Masao Hagihara

Summary

Affiliation: Tokai University
Country: Japan

Publications

  1. ncbi request reprint Platelets, after exposure to a high shear stress, induce IL-10-producing, mature dendritic cells in vitro
    Masao Hagihara
    Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Immunol 172:5297-303. 2004
  2. ncbi request reprint The effects of alphaGalCer-induced TCRValpha24 Vbeta11(+) natural killer T cells on NK cell cytotoxicity in umbilical cord blood
    Yoko Ueda
    Department of Hematology and Oncology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Cancer Immunol Immunother 52:625-31. 2003
  3. ncbi request reprint Umbilical cord blood dendritic cells are a rich source of soluble HLA-DR: synergistic effect of exosomes and dendritic cells on autologous or allogeneic T-Cell proliferation
    Balgansuren Gansuvd
    Departments of Hematology and Rheumatology, Tokai University School of Medicine, Kanagawa, Japan
    Hum Immunol 64:427-39. 2003
  4. ncbi request reprint Killing activity of human umbilical cord blood-derived TCRValpha24(+) NKT cells against normal and malignant hematological cells in vitro: a comparative study with NK cells or OKT3 activated T lymphocytes or with adult peripheral blood NKT cells
    Masao Hagihara
    Department of Hematology and Rheumatology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan 259 1193
    Cancer Immunol Immunother 51:1-8. 2002
  5. ncbi request reprint Induction of cytomegalovirus-specific CD4+ cytotoxic T lymphocytes from seropositive or negative healthy subjects or stem cell transplant recipients
    Kei Tazume
    Department of Hematology, Tokai University School of Medicine, Kanagawa, Japan
    Exp Hematol 32:95-103. 2004
  6. ncbi request reprint Human umbilical cord blood NK T cells kill tumors by multiple cytotoxic mechanisms
    Balgansuren Gansuvd
    Department of Hematology and Rheumatology, Kanagawa, Japan
    Hum Immunol 63:164-75. 2002
  7. ncbi request reprint The in vitro generation of Ph1+ ALL-specific HLA-A24-restricted cytotoxic T lymphocytes using a synthetic 16 mer minor bcr-abl peptide
    Masao Hagihara
    Department of Hematology and Rheumatology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Leuk Res 27:253-7. 2003
  8. ncbi request reprint Frequencies of dendritic cells (myeloid DC and plasmacytoid DC) and their ratio reduced in pregnant women: comparison with umbilical cord blood and normal healthy adults
    Yoko Ueda
    Department of Hematology and Oncology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
    Hum Immunol 64:1144-51. 2003
  9. ncbi request reprint A liver-derived immunosuppressive factor is an arginase: identification and mechanism of immunosuppression
    Yasuo Ohtani
    Department of Surgical Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Biomed Res 28:17-23. 2007
  10. ncbi request reprint Reconstitution of functional human B lymphocytes in NOD/SCID mice engrafted with ex vivo expanded CD34(+) cord blood cells
    Chenwgwen Li
    Department of Hematology, Tokai University School of Medicine, Kanagawa, Japan
    Exp Hematol 30:1036-43. 2002

