Research Topics
Species | Robert Y OsamuraSummaryAffiliation: Tokai University Country: Japan Publications
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Detail Information
Publications
HER2 testing on core needle biopsy specimens from primary breast cancers: interobserver reproducibility and concordance with surgically resected specimensHitoshi Tsuda
Diagnostic Pathology Section, Clinical Laboratory Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
BMC Cancer 10:534. 2010..The aim of the present study was to validate the application of HER2 testing with CNB specimens from primary breast cancers in terms of interobserver reproducibility and comparison with surgically resected specimens...
Applications of plastic embedding to electron microscopic immunocytochemistry and in situ hybridization in observations of production and secretion of peptide hormonesR Y Osamura
Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan
J Histochem Cytochem 48:885-91. 2000..This review article deals with technical aspects, procedures, and applications in endocrine cells...- Pathology of the human pituitary adenomasRobert Y Osamura
Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Boseidai Isehara, Kanagawa 259 1193, Japan
Histochem Cell Biol 130:495-507. 2008.... 
Current practices in performing frozen sections for thyroid and parathyroid pathologyRobert Y Osamura
Department of Pathology, Tokai University School of Medicine, Isehara City, Kanagawa, 259 1193, Japan
Virchows Arch 453:433-40. 2008..It is concluded that thyroid and parathyroid frozen section examination is restricted to selected situations...- Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell lineShunsuke Miyai
Department of Pathology, Tokai University School of Medicine, Bohseidai Isehara Campus, Kanagawa 259 1193, Japan
Cell Tissue Res 322:269-77. 2005.... - Molecular pathology of the pituitary. Development and functional differentiation of pituitary adenomasRobert Yoshiyuki Osamura
Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
Front Horm Res 32:20-33. 2004..Various mechanisms have been reported for the experimental pituitary oncogenesis. Among these, GHRH has been emphasized as one of oncogenic factors for both human GHomas as well as in the transgenic animals... - Roles of pathologists in molecular targeted cancer therapyRobert Y Osamura
Department of Pathology Tokai University School of Medicine, Kanagawa, Japan
J Cell Mol Med 13:4286-90. 2009..This introductory review of MTCT describes more details of each MTCT... - Endocrine pathology in translational medicine: an overview of current and future prospectsRobert Yoshiyuki Osamura
Department of Pathology, Tokai University School of Medicine, Boseidai Isehara City, Kanagawa, Japan
Endocr Pathol 14:117-21. 2003..The endocrine pathology is expected to play a major role in translational medicine... - Pit-1 positive alpha-subunit positive nonfunctioning human pituitary adenomas: a dedifferentiated GH cell lineage?R Y Osamura
Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan
Pituitary 1:269-71. 1999..From this background, this paper proposes that "alpha SU positive Pit-1 Positive" cells are the ones in the GH cell lineage, more specifically a dedifferentiated cell lineage toward alpha SU/GH/Pit-1... - Recent progress in studies of pituitary tumor pathogenesisTakeo Minematsu
Department of Pathology, Tokai University School of Medicine. Boseidai, Isehara, Kanagawa 259-1193, Japan
Endocrine 28:37-41. 2005..Recently, epigenetic regulation has been suggested to be related to pituitary tumor formation. This article presents a review and update of recent progress in studies of the development and differentiation of pituitary tumors... - Selection of buffer pH by the isoelectric point of the antigen for the efficient heat-induced epitope retrieval: re-appraisal for nuclear protein pathobiologyHanako Kajiya
Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Boseidai Isehara, Kanagawa, 259 1193, Japan
Histochem Cell Biol 132:659-67. 2009..It is concluded that the mechanism of HEIR may, therefore, depend to a large extent on the pI of the antigen under investigation... - Fine needle aspiration cytology of ductal adenoma of the breast with intracellular mucin: a report of three casesHitoshi Itoh
Division of Diagnostic Pathology, Tokai University Hospital, Shimokasuya 143, Isehara City, Kanagawa 259 1193, Japan
Acta Cytol 54:753-8. 2010..Here we present three cases of ductal adenoma of the breast with foci of intracellular mucin... - Pituitary changes in Prop1 transgenic mice: hormone producing tumors and signet-ring type gonadotropesNoboru Egashira
Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
Acta Histochem Cytochem 41:47-57. 2008..Taken together, our results suggest a (1) tumorigenic effect of Prop1 in the pituitaries, and (2) causative effects of signet ring-type gonadotropes... - Perivascular epithelioid cell tumor (PEComa) of the pancreas: immunoelectron microscopy and review of the literatureKenichi Hirabayashi
