H Tachibana

Summary

Affiliation: Tokai University
Country: Japan

Publications

  1. ncbi request reprint Differentiation of Entamoeba histolytica from E. dispar facilitated by monoclonal antibodies against a 150-kDa surface antigen
    H Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Japan
    Parasitol Res 83:435-9. 1997
  2. doi request reprint Isolation and characterization of a potentially virulent species Entamoeba nuttalli from captive Japanese macaques
    H Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Parasitology 136:1169-77. 2009
  3. doi request reprint Prevalence of Entamoeba nuttalli infection in wild rhesus macaques in Nepal and characterization of the parasite isolates
    Hiroshi Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Japan
    Parasitol Int 62:230-5. 2013
  4. pmc Characterization of Entamoeba histolytica intermediate subunit lectin-specific human monoclonal antibodies generated in transgenic mice expressing human immunoglobulin loci
    Hiroshi Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Infect Immun 77:549-56. 2009
  5. ncbi request reprint Primary structure, expression and localization of two intermediate subunit lectins of Entamoeba dispar that contain multiple CXXC motifs
    H Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Parasitology 134:1989-99. 2007
  6. ncbi request reprint An Entamoeba sp. strain isolated from rhesus monkey is virulent but genetically different from Entamoeba histolytica
    Hiroshi Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Mol Biochem Parasitol 153:107-14. 2007
  7. pmc Improved affinity of a human anti-Entamoeba histolytica Gal/GalNAc lectin Fab fragment by a single amino acid modification of the light chain
    Hiroshi Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Clin Diagn Lab Immunol 11:1085-8. 2004
  8. pmc Evaluation of recombinant fragments of Entamoeba histolytica Gal/GalNAc lectin intermediate subunit for serodiagnosis of amebiasis
    Hiroshi Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Clin Microbiol 42:1069-74. 2004
  9. pmc VH3 gene usage in neutralizing human antibodies specific for the Entamoeba histolytica Gal/GalNAc lectin heavy subunit
    Hiroshi Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Infect Immun 71:4313-9. 2003
  10. pmc Preparation of a monoclonal antibody specific for Entamoeba dispar and its ability to distinguish E. dispar from E. histolytica
    H Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Japan
    Clin Diagn Lab Immunol 4:409-14. 1997

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Differentiation of Entamoeba histolytica from E. dispar facilitated by monoclonal antibodies against a 150-kDa surface antigen
    H Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Japan
    Parasitol Res 83:435-9. 1997
    ..dispar. These results indicate that common antigenic epitopes of E. histolytica are on the 150-kDa surface molecule and that mAbs can distinguish between E. histolytica and E. dispar...
  2. doi request reprint Isolation and characterization of a potentially virulent species Entamoeba nuttalli from captive Japanese macaques
    H Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Parasitology 136:1169-77. 2009
    ..These results demonstrate that the NASA6 strain is potentially virulent and that E. nuttalli should be recognized as a common parasite in macaques...
  3. doi request reprint Prevalence of Entamoeba nuttalli infection in wild rhesus macaques in Nepal and characterization of the parasite isolates
    Hiroshi Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Japan
    Parasitol Int 62:230-5. 2013
    ..nuttalli is highly prevalent in wild rhesus macaques in Nepal. Rhesus macaques appear to be one of the natural hosts and heterogeneity of the serine-rich protein gene might be useful for geographical typing of isolates...
  4. pmc Characterization of Entamoeba histolytica intermediate subunit lectin-specific human monoclonal antibodies generated in transgenic mice expressing human immunoglobulin loci
    Hiroshi Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Infect Immun 77:549-56. 2009
    ..These results demonstrate that human MAbs to Igls may be applicable for immunoprophylaxis of amebiasis...
  5. ncbi request reprint Primary structure, expression and localization of two intermediate subunit lectins of Entamoeba dispar that contain multiple CXXC motifs
    H Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Parasitology 134:1989-99. 2007
    ..These results demonstrate that Igls are important proteins even in non-pathogenic amoeba and that Igl1 and Igl2 may possess different functions...
  6. ncbi request reprint An Entamoeba sp. strain isolated from rhesus monkey is virulent but genetically different from Entamoeba histolytica
    Hiroshi Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Mol Biochem Parasitol 153:107-14. 2007
    ..These results demonstrate that the strain is genetically different from E. histolytica and is virulent. Revival of the name Entamoeba nuttalli is proposed for the organism...
