Naoya Kojima

Summary

Affiliation: Tokai University
Country: Japan

Publications

  1. ncbi request reprint Carbohydrate carriers affect adhesion of H. pylori to immobilized Leb-oligosaccharide
    Naoya Kojima
    Department of Applied Biochemistry, and Institute of Glycotechnology, Tokai University, Hiratsuka, Kanagawa, Japan
    FEBS Lett 517:32-6. 2002
  2. doi request reprint Development of peritoneal macrophage along a dendritic cell lineage in response to uptake of oligomannose-coated liposomes
    Naoya Kojima
    Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa, Japan
    Cell Immunol 271:335-41. 2011
  3. doi request reprint Oligomannose-coated liposomes as a therapeutic antigen-delivery and an adjuvant vehicle for induction of in vivo tumor immunity
    Naoya Kojima
    Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa 259 1292, Japan
    J Control Release 129:26-32. 2008
  4. doi request reprint Cooperation of specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) and complement receptor type 3 (CR3) in the uptake of oligomannose-coated liposomes by macrophages
    Hideaki Takagi
    Institute of Glycoscience, Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa 259 1292, Japan
    Glycobiology 19:258-66. 2009
  5. ncbi request reprint Structural alterations in outer arms of IgG oligosaccharides in patients with Werner syndrome
    Yasuhiro Kuroda
    Institute of Glycotechnology, Tokai University, Hiratsuka, Kanagawa, Japan
    Exp Gerontol 42:545-53. 2007
  6. doi request reprint Mucosal adjuvant activity of oligomannose-coated liposomes for nasal immunization
    Mariko Ishii
    Institute of Glycoscience and Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa, 259 1292, Japan
    Glycoconj J 27:115-23. 2010
  7. doi request reprint Oligomannose-coated liposomes activate ERK via Src kinases and PI3K/Akt in J774A.1 cells
    Chiaki Kato
    Institute of Glycoscience, Tokai University, 1117 Kitakaname, Hiratsuka, Kanagawa 259 1292, Japan
    Biochem Biophys Res Commun 372:898-901. 2008
  8. doi request reprint Contribution of complement component C3 and complement receptor type 3 to carbohydrate-dependent uptake of oligomannose-coated liposomes by peritoneal macrophages
    Yu Abe
    Department of Applied Biochemistry Institute of Glycoscience, Tokai University, Hiratsuka, Kanagawa 259 1292, Japan
    J Biochem 144:563-70. 2008
  9. doi request reprint Anti-allergic potential of oligomannose-coated liposome-entrapped Cry j 1 as immunotherapy for Japanese cedar pollinosis in mice
    Mariko Ishii
    Institute of Glycoscience, Tokai University, Hiratsuka, Kanagawa 259 1292, Japan
    Int Immunopharmacol 10:1041-6. 2010
  10. doi request reprint Developmental changes in glycolipids and synchronized expression of nutrient transporters in the mouse small intestine
    Azusa Yoneshige
    Institute of Glycoscience, Tokai University, Kanagawa 259 1292, Japan
    J Nutr Biochem 21:214-26. 2010

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Carbohydrate carriers affect adhesion of H. pylori to immobilized Leb-oligosaccharide
    Naoya Kojima
    Department of Applied Biochemistry, and Institute of Glycotechnology, Tokai University, Hiratsuka, Kanagawa, Japan
    FEBS Lett 517:32-6. 2002
    ..Therefore, the carbohydrate carrier affects the affinity of H. pylori KH202 toward Le(b)-antigen, although the bacteria recognize Le(b)-antigen regardless of the carbohydrate carrier...
  2. doi request reprint Development of peritoneal macrophage along a dendritic cell lineage in response to uptake of oligomannose-coated liposomes
    Naoya Kojima
    Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa, Japan
    Cell Immunol 271:335-41. 2011
    ..These results show that a fraction of peritoneal macrophages can differentiate into mature DCs following uptake of OMLs...
  3. doi request reprint Oligomannose-coated liposomes as a therapeutic antigen-delivery and an adjuvant vehicle for induction of in vivo tumor immunity
    Naoya Kojima
    Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa 259 1292, Japan
    J Control Release 129:26-32. 2008
    ..These results indicate that an OML-based vaccine with an encased tumor antigen might be useful clinically to raise an effective immune response against a tumor...
