Tatehiro Kagawa

Summary

Affiliation: Tokai University
Country: Japan

Publications

  1. ncbi Differential expression of multidrug resistance (mdr) and canalicular multispecific organic anion transporter (cMOAT) genes following extrahepatic biliary obstruction in rats
    T Kagawa
    Department of Internal Medicine III, School of Medicine, Tokai University, Isehara, Kanagawa, Japan
    Biochem Mol Biol Int 44:443-52. 1998
  2. ncbi Transcatheter arterial chemoembolization plus radiofrequency ablation therapy for early stage hepatocellular carcinoma: comparison with surgical resection
    Tatehiro Kagawa
    Department of Gastroenterology, Tokai University School of Medicine, Isehara, Japan
    Cancer 116:3638-44. 2010
  3. ncbi Phenotypic differences in PFIC2 and BRIC2 correlate with protein stability of mutant Bsep and impaired taurocholate secretion in MDCK II cells
    Tatehiro Kagawa
    Department of Gastroenterology, Tokai Univ School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Am J Physiol Gastrointest Liver Physiol 294:G58-67. 2008
  4. ncbi Fatal liver failure due to reactivation of lamivudine-resistant HBV mutant
    Tatehiro Kagawa
    Department of Internal Medicine, Tokai University School of Medicine, Boseidai, Isehara, Kanagawa 259 1193, Japan
    World J Gastroenterol 10:1686-7. 2004
  5. ncbi Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells
    Kaori Mochizuki
    Department of Internal Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G818-28. 2007
  6. ncbi Initial site of bile regurgitation following extrahepatic biliary obstruction in living rats
    Norihito Watanabe
    Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Gastroenterol Hepatol 22:1983-92. 2007
  7. ncbi Effect of endothelin A receptor antagonist on hepatic hemodynamics in cirrhotic rats. Implications for endothelin-1 in portal hypertension
    Shinji Takashimizu
    Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine, Japan
    Tokai J Exp Clin Med 36:37-43. 2011
  8. ncbi Balloon-occluded retrograde transvenous obliteration of gastric varices: use of CT-guided foam sclerotherapy to optimize technique
    Jun Koizumi
    Department of Diagnostic Radiology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara, Kanagawa, 259 1193 Japan
    AJR Am J Roentgenol 199:200-7. 2012
  9. ncbi Taurolithocholate impairs bile canalicular motility and canalicular bile secretion in isolated rat hepatocyte couplets
    Norihito Watanabe
    Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    World J Gastroenterol 12:5320-5. 2006
  10. ncbi Eight-week oral administration of meloxicam, a non-steroidal anti-inflammatory drug, prevents dose reduction of pegylated interferon alpha-2a in the treatment of chronic hepatitis C
    Tatehiro Kagawa
    Department of Gastroenterology, Tokai University School of Medicine, Kanagawa, Japan
    Hepatol Res 38:259-66. 2008

