Atsushi Hashimoto

Summary

Affiliation: Tokai University
Country: Japan

Publications

  1. ncbi request reprint Free D-aspartate and D-serine in the mammalian brain and periphery
    A Hashimoto
    Department of Pharmacology, Takai University School of Medicine, Kanagawa, Japan
    Prog Neurobiol 52:325-53. 1997
  2. ncbi request reprint Effect of aminooxyacetic acid on extracellular level of D-serine in rat striatum: an in vivo microdialysis study
    Atsushi Hashimoto
    Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa, 259 1143, Japan
    Eur J Pharmacol 525:91-3. 2005
  3. doi request reprint Mice lacking d-amino acid oxidase activity exhibit marked reduction of methamphetamine-induced stereotypy
    Atsushi Hashimoto
    Department of Clinical Pharmacology, Tokai University School of Medicine, Isehara, Kanagawa 259 1143, Japan
    Eur J Pharmacol 586:221-5. 2008
  4. ncbi request reprint Effect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat
    Atsushi Hashimoto
    Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259 1143, Japan
    Eur J Pharmacol 495:153-8. 2004
  5. ncbi request reprint Effects of MK-801 on the expression of serine racemase and d-amino acid oxidase mRNAs and on the D-serine levels in rat brain
    Atsushi Hashimoto
    Department of Clinical Pharmacology, Tokai University School of Medicine, Isehara, Kanagawa 259 1143, Japan
    Eur J Pharmacol 555:17-22. 2007
  6. ncbi request reprint Effect of the intracerebroventricular and systemic administration of L-serine on the concentrations of D- and L-serine in several brain areas and periphery of rat
    Atsushi Hashimoto
    Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259 1193, Japan
    Brain Res 955:214-20. 2002
  7. ncbi request reprint Effects of N-methyl-D-aspartate, kainate or veratridine on extracellular concentrations of free D-serine and L-glutamate in rat striatum: an in vivo microdialysis study
    A Hashimoto
    Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa, Japan
    Brain Res Bull 53:347-51. 2000
  8. doi request reprint Midazolam attenuates the antinociception induced by d-serine or morphine at the supraspinal level in rats
    Kenji Ito
    Department of Anesthesiology, Tokai University School of Medicine, Isehara, Kanagawa, 259 1143, Japan
    Eur J Pharmacol 586:139-44. 2008
  9. ncbi request reprint Long-term treatment with morphine increases the D-serine content in the rat brain by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidase
    Masanobu Yoshikawa
    Department of Clinical Pharmacology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Pharmacol Sci 107:270-6. 2008
  10. ncbi request reprint Ketamine enhances the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain
    Kazuhide Takeyama
    Department of Anesthesiology, Tokai University School of Medicine, Isehara, Kanagawa, 259 1143, Japan
    Eur J Pharmacol 540:82-6. 2006