Department of Pathology, Tokai University School of Medicine, Kanagawa 259 1193, Japan
Pathol Int 59:650-5. 2009..The results of immunoelectron microscopy show that some PEComas possess not only typical melanosomes or premelanosomes but also aberrant melanosomes... - Lower HER-2/chromosome enumeration probe 17 ratio in cytologic HER-2 fluorescence in situ hybridization for breast cancers: three-dimensional analysis of intranuclear localization of centromere 17 and HER-2 signalsHitoshi Itoh
Division of Diagnostic Pathology, Department of Pathology, Tokai, University School of Medicine, Kanagawa, Japan
Cancer 114:134-40. 2008..Cytologic samples also are used, but to the authors' knowledge, little is known regarding the reliability of these samples. The objective of this study was to elucidate the usefulness of cytologic specimens for HER-2 FISH testing... - Expression of proliferation markers in human pituitary incidentalomasMasanori Suzuki
Department of Neurosurgery, Nippon Medical School, Japan
Endocr Pathol 17:263-75. 2006..Large or invasive incidentalomas should be surgically treated if the patients show visual disturbances, hypopituitarism, or pituitary apoplexy during the follow-up period... - Vascular networks and endothelial cells in the rat experimental pituitary glands and in the human pituitary adenomasJohbu Itoh
Laboratories for Structure and Function Research, Tokai University School of Medicine, Tokai University School of Medicine, Kanagawa, 259 1193 Japan
Microsc Res Tech 60:231-5. 2003..Therefore, 3D reconstructed imaging by CLSM is a useful technique with which to investigate the microvessel environment of hormone-secreting cells and has the potential to reveal dynamic hormone-secreting pathways... - Serum carbohydrate antigen elevations in endometrial adenocarcinomas: characterization of DU-PAN-2 expression as a tumor markerMasanori Yasuda
Department of Pathology, School of Medicine, Tokai University, Kanagawa, Japan
J Obstet Gynaecol Res 30:59-64. 2004..To characterize serum elevations of carbohydrate antigens; DU-PAN-2, CA19-9, sialyl Lewisx and CA125 in endometrial adenocarcinomas (EMACs), particularly focusing on the clarification of DU-PAN-2 expression profiles... - Immunonegative "null cell" adenomas and gonadotropin (Gn) subunit (SUs) immunopositive adenomas share frequent expression of multiple transcription factorsYudo Ishii
Department of Neurosurgery, Nippon Medical School, Tokai University School of Medicine, Japan
Endocr Pathol 17:35-43. 2006..The questions, why a certain proportion of these pituitary tumor groups lack hormone production and why they are molecularly more committed to Gn transcription, remain to be further investigated... - Variation of alpha-methylacyl-CoA racemase expression in prostate adenocarcinoma cases receiving hormonal therapyXiaoyan Tang
Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
Hum Pathol 37:1186-92. 2006..Further investigation of the relationship between AMACR expression and androgen or androgen receptors may provide new insight into novel preventive and curative medicine for prostate adenocarcinoma... - Usefulness of hypoxia inducible factor-1 alpha in evaluating the prostatic adenocarcinoma viability following neoadjuvant hormone therapyMasanori Yasuda
Department of Pathology, Saitama Medical University, International Medical Center, Japan
Cancer Detect Prev 31:396-401. 2007..This study was designed to elucidate whether or not HIF-1 alpha expression would be associated with PA recurrence after neoadjuvant hormone therapy (NHT)... - PTTG is a secretory protein in human pituitary adenomas and in mouse pituitary tumor cell linesTakeo Minematsu
Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
Endocr Pathol 18:8-15. 2007..Our results suggested that PTTG is a secretory protein produced by pituitary tumor cells. In addition, PTTG may exert autocrine and/or paracrine functions as a newly proposed important pathway for the action of PTTG... - [Pituitary gangliocytoma]Mao Takei
Department of Pathology, Tokai University
Nippon Rinsho . 2006 - Immunohistochemical detection of somatostatin receptor (SSTR) subtypes 2A and 5 in pituitary adenoma from acromegalic patients: good correlation with preoperative response to octreotideMao Takei
Department of Neurosurgery, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8603, Japan
Endocr Pathol 18:208-16. 2007..The aim of this study was to determine the correlation between the expression of somatostatin receptors by immunohistochemistry and the percent suppression of GH levels in the octreotide suppression test... - Quantum dots for multicolor tumor pathology and multispectral imagingJohbu Itoh
Teaching and Research Support Center, Division of Cell Science, Tokai University School of Medicine, Kanegawa, Japan
Methods Mol Biol 374:29-42. 2007..Our results suggest that very weak immunoreactions seen by traditional immunohistochemical techniques can be greatly intensified, a useful feature for pathology diagnostics...