preoperative chemoradiotherapy regimen with S-1 plus irinotecan is feasible, safe, and active for the management of locally advanced rectal cancer in a single-arm Phase II setting...
  12. doi request reprint Retrospective, matched case-control study comparing the oncologic outcomes between laparoscopic surgery and open surgery in patients with right-sided colon cancer
    Takatoshi Nakamura
    Department of Surgery, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa, 228 8555, Japan
    Surg Today 39:1040-5. 2009
    ..This study was undertaken to compare the morbidity and mortality after either a laparoscopic right hemicolectomy (LRHC) or an open right hemicolectomy (ORHC) for this type of tumor...
  13. ncbi request reprint Liver metastasis of colorectal cancer by protein-tyrosine phosphatase type 4A, 3 (PRL-3) is mediated through lymph node metastasis and elevated serum tumor markers such as CEA and CA19-9
    Kazuhiko Hatate
    Department of Surgery, Kitasato University, Kanagawa, Japan
    Oncol Rep 20:737-43. 2008
    ..Our data suggested that liver metastasis by PRL-3 is putatively mediated through lymph node metastasis and elevated tumor markers in the serum and the PRL-3 expression may not represent a direct causative mechanism of liver metastasis...
  14. ncbi request reprint Phosphatase of regenerating liver-3 as a prognostic biomarker in histologically node-negative gastric cancer
    Akira Ooki
    Department of Surgery, Kitasato University Hospital, Sagamihara 228 8555, Kanagawa, Japan
    Oncol Rep 21:1467-75. 2009
    ..We propose that PRL-3 expression can have a clinical potential as a prognostic biomarker that may facilitate the development of adjuvant chemotherapy for advanced gastric cancer with stage I disease...
  15. ncbi request reprint Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma
    Akira Ooki
    Department of Surgery, Kitasato University Hospital, Sagamihara, Kanagawa, Japan
    Int J Cancer 127:543-54. 2010
    ..Moreover, the expression status may be a landmark to select patients with benefit from PRL-3-targeted therapy. Thus, PRL-3 could be a convergent therapeutic target against ESCC with LNM...
  16. doi request reprint Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis
    Hidefumi Kubo
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan
    Biomed Pharmacother 64:101-6. 2010
    ..Host EP3 blockade together with COX-2 inhibition may be a novel therapeutic strategy to suppress tumor-associated lymphangiogenesis...
  17. doi request reprint Short- and long-term outcomes of laparoscopic surgery in patients with pathological stage II and III colon cancer
    Takatoshi Nakamura
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Hepatogastroenterology 58:1947-50. 2011
    ..We studied the safety and outcomes of laparoscopic surgery in patients with pathological stage II and III colon cancer...
  18. doi request reprint Treatment of advanced or recurrent colorectal cancer with irinotecan in Japan and elsewhere
    Takeo Sato
    Kitasato University East Hospital, Department of Surgery, 2 1 1, Asamizodai, Sagamihara, Kanagawa, 228 8520, Japan
    Expert Opin Pharmacother 9:1223-8. 2008
    ....
  19. doi request reprint Genetic alterations of K-ras may reflect prognosis in stage III colon cancer patients below 60 years of age
    Wataru Onozato
    Department of Surgery, Kitasato University Hospital, Sagamihara, Kanagawa, Japan
    J Surg Oncol 103:25-33. 2011
    ..Genetic alterations that are closely associated with patient prognosis can be landmarks of definitive therapeutic targets as well as useful biomarkers in human cancer clinics...
  20. doi request reprint Oncological outcomes of laparoscopic surgery in elderly patients with colon cancer: a comparison of patients 64 years or younger with those 75 years or older
    Takatoshi Nakamura
    Department of Surgery, Kitasato University, Kanagawa, Japan
    Hepatogastroenterology 58:1200-4. 2011
    ..We compared the results of laparoscopic resection of colon cancer between patients 75 years or older and those 64 years or younger, to confirm whether this procedure is warranted in elderly patients...
  21. ncbi request reprint Development of stiff shoulder in asymptomatic volunteers during ten-year follow-up in Japan
    Eijiro Okada
    Department of Orthopaedic Surgery, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Back Musculoskelet Rehabil 23:69-75. 2010
    ....
