Naoaki Ishii

Summary

Affiliation: Tokai University
Country: Japan

Publications

  1. ncbi request reprint The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei
    Masaki Kondo
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Mech Ageing Dev 126:642-7. 2005
  2. ncbi request reprint A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes
    N Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Nature 394:694-7. 1998
  3. ncbi request reprint The role of the electron transport gene SDHC on lifespan and cancer
    Naoaki Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Exp Gerontol 41:952-6. 2006
  4. ncbi request reprint Role of oxidative stress from mitochondria on aging and cancer
    Naoaki Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Cornea 26:S3-9. 2007
  5. ncbi request reprint The role of stress in ageing: research on the nematode, Caenorhabditis elegans
    N Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan
    Br J Dermatol 153:1-5. 2005
  6. ncbi request reprint Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress
    Naoaki Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
    Mech Ageing Dev 125:41-6. 2004
  7. ncbi request reprint Protein oxidation during aging of the nematode Caenorhabditis elegans
    Naoaki Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Free Radic Biol Med 33:1021-5. 2002
  8. ncbi request reprint The role of the electron transport SDHC gene on lifespan and cancer
    Naoaki Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Mitochondrion 7:24-8. 2007
  9. ncbi request reprint Oxidative stress and aging in Caenorhabditis elegans
    N Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Free Radic Res 33:857-64. 2000
  10. doi request reprint Mitochondrial superoxide anion overproduction in Tet-mev-1 transgenic mice accelerates age-dependent corneal cell dysfunctions
    Hiromi Onouchi
    Department of Ophthalmology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Invest Ophthalmol Vis Sci 53:5780-7. 2012

Collaborators

  • Phil S Hartman
  • Okio Hino
  • Koichiro Yasuda
  • Sataro Goto
  • Hitoshi Suda
  • Naoki Maruyama
  • Kazuo Tsubota
  • Tetsuya Kawakita
  • Kenji Kawai
  • K Suzuki
  • M Tsuda
  • H Adachi
  • K Ihara
  • Tetsuro Ishii
  • Siegfried Hekimi
  • Tetsuya Sakashita
  • T Aigaki
  • Kenji Hasegawa
  • Masaki Miyazawa
  • Sumino Yanase
  • Yuichi Uchino
  • Hiromi Onouchi
  • Nanami Senoo-Matsuda
  • Masaki Kondo
  • Akira Onodera
  • Yasuhiro Nishizaki
  • Nobuya Nakamura
  • Tetsuji Shoyama
  • N Senoo-Matsuda
  • Masahito Watanabe
  • Michihiko Fujii
  • Harumi Ichimiya
  • Naoyuki Kitagawa
  • Hiroko Miyadera
  • Tetsu Saigusa
  • Yoko Ogawa
  • T Ohkubo
  • Shigeto Shimmura
  • H Ishiguro
  • Toshiharu Sueno
  • Ryuzaburo Tanino
  • Setsuko Noda
  • Ichiro Kuwahira
  • Yutaka Nakamura
  • Akira Kubo
  • Seiichi Tanaka
  • Hidetoshi Inoko
  • Mitsuhiro Isozaki
  • Hiroyuki Kobayashi
  • Hiroshi Kawada
  • Kunizou Kataoka
  • Masahiro Kikuchi
  • Hironobu Morinaga
  • Shin Ichiro Yonekura
  • Qiu Mei Zhang
  • Mika Kirinashizawa
  • Kazuo Yamamoto
  • Shuji Yonei
  • Shigefumi Yokota
  • Takami Ozaki
  • Kunihiro Matsumoto
  • Nanako Mitani
  • Keizaburo Miki
  • Yuki Matsumoto
  • Kensuke Miki
  • Dai Ayusawa
  • Toshikazu Suzuki
  • Nanae Tanaka
  • Akira Akatsuka
  • Ryuichi Kohno
  • Hiroshi Shibasaki
  • Shinichi Yoshimura
  • Yuji Kohara
  • Akira Kuzuya
  • Tomoko Oeda
  • Shun Shimohama
  • Kengo Uemura
  • Kenji Kano
  • Kiyoshi Kita
  • Shigeo Ishizaki
  • Akihiro Tanakadate
  • Satoshi Watabiki
  • Yoichi Tamai
  • Hideto Miyoshi
  • M Murakami
  • F Yosshii
  • K Ono
  • O Shinohara
  • S Yoshimura
  • H Nakazawa