  7. pmc Improved affinity of a human anti-Entamoeba histolytica Gal/GalNAc lectin Fab fragment by a single amino acid modification of the light chain
    Hiroshi Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Clin Diagn Lab Immunol 11:1085-8. 2004
    ..These results demonstrate that modification of antibody genes by recombination PCR is a useful method for affinity maturation and that amino acid substitution at position 91 yields Fabs with increased affinity for the lectin...
  8. pmc Evaluation of recombinant fragments of Entamoeba histolytica Gal/GalNAc lectin intermediate subunit for serodiagnosis of amebiasis
    Hiroshi Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Clin Microbiol 42:1069-74. 2004
    ..histolytica infection and that the carboxyl terminus of Igl is an especially useful antigen for the serodiagnosis of amebiasis...
  9. pmc VH3 gene usage in neutralizing human antibodies specific for the Entamoeba histolytica Gal/GalNAc lectin heavy subunit
    Hiroshi Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Infect Immun 71:4313-9. 2003
    ..These results demonstrate the utility of a combinatorial human immunoglobulin gene library for identifying and characterizing neutralizing antibodies from humans with amebiasis...
  10. pmc Preparation of a monoclonal antibody specific for Entamoeba dispar and its ability to distinguish E. dispar from E. histolytica
    H Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Japan
    Clin Diagn Lab Immunol 4:409-14. 1997
    ..dispar and E. histolytica. This method may prove to be useful for the accurate identification of E. dispar and E. histolytica, even in mixed infections...
  11. pmc Preparation of recombinant human monoclonal antibody Fab fragments specific for Entamoeba histolytica
    H Tachibana
    Departments of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Clin Diagn Lab Immunol 6:383-7. 1999
    ..histolytica. The recombinant human monoclonal antibody Fab fragments may be applicable for distinguishing E. histolytica from E. dispar and for use in the serodiagnosis of amebiasis...
  12. ncbi request reprint High prevalence of infection with Entamoeba dispar, but not E. histolytica, in captive macaques
    H Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Parasitol Res 87:14-7. 2001
    ..histolytica, showing the lowest titer. These results demonstrate that infection with E. dispar, but not E. histolytica, is predominant in macaques...
  13. ncbi request reprint Asymptomatic cyst passers of Entamoeba histolytica but not Entamoeba dispar in institutions for the mentally retarded in Japan
    H Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
    Parasitol Int 49:31-5. 2000
    ..All isolates were identified as E. histolytica. The results lead us to conceive that, in Japan, E. histolytica is predominant even in asymptomatic cyst passers...
  14. ncbi request reprint Entamoeba dispar, but not E. histolytica, detected in a colony of chimpanzees in Japan
    H Tachibana
    Department of Infectious Diseases, Tokai University School of Medicine, Bohseidai, Isehara, Japan
    Parasitol Res 86:537-41. 2000
    ..histolytica was absent in this colony, regardless of the high degree of prevalence of other amebas. For an accurate diagnosis, PCR analysis is recommended in addition to microscopic examination...
  15. ncbi request reprint Survey for Trypanosoma cruzi infection in a municipality in northeast Brazil
    H Tachibana
    Laboratório de Imunopatologia Prof Keizo Asami, Federal Universidade de Pernambuco, Recife, Brazil
    Tokai J Exp Clin Med 24:131-6. 1999
    ..cruzi, labeled organisms in jird tissues. These observations demonstrate that the jird is a suitable host for experimental T. cruzi infections and that monoclonal antibody is effective for detection of the parasite in host tissues...
  16. ncbi request reprint Protection of hamsters from amebic liver abscess formation by immunization with the 150- and 170-kDa surface antigens of Entamoeba histolytica
    X J Cheng
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Parasitol Res 87:126-30. 2001
    ..In the immunized hamsters, the abscesses in the two groups were significantly smaller than in the controls. These results demonstrate that the E. histolytica antigens are possible vaccine candidates for amebiasis...
  17. ncbi request reprint Serologic response to Blastocystis hominis infection in asymptomatic individuals
    Y Kaneda
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Japan
    Tokai J Exp Clin Med 25:51-6. 2000
    ..hominis. 4) The strongest positive reaction was obtained in an individual chronically infected for more than 2 years. It may be that long exposure to the parasite is necessary for a serologic response...