  22. doi request reprint Prospective ten-year follow-up study comparing patients with whiplash-associated disorders and asymptomatic subjects using magnetic resonance imaging
    Morio Matsumoto
    Department of Orthopaedic Surgery, Keio University, Tokyo, Japan
    Spine (Phila Pa 1976) 35:1684-90. 2010
    ..A prospective 10-year follow-up study of patients with whiplash-associated disorders (WAD) and asymptomatic volunteers...
  23. pmc Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer
    Akira Ooki
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    BMC Cancer 11:122. 2011
    ..In the present study, we examined the mechanisms regulating PRL-3 expression, and assessed the clinical potential of PRL-3-targeted therapy in gastric cancer...
  24. pmc Cancer specific promoter CpG Islands hypermethylation of HOP homeobox (HOPX) gene and its potential tumor suppressive role in pancreatic carcinogenesis
    Mina Waraya
    Department of Surgery, Kitasato University Hospital, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa, 252 0375, Japan
    BMC Cancer 12:397. 2012
    ..In this current study, we for the first time examined methylation level of HOPX and tested the functional relevance in pancreatic cancer (PC)...
  25. doi request reprint Longitudinal magnetic resonance imaging study on whiplash injury patients: minimum 10-year follow-up
    Daisuke Ichihara
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Shinjukuku, Tokyo, Japan
    J Orthop Sci 14:602-10. 2009
    ..We conducted a prospective long-term follow-up study to assess associations between magnetic resonance imaging (MRI) findings and changes in clinical symptoms, as well as factors relating to the prognosis of symptoms...
  26. ncbi request reprint Phase I trial of neoadjuvant preoperative chemotherapy with S-1 and irinotecan plus radiation in patients with locally advanced rectal cancer
    Takeo Sato
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Int J Radiat Oncol Biol Phys 69:1442-7. 2007
    ..To determine the maximum tolerated dose (MTD) and recommended dose (RD) of irinotecan combined with preoperative chemoradiotherapy with S-1 in patients with locally advanced rectal cancer...
  27. pmc COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems
    Hiroshi Katoh
    Department of Pharmacology, Kitasato University, School of Medicine, Kitasato 1 15 1, Sagamihara, Kanagawa, 228 8555, Japan
    Am J Pathol 176:1469-83. 2010
    ....
  28. ncbi request reprint Clinical significance of total gastrectomy for proximal gastric cancer
    Akira Ooki
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    Anticancer Res 28:2875-83. 2008
    ..The principal difference between total gastrectomy (TG) and proximal gastrectomy (PG) is whether lymph node (LN) 4d is dissected by radical lymphadenectomy...
  29. doi request reprint Predictors of psychological distress after diagnosis in breast cancer patients and patients with benign breast problems
    Noriko Ando
    Department of Medical Psychology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa, Japan
    Psychosomatics 52:56-64. 2011
    ..The objective of this study was to determine how age and psychological characteristics assessed prior to diagnosis could predict psychological distress in outpatients immediately after disclosure of their diagnosis...
  30. doi request reprint Surgical resection of stage IV colorectal cancer and prognosis
    Hiroshi Katoh
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    World J Surg 32:1130-7. 2008
    ..Colorectal cancer (CRC) harbors accumulated genetic alterations with cancer progression, which results in uncontrollable disease. To regulate the most malignant CRC, we have to know the most dismal phenotype of stage IV disease...
  31. ncbi request reprint Strong association of lymph node metastasis with intraperitoneal free cancer cell (IFCC) in advanced gastric cancer
    Keishi Yamashita
    Department of Surgery, Kitasato University Higashi Hospital, Kanagawa, Japan
    Hepatogastroenterology 55:1873-7. 2008
    ..Advanced gastric cancer is a disease with dismal prognosis, which is mainly characterized by the emerging intraperitoneal free gastric cancer cells (IFCC). Our interest is to elucidate a causative phenotype linking to IFCC...
  32. pmc Does the sagittal alignment of the cervical spine have an impact on disk degeneration? Minimum 10-year follow-up of asymptomatic volunteers
    Eijiro Okada
    Department of Orthopaedic Surgery, Keio University, Tokyo, Japan
    Eur Spine J 18:1644-51. 2009
    ..Sagittal alignment of the cervical spine had some impact on the progression of degenerative changes of the cervical spine with aging; however, it had no correlation with the occurrence of future clinical symptoms...
