Research Topics
Genomes and Genes | Kenichi HirabayashiSummaryAffiliation: Tokai University Country: Japan Publications
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Publications
IgG4-related diseaseK Hirabayashi
Department of Pathology, Ospedale Sacro Cuore Don Calabria, Negrar VR, Italy
Pathologica 104:43-55. 2012..Correct identification is crucial to avoid unnecessary major surgical procedures and initiate corticosteroid therapy...
First case of primary phyllodes tumor of the pancreas: case report and findings of immunohistochemical and ultrastructural studiesKenichi Hirabayashi
Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan
Virchows Arch 456:587-93. 2010..However, the histological findings in the present case differed from those of these tumors. The present lesion is the first reported case of a primary pancreatic phyllodes tumor...
Clear cell adenocarcinoma arising from adenomyosisKenichi Hirabayashi
Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
Int J Gynecol Pathol 28:262-6. 2009..Malignant tumor arising from adenomyosis should be considered as a differential diagnosis when the serum level of tumor markers such as CA125 is high and when the tumor is intramyometrial...
Wall-invasion pattern correlates with survival of patients with gallbladder adenocarcinomaKen Ichi Okada
Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
Anticancer Res 29:685-91. 2009..039-0.629) was an independent predictor of mortality. In conclusion, the DG invasion pattern is an indicator of high malignant potential and indirectly worsens the prognosis of patients with gallbladder adenocarcinoma...
Stromal thrombospondin-1 expression is a prognostic indicator and a new marker of invasiveness in intraductal papillary-mucinous neoplasm of the pancreasKen Ichi Okada
Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan
Biomed Res 31:13-9. 2010..001). In conclusion, stromal TSP1 expression is a prognostic indicator and a new marker of invasiveness in IPMN...
Nonfunctioning pancreatic endocrine tumor with extension into the main pancreatic duct: report of a caseNaoki Yazawa
Department of Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259 1193, Japan
Surg Today 41:737-40. 2011..Histological examination confirmed well-differentiated endocrine carcinoma. We review reported cases of the intraductal growth of NFPETs and discuss the pathogenesis of these unusual tumors...
The distance of tumor spread in the main pancreatic duct of an intraductal papillary-mucinous neoplasm: where to resect and how to predict itKen Ichi Okada
Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
J Hepatobiliary Pancreat Sci 17:516-22. 2010..We analyzed the appropriate surgical margin based on the DTS in the main pancreatic duct of IPMN and the positive rate at the pancreatic cut end margin...
Granulosa cell tumor with activated mTOR-HIF-1alpha-VEGF pathwayMasaki Miyazawa
Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan
J Obstet Gynaecol Res 36:448-53. 2010..It was concluded that mTOR-targeted therapy may represent a promising strategy for some GCT with an activated mTOR-HIF-1alpha-VEGF pathway...
Therapeutic strategy targeting the mTOR-HIF-1alpha-VEGF pathway in ovarian clear cell adenocarcinomaMasaki Miyazawa
Department of Pathology, Tokai University School of Medicine, Isehara, Japan
Pathol Int 59:19-27. 2009..In conclusion, mTOR-targeted therapy through usage of drugs such as everolimus may be more effective for CLA of the ovary because of its significant expression of p-mTOR...
Curative surgical treatment after preoperative chemotherapy for primarily inoperable locally advanced pancreatic carcinoma: report of a caseKen Ichi Okada
Department of Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
Tokai J Exp Clin Med 34:53-7. 2009....
Clinical significance of wall invasion pattern of subserosa-invasive gallbladder carcinomaKen Ichi Okada
Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
Oncol Rep 28:1531-6. 2012..0023, log-rank test). The wall invasion pattern could contribute to decision-making concerning curative resection for subserosal invasive GBC...
Leiomyosarcoma of the pancreas: report of a caseHideki Izumi
Department of Gastroenterological Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259 1193, Japan
Surg Today 41:1556-61. 2011..Based on these findings, we confirmed a diagnosis of leiomyosarcoma originating from the pancreas. During 14 months of follow-up to date, there has not been any evidence of local recurrence or distant metastasis...
Immunohistochemical expression of somatostatin type 2A receptor in neuroendocrine carcinoma of uterine cervixHiroshi Kajiwara
Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
Arch Gynecol Obstet 279:521-5. 2009..SSTR2A-positive neuroendocrine tumors may be treatable by SS analogues. Uterine cervical neuroendocrine carcinoma is generally associated with poor prognosis...
An annular pancreas associated with carcinoma of the papilla of Vater: report of a caseNaoki Yazawa
Department of Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259 1193, Japan
Surg Today 42:497-501. 2012..We also provide a review of the reported cases of an annular pancreas with periampullary neoplasms and discuss the clinical characteristics of this anomaly...
A case of oncocytic carcinoma of the endometriumHiroshi Kajiwara
Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
Arch Gynecol Obstet 279:733-8. 2009..The Ki-67 labeling index was approximately 50%. Immunostaining revealed endometrial oncocytic carcinoma. Distinguishing between primary uterine neoplasm and carcinoma caused by metastasis of breast cancer appears important...
Perivascular epithelioid cell tumor (PEComa) of the pancreas: immunoelectron microscopy and review of the literatureKenichi Hirabayashi
Department of Pathology, Tokai University School of Medicine, Kanagawa 259 1193, Japan
Pathol Int 59:650-5. 2009..The results of immunoelectron microscopy show that some PEComas possess not only typical melanosomes or premelanosomes but also aberrant melanosomes...
Association of hypoxia-inducible factor-1 expression with histology in epithelial ovarian tumors: a quantitative analysis of HIF-1Masaki Miyazawa
Department of Pathology, Tokai University, Tokyo, Japan
Arch Gynecol Obstet 279:789-96. 2009....
Stromal laminin-5gamma2 chain expression is associated with the wall-invasion pattern of gallbladder adenocarcinomaKen Ichi Okada
Departments of Surgery, Tokai University School of Medicine, Kanagawa, Japan
Biomed Res 30:53-62. 2009..068). In conclusion, high-grade cell proliferation and stromal laminin-5gamma2 staining were significantly correlated with a wall-invasion pattern of aggressive gallbladder carcinoma indicating destructive growth (DG type)...
Cytological features of the cystic fluid of pancreatic schwannoma with cystic degeneration. A case reportKenichi Hirabayashi
Department of Pathology, Tokai University School of Medicine Kanagawa, Japan
JOP 9:203-8. 2008..Schwannomas are benign neoplasms arising from peripheral nerve tissue. Pancreatic schwannoma is a very rare condition. We present the histological and cytological features of a pancreatic schwannoma with cystic degeneration...
Small serotonin-positive pancreatic endocrine tumors caused obstruction of the main pancreatic ductMasami Ogawa
Department of Gastroenterology, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259 1193, Japan
World J Gastroenterol 18:6669-73. 2012..We report 2 cases of serotonin-positive pancreatic endocrine tumors that caused stricture of the MPD in spite of the small size of the tumor...
Ovarian nongestational choriocarcinoma mixed with various epithelial malignancies in association with endometriosisKenichi Hirabayashi
Department of Pathology, Tokai University, School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan
Gynecol Oncol 102:111-7. 2006..Coexistence of CC with small cell carcinoma is considered to be responsible for relative chemoresistance leading to poor prognosis...
Inflammatory pseudotumor of the liver: case report and review of literatureMegumi Motojuku
Department of Critical Care and Emergency Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan
Tokai J Exp Clin Med 33:70-4. 2008..On the other hand, since it may show spontaneous regression, indications for surgery must be assessed very carefully...
