Yutaka Inagaki

Summary

Affiliation: Tokai University
Country: Japan

Publications

  1. ncbi request reprint Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice
    Yutaka Inagaki
    Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Isehara, Japan
    Gastroenterology 129:259-68. 2005
  2. doi request reprint Novel anti-fibrotic modalities for liver fibrosis: molecular targeting and regenerative medicine in fibrosis therapy
    Yutaka Inagaki
    Department of Regenerative Medicine, School of Medicine and Institute of Medical Sciences, Tokai University, Isehara, Japan
    J Gastroenterol Hepatol 27:85-8. 2012
  3. ncbi request reprint Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice
    Yutaka Inagaki
    Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Bohseidai, Isehara 259 1193, Japan
    Hepatology 38:890-9. 2003
  4. pmc Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis
    Y Inagaki
    Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Bohseidai, Isehara 259 1193, Japan
    Gut 56:284-92. 2007
  5. doi request reprint Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7
    Yutaka Inagaki
    Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Isehara, Japan
    Gastroenterology 134:1180-90. 2008
  6. doi request reprint Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice
    Reiichi Higashiyama
    Research Unit for Tissue Remodeling and Regeneration, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Gastroenterology 137:1459-66.e1. 2009
  7. doi request reprint Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis
    Tadashi Moro
    Tokai University School of Medicine, 143 Shimo Kasuya, Isehara, Kanagawa 259 1193, Japan
    Life Sci 83:531-9. 2008
  8. ncbi request reprint Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice
    Reiichi Higashiyama
    Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Isehara, Japan
    Hepatology 45:213-22. 2007
  9. doi request reprint Differential contribution of dermal resident and bone marrow-derived cells to collagen production during wound healing and fibrogenesis in mice
    Reiichi Higashiyama
    Department of Regenerative Medicine, Tokai University School of Medicine, Isehara, Japan
    J Invest Dermatol 131:529-36. 2011
  10. ncbi request reprint Activation of two distinct MAPK pathways governs constitutive expression of matrix metalloproteinase-1 in human pancreatic cancer cell lines
    Hitoshi Endo
    Department of Community Health, Tokai University School of Medicine, Isehara, Kanagawa Prefecture 259 1193, Japan
    Int J Oncol 35:1237-45. 2009