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Free D-aspartate and D-serine in the mammalian brain and periphery
    A Hashimoto
    Department of Pharmacology, Takai University School of Medicine, Kanagawa, Japan
    Prog Neurobiol 52:325-53. 1997
    ....
  2. ncbi request reprint Effect of aminooxyacetic acid on extracellular level of D-serine in rat striatum: an in vivo microdialysis study
    Atsushi Hashimoto
    Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa, 259 1143, Japan
    Eur J Pharmacol 525:91-3. 2005
    ....
  3. doi request reprint Mice lacking d-amino acid oxidase activity exhibit marked reduction of methamphetamine-induced stereotypy
    Atsushi Hashimoto
    Department of Clinical Pharmacology, Tokai University School of Medicine, Isehara, Kanagawa 259 1143, Japan
    Eur J Pharmacol 586:221-5. 2008
    ....
  4. ncbi request reprint Effect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat
    Atsushi Hashimoto
    Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259 1143, Japan
    Eur J Pharmacol 495:153-8. 2004
    ....
  5. ncbi request reprint Effects of MK-801 on the expression of serine racemase and d-amino acid oxidase mRNAs and on the D-serine levels in rat brain
    Atsushi Hashimoto
    Department of Clinical Pharmacology, Tokai University School of Medicine, Isehara, Kanagawa 259 1143, Japan
    Eur J Pharmacol 555:17-22. 2007
    ....
  6. ncbi request reprint Effect of the intracerebroventricular and systemic administration of L-serine on the concentrations of D- and L-serine in several brain areas and periphery of rat
    Atsushi Hashimoto
    Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259 1193, Japan
    Brain Res 955:214-20. 2002
    ....
  7. ncbi request reprint Effects of N-methyl-D-aspartate, kainate or veratridine on extracellular concentrations of free D-serine and L-glutamate in rat striatum: an in vivo microdialysis study
    A Hashimoto
    Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa, Japan
    Brain Res Bull 53:347-51. 2000
    ....
  8. doi request reprint Midazolam attenuates the antinociception induced by d-serine or morphine at the supraspinal level in rats
    Kenji Ito
    Department of Anesthesiology, Tokai University School of Medicine, Isehara, Kanagawa, 259 1143, Japan
    Eur J Pharmacol 586:139-44. 2008
    ....
  9. ncbi request reprint Long-term treatment with morphine increases the D-serine content in the rat brain by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidase
    Masanobu Yoshikawa
    Department of Clinical Pharmacology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Pharmacol Sci 107:270-6. 2008
    ..These results indicate the elevated D-serine level following the chronic morphine treatment could at least in part be involved in the activation of NMDA receptors via the glycine site...
  10. ncbi request reprint Ketamine enhances the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain
    Kazuhide Takeyama
    Department of Anesthesiology, Tokai University School of Medicine, Isehara, Kanagawa, 259 1143, Japan
    Eur J Pharmacol 540:82-6. 2006
    ..These findings suggest that there is a relationship between the gene expression of the d-serine-related enzymes and the blockade of the N-methyl-D-aspartate receptors...
  11. ncbi request reprint Acute administration of methamphetamine decreases the mRNA expression of diazepam binding inhibitor in rat brain
    Raita Tamaki
    Department of Clinical Pharmacology, Tokai University School of Medicine, Japan
    Tokai J Exp Clin Med 33:51-6. 2008
    ..These results suggest that MAP, at this dose, has an anxiolytic effect, based on the reduction of the putative anxiogenic peptides, DBI...
  12. ncbi request reprint Acute treatment with morphine augments the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain
    Masanobu Yoshikawa
    Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa, 259 1143, Japan
    Eur J Pharmacol 525:94-7. 2005
    ..The present results are the first to suggest an interaction between the expression of the mRNAs for the D-serine-related enzymes and the opioid receptor activation...
  13. ncbi request reprint The serine racemase mRNA is predominantly expressed in rat brain neurons
    Masanobu Yoshikawa
    Department of Clinical Pharmacology, Laboratory for Molecular Science Research, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Arch Histol Cytol 70:127-34. 2007
    ..These results suggest that neuron-derived D-serine could modulate neurotransmission via the glycine site of N-methyl-D-aspartate receptors...
  14. ncbi request reprint MK-801 upregulates the expression of d-amino acid oxidase mRNA in rat brain
    Masanobu Yoshikawa
    Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa, 259 1143, Japan
    Brain Res Mol Brain Res 131:141-4. 2004
    ..The present results suggest that there is a link between the expression of DAO mRNA and the N-methyl-D-aspartate (NMDA) receptor activity...
  15. ncbi request reprint Activation of supraspinal NMDA receptors by both D-serine alone or in combination with morphine leads to the potentiation of antinociception in tail-flick test of rats
    Masanobu Yoshikawa
    Department of Clinical Pharmacology, Tokai University School of Medicine, Isehara, Kanagawa, 259 1193, Japan
    Eur J Pharmacol 565:89-97. 2007
    ....
  16. ncbi request reprint Distribution and MK-801-induced expression of serine racemase mRNA in rat brain by real-time quantitative PCR
    Masanobu Yoshikawa
    Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259 1143, Japan
    Brain Res Mol Brain Res 128:90-4. 2004
    ..The present findings suggest that there is a link between the expression of serine racemase mRNA and the activity of the NMDA receptors...
  17. ncbi request reprint Chronic administration of methamphetamine increases the mRNA expression of diazepam binding inhibitor in rat brain
    Raita Tamaki
    Department of Clinical Pharmacology, Tokai University School of Medicine, Isehara, Kanagawa 259 1143, Japan
    Tokai J Exp Clin Med 33:46-50. 2008