Detail Information

Publications46

  1. ncbi request reprint The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei
    Masaki Kondo
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Mech Ageing Dev 126:642-7. 2005
    ....
  2. ncbi request reprint A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes
    N Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Nature 394:694-7. 1998
    ..Our results indicate that mev-1 governs the rate of ageing by modulating the cellular response to oxidative stress...
  3. ncbi request reprint The role of the electron transport gene SDHC on lifespan and cancer
    Naoaki Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Exp Gerontol 41:952-6. 2006
    ..These data support the notion that oxidative stress from mitochondria play an important role of both apoptosis, which leads to precocious aging, and cancer...
  4. ncbi request reprint Role of oxidative stress from mitochondria on aging and cancer
    Naoaki Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Cornea 26:S3-9. 2007
    ..Furthermore, oxidative stress seems to cause mutations in DNA and leads to cancer. It is suggested that oxidative stress from mitochondria plays an important role in apoptosis, which leads to precocious aging and cancer...
  5. ncbi request reprint The role of stress in ageing: research on the nematode, Caenorhabditis elegans
    N Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan
    Br J Dermatol 153:1-5. 2005
    ..The former are known to be controlled by an insulin/insulin-like signaling pathway, while the latter are affected by mitochondrial functions...
  6. ncbi request reprint Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress
    Naoaki Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
    Mech Ageing Dev 125:41-6. 2004
    ..The latter activity has not been ascribed to CoQ(10); however, it is known that conditions that uncouple electron transport reactions can lead to elevated superoxide anion production...
  7. ncbi request reprint Protein oxidation during aging of the nematode Caenorhabditis elegans
    Naoaki Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Free Radic Biol Med 33:1021-5. 2002
    ..The former are known to control an insulin/IGF-1-like pathway in C. elegans, while the latter affect mitochondrial function...
  8. ncbi request reprint The role of the electron transport SDHC gene on lifespan and cancer
    Naoaki Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Mitochondrion 7:24-8. 2007
    ..Furthermore, oxidative stress must cause mutations in DNA and leads to cancer. It is suggested that oxidative stress from mitochondria play an important role of both apoptosis, which leads to precocious aging, and cancer...
  9. ncbi request reprint Oxidative stress and aging in Caenorhabditis elegans
    N Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Free Radic Res 33:857-64. 2000
    ..Moreover, mutational inactivation of this process renders animals susceptible to oxidative stress and, as a result, leads to premature aging...
  10. doi request reprint Mitochondrial superoxide anion overproduction in Tet-mev-1 transgenic mice accelerates age-dependent corneal cell dysfunctions
    Hiromi Onouchi
    Department of Ophthalmology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Invest Ophthalmol Vis Sci 53:5780-7. 2012
    ..Here we report a series of age-dependent variations in corneal epithelium, endothelium, and parenchymal cells of the Tet-mev-1 mice relative to wild-type C57BL/6j mice...
  11. ncbi request reprint Age-related changes of mitochondrial structure and function in Caenorhabditis elegans
    Kayo Yasuda
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Mech Ageing Dev 127:763-70. 2006
    ..In concert, these data support the notion that the mitochondrial function is an important aging determinant in wild-type C. elegans...
  12. ncbi request reprint A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis
    Takamasa Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan
    Cancer Res 65:203-9. 2005
    ..These results underscore the notion that mitochondrially generated oxidative stress can contribute to nuclear DNA damage, mutagenesis, and ultimately, tumorigenesis...
  13. doi request reprint Interrelationships between mitochondrial fusion, energy metabolism and oxidative stress during development in Caenorhabditis elegans