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice
    Yutaka Inagaki
    Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Isehara, Japan
    Gastroenterology 129:259-68. 2005
    ..Here we have attempted to suppress hepatic fibrosis by expressing a transforming growth factor beta/Smad antagonist selectively in collagen-producing cells only in the fibrotic liver...
  2. doi request reprint Novel anti-fibrotic modalities for liver fibrosis: molecular targeting and regenerative medicine in fibrosis therapy
    Yutaka Inagaki
    Department of Regenerative Medicine, School of Medicine and Institute of Medical Sciences, Tokai University, Isehara, Japan
    J Gastroenterol Hepatol 27:85-8. 2012
    ..We have recently identified novel unknown factors expressed by bone marrow-derived cells that not only ameliorate liver fibrosis but also accelerate regeneration of fibrotic liver...
  3. ncbi request reprint Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice
    Yutaka Inagaki
    Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Bohseidai, Isehara 259 1193, Japan
    Hepatology 38:890-9. 2003
    ....
  4. pmc Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis
    Y Inagaki
    Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Bohseidai, Isehara 259 1193, Japan
    Gut 56:284-92. 2007
  5. doi request reprint Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7
    Yutaka Inagaki
    Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Isehara, Japan
    Gastroenterology 134:1180-90. 2008
    ..Here, we propose a novel molecular mechanism by which HGF counter represses TGF-beta-stimulated profibrogenic signal transduction...
  6. doi request reprint Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice
    Reiichi Higashiyama
    Research Unit for Tissue Remodeling and Regeneration, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Gastroenterology 137:1459-66.e1. 2009
    ..We revisited this issue by using 2 mechanistically distinct liver fibrosis models introduced into transgenic collagen reporter mice and their BM recipients...
  7. doi request reprint Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis
    Tadashi Moro
    Tokai University School of Medicine, 143 Shimo Kasuya, Isehara, Kanagawa 259 1193, Japan
    Life Sci 83:531-9. 2008
    ..This study was aimed to explore molecular mechanisms responsible for the inhibitory effect of glycyrrhizin on type I collagen gene transcription...
  8. ncbi request reprint Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice
    Reiichi Higashiyama
    Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Isehara, Japan
    Hepatology 45:213-22. 2007
    ..CONCLUSION: Autologous BM cells contribute to the spontaneous regression of liver fibrosis, and their therapeutic derivation could be a new treatment strategy for intractable liver fibrosis...
  9. doi request reprint Differential contribution of dermal resident and bone marrow-derived cells to collagen production during wound healing and fibrogenesis in mice
    Reiichi Higashiyama
    Department of Regenerative Medicine, Tokai University School of Medicine, Isehara, Japan
    J Invest Dermatol 131:529-36. 2011
    ....
  10. ncbi request reprint Activation of two distinct MAPK pathways governs constitutive expression of matrix metalloproteinase-1 in human pancreatic cancer cell lines
    Hitoshi Endo
    Department of Community Health, Tokai University School of Medicine, Isehara, Kanagawa Prefecture 259 1193, Japan
    Int J Oncol 35:1237-45. 2009
    ..This study contributes to provide new insights into strategies for inhibiting tumor cell invasion in pancreatic cancer...
  11. ncbi request reprint c-Jun NH2-terminal kinase pathway is involved in constitutive matrix metalloproteinase-1 expression in a hepatocellular carcinoma-derived cell line
    Yoshihiko Sugioka
    Department of Community Health, Tokai University School of Medicine, Kanagawa, Japan
    Int J Cancer 109:867-74. 2004
    ..Taken together, this study suggests that the JNK pathway is involved in the expression of MMP-1 in HCC cells and may represent a new functional role of c-Jun for HCC development...
  12. ncbi request reprint Effect of ethanol and docosahexaenoic acid on nerve growth factor-induced neurite formation and neuron specific growth-associated protein gene expression in PC12 cells
    Hiroyuki Furuya
    Department of Community Health, Division of Community and Environmental Health, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, 259 1193 Japan
    Nihon Arukoru Yakubutsu Igakkai Zasshi 37:513-22. 2002
    ..Interaction of ethanol and docosahexaenoic acid in NGF-induced neurite formation, as well as the mechanisms by which DHA ameliorate the hyperactivity induced by in utero ethanol exposure, are to be elucidated...
  13. ncbi request reprint [Recent advance in understanding mechanisms of fibrogenesis and fibrolysis in hepatic fibrosis]
    Isao Okazaki
    Department of Community Health, Tokai University School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 99:353-64. 2002
  14. doi request reprint Interplay between bone marrow and liver in the pathogenesis of hepatic fibrosis
    Yutaka Inagaki
    Department of Regenerative Medicine, Tokai University School of Medicine and the Institute of Medical Sciences, Isehara, Japan
