Robert Y Osamura

Summary

Affiliation: Tokai University
Country: Japan

Publications

  1. ncbi request reprint Applications of plastic embedding to electron microscopic immunocytochemistry and in situ hybridization in observations of production and secretion of peptide hormones
    R Y Osamura
    Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan
    J Histochem Cytochem 48:885-91. 2000
  2. pmc HER2 testing on core needle biopsy specimens from primary breast cancers: interobserver reproducibility and concordance with surgically resected specimens
    Hitoshi Tsuda
    Diagnostic Pathology Section, Clinical Laboratory Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    BMC Cancer 10:534. 2010
  3. pmc Pathology of the human pituitary adenomas
    Robert Y Osamura
    Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Boseidai Isehara, Kanagawa 259 1193, Japan
    Histochem Cell Biol 130:495-507. 2008
  4. doi request reprint Current practices in performing frozen sections for thyroid and parathyroid pathology
    Robert Y Osamura
    Department of Pathology, Tokai University School of Medicine, Isehara City, Kanagawa, 259 1193, Japan
    Virchows Arch 453:433-40. 2008
  5. ncbi request reprint Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line
    Shunsuke Miyai
    Department of Pathology, Tokai University School of Medicine, Bohseidai Isehara Campus, Kanagawa 259 1193, Japan
    Cell Tissue Res 322:269-77. 2005
  6. ncbi request reprint Molecular pathology of the pituitary. Development and functional differentiation of pituitary adenomas
    Robert Yoshiyuki Osamura
    Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
    Front Horm Res 32:20-33. 2004
  7. doi request reprint Roles of pathologists in molecular targeted cancer therapy
    Robert Y Osamura
    Department of Pathology Tokai University School of Medicine, Kanagawa, Japan
    J Cell Mol Med 13:4286-90. 2009
  8. ncbi request reprint Endocrine pathology in translational medicine: an overview of current and future prospects
    Robert Yoshiyuki Osamura
    Department of Pathology, Tokai University School of Medicine, Boseidai Isehara City, Kanagawa, Japan
    Endocr Pathol 14:117-21. 2003
  9. ncbi request reprint Pit-1 positive alpha-subunit positive nonfunctioning human pituitary adenomas: a dedifferentiated GH cell lineage?
    R Y Osamura
    Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan
    Pituitary 1:269-71. 1999
  10. ncbi request reprint Recent progress in studies of pituitary tumor pathogenesis
    Takeo Minematsu
    Department of Pathology, Tokai University School of Medicine Boseidai, Isehara, Kanagawa 259 1193, Japan
    Endocrine 28:37-41. 2005