    Kayo Yasuda
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Biochem Biophys Res Commun 404:751-5. 2011
    ..fzo-1 animals had significantly lower metabolism than did N2 and mev-1. These data indicate that mitochondrial fusion can profoundly affect energy metabolism and development...
  14. doi request reprint Mitochondrial reactive oxygen species generation by the SDHC V69E mutation causes low birth weight and neonatal growth retardation
    Takamasa Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Mitochondrion 11:155-65. 2011
    ..The mitochondrial oxidative stress resulted in excessive apoptosis leading to low birth weight and growth retardation in the neonatal developmental phase in Tet-mev-1 mice...
  15. doi request reprint Model animals for the study of oxidative stress from complex II
    Takamasa Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Biochim Biophys Acta 1827:588-97. 2013
    ..This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease...
  16. ncbi request reprint Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span
    Sumino Yanase
    Department of Molecular Life Science, Tokai University School of Medicine, Boseidai, Isehara, Kanagawa 259 1193, Japan
    Mech Ageing Dev 123:1579-87. 2002
    ..This suggests that SOD and catalase do not play a role in the adaptive response against oxidative stress under hyperoxia, at least under these experimental conditions...
  17. ncbi request reprint Cell growth of the mouse SDHC mutant cells was suppressed by apoptosis throughout mitochondrial pathway
    Masaki Miyazawa
    Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Biosci Trends 2:22-30. 2008
    ....
  18. ncbi request reprint [Aging and age-related diseases caused by superoxide anion production from mitochondria]
    Takamasa Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1143, Japan
    Seikagaku 78:201-7. 2006
  19. ncbi request reprint A complex II defect affects mitochondrial structure, leading to ced-3- and ced-4-dependent apoptosis and aging
    Nanami Senoo-Matsuda
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    J Biol Chem 278:22031-6. 2003
    ..These defects likely explain the failure of mev-1 to complete embryonic development under hyperoxia as well as its reduced life span...
  20. ncbi request reprint Effect of oxidative stress on translocation of DAF-16 in oxygen-sensitive mutants, mev-1 and gas-1 of Caenorhabditis elegans
    Masaki Kondo
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Mech Ageing Dev 126:637-41. 2005
    ..Since both gas-1 and mev-1 encode subunits of electron transport chain complexes, these data illustrate how mitochondrial perturbations can impact signal transduction pathways...
  21. ncbi request reprint The role of mitochondrial superoxide anion (O2(-)) on physiological aging in C57BL/6J mice
    Masaki Miyazawa
    Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    J Radiat Res 50:73-83. 2009
    ..In addition, O2(-) from mitochondria plays a core role in physiological aging...
  22. ncbi request reprint [Mitochondrial function and aging]
    Nanami Senoo-Matsuda
    Department of Molecular Life Science, Tokai University School of Medicine
    Nihon Rinsho 60:205-10. 2002
  23. doi request reprint Mitochondrial superoxide anion (O(2)(-)) inducible "mev-1" animal models for aging research
    Takamasa Ishii
    Department of Molecular Life Science, Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Shimokasuya, Isehara, Kanagawa, Japan
    BMB Rep 44:298-305. 2011
    ..Here, we briefly describe the relationships between mitochondrial O(2)(-) and aging phenomena in mev-1 animal models. [BMB reports 2011; 44(5): 298-305]...
  24. ncbi request reprint Post-dauer life span of Caenorhabditis elegans dauer larvae can be modified by X-irradiation
    Akira Onodera
    Department of Molecular Life Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan
    J Radiat Res 51:67-71. 2010
    ..We present a model to explain these results. These experiments demonstrate that dauer larvae provide an excellent opportunity to study mechanisms by which X irradiation can extend life span...
  25. pmc Oxidative stress induced inflammation initiates functional decline of tear production
    Yuichi Uchino
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 7:e45805. 2012