    Hepatol Res 42:543-8. 2012
    ....
  15. pmc Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats
    Kohji Kinoshita
    First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
    Gut 56:706-14. 2007
    ..Transforming growth factor-beta (TGFbeta) plays a pivotal role in extracellular matrix production, but bone morphogenetic protein (BMP)-7, a member of the TGFbeta superfamily, can antagonise the fibrogenic activity of TGFbeta...
  16. pmc Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre/loxP system to antagonise hepatic fibrosis
    Kohji Kinoshita
    First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
    Gut 56:396-404. 2007
    ..Activated hepatic stellate cells (HSCs) are an attractive target for antifibrotic therapy based on their key role in extracellular matrix accumulation during liver injury...
  17. ncbi request reprint BMP-7 opposes TGF-beta1-mediated collagen induction in mouse pulmonary myofibroblasts through Id2
    Nobuhiro Izumi
    Department of Surgery, Graduate School of Medicine, Osaka City University, Osaka 545 8585, Japan
    Am J Physiol Lung Cell Mol Physiol 290:L120-6. 2006
    ..In conclusion, these data demonstrate that BMP-7 antagonizes the TGF-beta1-dependent fibrogenic activity of mouse pulmonary myofibroblastic cells by inducing Id2 and Id3...
  18. ncbi request reprint Transforming growth factor-beta isoforms differently stimulate proalpha2 (I) collagen gene expression during wound healing process in transgenic mice
    Takuro Kinbara
    Department of Dermatology, Kanazawa University School of Medicine, Kanazawa, Ishikawa, Japan
    J Cell Physiol 190:375-81. 2002
    ..These findings suggest that TGF-beta1 and -beta3 have similar but not identical regulatory mechanisms of COL1A2 expression, and that their pathophysiological roles in wound healing might be different from each other...
  19. ncbi request reprint Y-box-binding protein YB-1 mediates transcriptional repression of human alpha 2(I) collagen gene expression by interferon-gamma
    Kiyoshi Higashi
    Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd, Konohana ku, Osaka 554 8558, Japan
    J Biol Chem 278:5156-62. 2003
    ..Altogether, this study represents the definitive identification of the transcription factor responsible for IFN-gamma-elicited inhibition of COL1A2 expression, namely YB-1...
  20. ncbi request reprint Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3
    Kiyoshi Higashi
    Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, Konohana ku, Osaka 554 8558, Japan
    J Biol Chem 278:43470-9. 2003
    ..They also indicate that IFN-gamma/YB-1 inhibits COL1A2 transcription by dual actions: via the IFN-gamma response element and through a cross-talk with the TGF-beta/Smad signaling pathway...
  21. ncbi request reprint p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts
    Fukiko Furukawa
    Third Department of Internal Medicine, Kansai Medical University, 10 15 Fumizonocho, Moriguchi, Osaka 570 8506, Japan
    Hepatology 38:879-89. 2003
    ..In conclusion, p38 MAPK-dependent Smad3 phosphorylation promoted extracellular matrix production in MFBs both in vitro and in vivo...
  22. ncbi request reprint Involvement of p300 in TGF-beta/Smad-pathway-mediated alpha2(I) collagen expression in mouse mesangial cells
    Yutaka Kanamaru
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Nephron Exp Nephrol 95:e36-42. 2003
    ..However, the role of p300 in TGF-beta1/Smad-pathway-mediated transcriptional activation of the COL1A2 gene in mesangial cells is still obscure...
  23. ncbi request reprint Connective tissue growth factor causes persistent proalpha2(I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model
    Sonoko Chujo
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa, Ishikawa 920 8641, Japan
    J Cell Physiol 203:447-56. 2005
    ..The infiltrated mast cells and macrophages may also contribute to the maintenance of fibrosis...
  24. pmc Early response of alpha2(I) collagen to acetaldehyde in human hepatic stellate cells is TGF-beta independent
    Gianluca Svegliati-Baroni
    Clinica di Gastroenterologia, Universita Politecnica delle Marche, Ancona, Italy
    Hepatology 42:343-52. 2005
    ..We suggest that early acetaldehyde-dependent events induce the late expression of TGF-beta1 and create an H(2)O(2)-dependent autocrine loop that may sustain and amplify the fibrogenic response of this alcohol metabolite...
  25. ncbi request reprint Differential regulation of TGF-beta signal in hepatic stellate cells between acute and chronic rat liver injury
    Yoshiya Tahashi
    Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan
    Hepatology 35:49-61. 2002
    ..This constitutive phosphorylation of Smad 2 by endogenous TGF-beta under a low level of Smad 7 could be involved in the progression of liver fibrosis...
  26. ncbi request reprint Multiple proteins are involved in the protein-DNA complex in the proximal promoter of the human alpha1(III) collagen gene (COL3A1)
    Tomoaki Yoshino
    Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Biochim Biophys Acta 1729:94-104. 2005
    ..Biol. Chem., 1993). In the rhabdomyosarcoma cell line, A204, at least two proteins of 92-118 kDa and 40-52 kDa are involved in the DNA-protein complex bound to this motif...