  33. ncbi request reprint [Neoadjuvant chemotherapy for colorectal cancer]
    Takeo Sato
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Gan To Kagaku Ryoho 39:871-5. 2012
    ..Studying how treatment regimens highly effective against unresectable or recurrent colorectal cancer can be adapted to patients with resectable disease is thus an important issue...
  34. doi request reprint Clinical experience of laparoscopy-assisted proximal gastrectomy with Toupet-like partial fundoplication in early gastric cancer for preventing reflux esophagitis
    Shinichi Sakuramoto
    Department of Surgery, Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara, Kanagawa, Japan
    J Am Coll Surg 209:344-51. 2009
    ..Clinical outcomes are described here in patients with reconstruction by esophagogastrostomy with Toupet-like partial fundoplication (TPF) in LAPG...
  35. doi request reprint Laparoscopy-assisted distal gastrectomy for early gastric cancer with complete situs inversus: report of a case
    Nobue Futawatari
    Department of Surgery, School of Medicine, Kitasato University, 2 1 1 Asamizodai, Sagamihara, Kanagawa, 228 8520, Japan
    Surg Today 40:64-7. 2010
    ..Based on a histopathological examination, a 5.0 x 5.0-cm, mucosal, poorly differentiated adenocarcinoma (pT1, pN0, sH0, sP0, sM0, Stage IA) was diagnosed...
  36. ncbi request reprint Abnormal expression of p16(INK4a), cyclin D1, cyclin-dependent kinase 4 and retinoblastoma protein in gastric carcinomas
    Ichiro Kishimoto
    Department of Surgery, National Hospital Organization Sagamihara Hospital, Kanagawa, Japan
    J Surg Oncol 98:60-6. 2008
    ..The aim of this study was to assess the relationship between their abnormalities and clinicopathological features in gastric carcinomas...
  37. doi request reprint Risk factors for wound infection after surgery for colorectal cancer
    Takatoshi Nakamura
    Department of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    World J Surg 32:1138-41. 2008
    ..This study was designed to clarify the incidence, risk factors, and pathogens responsible for wound infections after surgery for colorectal cancer...
  38. ncbi request reprint [Neoadjuvant chemoradiation therapy for locally advanced rectal cancer]
    Takeo Sato
    Dept of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Gan To Kagaku Ryoho 34:1553-6. 2007
    ..We describe the current status of adjuvant chemoradiotherapy for advanced local rectal cancer in Japan and other countries, along with a review of the literature...
  39. doi request reprint Successful laparoscopic resection of a sacrococcygeal teratoma in an adult: report of a case
    Atsuko Tsutsui
    Department of Surgery, Kitasato University Hospital, 1 15 1 Kitasato, Sagamihara, Kanagawa, 228 8555, Japan
    Surg Today 41:572-5. 2011
    ..The magnifying function of the laparoscope allowed an en bloc resection in the narrow pelvic cavity, without damaging the tumor. The aesthetic outcome was excellent. The patient remains relapse-free at 1 year 6 months after surgery...
  40. doi request reprint Prognostic significance of preoperative bowel obstruction in stage III colorectal cancer
    Hiroshi Katoh
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Ann Surg Oncol 18:2432-41. 2011
    ..If such a detrimental effect is preserved in each stage of advanced (stage II or III) CRC, we can identify high-risk patients...
  41. doi request reprint Evaluation of prognostic factors for the response to S-1 in patients with stage II or III advanced gastric cancer who underwent gastrectomy
    Kenji Ishido
    Department of Gastroenterology, Kitasato University East Hospital, 2 1 1 Asamizodai, Sagamihara, Kanagawa, Japan
    Pharmacogenet Genomics 19:955-64. 2009
    ..However, the role of gene expression profile of patients who received postoperative adjuvant chemotherapy remains unclear. In this study, we evaluated how TS and other associated genes related to outcome...
  42. doi request reprint Upper cervical spinal cord tumors: review of 13 cases
    Masahiko Watanabe
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259 1193, Japan
    J Orthop Sci 14:175-81. 2009
    ..Clinical features of upper cervical spinal cord tumors are not clear because there have been too few published reports. The purpose of this study was to review the clinical features of these tumors...
  43. doi request reprint Delayed accumulation of activated macrophages and inhibition of remyelination after spinal cord injury in an adult rodent model
    Masaaki Imai
    Department of Neurosurgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Neurosurg Spine 8:58-66. 2008
    ..The object of this study was to investigate the mechanisms underlying the failure of significant remyelination after SCI...