  4. doi request reprint Cooperation of specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) and complement receptor type 3 (CR3) in the uptake of oligomannose-coated liposomes by macrophages
    Hideaki Takagi
    Institute of Glycoscience, Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa 259 1292, Japan
    Glycobiology 19:258-66. 2009
    ..Administration of ER-TR9 or M1/70 into the peritoneal cavity led to a significant decrease of OML uptake by PEMs. Therefore, SIGNR1 expressed on macrophages acts as a receptor for recognition of OMLs under physiological conditions...
  5. ncbi request reprint Structural alterations in outer arms of IgG oligosaccharides in patients with Werner syndrome
    Yasuhiro Kuroda
    Institute of Glycotechnology, Tokai University, Hiratsuka, Kanagawa, Japan
    Exp Gerontol 42:545-53. 2007
    ..These results suggest that WS patients exhibit an aging phenotype for structural alterations such as sialylation and galactosylation in the outer arms of IgG oligosaccharides...
  6. doi request reprint Mucosal adjuvant activity of oligomannose-coated liposomes for nasal immunization
    Mariko Ishii
    Institute of Glycoscience and Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa, 259 1292, Japan
    Glycoconj J 27:115-23. 2010
    ..Thus, liposomes coated with synthetic neoglycolipids might be useful as adjuvants for induction of mucosal immunity...
  7. doi request reprint Oligomannose-coated liposomes activate ERK via Src kinases and PI3K/Akt in J774A.1 cells
    Chiaki Kato
    Institute of Glycoscience, Tokai University, 1117 Kitakaname, Hiratsuka, Kanagawa 259 1292, Japan
    Biochem Biophys Res Commun 372:898-901. 2008
    ..Therefore, OMLs may activate the PI3K/Akt pathway through phosphorylation of Src family kinases to induce ERK activation...
  8. doi request reprint Contribution of complement component C3 and complement receptor type 3 to carbohydrate-dependent uptake of oligomannose-coated liposomes by peritoneal macrophages
    Yu Abe
    Department of Applied Biochemistry Institute of Glycoscience, Tokai University, Hiratsuka, Kanagawa 259 1292, Japan
    J Biochem 144:563-70. 2008
    ..Thus, our results indicate that OMLs are opsonized with iC3b in a mannose-dependent manner in the peritoneal cavity and then incorporated into PEMs via CR3...
  9. doi request reprint Anti-allergic potential of oligomannose-coated liposome-entrapped Cry j 1 as immunotherapy for Japanese cedar pollinosis in mice
    Mariko Ishii
    Institute of Glycoscience, Tokai University, Hiratsuka, Kanagawa 259 1292, Japan
    Int Immunopharmacol 10:1041-6. 2010
    ..Thus, Cry j 1/OMLs may be useful for immunotherapeutic control of allergic reactions to Japanese cedar pollinosis...
  10. doi request reprint Developmental changes in glycolipids and synchronized expression of nutrient transporters in the mouse small intestine
    Azusa Yoneshige
    Institute of Glycoscience, Tokai University, Kanagawa 259 1292, Japan
    J Nutr Biochem 21:214-26. 2010
    ....
  11. doi request reprint Cross-linking of SIGNR1 activates JNK and induces TNF-alpha production in RAW264.7 cells that express SIGNR1
    Maki Numazaki
    Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa 259 1292, Japan
    Biochem Biophys Res Commun 386:202-6. 2009
    ..These results show that cross-linking of SIGNR1 triggers phosphorylation of SFKs, which leads to activation of the JNK pathway and induction of TNF-alpha production in macrophage-like RAW264.7 cells...
  12. doi request reprint Preferences for uptake of carbohydrate-coated liposomes by C-type lectin receptors as antigen-uptake receptors
    Yoko Kawauchi
    Department of Applied Biochemistry, Tokai University, 4 1 1 Kita kaname, Hiratsuka shi, Kanagawa 259 1292, Japan
    Glycoconj J 29:481-90. 2012
    ..These results indicate that CLRs with similar carbohydrate-recognition characteristics have distinct properties as pathogen-uptake receptors for carbohydrate-decorated particles...