    ..These findings strongly suggest that oxidative stress can be a causative factor for the development of dry eye disease...
  26. ncbi request reprint VBP-1 is necessary for morphogenesis in Caenorhabditis elegans
    Harumi Ichimiya
    Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Oncol Rep 10:293-5. 2003
    ..Double-stranded RNA interference (RNAi) against VBP-1 resulted in an arrest of embryogenesis at morula stages. This suggests that the VBP-1 product is necessary for morphogenesis...
  27. ncbi request reprint Beneficial effects of medical advice provided to elderly persons under the anti-aging health check-up system at Tokai University Tokyo Hospital
    Yasuhiro Nishizaki
    Life Care Center, School of Medicine, Tokai University, Tokyo, Japan
    Tokai J Exp Clin Med 34:142-51. 2009
    ..We analyzed aging-related changes in subjects who had completed their second check-up in order to determine the difference before and after coaching type of medical advice...
  28. ncbi request reprint Direct measurement of oxygen consumption rate on the nematode Caenorhabditis elegans by using an optical technique
    Hitoshi Suda
    Department of Biological Science and Technology, School of High Technology for Human Welfare, Tokai University, 317 Nishino, Numazu, Shizuoka 410 0321, Japan
    Biochem Biophys Res Commun 330:839-43. 2005
    ..The metabolic rate of a 4-day-old hermaphrodite animal, for example, was approximately 80 nW. Our method using C. elegans has the potential to become a useful technique for research on aging correlated with energy metabolism...
  29. doi request reprint A new mouse model of dry eye disease: oxidative stress affects functional decline in the lacrimal gland
    Yuichi Uchino
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Cornea 31:S63-7. 2012
    ..The molecular mechanism(s) of how oxidative stress affects the secretory function of lacrimal glands was investigated because this is currently unclear...
  30. ncbi request reprint Enhancement of oxidative damage to cultured cells and Caenorhabditis elegans by mitochondrial electron transport inhibitors
    H Ishiguro
    Department of Pediatrics, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
    IUBMB Life 51:263-8. 2001
    ..elegans. In addition the cell damage is different dependent on cell type and organism...
  31. ncbi request reprint A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans
    N Senoo-Matsuda
    Department of Molecular Life Science and Department of Physiology, Tokai University School of Medicine, Ishehara, Kanagawa 259-1193, Japan
    J Biol Chem 276:41553-8. 2001
    ..These data indicate that Cyt-1/ceSDHC plays an important role not only in energy metabolism but also in superoxide anion production that is critically involved in sensitivity to atmospheric oxygen...
  32. ncbi request reprint Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans
    H Adachi
    Life Science Research Center, Lion Corporation, Kanagawa, Japan
    J Gerontol A Biol Sci Med Sci 55:B280-5. 2000
    ..In addition, they suggest that C. elegans will continue to provide provocative clues into the mechanisms of aging...
  33. ncbi request reprint Hyperoxia exposure induced hormesis decreases mitochondrial superoxide radical levels via Ins/IGF-1 signaling pathway in a long-lived age-1 mutant of Caenorhabditis elegans
    Sumino Yanase
    Department of Health Science, Daito Bunka University School of Sports and Health Science, Iwadono, Saitama, Japan
    J Radiat Res 49:211-8. 2008
    ..These data suggest that oxidative stress-inducible hormesis is associated with a reduction of the mitochondrial *O(2)(-) production by activation of the antioxidant system via the Ins/IGF-1 signaling pathway...
  34. ncbi request reprint A mev-1-like dominant-negative SdhC increases oxidative stress and reduces lifespan in Drosophila
    Manabu Tsuda
    Department of Biological Sciences, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji shi, Tokyo 192 0397, Japan
    Biochem Biophys Res Commun 363:342-6. 2007
    ..The transgenic flies should serve as a model for studying the biological processes associated with increased levels of oxidative stress and mitochondrial dysfunction in Drosophila...
  35. ncbi request reprint Basic principle of the lifespan in the nematode C. elegans
    Tetsuji Shoyama