  44. doi request reprint Upper cervical spine injuries: age-specific clinical features
    Masahiko Watanabe
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    J Orthop Sci 15:485-92. 2010
    ..There are few reports on the age-specific clinical features of upper cervical spine injury. To identify these age-specific changes, we reviewed 103 patients with upper cervical spine injury...
  45. ncbi request reprint Lymph node metastasis density (ND)-factor association with malignant degree and ND40 as "non-curative factor" in gastric cancer
    Keishi Yamashita
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    Anticancer Res 28:435-41. 2008
    ..A search for the molecules associated with higher ND value within an identical stage could lead to objective determination of the degree of malignancy and development of novel strategies against advanced gastric cancer...
  46. doi request reprint Anastomotic leakage contributes to the risk for systemic recurrence in stage II colorectal cancer
    Hiroshi Katoh
    Department of Surgery, Kitasato University School of Medicine, Kitasato 1 15 1, Minami Ku, Sagamihara, 252 0374, Kanagawa, Japan
    J Gastrointest Surg 15:120-9. 2011
    ..Our concern was whether anastomotic leakage (Lk) is a potential available clinicopathological factor for selecting high-risk stage II...
  47. doi request reprint Intratumoral lymphangiogenesis of esophageal squamous cell carcinoma and relationship with regulatory factors and prognosis
    Akemi Inoue
    Department of Biological Structure, Kitasato University Graduate School of Medical Sciences, Kitasato, Kanagawa, Japan
    Pathol Int 58:611-9. 2008
    ..Multivariate analysis using Cox proportional hazard method showed that invasion depth, lymph node metastasis and ITL were independent prognostic factors...
  48. ncbi request reprint DNA damage-inducible gene, reprimo functions as a tumor suppressor and is suppressed by promoter methylation in gastric cancer
    Akira Ooki
    Department of Surgery, Kitasato University School of Medicine, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    Mol Cancer Res 11:1362-74. 2013
    ..However, Reprimo methylation abrogates its expression and effects. The clinical assessment of Reprimo promoter methylation may serve not only as a predictive marker for chemotherapy, but also as a marker for tumor aggressiveness...
  49. ncbi request reprint Recent trends in the management of achalasia
    Natsuya Katada
    Department of Surgery, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan
    Ann Thorac Cardiovasc Surg 18:420-8. 2012
    ..Definitive conclusions regarding the benefits and risks of currently available treatments for achalasia must await the accumulation of evidence from well-designed clinical trials...
  50. doi request reprint Benefits of a straight laparoscopic restorative proctocolectomy with ileal pouch anal anastomosis for ulcerative colitis: a retrospective case-matched study
    Heita Ozawa
    Department of Surgery, Tochigi Cancer Center, Tochigi, Japan
    Surg Laparosc Endosc Percutan Tech 22:118-21. 2012
    ..The aim of this study was to evaluate the benefit of straight laparoscopic restorative proctocolectomy (sLRP) with ileal pouch anal anastomosis for ulcerative colitis (UC)...
  51. ncbi request reprint Surgical resection of stage IV gastric cancer and prognosis
    Keishi Yamashita
    Department of Surgery, Kitasato University Higashi Hospital, Kanagawa, Japan
    Anticancer Res 27:4381-6. 2007
    ..Our results suggested that stage IV gastric cancer is subdivided into the definite prognostic group by tumor factors and rigorous surgical treatment might have the potential to prolong survival...
  52. ncbi request reprint Irinotecan and S-1 neoadjuvant chemoradiation therapy in patients with advanced rectal cancer
    Takeo Sato
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Hepatogastroenterology 54:1391-3. 2007
    ..Preoperative chemoradiotherapy with a combination of S-1 and CPT-11 may be a new treatment for rectal cancer...
  53. doi request reprint Feasibility and outcomes of surgical therapy in very elderly patients with colorectal cancer
    Takatoshi Nakamura
    Department of Surgery, School of Medicine, Kitasato University, Kitasato, Kanagawa, Japan
    Surg Laparosc Endosc Percutan Tech 24:85-8. 2014
    ..We compared postoperative short-term and midterm outcomes between laparoscopic surgery and open surgery to evaluate the feasibility of laparoscopic surgery in very elderly patients...