  13. ncbi request reprint Long- and short-time immunological memory in different strains of mice given nasally an adjuvant-combined nasal influenza vaccine
    Hideki Asanuma
    Department of Applied Biochemistry, School or Engineering, Tokai University, Kitakaname 1117, Hiratsuka shi, Kanagawa 259 1292, Japan
    Vaccine 25:6975-80. 2007
    ..These results indicate that low doses of cholera toxin B subunit (supplemented with 0.2% of hole toxin) combined nasal vaccine may required further improvement in order to provide protective immunity in human use...
  14. doi request reprint Targeting with oligomannose-coated liposomes promotes maturation and splenic trafficking of dendritic cells in the peritoneal cavity
    Mariko Ishii
    Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa 259 1292, Japan
    Int Immunopharmacol 11:164-71. 2011
    ..These results indicate that OMLs can be used as a vehicle for delivery of antigens to DCs and as an adjuvant to promote DC maturation, activation, and trafficking into lymphoid organs, thereby eliciting a Th1 immune response...
  15. ncbi request reprint High-performance thin-layer chromatography/mass spectrometry for rapid analysis of neutral glycosphingolipids
    Masao Miyazaki
    Tokai University, Institute of Glycoscience, Hiratsuka, Kanagawa 259 1292, Japan
    J AOAC Int 91:1218-26. 2008
    ..Possible structures for each GSL are proposed based on HPTLC/MS analyses. This fast and simple method can be used to screen neutral GSL extracts obtained from tissues and cells without isolation and purification into individual GSLs...
  16. ncbi request reprint Preferential production of IL-12 by peritoneal macrophages activated by liposomes prepared from neoglycolipids containing oligomannose residues
    Hideaki Takagi
    Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa 259 1292, Japan
    Cytokine 40:241-50. 2007
    ..Thus, OMLs can be used as a novel adjuvant for efficient activation of specific cellular immunity...
  17. ncbi request reprint Structural studies on IgG oligosaccharides of patients with primary Sjögren's syndrome
    Yasuhiro Kuroda
    Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University, Hiratsuka, Kanagawa, 259 1292, Japan
    Glycoconj J 19:23-31. 2002
    ..These results suggest that appearance of IgG carrying abnormal N-linked oligosaccharides in primary SS may be related to future complication with RA...
  18. ncbi request reprint Protection against Leishmania major infection by oligomannose-coated liposomes
    Yoshitaka Shimizu
    The Institute of Glycotechnology and the Department of Applied Biochemistry, Tokai University, Kanagawa Hiratsuka, 259 1292, Japan
    Bioorg Med Chem 11:1191-5. 2003
    ..Taken together, these results indicate the possibility that Man5-DPPE-coated liposome-encapsulated antigens could serve as a vaccine that triggers protection against infectious disease...
  19. pmc Origin of the classical complement pathway: Lamprey orthologue of mammalian C1q acts as a lectin
    Misao Matsushita
    Department of Biochemistry, Fukushima Medical University School of Medicine, and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Fukushima 960 1295, Japan
    Proc Natl Acad Sci U S A 101:10127-31. 2004
    ....
  20. pmc Regional expression of prosaposin in the wild-type and saposin D-deficient mouse brain detected by an anti-mouse prosaposin-specific antibody
    Azusa Yoneshige
    Institute of Glycoscience, Tokai University, Kanagawa, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 85:422-34. 2009
    ..Further characterization of these prosaposin-rich neurons may provide new insights into the physiological functions of prosaposin in the nervous system...
  21. ncbi request reprint Isolation and characterization of phage-displayed single chain antibodies recognizing nonreducing terminal mannose residues. 1. A new strategy for generation of anti-carbohydrate antibodies
    Keiko Sakai
    Institute of Glycotechnology, Tokai University, Kanagawa 259 1292, Japan
    Biochemistry 46:253-62. 2007
    ..Further studies on the purification and characterization of these scFvs are presented in an accompanying paper in this issue...
  22. ncbi request reprint Chemoenzymatic synthesis of a MUC1 glycopeptide carrying non-natural sialyl TF-beta O-glycan
    Eriko Tanaka
    Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University, Japan
    Biosci Biotechnol Biochem 70:2515-22. 2006
    ..Enzymatic glycosylation with CMP-NeuAc was successful with both natural and non-natural O-glycans of the synthetic glycopeptide...