Collaborators

Detail Information

Publications24

  1. ncbi Differential expression of multidrug resistance (mdr) and canalicular multispecific organic anion transporter (cMOAT) genes following extrahepatic biliary obstruction in rats
    T Kagawa
    Department of Internal Medicine III, School of Medicine, Tokai University, Isehara, Kanagawa, Japan
    Biochem Mol Biol Int 44:443-52. 1998
    ..The expression of canalicular transporters was differentially regulated in extrahepatic biliary obstruction, indicating the different roles are played by mdr and cMOAT in the pathogenesis of cholestasis...
  2. ncbi Transcatheter arterial chemoembolization plus radiofrequency ablation therapy for early stage hepatocellular carcinoma: comparison with surgical resection
    Tatehiro Kagawa
    Department of Gastroenterology, Tokai University School of Medicine, Isehara, Japan
    Cancer 116:3638-44. 2010
    ..However, the long-term efficacy of this combined therapy has not been elucidated. In this study, the survival rates of patients who received TACE combined with RFA (TACE + RFA) were compared with those of patients treated surgically...
  3. ncbi Phenotypic differences in PFIC2 and BRIC2 correlate with protein stability of mutant Bsep and impaired taurocholate secretion in MDCK II cells
    Tatehiro Kagawa
    Department of Gastroenterology, Tokai Univ School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Am J Physiol Gastrointest Liver Physiol 294:G58-67. 2008
    ..These results may explain the phenotypic difference between BRIC2 and PFIC2...
  4. ncbi Fatal liver failure due to reactivation of lamivudine-resistant HBV mutant
    Tatehiro Kagawa
    Department of Internal Medicine, Tokai University School of Medicine, Boseidai, Isehara, Kanagawa 259 1193, Japan
    World J Gastroenterol 10:1686-7. 2004
    ..24). For religious reasons, the patient and his family refused blood transfusion, plasma exchange and liver transplantation. The patient died 10 d after admission. The autopsy revealed remarkable liver atrophy...
  5. ncbi Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells
    Kaori Mochizuki
    Department of Internal Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G818-28. 2007
    ..In conclusion, at least two N-linked glycans are required for Bsep protein stability, intracellular trafficking, and function in the apical membrane...
  6. ncbi Initial site of bile regurgitation following extrahepatic biliary obstruction in living rats
    Norihito Watanabe
    Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Gastroenterol Hepatol 22:1983-92. 2007
    ..The aim of this study was to examine the initial site of bile regurgitation in vivo after common bile duct (CBD) obstruction by digitally enhanced fluorescence microscopy...
  7. ncbi Effect of endothelin A receptor antagonist on hepatic hemodynamics in cirrhotic rats. Implications for endothelin-1 in portal hypertension
    Shinji Takashimizu
    Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine, Japan
    Tokai J Exp Clin Med 36:37-43. 2011
    ..The effect of an endothelin (ET) A receptor antagonist on hepatic hemodynamics in cirrhotic rats was examined...
  8. ncbi Balloon-occluded retrograde transvenous obliteration of gastric varices: use of CT-guided foam sclerotherapy to optimize technique
    Jun Koizumi
    Department of Diagnostic Radiology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara, Kanagawa, 259 1193 Japan
    AJR Am J Roentgenol 199:200-7. 2012
    ....
  9. ncbi Taurolithocholate impairs bile canalicular motility and canalicular bile secretion in isolated rat hepatocyte couplets
    Norihito Watanabe
    Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    World J Gastroenterol 12:5320-5. 2006
    ..To investigate the effects of taurolithocholate (TLC) on the canalicular motility in isolated rat hepatocyte couplets (IRHC)...
  10. ncbi Eight-week oral administration of meloxicam, a non-steroidal anti-inflammatory drug, prevents dose reduction of pegylated interferon alpha-2a in the treatment of chronic hepatitis C
    Tatehiro Kagawa
    Department of Gastroenterology, Tokai University School of Medicine, Kanagawa, Japan
    Hepatol Res 38:259-66. 2008
    ..Conclusion: Eight-week administration of meloxicam prevented dose reduction of pegylated interferon by relieving a decline of neutrophil count in the treatment of chronic hepatitis C...
  11. ncbi Clinical significance of serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in chronic liver disease
    Norihito Watanabe
    Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Japan
    Tokai J Exp Clin Med 31:96-101. 2006
    ....
  12. ncbi An endothelin A receptor antagonist induces dilatation of sinusoidal endothelial fenestrae: implications for endothelin-1 in hepatic microcirculation
    Norihito Watanabe
    Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine, Bohseidai, Isehara, 259 1193, Japan
    J Gastroenterol 42:775-82. 2007
    ..Sinusoidal endothelial fenestrae (SEF) regulate the sinusoidal circulation by altering their diameter and number. This study documented the effects of endothelin (ET) receptor antagonists on SEF and hepatic microcirculation...