    ..These results suggest that anxiety is associated with the mRNA expression of DBI as well as DBI-related genes...
  18. ncbi request reprint Subchronic administration of ketamine decreases the mRNA expression of serine racemase in rat brain
    Mariko Watanabe
    Department of Anesthesiology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Tokai J Exp Clin Med 35:137-43. 2010
    ..These findings suggest that there is a relationship between the gene expression of the D-serine-related enzymes and the blockade of the NMDA receptors...
  19. ncbi request reprint Antiinflammatory mediator lipoxin A4 and its receptor in synovitis of patients with rheumatoid arthritis
    Atsushi Hashimoto
    Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa, Japan
    J Rheumatol 34:2144-53. 2007
    ....
  20. ncbi request reprint Mice lacking D-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801
    Atsushi Hashimoto
    Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259 1143, Japan
    Brain Res 1033:210-5. 2005
    ..Because the D-serine level in the brain of mutant mice is significantly higher than that of normal mice, the elevated D-serine in the brain of mutant mice could antagonize MK-801-induced stereotypy and ataxia...
  21. ncbi request reprint Expression of the mRNA and protein of serine racemase in primary cultures of rat neurons
    Masanobu Yoshikawa
    Department of Clinical Pharmacology, Tokai University School of Medicine, Isehara, Kanagawa 259 1143, Japan
    Eur J Pharmacol 548:74-6. 2006
    ..These data are the first to demonstrate that a substantial amount of serine racemase exists in the cultured neurons...
  22. ncbi request reprint Inhibition of skin sclerosis by 15deoxy delta12,14-prostaglandin J2 and retrovirally transfected prostaglandin D synthase in a mouse model of bleomycin-induced scleroderma
    Shizuka Kohno
    Division of Rheumatology, Department of Internal Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Biomed Pharmacother 60:18-25. 2006
    ..These results show that 15-d PGJ(2) and PGDS-expressing cells can prevent experimental skin sclerosis induced by BLM and raise the possibility of therapeutic approaches targeting of PPARgamma for the skin lesion of scleroderma...
  23. doi request reprint Henoch-Schönlein pupura complicated by perforation of the gallbladder
    Atsushi Hashimoto
    Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Rheumatol Int 29:441-3. 2009
    ..It is suggested that inflammatory disruption of capillary walls might lead to the perforation of the gallbladder...
  24. doi request reprint Clinical features of 405 Japanese patients with systemic sclerosis
    Atsushi Hashimoto
    Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa 252 0374, Japan
    Mod Rheumatol 22:272-9. 2012
    ..In conclusion, these results not only confirmed previous reports but revealed several other findings, such as the increased proportion of male patients in recent years and the relationships between clinical features...
  25. doi request reprint Predictors of survival and causes of death in Japanese patients with systemic sclerosis
    Atsushi Hashimoto
    Department of Rheumatology, Sagamihara National Hospital, National Hospital Organization, 18 1 Sakuardai, Minami Ku, Sagamihara, Kanagawa, 252 0392, Japan
    J Rheumatol 38:1931-9. 2011
    ..To clarify the mortality rates, causes of death, and contributing clinical factors in Japanese patients with systemic sclerosis (SSc)...
  26. pmc Association of human leukocyte antigen with interstitial lung disease in rheumatoid arthritis: a protective role for shared epitope
    Hiroshi Furukawa
    Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Kanagawa, Japan
    PLoS ONE 7:e33133. 2012
    ..In this study, we investigated the association of HLA class II alleles with ILD in RA...
  27. doi request reprint An autopsy case of necrotizing fasciitis with rapidly progressive purpura caused by hemolytic streptococcal infection in a patient with rheumatoid arthritis
    Kanako Iwata
    Department of Rheumatology, Sagamihara National Hospital, National Hospital Organization, 18 1 Sakuradai, Minami Ku, Sagamihara, Kanagawa 252 0392, Japan
    Mod Rheumatol 21:669-72. 2011
    ..Physicians should consider that necrotizing fasciitis may be present when soft-tissue disorder is suspected in patients receiving corticosteroid therapy, which is associated with tissue fragility and immunosuppression...
  28. ncbi request reprint Down-regulation of lipoxin A4 receptor by thromboxane A2 signaling in RAW246.7 cells in vitro and bleomycin-induced lung fibrosis in vivo
    Yoshinori Sato
    Department of Microbiology, School of Medicine, Kitasato University, 1 15 1, Sagamihara shi, Kanagawa 228 8555, Japan
    Biomed Pharmacother 58:381-7. 2004
    ..Concomitantly, selective blockade of TXA2-TP signaling could be suggested to lead to anti-inflammation through active role of LXA4...
  29. ncbi request reprint Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin
    Miyuki Ando
    Department of Internal Medicine, Kitasato University School of Medicine, Sagamihara shi, Kanagawa, Japan
    Am J Respir Cell Mol Biol 28:582-91. 2003
    ..These data suggest that the suppressive effect of PGDS on the lung injury could be partly mediated by edema formation and inhibition of genes involved in the fibrotic change...
  30. pmc Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol
    Yuka Nagata
    Recognition and Formation, Precursory Research for Embryonic Science and Technology, Japan Science and Technology Corporation, Japan
    Genes Dev 17:2864-9. 2003
    ..We conclude that autocrine estradiol action regulates platelet production by triggering PPF...
  31. ncbi request reprint Inhibition of monosodium urate monohydrate crystal-induced acute inflammation by retrovirally transfected prostaglandin D synthase
    Yousuke Murakami
    Kitasato University School of Medicine, Sagamihara, Japan
    Arthritis Rheum 48:2931-41. 2003
    ..We evaluated the antiinflammatory effect of retrovirally transfected H-PGDS in order to investigate the role of H-PGDS in monosodium urate monohydrate (MSU) crystal-induced acute inflammation...