Daisuke Sakai


Affiliation: Tokai University
Country: Japan


  1. Lyu F, Cheung K, Zheng Z, Wang H, Sakai D, Leung V. IVD progenitor cells: a new horizon for understanding disc homeostasis and repair. Nat Rev Rheumatol. 2019;15:102-112 pubmed publisher
  2. Schol J, Sakai D. Cell therapy for intervertebral disc herniation and degenerative disc disease: clinical trials. Int Orthop. 2019;43:1011-1025 pubmed publisher
    ..We aim to highlight current trends, shortcomings, and hurdles for effective clinical trials and consecutive commercialization. ..
  3. Sakai D. Stem cell regeneration of the intervertebral disk. Orthop Clin North Am. 2011;42:555-62, viii-ix pubmed publisher
    ..Successful results have been reported, although limitations remain. This article reviews the current status of stem cell research as applied to the intervertebral disk. ..
  4. Sakai D, Nishimura K, Tanaka M, Nakajima D, Grad S, Alini M, et al. Migration of bone marrow-derived cells for endogenous repair in a new tail-looping disc degeneration model in the mouse: a pilot study. Spine J. 2015;15:1356-65 pubmed publisher
  5. Bach F, Zhang Y, Miranda Bedate A, Verdonschot L, Bergknut N, Creemers L, et al. Increased caveolin-1 in intervertebral disc degeneration facilitates repair. Arthritis Res Ther. 2016;18:59 pubmed publisher
    ..Further studies are needed to investigate how caveolin-1 modifies other signaling pathways and facilitates IVD repair. ..
  6. Hiyama A, Yokoyama K, Nukaga T, Sakai D, Mochida J. A complex interaction between Wnt signaling and TNF-? in nucleus pulposus cells. Arthritis Res Ther. 2013;15:R189 pubmed publisher
    ..We speculate that blocking this pathway might protect nucleus pulposus cells against degeneration. ..
  7. Nakai T, Mochida J, Sakai D. Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF beta-1 in cultured rat nucleus pulposus cells. Arthritis Res Ther. 2008;10:R140 pubmed publisher
  8. Hiyama A, Arai F, Sakai D, Yokoyama K, Mochida J. The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells. Arthritis Res Ther. 2012;14:R105 pubmed publisher
    ..These results suggest that the expression of Klotho is regulated by the balance between upregulation and downregulation of Wnt signaling. ..
  9. request reprint
    Sakai D, Mochida J, Iwashina T, Watanabe T, Suyama K, Ando K, et al. Atelocollagen for culture of human nucleus pulposus cells forming nucleus pulposus-like tissue in vitro: influence on the proliferation and proteoglycan production of HNPSV-1 cells. Biomaterials. 2006;27:346-53 pubmed

More Information


  1. Sakai D, Nakamura Y, Nakai T, Mishima T, Kato S, Grad S, et al. Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. Nat Commun. 2012;3:1264 pubmed publisher
    ..Moreover, angiopoietin-1, a ligand of Tie2, is crucial for the survival of nucleus pulposus cells. Our results offer insights for regenerative therapy and a new diagnostic standard. ..
  2. Hiyama A, Katoh H, Sakai D, Tanaka M, Sato M, Watanabe M. Clinical impact of JOABPEQ mental health scores in patients with low back pain: Analysis using the neuropathic pain screening tool painDETECT. J Orthop Sci. 2017;22:1009-1014 pubmed publisher
    ..We found that psychological factors may modify pain intensity and may lead to an exaggerated or histrionic presentation of the pain, or neuropathic LBP may be exacerbating psychological factors. ..