  54. doi request reprint Laparoscopic antireflux surgery improves esophageal body motility in patients with severe reflux esophagitis
    Natsuya Katada
    Department of Surgery, School of Medicine, Kitasato University, 2 1 1, Asamizodai, Minami Ku, Sagamihara, Kanagawa, 252 0380, Japan
    Surg Today 44:740-7. 2014
    ..This study was designed to clarify whether laparoscopic antireflux surgery (LARS) improves the esophageal body motility (EBM) in patients with reflux esophagitis...
  55. doi request reprint Comparison of the Heller-Toupet procedure with the Heller-Dor procedure in patients who underwent laparoscopic surgery for achalasia
    Natsuya Katada
    Department of Surgery, Kitasato University School of Medicine, 2 1 1, Asamizodai, Minami Ku, Sagamihara, Kanagawa, 252 0380, Japan
    Surg Today 44:732-9. 2014
    ..We compared the outcomes of Toupet fundoplication with those of Dor fundoplication in patients with achalasia who underwent laparoscopic Heller myotomy...
  56. doi request reprint Laparoscopy versus open distal gastrectomy by expert surgeons for early gastric cancer in Japanese patients: short-term clinical outcomes of a randomized clinical trial
    Shinichi Sakuramoto
    Department of Surgery, Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara, Kanagawa 228 8520, Japan
    Surg Endosc 27:1695-705. 2013
    ..The purpose of this study was to compare laparoscopic versus ODG with respect to specific primary and secondary short-term outcomes...
  57. doi request reprint Tumor budding as an index to identify high-risk patients with stage II colon cancer
    Takatoshi Nakamura
    Department of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Dis Colon Rectum 51:568-72. 2008
    ..We assessed the value of tumor budding, defined as small clusters of undifferentiated cancer cells at invasive margins, as a predictor of outcomes in patients with Stage II colon cancer...
  58. doi request reprint Aging of the cervical spine in healthy volunteers: a 10-year longitudinal magnetic resonance imaging study
    Eijiro Okada
    Department of Orthopaedic Surgery, Advanced Therapy for Spine and Spinal Cord Diseases, Keio University, Shinanomachi 35, Shinjuku ku, Tokyo, Japan
    Spine (Phila Pa 1976) 34:706-12. 2009
    ..Prospective longitudinal study, mean follow-up period; 11.7 +/- 0.8 years was conducted from 1995 to 2007...
  59. ncbi request reprint Neoadjuvant chemoradiation therapy using concurrent s-1 and irinotecan in rectal cancer: impact on long-term clinical outcomes and prognostic factors
    Takatoshi Nakamura
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Int J Radiat Oncol Biol Phys 89:547-55. 2014
    ..To assess the long-term outcomes of patients with rectal cancer who received neoadjuvant chemoradiation therapy (NCRT) with concurrent S-1 and irinotecan (S-1/irinotecan) therapy...
  60. doi request reprint Overexpression of GRP78 protects glial cells from endoplasmic reticulum stress
    Kaori Suyama
    Department of Anatomy and Cellular Biology, Basic Medical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    Neurosci Lett 504:271-6. 2011
    ..Our findings support the hypothesis that GRP78 inhibits cell death associated with ER stress...
  61. doi request reprint Survival outcome of laparoscopic gastrectomy for clinical early (cT1) gastric cancer
    Keishi Yamashita
    Department of Surgery, Kitasato University School of Medicine, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa 252 0374, Japan
    Surg Today 43:1013-8. 2013
    ..Laparoscopy-assisted gastrectomy (LAG) for clinical early (cT1) gastric cancer (EGC) is superior to open gastrectomy in terms of the short-term outcome; however, long-term survival outcome remains elusive...
  62. doi request reprint Preoperative serum CA19-9 and dissected peripancreatic tissue margin as determiners of long-term survival in pancreatic cancer
    Mina Waraya
    Department of Surgery, Medical School, Kitasato University Hospital, Sagamihara, Kanagawa, Japan
    Ann Surg Oncol 16:1231-40. 2009
    ..The purpose of this study is to identify markers for determining and identifying possible long-term survivors in cases of advanced pancreatic cancer...
  63. pmc Surgical treatment for injuries of the middle and lower cervical spine
    Eiren Toh
    Department of Orthopaedic Surgery, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, 259 1193, Japan
    Int Orthop 30:54-8. 2006
    ....
  64. doi request reprint Telomere shortening in Barrett's mucosa and esophageal adenocarcinoma and its association with loss of heterozygosity
    Hiroaki Shiraishi
    Departments of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Scand J Gastroenterol 44:538-44. 2009
    ....