    Department of Biological Science and Technology, School of High Technology for Human Welfare, Tokai University, 317 Nishino, Numazu, Shizuoka 410 0395, Japan
    Mech Ageing Dev 128:529-37. 2007
    ....
  36. ncbi request reprint Quinones in long-lived clk-1 mutants of Caenorhabditis elegans
    Hiroko Miyadera
    Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 0033, Tokyo, Japan
    FEBS Lett 512:33-7. 2002
    ..Here we elucidate the possible mechanisms of life span extension in clk-1 mutants, with particular emphasis on the electrochemical property of DMQ. Recent findings on the biochemical function of CLK-1 are also discussed...
  37. ncbi request reprint The role of the presenilin-1 homologue gene sel-12 of Caenorhabditis elegans in apoptotic activities
    Naoyuki Kitagawa
    Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 278:12130-4. 2003
    ....
  38. ncbi request reprint Mitochondrial oxidative stress can lead to nuclear hypermutability
    Phil Hartman
    Biology Department, Texas Christian University, Fort Worth, TX 76129, USA
    Mech Ageing Dev 125:417-20. 2004
    ..We propose that this three-step process (mitochondrial ROS --> nuclear DNA damage --> mutation) contributes to aging and age-associated diseases...
  39. ncbi request reprint Mutations in chemosensory cilia cause resistance to paraquat in nematode Caenorhabditis elegans
    Michihiko Fujii
    Kihara Institute for Biological Research, Yokohama City University, Maioka cho 641 12, Totsuka ku, Yokohama 244 0813, Japan
    J Biol Chem 279:20277-82. 2004
    ..Expression of antioxidant enzyme genes seemed normal. These results suggest that chemosensory neurons are a target of oxidative stress and influence longevity dependent on the daf-16 signaling in C. elegans...
  40. ncbi request reprint Circadian behavioural rhythm in Caenorhabditis elegans
    Tetsu Saigusa
    Curr Biol 12:R46-7. 2002
  41. ncbi request reprint A mutation in a cuticle collagen causes hypersensitivity to the endocrine disrupting chemical, bisphenol A, in Caenorhabditis elegans
    Masahito Watanabe
    Department of Cell Biology, Japanese Institute of Pearl Science, 4 28 Amanuma, Hiratsuka, Kanagawa 254 0031, Japan
    Mutat Res 570:71-80. 2005
    ..The isolated mutant may work as a useful tool for the assay of EDC toxicity since the physiological effect of the collagen mutation (glycine substitution) indicates an increased sensitivity to BPA...
  42. ncbi request reprint [Why do peoples age? the mechanisms of organismal aging and longevity]
    Naoaki Ishii
    Tokai University School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 103:143-8. 2006
  43. doi request reprint Cloning and characterization of uracil-DNA glycosylase and the biological consequences of the loss of its function in the nematode Caenorhabditis elegans
    Nobuya Nakamura
    Department of Biological Sciences, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Mutagenesis 23:407-13. 2008
    ..The present experiments also showed that the ung-1 mutant of C.elegans was more resistant to NaHSO(3)-inducing cytosine deamination than wild-type strain...
  44. ncbi request reprint Locomotion-learning behavior relationship in Caenorhabditis elegans following gamma-ray irradiation
    Tetsuya Sakashita
    Microbeam Radiation Biology Group, Japan Atomic Energy Agency, Takasaki, Gunma, Japan
    J Radiat Res 49:285-91. 2008
    ..elegans, and that IR inhibits the innate relationship between locomotion and chemotaxis, which is related to salt chemotaxis learning conditioning of C. elegans...
  45. ncbi request reprint Modulatory effect of ionizing radiation on food-NaCl associative learning: the role of gamma subunit of G protein in Caenorhabditis elegans
    Tetsuya Sakashita
    Microbeam Radiation Biology Group, Quantum Beam Science Directorate, Japan Atomic Energy Agency, 1233 Watanuki machi, Takasaki, Gunma 370 1292, Japan
    FASEB J 22:713-20. 2008
    ..Our novel findings suggest that IR behaves as a modulator in the food-NaCl associative learning via C. elegans GPC-1 and a specific neuronal network and may shed light on the modulatory effect of IR on learning...
  46. ncbi request reprint Chromosome dosage as a life span determinant in Caenorhabiditis elegans
    Phil S Hartman
    Biology Department, Texas Christian University, Fort Worth, TX 76129, USA
    Mech Ageing Dev 128:437-43. 2007
    ....