  18. ncbi request reprint Molecular characterization of peroxiredoxin from Entamoeba moshkovskii and a comparison with Entamoeba histolytica
    Xun Jia Cheng
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Mol Biochem Parasitol 138:195-203. 2004
    ..histolytica. These results suggest that the antioxidant peroxiredoxin is important for protection against endogenously generated hydrogen peroxide in the nonpathogenic ameba...
  19. pmc Intermediate subunit of the Gal/GalNAc lectin of Entamoeba histolytica is a member of a gene family containing multiple CXXC sequence motifs
    X J Cheng
    Department of Infectious Diseases, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan
    Infect Immun 69:5892-8. 2001
    ..These data indicate that Igl is part of the parasite's multimolecular Gal/GalNAc adhesin required for host interaction...
  20. ncbi request reprint Ribodemes of Blastocystis hominis isolated in Japan
    Y Kaneda
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Japan
    Am J Trop Med Hyg 65:393-6. 2001
    ..However, we noted a possible relationship between ribodeme type and pathogenicity. The results suggest that ribodemes I, III, and VI may be responsible for gastrointestinal symptoms...
  21. doi request reprint Comparison of serine-rich protein genes of Entamoeba histolytica isolates obtained from institutions for the mentally retarded in Kanagawa and Shizuoka Prefectures, Japan
    Yong Feng Fu
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa, 259 1193, Japan
    Parasitol Res 107:999-1002. 2010
    ..histolytica isolates were identical. This retrospective study led us to conclude that the outbreak of amebiasis in different municipalities was derived from a single source of E. histolytica...
  22. ncbi request reprint Pramipexole safely replaces ergot dopamine agonists with either rapid or slow switching
    H Takahashi
    Division of Neurology, Department of Internal Medicine, Tokai University, Isehara, Kanagawa, Japan
    J Int Med Res 36:106-14. 2008
    ..Switching patients with PD from ergot DA to pramipexole, using either a slow or rapid switching method, appeared to be well tolerated and effective, although further dose adjustment may be necessary in some patients after the switch...
  23. ncbi request reprint Application of the polymerase chain reaction (PCR) in the epidemiology of Entamoeba histolytica and Entamoeba dispar infections
    W L Rivera
    Department of Protozoology, Institute of Tropical Medicine, Nagasaki University, Japan
    Tokai J Exp Clin Med 23:413-5. 1998
    ..The assay is, sensitive enough to detect as few as five cysts in the stool sample, rapid and selectively differentiates E. histolytica from E. dispar DNA from stool specimens without the need for prior cultivation...
  24. pmc Production of high-affinity human monoclonal antibody fab fragments to the 19-kilodalton C-terminal merozoite surface protein 1 of Plasmodium falciparum
    Xun Jia Cheng
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Infect Immun 75:3614-20. 2007
    ..falciparum MSP-1(19). The combinatorial immunoglobulin gene library derived from malaria patients provides a potential tool for producing high-affinity human antibodies specific for P. falciparum...
  25. pmc Bacterial expression of a human monoclonal antibody-alkaline phosphatase conjugate specific for Entamoeba histolytica
    Hiroshi Tachibana
    Departments of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Clin Diagn Lab Immunol 11:216-8. 2004
    ..histolytica and that the antibody can be used to detect E. histolytica antigen without the use of chemically conjugated secondary antibodies...
  26. pmc Generation of a neutralizing human monoclonal antibody Fab fragment to surface antigen 1 of Toxoplasma gondii tachyzoites
    Yong Feng Fu
    Department of Medical Microbiology and Parasitology, Fudan University School of Medicine, Shanghai 200032, China
    Infect Immun 79:512-7. 2011
    ..This is the first report of bacterial expression of human monoclonal antibody Fab fragments to SAG1 of T. gondii. These results also demonstrate that human Fab fragments to SAG1 might be applicable for immunoprophylaxis of toxoplasmosis...