  65. ncbi request reprint Laparoscopic low anterior resection for rectal cancer
    Yukihito Kokuba
    Department of Surgery, Kitasato University School of Medicine, Sagamihara shi, Kanagawa, Japan
    Surg Technol Int 15:87-94. 2006
    ..Indications for surgical intervention should be broadened carefully, based on a deeper understanding of the surgical anatomy within the pelvis and on various relevant oncological and technical factors...
  66. doi request reprint Calcitonin gene-related peptide facilitates revascularization during hindlimb ischemia in mice
    Toshiaki Mishima
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Am J Physiol Heart Circ Physiol 300:H431-9. 2011
    ..These results indicate that endogenous CGRP facilitates angiogenesis in response to ischemia. Targeting CGRP may provide a promising approach for controlling angiogenesis related to pathophysiological conditions...
  67. ncbi request reprint The advantage of Kakita's method with pancreaticojejunal anastomosis for pancreatic resection
    Kazunori Furuta
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Surg Technol Int 17:150-5. 2008
    ..The newly devised pancreatojejunostomy in our department is a simple, safe, and reliable procedure with excellent results...
  68. doi request reprint Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth
    Yasuhumi Ogawa
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan
    Biochem Biophys Res Commun 382:720-5. 2009
    ..The present study suggests that the blockade of EP3 signaling and the recruitment of EP3-expressing stromal cells may become a novel strategy to treat solid tumors...
  69. ncbi request reprint Clinicopathologic characteristics of pancreatic neuroendocrine tumors and relation of somatostatin receptor type 2A to outcomes
    Kosuke Okuwaki
    Department of Gastroenterology, Kitasato University East Hospital, Kanagawa, Japan
    Cancer 119:4094-102. 2013
    ..The impact of somatostatin receptor type 2 (SSTR-2a) expression levels on outcomes in patients with pancreatic neuroendocrine tumors (PNETs) has not been evaluated...
  70. ncbi request reprint Acute cervical spinal cord injury complicated by preexisting ossification of the posterior longitudinal ligament: a multicenter study
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 36:1453-8. 2011
    ..Retrospective multicenter study...
  71. doi request reprint Clinical significance of tumor markers and an emerging perspective on colorectal cancer
    Keishi Yamashita
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara, Kanagawa, Japan
    Cancer Sci 100:195-9. 2009
    ..The optimal tumor markers would be generalized, easy to assess, and accurate, and such markers are eagerly anticipated to enable personalized tailored therapy for CRC patients...
  72. ncbi request reprint Nkx2.2 expression in differentiation of oligodendrocyte precursor cells and inhibitory factors for differentiation of oligodendrocytes after traumatic spinal cord injury
    Kaori Suyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Kanagawa, Japan
    J Neurotrauma 24:1013-25. 2007
    ..These results suggest that environmental factors such as cytokines may affect Nkx2.2 expression or oligodendrocyte precursor cell differentiation in the contusion-induced spinal cord injury model...
  73. doi request reprint SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses
    Masahiro Fukaya
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    J Neurochem 116:1122-37. 2011
    ..Taken together, these findings suggest that synArfGEF functions as a novel regulator of Arf6 at inhibitory synapses and associates with the dystrophin-associated glycoprotein complex and S-SCAM...
  74. ncbi request reprint Randomized trial of the efficacy of adjuvant chemotherapy for colon cancer with combination therapy incorporating the oral pyrimidine 1-hexylcarbamoyl-5-fluorouracil
    Masahiko Watanabe
    Department of Surgery, School of Medicine, Kitasato University, 1 15 1, Kitasato, Sagamihara, Kanagawa, 228 8555, Japan
    Langenbecks Arch Surg 391:330-7. 2006
    ..The purpose of the present trial was to clarify the efficacy of postoperative adjuvant chemotherapy including an oral fluoropyrimidine anticancer drug, the 1-hexylcarbamoyl-5-fluorouracil (HCFU), for the treatment of colon cancer...
  75. ncbi request reprint Comparison of long-term outcome of laparoscopic and conventional surgery for advanced colon and rectosigmoid cancer
    Takatoshi Nakamura
    Department of Surgery, Kitasato University Hospital, Kanagawa, Japan
    Hepatogastroenterology 53:351-3. 2006
    ..In this study we tested the null hypothesis that there is no difference in the outcome of advanced colorectal cancer according to whether it is treated by laparoscopic or conventional open resection...