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Applications of plastic embedding to electron microscopic immunocytochemistry and in situ hybridization in observations of production and secretion of peptide hormones
    R Y Osamura
    Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan
    J Histochem Cytochem 48:885-91. 2000
    ..This review article deals with technical aspects, procedures, and applications in endocrine cells...
  2. pmc HER2 testing on core needle biopsy specimens from primary breast cancers: interobserver reproducibility and concordance with surgically resected specimens
    Hitoshi Tsuda
    Diagnostic Pathology Section, Clinical Laboratory Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    BMC Cancer 10:534. 2010
    ..The aim of the present study was to validate the application of HER2 testing with CNB specimens from primary breast cancers in terms of interobserver reproducibility and comparison with surgically resected specimens...
  3. pmc Pathology of the human pituitary adenomas
    Robert Y Osamura
    Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Boseidai Isehara, Kanagawa 259 1193, Japan
    Histochem Cell Biol 130:495-507. 2008
    ....
  4. doi request reprint Current practices in performing frozen sections for thyroid and parathyroid pathology
    Robert Y Osamura
    Department of Pathology, Tokai University School of Medicine, Isehara City, Kanagawa, 259 1193, Japan
    Virchows Arch 453:433-40. 2008
    ..It is concluded that thyroid and parathyroid frozen section examination is restricted to selected situations...
  5. ncbi request reprint Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line
    Shunsuke Miyai
    Department of Pathology, Tokai University School of Medicine, Bohseidai Isehara Campus, Kanagawa 259 1193, Japan
    Cell Tissue Res 322:269-77. 2005
    ....
  6. ncbi request reprint Molecular pathology of the pituitary. Development and functional differentiation of pituitary adenomas
    Robert Yoshiyuki Osamura
    Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
    Front Horm Res 32:20-33. 2004
    ..Various mechanisms have been reported for the experimental pituitary oncogenesis. Among these, GHRH has been emphasized as one of oncogenic factors for both human GHomas as well as in the transgenic animals...
  7. doi request reprint Roles of pathologists in molecular targeted cancer therapy
    Robert Y Osamura
    Department of Pathology Tokai University School of Medicine, Kanagawa, Japan
    J Cell Mol Med 13:4286-90. 2009
    ..This introductory review of MTCT describes more details of each MTCT...
  8. ncbi request reprint Endocrine pathology in translational medicine: an overview of current and future prospects
    Robert Yoshiyuki Osamura
    Department of Pathology, Tokai University School of Medicine, Boseidai Isehara City, Kanagawa, Japan
    Endocr Pathol 14:117-21. 2003
    ..The endocrine pathology is expected to play a major role in translational medicine...
  9. ncbi request reprint Pit-1 positive alpha-subunit positive nonfunctioning human pituitary adenomas: a dedifferentiated GH cell lineage?
    R Y Osamura
    Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan
    Pituitary 1:269-71. 1999
    ..From this background, this paper proposes that "alpha SU positive Pit-1 Positive" cells are the ones in the GH cell lineage, more specifically a dedifferentiated cell lineage toward alpha SU/GH/Pit-1...
  10. ncbi request reprint Recent progress in studies of pituitary tumor pathogenesis
    Takeo Minematsu
    Department of Pathology, Tokai University School of Medicine Boseidai, Isehara, Kanagawa 259 1193, Japan
    Endocrine 28:37-41. 2005
    ..Recently, epigenetic regulation has been suggested to be related to pituitary tumor formation. This article presents a review and update of recent progress in studies of the development and differentiation of pituitary tumors...
  11. doi request reprint Selection of buffer pH by the isoelectric point of the antigen for the efficient heat-induced epitope retrieval: re-appraisal for nuclear protein pathobiology
    Hanako Kajiya
    Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Boseidai Isehara, Kanagawa, 259 1193, Japan
    Histochem Cell Biol 132:659-67. 2009
    ..It is concluded that the mechanism of HEIR may, therefore, depend to a large extent on the pI of the antigen under investigation...
  12. ncbi request reprint Fine needle aspiration cytology of ductal adenoma of the breast with intracellular mucin: a report of three cases
    Hitoshi Itoh
    Division of Diagnostic Pathology, Tokai University Hospital, Shimokasuya 143, Isehara City, Kanagawa 259 1193, Japan
    Acta Cytol 54:753-8. 2010
    ..Here we present three cases of ductal adenoma of the breast with foci of intracellular mucin...
  13. pmc Pituitary changes in Prop1 transgenic mice: hormone producing tumors and signet-ring type gonadotropes
    Noboru Egashira
    Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Acta Histochem Cytochem 41:47-57. 2008
    ..Taken together, our results suggest a (1) tumorigenic effect of Prop1 in the pituitaries, and (2) causative effects of signet ring-type gonadotropes...
  14. doi request reprint Perivascular epithelioid cell tumor (PEComa) of the pancreas: immunoelectron microscopy and review of the literature
    Kenichi Hirabayashi
    Department of Pathology, Tokai University School of Medicine, Kanagawa 259 1193, Japan