  27. doi request reprint Sudden death caused by chronic Chagas disease in a non-endemic country: Autopsy report
    Fumiko Satoh
    Department of Forensic Medicine, Tokai University School of Medicine, Shimokasuya 143, Isehara, Kanagawa 259 1193, Japan
    Pathol Int 60:235-40. 2010
    ..It is important for pathologists to know the possible involvement of chronic Chagas disease in sudden unexpected deaths in the current globalized society of Japan...
  28. ncbi request reprint Comparison of Entamoeba histolytica DNA isolated from a cynomolgus monkey with human isolates
    Jun ichiro Takano
    The Corporation for Production and Research of Laboratory Primates, 1 Hachimandai, Tsukuba shi, Ibaraki 305 0843, Japan
    Parasitol Res 101:539-46. 2007
    ..dispar. To our knowledge, this is the first molecular characterization of E. histolytica isolated from cynomolgus monkey, and our results indicate that EHMfas1 may be a subspecies of E. histolytica that infects cynomolgus monkey...
  29. doi request reprint Modification of a human monoclonal antibody Fab fragment specific for Plasmodium falciparum 19-kDa C-terminal merozoite surface protein 1 by site-directed mutagenesis
    Yan Lin Tao
    Department of Medical Microbiology and Parasitology, Fudan University School of Medicine, Shanghai, 200032, China
    Parasitol Res 103:429-33. 2008
    ..Of these modified Fab fragments, the affinities of Fabs with Ile(97)-Leu and Trp(107)-Ser mutations were slightly higher than that of the original Fab. The effects of these modifications on the antigen-antibody interaction are discussed...
  30. ncbi request reprint Seroprevalence of Entamoeba histolytica infection in HIV-infected patients in China
    Yi Chen
    Department of Medical Microbiology and Parasitology, Fudan University School of Medicine, Shanghai, China
    Am J Trop Med Hyg 77:825-8. 2007
    ..This is the first report showing a higher seroprevalence of E. histolytica infection in HIV-infected patients in China. Our results also suggest that HIV infection is a risk factor for infection with E. histolytica...
  31. ncbi request reprint [Screening and expression of recombinant human monoclonal antibody Fab fragments specific to Entamoeba histolytica]
    Qing Shu
    Department of Medical Microbiology and Parasitology, Shanghai Medical Center of Fudan University, Shanghai 200032, China
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 22:65-9. 2004
    ..To prepare recombinant human monoclonal antibody Fab fragments specific to the surface antigen of Entamoeba histolytica...
  32. ncbi request reprint Construction of human naïve Fab library and characterization of anti-met Fab fragment generated from the library
    Yongjun Jiao
    Antibody Technology Laboratory, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Mol Biotechnol 31:41-54. 2005
    ..In conclusion, hFab-Met-1 interacts with Met both in vitro and in vivo, and is a promising candidate for clinical diagnosis and therapeutics...
  33. ncbi request reprint Entamoeba histolytica and Entamoeba dispar infections in cynomolgus monkeys imported into Japan for research
    Jun ichiro Takano
    The Corporation for Production and Research of Laboratory Primates, 1 Hachimandai, Tsukuba shi Ibaraki, 305 0843, Japan
    Parasitol Res 97:255-7. 2005
    ..To our knowledge, this is the first report of E. histolytica isolation from cynomolgus monkeys based on the discrimination between E. histolytica and E. dispar...
  34. pmc Production of an anti-severe acute respiratory syndrome (SARS) coronavirus human monoclonal antibody Fab fragment by using a combinatorial immunoglobulin gene library derived from patients who recovered from SARS
    Jinye Liu
    Department of Medical Microbiology and Parasitology, Fudan University School of Medicine, Shanghai, China
    Clin Vaccine Immunol 13:594-7. 2006
    ..The dissociation constant of AS3-3 was 1.98 x 10(-8) M. Immunofluorescent microscopy revealed that it reacted with SARS-CoV-infected cells. The library seems to be a potent tool for the production of human antibodies to SARS-CoV...
  35. ncbi request reprint Axenic cultivation of Entamoeba dispar in newly designed yeast extract-iron-gluconic acid-dihydroxyacetone-serum medium
    Seiki Kobayashi
    Department of Tropical Medicine and Parasitology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Parasitol 91:1-4. 2005
    ..dispar in this medium, analyses of relevant enzymes on the glycolytic pathway of the amoebae as well as of the protozoans that are the best culture supplement for amoebae are being performed...