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Platelets, after exposure to a high shear stress, induce IL-10-producing, mature dendritic cells in vitro
    Masao Hagihara
    Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Immunol 172:5297-303. 2004
    ..Furthermore, it was abrogated after the depletion of protein fraction. Thus, soluble protein factors excreted from activated platelets contribute to IL-10-producing DC maturation...
  2. ncbi request reprint The effects of alphaGalCer-induced TCRValpha24 Vbeta11(+) natural killer T cells on NK cell cytotoxicity in umbilical cord blood
    Yoko Ueda
    Department of Hematology and Oncology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Cancer Immunol Immunother 52:625-31. 2003
    ..The second one is to examine whether purified NKT cells could affect the cytotoxicity of UCB-NK cells either in the presence or absence of dendritic cells (DCs)...
  3. ncbi request reprint Umbilical cord blood dendritic cells are a rich source of soluble HLA-DR: synergistic effect of exosomes and dendritic cells on autologous or allogeneic T-Cell proliferation
    Balgansuren Gansuvd
    Departments of Hematology and Rheumatology, Tokai University School of Medicine, Kanagawa, Japan
    Hum Immunol 64:427-39. 2003
    ..These sHLA-DR containing vesicles/exosomes alone evoked weak proliferative responses from autologous and allogeneic T cells, but the immune response was significantly increased when vesicles/exosomes were presented with DCs...
  4. ncbi request reprint Killing activity of human umbilical cord blood-derived TCRValpha24(+) NKT cells against normal and malignant hematological cells in vitro: a comparative study with NK cells or OKT3 activated T lymphocytes or with adult peripheral blood NKT cells
    Masao Hagihara
    Department of Hematology and Rheumatology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan 259 1193
    Cancer Immunol Immunother 51:1-8. 2002
    ....
  5. ncbi request reprint Induction of cytomegalovirus-specific CD4+ cytotoxic T lymphocytes from seropositive or negative healthy subjects or stem cell transplant recipients
    Kei Tazume
    Department of Hematology, Tokai University School of Medicine, Kanagawa, Japan
    Exp Hematol 32:95-103. 2004
    ..We generated cytomegalovirus (CMV)-specific cytotoxic T lymphocytes (CTL) in vitro using dendritic cells (DC) pulsed with crude CMV antigens (Ag)...
  6. ncbi request reprint Human umbilical cord blood NK T cells kill tumors by multiple cytotoxic mechanisms
    Balgansuren Gansuvd
    Department of Hematology and Rheumatology, Kanagawa, Japan
    Hum Immunol 63:164-75. 2002
    ..NK T cells can kill tumor targets by perforin, Fas-FasL, and TNF-alpha mechanisms. TNF-alpha killing requires longer contact between effectors and targets, suggesting that TNF-alpha acts by enhancing perforin killing...
  7. ncbi request reprint The in vitro generation of Ph1+ ALL-specific HLA-A24-restricted cytotoxic T lymphocytes using a synthetic 16 mer minor bcr-abl peptide
    Masao Hagihara
    Department of Hematology and Rheumatology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Leuk Res 27:253-7. 2003
    ..Those CTLs consisted predominantly of CD8+ T cells whose cytotoxicity could be neutralized by monoclonal antibodies to HLA-class I or HLA-A24, and also produced interferon (IFN)-gamma after being stimulated with peptide-pulsed DCs...
  8. ncbi request reprint Frequencies of dendritic cells (myeloid DC and plasmacytoid DC) and their ratio reduced in pregnant women: comparison with umbilical cord blood and normal healthy adults
    Yoko Ueda
    Department of Hematology and Oncology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
    Hum Immunol 64:1144-51. 2003
    ..79 +/- 0.91) in comparison with that in age-matched, nonpregnant females (3.96 +/- 2.95). It was assumed that reduction of MDC during pregnancy plays an important role in maintaining immune tolerance against the embryo...
  9. ncbi request reprint A liver-derived immunosuppressive factor is an arginase: identification and mechanism of immunosuppression
    Yasuo Ohtani
    Department of Surgical Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Biomed Res 28:17-23. 2007
    ..These results led us to the conclusion that immunosuppressive effect of ISF was due to arginase activity that decreased arginine concentration in culture medium, not to another function of ISF...
  10. ncbi request reprint Reconstitution of functional human B lymphocytes in NOD/SCID mice engrafted with ex vivo expanded CD34(+) cord blood cells
    Chenwgwen Li
    Department of Hematology, Tokai University School of Medicine, Kanagawa, Japan
    Exp Hematol 30:1036-43. 2002
    ..Therefore, we investigated the antigen-specific antibody production in human B cells maturated from ex vivo expanded cord blood (CB) CD34(+) cells in NOD/Shi-scid (NOD/SCID) mice...
  11. ncbi request reprint Clinical effects of infusing anti-Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes into patients with severe chronic active EBV infection
    Masao Hagihara
    Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Int J Hematol 78:62-8. 2003
    ..Thus the effect of auto-CTL treatment was limited or deteriorative in SCAEBV patients...
  12. ncbi request reprint Comparison of soluble and membrane bound HLA-class I and DR levels in umbilical cord blood and adult peripheral blood
    Ayako Higuchi
    Department Cell Transplantation and Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Tokai J Exp Clin Med 28:1-7. 2003
    ..Alternatively, fetal sHLA antigens might be unstable and degradated compared to those of adult...
  13. ncbi request reprint The sharing of target-epitopes between human anti-ABO hemagglutinating and anti-Pig (xeno) endothelium or anti-Pig thyroglobulin antibodies
    Naokatsu Morita
    Department of Nephrology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Tokai J Exp Clin Med 28:71-80. 2003
    ..We conclude that human anti-B-RBC and anti-Pig xeno NAb have certain common binding epitopes, which might be a branched B carbohydrate structure...
  14. ncbi request reprint The generation of immunocompetent dendritic cells from CD34+ acute myeloid or lymphoid leukemia cells
    Takahide Tsuchiya
    Department of Hematology and Rheumatology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Int J Hematol 75:55-62. 2002
    ..In Philadelphia chromosome-positive ALL or AML patients with t (8;21), DCs were confirmed to be of leukemic origin by fluorescence in situ hybridization analysis...
  15. ncbi request reprint Hepatocyte proliferation factors from neonatal pig liver: purification and characterization
    Mineyoshi Hiyoshi
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, 259 1193 Japan
    Biofactors 16:1-14. 2002
    ....
  16. ncbi request reprint Intravenous injection of phagocytes transfected ex vivo with FGF4 DNA/biodegradable gelatin complex promotes angiogenesis in a rat myocardial ischemia/reperfusion injury model
    Naoto Fukuyama
    Depts of Physiology, Tokai University School of Medicine, Isehara, 259 1193, Japan
    Basic Res Cardiol 102:209-16. 2007
    ..Phagocytes transfected ex vivo with FGF4 DNA/gelatin promoted angiogenesis. This approach might have potential for non-viral angiogenic gene therapy...
  17. ncbi request reprint Rapid and efficient generation of lentivirally gene-modified dendritic cells from DC progenitors with bone marrow stromal cells
    Hidetoshi Sumimoto
    Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    J Immunol Methods 271:153-65. 2002
    ..The two-step culture method with HESS-5 is useful for rapid expansion of DC progenitors and subsequent lentiviral gene transduction to DC...
  18. ncbi request reprint [Epstein-Barr virus related B-cell lymphoproliferative disorder complicated with bone marrow fibrosis, which was successfully treated with 2 courses of CHOP regimen]
    Masao Hagihara
    Department of Internal Medicine, Ebina General Hopital
    Rinsho Ketsueki 46:1129-35. 2005
    ..This unique case was considered to be "a senile EBV positive B-LPD" complicated with a secondary myelofibrosis, a category of the disorder which has recently been proposed by Shigeo Nakamura at the Aichi Cancer Center...