  76. ncbi request reprint Segmental motor paralysis after expansive open-door laminoplasty
    Kazuhiro Chiba
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    Spine (Phila Pa 1976) 27:2108-15. 2002
    ..A retrospective study was conducted to investigate patients in whom segmental motor paralysis developed after expansive open-door laminoplasty for cervical myelopathy...
  77. ncbi request reprint Interaction between stromal fibroblasts and colorectal cancer cells in the expression of vascular endothelial growth factor
    Yoshitomo Koshida
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    J Surg Res 134:270-7. 2006
    ..Vascular endothelial growth factor (VEGF), a potent angiogenic factor, has been implicated in metastasis of colorectal cancer (CRC). The present study aimed to clarify whether cancer-stromal interaction induces the production of VEGF...
  78. ncbi request reprint Transfusion alert for patients with curable cancer
    Keishi Yamashita
    Department of Surgery, Kitasato University Hospital, Kanagawa, Japan
    World J Surg 31:2315-22. 2007
    ..However, the prognostic independence among related factors and clinical significance of the interaction remains elusive...
  79. doi request reprint The psychological responses of outpatient breast cancer patients before and during first medical consultation
    Shigemi Okazaki
    Department of Medical Psychology, Kitasato University, Graduate School of Medical Sciences, Kanagawa, Japan
    Palliat Support Care 7:307-14. 2009
    ..The purpose of this study was to qualitatively examine the content of the psychological responses in interviews with breast cancer outpatients receiving initial medical consultation...
  80. doi request reprint TNF-alpha induces thromboxane receptor signaling-dependent microcirculatory dysfunction in mouse liver
    Hiroyuki Katagiri
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan
    Shock 30:463-7. 2008
    ..Blockade of TNF-alpha generation and TP receptor signaling may be a good strategy for managing endotoxin-induced hepatic injury...
  81. ncbi request reprint Diffusion-weighted imaging of malignant breast tumors: the usefulness of apparent diffusion coefficient (ADC) value and ADC map for the detection of malignant breast tumors and evaluation of cancer extension
    Reiko Woodhams
    Department of Radiology, Kitasato University School of Medicine, Kanagawa, Japan
    J Comput Assist Tomogr 29:644-9. 2005
    ..Benign proliferative change showed a low ADC value. The authors conclude that DWI has a potential for clinical appreciation in detecting breast cancer...
  82. pmc Identification of the sites of 2-arachidonoylglycerol synthesis and action imply retrograde endocannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area
    Ferenc Matyas
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony utca 43, H 1083 Budapest, Hungary
    Neuropharmacology 54:95-107. 2008
    ..These findings indicate that retrograde synaptic signaling mediated by 2-AG via CB(1) may influence the drug-reward circuitry at multiple types of synapses in the VTA...
  83. ncbi request reprint Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain
    Michiko Nakamura
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Eur J Neurosci 20:2929-44. 2004
    ..This close molecular relationship might provide PLCbeta4 with a high-fidelity effector function to mediate various neuronal responses under physiological and pathophysiological conditions...
  84. ncbi request reprint Docetaxel enhances the cytotoxicity of anthracyclines by increasing intracellular drug accumulation
    Tomohisa Egawa
    Department of Surgery, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Oncol Rep 9:777-81. 2002
    ..Thus, docetaxel increased the antitumor activity of anthracyclines by increasing their intracellular concentrations...
  85. ncbi request reprint Control of synaptic connection by glutamate receptor delta2 in the adult cerebellum
    Tomonori Takeuchi
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, and Solution Oriented Research for Science and Technology, Japan Science and Technology Agency, Tokyo 113 0033, Japan
    J Neurosci 25:2146-56. 2005
    ..We thus identified postsynaptic GluRdelta2 as a key regulator of the presynaptic active zone and PSD organization at parallel fiber-PC synapses in the adult brain...
  86. ncbi request reprint Identification and characterization of a novel member of murine semaphorin family
    Masahiko Taniguchi
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Genes Cells 10:785-92. 2005
    ....
  87. ncbi request reprint ADC mapping of benign and malignant breast tumors
    Reiko Woodhams
    Department of Radiology, Kitasato University School of Medicine, Japan
    Magn Reson Med Sci 4:35-42. 2005
    ....