    Pathol Int 59:650-5. 2009
    ..The results of immunoelectron microscopy show that some PEComas possess not only typical melanosomes or premelanosomes but also aberrant melanosomes...
  15. doi request reprint Lower HER-2/chromosome enumeration probe 17 ratio in cytologic HER-2 fluorescence in situ hybridization for breast cancers: three-dimensional analysis of intranuclear localization of centromere 17 and HER-2 signals
    Hitoshi Itoh
    Division of Diagnostic Pathology, Department of Pathology, Tokai, University School of Medicine, Kanagawa, Japan
    Cancer 114:134-40. 2008
    ..Cytologic samples also are used, but to the authors' knowledge, little is known regarding the reliability of these samples. The objective of this study was to elucidate the usefulness of cytologic specimens for HER-2 FISH testing...
  16. ncbi request reprint Expression of proliferation markers in human pituitary incidentalomas
    Masanori Suzuki
    Department of Neurosurgery, Nippon Medical School, Japan
    Endocr Pathol 17:263-75. 2006
    ..Large or invasive incidentalomas should be surgically treated if the patients show visual disturbances, hypopituitarism, or pituitary apoplexy during the follow-up period...
  17. ncbi request reprint Vascular networks and endothelial cells in the rat experimental pituitary glands and in the human pituitary adenomas
    Johbu Itoh
    Laboratories for Structure and Function Research, Tokai University School of Medicine, Tokai University School of Medicine, Kanagawa, 259 1193 Japan
    Microsc Res Tech 60:231-5. 2003
    ..Therefore, 3D reconstructed imaging by CLSM is a useful technique with which to investigate the microvessel environment of hormone-secreting cells and has the potential to reveal dynamic hormone-secreting pathways...
  18. ncbi request reprint Serum carbohydrate antigen elevations in endometrial adenocarcinomas: characterization of DU-PAN-2 expression as a tumor marker
    Masanori Yasuda
    Department of Pathology, School of Medicine, Tokai University, Kanagawa, Japan
    J Obstet Gynaecol Res 30:59-64. 2004
    ..To characterize serum elevations of carbohydrate antigens; DU-PAN-2, CA19-9, sialyl Lewisx and CA125 in endometrial adenocarcinomas (EMACs), particularly focusing on the clarification of DU-PAN-2 expression profiles...
  19. ncbi request reprint Immunonegative "null cell" adenomas and gonadotropin (Gn) subunit (SUs) immunopositive adenomas share frequent expression of multiple transcription factors
    Yudo Ishii
    Department of Neurosurgery, Nippon Medical School, Tokai University School of Medicine, Japan
    Endocr Pathol 17:35-43. 2006
    ..The questions, why a certain proportion of these pituitary tumor groups lack hormone production and why they are molecularly more committed to Gn transcription, remain to be further investigated...
  20. ncbi request reprint Variation of alpha-methylacyl-CoA racemase expression in prostate adenocarcinoma cases receiving hormonal therapy
    Xiaoyan Tang
    Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Hum Pathol 37:1186-92. 2006
    ..Further investigation of the relationship between AMACR expression and androgen or androgen receptors may provide new insight into novel preventive and curative medicine for prostate adenocarcinoma...
  21. ncbi request reprint Usefulness of hypoxia inducible factor-1 alpha in evaluating the prostatic adenocarcinoma viability following neoadjuvant hormone therapy
    Masanori Yasuda
    Department of Pathology, Saitama Medical University, International Medical Center, Japan
    Cancer Detect Prev 31:396-401. 2007
    ..This study was designed to elucidate whether or not HIF-1 alpha expression would be associated with PA recurrence after neoadjuvant hormone therapy (NHT)...
  22. ncbi request reprint PTTG is a secretory protein in human pituitary adenomas and in mouse pituitary tumor cell lines
    Takeo Minematsu
    Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Endocr Pathol 18:8-15. 2007
    ..Our results suggested that PTTG is a secretory protein produced by pituitary tumor cells. In addition, PTTG may exert autocrine and/or paracrine functions as a newly proposed important pathway for the action of PTTG...
  23. ncbi request reprint [Pituitary gangliocytoma]
    Mao Takei
    Department of Pathology, Tokai University
    Nihon Rinsho . 2006
  24. ncbi request reprint Immunohistochemical detection of somatostatin receptor (SSTR) subtypes 2A and 5 in pituitary adenoma from acromegalic patients: good correlation with preoperative response to octreotide
    Mao Takei
    Department of Neurosurgery, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8603, Japan
    Endocr Pathol 18:208-16. 2007
    ..The aim of this study was to determine the correlation between the expression of somatostatin receptors by immunohistochemistry and the percent suppression of GH levels in the octreotide suppression test...
  25. ncbi request reprint Quantum dots for multicolor tumor pathology and multispectral imaging
    Johbu Itoh
    Teaching and Research Support Center, Division of Cell Science, Tokai University School of Medicine, Kanegawa, Japan
    Methods Mol Biol 374:29-42. 2007
    ..Our results suggest that very weak immunoreactions seen by traditional immunohistochemical techniques can be greatly intensified, a useful feature for pathology diagnostics...