  13. ncbi Altered cell motility behaviour and reorganization of contractile proteins after primary monolayer cultures of isolated hepatocytes
    Norihito Watanabe
    Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Tokai J Exp Clin Med 32:34-41. 2007
    ..The aim of this study is to elucidate the temporal changes of the cell motility and the localization of contractile proteins in isolated hepatocytes after primary monolayer cultures...
  14. ncbi Efficacy of balloon-occluded retrograde transvenous obliteration (B-RTO) performed in a patient with primary biliary cirrhosis with severe recurrent hepatic encephalopathy due to splenorenal shunt
    Shinji Takashimizu
    Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Tokai J Exp Clin Med 32:70-4. 2007
    ..CONCLUSIONS: B-RTO may be considered useful for the treatment of severe recurrent hepatic encephalopathy due to the collateral shunt in portal hypertension...
  15. ncbi Clinical and pathological features of a prolonged type of acute intrahepatic cholestasis
    Norihito Watanabe
    Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan
    Hepatol Res 37:598-607. 2007
    ..The histological findings of the liver at the acute icteric phase may be important to understand the pathogenesis and to predict the prognosis in AIC...
  16. ncbi Differential impact of adherence to pegylated interferon and ribavirin in the treatment of genotype 1 high viral titer chronic hepatitis C
    Makoto Numata
    Department of Gastroenterology, Tokai University School of Medicine, Isehara 259 1193, Japan
    Hepat Res Treat 2010:702748. 2010
    ..Therefore, ≥80% of peg-IFN and as much as possible dose of ribavirin are desired to achieve SVR in the treatment of genotype 1 high viral titer chronic hepatitis C...
  17. ncbi Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C
    Kaori Mochizuki
    Department of Internal Medicine, Division of Gastroenterology, Tokai University School of Medicine, Bohseidai, Isehara 259-1193, Japan
    World J Gastroenterol 10:733-6. 2004
    ..05). CONCLUSION: The effect of in vitro IFN-beta on HCV in PBMC reflects clinical response and would be taken into account as a predictive marker of IFN therapy for chronic hepatitis C...
  18. ncbi Partial splenic embolisation using n-butyl cyanoacrylate: intraprocedural evaluation by magnetic resonance imaging
    Jun Koizumi
    Department of Diagnostic Radiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara City, Kanagawa Prefecture, 259 1193, Japan
    Eur Radiol 23:1429-42. 2013
    ..To evaluate the use of diffusion-weighted imaging (DWI) for estimating infarcted splenic volume during partial splenic embolisation (PSE) using n-butyl cyanoacrylate (NBCA)...
  19. ncbi C-arm CT-guided foam sclerotherapy for the treatment of gastric varices
    Jun Koizumi
    Department of Diagnostic Radiology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara City, Kanagawa Prefecture 259 1193, Japan
    J Vasc Interv Radiol 21:1583-7. 2010
    ..Foam sclerotherapy under C-arm CT guidance is a promising tool in the therapeutic armamentarium against gastric varices...
  20. ncbi Predictive factors for the response to lamivudine in HBV-infected patients with chronic hepatitis and cirrhosis
    Yasuhiro Nishizaki
    Digestive and Liver Disease Center, Tokai University Tokyo Hospital, 1 2 5 Yoyogi, Shibuya ku, Tokyo 153 0065, Japan
    Tokai J Exp Clin Med 31:121-4. 2006
    ..Multivariate analysis showed HBeAg is the relevant factor for the response to lamivudine. Conclusions: The presence of HBeAg was a risk for non-response to lamivudine therapy...
  21. ncbi Complete response after short-term sorafenib treatment in a patient with lymph node metastasis of hepatocellular carcinoma
    Hajime Mizukami
    Department of Gastroenterology, Tokai University School of Medicine, Hachioji, Japan
    Case Rep Oncol 5:380-4. 2012
    ..The patient maintains remission up to June 2012, more than 1 year after the discontinuation of sorafenib therapy. Sorafenib could be a good option for unresectable or recurrent HCC...
  22. ncbi A case of adult-onset type II citrullinemia--deterioration of clinical course after infusion of hyperosmotic and high sugar solutions
    Hirohide Takahashi
    Division of Neurology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan
    Med Sci Monit 12:CS13-5. 2006
    ....
  23. ncbi Taurocholate transport by hepatic and intestinal bile acid transporters is independent of FIC1 overexpression in Madin-Darby canine kidney cells
    Matthew J Harris
    Tufts University School of Medicine, Department of Physiology, Boston, Massachusetts, USA
    J Gastroenterol Hepatol 19:819-25. 2004
    ..CONCLUSIONS: These results indicate that FIC1 does not transport taurocholate and, when overexpressed in MDCK cells, had no effect on the function of BSEP or ABST...
  24. ncbi Mechanism by which cAMP activates PI3-kinase and increases bile acid secretion in WIF-B9 cells
    Tatehiro Kagawa
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Physiol Cell Physiol 283:C1655-66. 2002
    ..These data indicate that cAMP activates PI3-K in a cell type-specific manner and provide insight regarding mechanisms of PI3-K activation required for bile acid secretion...