  88. ncbi request reprint Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses
    Yukihiro Takayasu
    Department of Neurophysiology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    J Neurosci 25:8788-93. 2005
    ..In contrast, the main role of EAAT4 is to remove low concentrations of glutamate that escape from the uptake by glial transporters at late times and thus prevents the transmitter from spilling over to neighboring synapses...
  89. ncbi request reprint Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain
    Masanori Tachikawa
    Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    J Neurochem 95:294-304. 2005
    ..The distinct spatio-temporal expressions of individual ABCA and G transporters may reflect their distinct cellular expressions in the developing and adult brains, presumably, to regulate and maintain lipid homeostasis in the brain...
  90. ncbi request reprint Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain
    Tetsuya Abe
    Department of Medical Chemistry, Kansai Medical University, Moriguchi 570 8506, Japan
    Eur J Neurosci 22:1445-54. 2005
    ....
  91. ncbi request reprint Target-cell-specific left-right asymmetry of NMDA receptor content in schaffer collateral synapses in epsilon1/NR2A knock-out mice
    Yue Wu
    Department of Physiology, School of Life Science, Graduate University for Advanced Studies SOKENDAI, Okazaki, Aichi 444 8787, Japan
    J Neurosci 25:9213-26. 2005
    ..These results indicate that the asymmetry of epsilon2 distribution is target cell specific, resulting in the left-right difference in NMDA receptor content and plasticity in Sch-CA1 pyramidal cell synapses in epsilon1 KO mice...
  92. pmc Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain
    Sho Kakizawa
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    Proc Natl Acad Sci U S A 102:19180-5. 2005
    ..These results indicate that, in the mature cerebellum, AMPA receptor-mediated excitatory postsynaptic activity maintains CF's functional glutamate-release sites and its innervation of PC shaft dendrites...
  93. ncbi request reprint The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum
    Yoshinobu Kawamura
    Department of Cellular Neuroscience, Graduate School of Medicine, Osaka University, Suita 565 0871, Japan
    J Neurosci 26:2991-3001. 2006
    ....
  94. ncbi request reprint Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse--possible implications for pain processing
    Pablo Brumovsky
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Chem Neuroanat 31:243-62. 2006
    ..Hao, J.X., Xu, X.J., Hökfelt, T., Crawley, J.N., Wiesenfeld-Hallin, Z., 2004. Galanin over-expression decreases the development of neuropathic pain-like behaviour in mice after partial sciatic nerve injury. Brain Res. 1025, 152-158]...
  95. ncbi request reprint [A case of local advanced breast cancer with multiple lung metastases successfully treated with multimodal therapy]
    Norihiko Sengoku
    Dept of Surgery, Kitasato University School of Medicine
    Gan To Kagaku Ryoho 31:1927-9. 2004
    ..No signs of recurrence were observed for more than 14 months of treatment by trastuzumab. Multimodal therapy can improve patient QOL and the clinical outcomes in Stage IV local advanced breast cancer...
  96. ncbi request reprint Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E
    Hiroyuki W Kitamura
    Laboratory for Neurodegeneration Signal, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Neurosci Lett 369:173-8. 2004
    ....
  97. ncbi request reprint TZT-1027 elucidates antitumor activity through direct cytotoxicity and selective blockade of blood supply
    Naoko Hashiguchi
    Department of Surgery, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Anticancer Res 24:2201-8. 2004
    ..TZT-1027 is a newly developed antitumor agent derived from dolastatin 10...
  98. ncbi request reprint Early onset of NMDA receptor GluR epsilon 1 (NR2A) expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus
    Shohei Oshima
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Neurosci Res 43:239-50. 2002
    ....
  99. ncbi request reprint A simple and reliable behavioral analysis of locomotor function after spinal cord injury in mice. Technical note
    Yuji Mikami
    Division of Cellular Signaling, Institute for Advanced Medical Research, Tokyo, Japan
    J Neurosurg 97:142-7. 2002
    ..The analysis of vertical movement is useful for assessing the recovery of limb function in mice following thoracic hemisection...
  100. ncbi request reprint Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion
    Masahiko Watanabe
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, USA
    J Neurosci Res 69:826-36. 2002
    ....
  101. ncbi request reprint Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries
    Kazuhisa Sakai
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 23:550-60. 2003
    ..Therefore, ASCT1 appears to be regulated to meet metabolic demands by differentiating and mature neurons through the transport of glia- and blood-borne small neutral amino acids...