Naoaki Ishii

..Our results indicate that mev-1 governs the rate of ageing by modulating the cellular response to oxidative stress...

....

..The former are known to control an insulin/IGF-1-like pathway in C. elegans, while the latter affect mitochondrial function...

..The former are known to be controlled by an insulin/insulin-like signaling pathway, while the latter are affected by mitochondrial functions...

..The latter activity has not been ascribed to CoQ(10); however, it is known that conditions that uncouple electron transport reactions can lead to elevated superoxide anion production...

..These data support the notion that oxidative stress from mitochondria play an important role of both apoptosis, which leads to precocious aging, and cancer...

..Furthermore, oxidative stress must cause mutations in DNA and leads to cancer. It is suggested that oxidative stress from mitochondria play an important role of both apoptosis, which leads to precocious aging, and cancer...

..Moreover, mutational inactivation of this process renders animals susceptible to oxidative stress and, as a result, leads to premature aging...

..Furthermore, oxidative stress seems to cause mutations in DNA and leads to cancer. It is suggested that oxidative stress from mitochondria plays an important role in apoptosis, which leads to precocious aging and cancer...

..Here we report a series of age-dependent variations in corneal epithelium, endothelium, and parenchymal cells of the Tet-mev-1 mice relative to wild-type C57BL/6j mice...

..In concert, these data support the notion that the mitochondrial function is an important aging determinant in wild-type C. elegans...

..fzo-1 animals had significantly lower metabolism than did N2 and mev-1. These data indicate that mitochondrial fusion can profoundly affect energy metabolism and development...

..These results underscore the notion that mitochondrially generated oxidative stress can contribute to nuclear DNA damage, mutagenesis, and ultimately, tumorigenesis...

..The mitochondrial oxidative stress resulted in excessive apoptosis leading to low birth weight and growth retardation in the neonatal developmental phase in Tet-mev-1 mice...

..This suggests that SOD and catalase do not play a role in the adaptive response against oxidative stress under hyperoxia, at least under these experimental conditions...

..These defects likely explain the failure of mev-1 to complete embryonic development under hyperoxia as well as its reduced life span...

....

..Since both gas-1 and mev-1 encode subunits of electron transport chain complexes, these data illustrate how mitochondrial perturbations can impact signal transduction pathways...

..In addition, O2(-) from mitochondria plays a core role in physiological aging...

..Here, we briefly describe the relationships between mitochondrial O(2)(-) and aging phenomena in mev-1 animal models. [BMB reports 2011; 44(5): 298-305]...

..We present a model to explain these results. These experiments demonstrate that dauer larvae provide an excellent opportunity to study mechanisms by which X irradiation can extend life span...

..These findings strongly suggest that oxidative stress can be a causative factor for the development of dry eye disease...

..Double-stranded RNA interference (RNAi) against VBP-1 resulted in an arrest of embryogenesis at morula stages. This suggests that the VBP-1 product is necessary for morphogenesis...

..The metabolic rate of a 4-day-old hermaphrodite animal, for example, was approximately 80 nW. Our method using C. elegans has the potential to become a useful technique for research on aging correlated with energy metabolism...

..We analyzed aging-related changes in subjects who had completed their second check-up in order to determine the difference before and after coaching type of medical advice...

..The molecular mechanism(s) of how oxidative stress affects the secretory function of lacrimal glands was investigated because this is currently unclear...

..elegans. In addition the cell damage is different dependent on cell type and organism...

..These data indicate that Cyt-1/ceSDHC plays an important role not only in energy metabolism but also in superoxide anion production that is critically involved in sensitivity to atmospheric oxygen...

..In addition, they suggest that C. elegans will continue to provide provocative clues into the mechanisms of aging...

..These data suggest that oxidative stress-inducible hormesis is associated with a reduction of the mitochondrial *O(2)(-) production by activation of the antioxidant system via the Ins/IGF-1 signaling pathway...

..Here we elucidate the possible mechanisms of life span extension in clk-1 mutants, with particular emphasis on the electrochemical property of DMQ. Recent findings on the biochemical function of CLK-1 are also discussed...

..The transgenic flies should serve as a model for studying the biological processes associated with increased levels of oxidative stress and mitochondrial dysfunction in Drosophila...

....

....

..Expression of antioxidant enzyme genes seemed normal. These results suggest that chemosensory neurons are a target of oxidative stress and influence longevity dependent on the daf-16 signaling in C. elegans...

..We propose that this three-step process (mitochondrial ROS --> nuclear DNA damage --> mutation) contributes to aging and age-associated diseases...

..Our novel findings suggest that IR behaves as a modulator in the food-NaCl associative learning via C. elegans GPC-1 and a specific neuronal network and may shed light on the modulatory effect of IR on learning...

..The isolated mutant may work as a useful tool for the assay of EDC toxicity since the physiological effect of the collagen mutation (glycine substitution) indicates an increased sensitivity to BPA...

....

..elegans, and that IR inhibits the innate relationship between locomotion and chemotaxis, which is related to salt chemotaxis learning conditioning of C. elegans...

..The present experiments also showed that the ung-1 mutant of C.elegans was more resistant to NaHSO(3)-inducing cytosine deamination than wild-type strain...