  23. doi request reprint SIGNR1 ligation on murine peritoneal macrophages induces IL-12 production through NFkappaB activation
    Chiaki Kato
    Institute of Glycoscience, Tokai University, Hiratsuka, Kanagawa, 259 1292, Japan
    Glycoconj J 27:525-31. 2010
    ..These results indicate that SIGNR1-mediated intercellular signaling may induce production of cytokines such as IL-12 through NFkappaB activation...
  24. doi request reprint Effective stimulation of invariant natural killer T cells by oligomannose-coated liposomes
    Mariko Ishii
    Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa 259 1292, Japan
    Int Immunopharmacol 15:685-92. 2013
    ..Collectively, our results suggest that αGC-OMLs can be used as a preferential delivery system for lipid antigens to DCs to activate iNKT cells in vivo and ex vivo...
  25. ncbi request reprint A cholesterol-independent membrane microdomain serves as a functional counter-receptor for E-selectin at the Colo201 cell surface and initiates signalling on E-selectin binding
    Chikako Suzuki
    The Institute of Glycotechnology, Tokai University, Hiratsuka, Kanagawa 259 1292, Japan
    J Biochem 142:55-64. 2007
    ....
  26. ncbi request reprint [Development of rheumatoid arthritis and abnormal IgG galactosylation]
    Yasuhiro Kuroda
    Institute of Glycotechnology, Tokai University, 1117 Kitakaname, Hiratsuka, Kanagawa 259 1292
    Seikagaku 74:1363-8. 2002
  27. ncbi request reprint Effective induction of anti-tumor immune responses with oligomannose-coated liposome targeting to intraperitoneal phagocytic cells
    Yuzuru Ikehara
    Molecular Medicine Team of Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Centeral 2 12, Room 211, 1 1 1 Umezono, Tsukuba, Japan
    Cancer Lett 260:137-45. 2008
    ..G7-OVA (OVA-transfected EL4) but not EL4. These results indicate that the OMLs can also be used as an effective antigen delivery system for cancer immunotherapy activating both CTL and Th subsets...
  28. ncbi request reprint Novel role of the Ras cascade in memory B cell response
    Yoshimasa Takahashi
    Department of Immunology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan
    Immunity 23:127-38. 2005
    ..Thus, our data suggest that upon antigen stimulation, memory B cells are susceptible to apoptosis but can be rescued via an antiapoptotic effect mediated through the Ras cascade...
  29. ncbi request reprint Level of galactosylation determines cryoglobulin activity of murine IgG3 monoclonal rheumatoid factor
    Aki Kuroki
    Department of Pathology, Faculty of Medicine, University of Geneva, Switzerland
    Blood 99:2922-8. 2002
    ....
  30. ncbi request reprint Efficacy of dipalmitoylphosphatidylcholine liposome against African trypanosomes
    Noritaka Kuboki
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    J Parasitol 92:389-93. 2006
    ..congolense-infected mice. These results suggest that parasites were killed by specific binding of the DPPC liposome to the trypanosomes. This work demonstrates for the first time that a liposome has antitrypanosomal activity...
  31. ncbi request reprint A carbohydrate recognition-based drug delivery and controlled release system using intraperitoneal macrophages as a cellular vehicle
    Yuzuru Ikehara
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Res 66:8740-8. 2006
    ..Thus, we have established the use of i.p. macrophages as a novel drug delivery system for the control of cancer metastatic to milky spots...
  32. ncbi request reprint Development of a novel oligomannose-coated liposome-based anticancer drug-delivery system for intraperitoneal cancer
    Yuzuru Ikehara
    Research Center for Glycoscience, National Institute of Advanced Industrial Technology, 1 1 1 Umezono, Tsukuba shi, Ibaraki 305 8568, Japan
    Curr Opin Mol Ther 9:53-61. 2007
    ....
  33. pmc Binding of rainbow trout sperm to egg is mediated by strong carbohydrate-to-carbohydrate interaction between (KDN)GM3 (deaminated neuraminyl ganglioside) and Gg3-like epitope
    Song Yu
    Division of Biomembrane Research, Pacific Northwest Research Institute, Seattle, WA 98122, USA
    Proc Natl Acad Sci U S A 99:2854-9. 2002
    ....