S Goto

Summary

Affiliation: Tokai University
Country: Japan

Publications

  1. ncbi request reprint One-year cardiovascular event rates in Japanese outpatients with myocardial infarction, stroke, and atrial fibrillation. -Results From the Japan Thrombosis Registry for Atrial Fibrillation, Coronary, or Cerebrovascular Events (J-TRACE).-
    Shinya Goto
    Department of Medicine Cardiology, Tokai University School of Medicine, Japan
    Circ J 75:2598-604. 2011
  2. ncbi request reprint Factor XIa as a possible new target of antithrombotic therapy
    S Goto
    Department of Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1143, Japan
    J Thromb Haemost 4:1494-5. 2006
  3. ncbi request reprint Effects of ticlopidine on von Willebrand factor-mediated shear-induced platelet activation and aggregation
    S Goto
    Division of Cardiology, Department of Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    Platelets 12:406-14. 2001
  4. doi request reprint Prevalence, clinical profile, and cardiovascular outcomes of atrial fibrillation patients with atherothrombosis
    Shinya Goto
    Department of Medicine and Metabolic Disease Center, Tokai University School of Medicine, Tokai University, Kanagawa, Japan
    Am Heart J 156:855-63, 863.e2. 2008
  5. ncbi request reprint Functional significance of adenosine 5'-diphosphate receptor (P2Y(12)) in platelet activation initiated by binding of von Willebrand factor to platelet GP Ibalpha induced by conditions of high shear rate
    Shinya Goto
    Division of Cardiology, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan
    Circulation 105:2531-6. 2002
  6. ncbi request reprint Involvement of glycoprotein VI in platelet thrombus formation on both collagen and von Willebrand factor surfaces under flow conditions
    Shinya Goto
    Division of Cardiology, Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Circulation 106:266-72. 2002
  7. ncbi request reprint Different effects of various anti-GPIIb-IIIa agents on shear-induced platelet activation and expression of procoagulant activity
    S Goto
    Division of Cardiology, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan
    J Thromb Haemost 1:2022-30. 2003
  8. ncbi request reprint Understanding the mechanism and prevention of arterial occlusive thrombus formation by anti-platelet agents
    S Goto
    Division of Cardiology, Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Curr Med Chem Cardiovasc Hematol Agents 2:149-56. 2004
  9. ncbi request reprint Understanding the mechanism of platelet thrombus formation under blood flow conditions and the effect of new antiplatelet agents
    Shinya Goto
    Division of Cardiology, Department of Medicine Tokai University School of Medicine Kanagawa, Japan
    Curr Vasc Pharmacol 2:23-32. 2004
  10. ncbi request reprint Dependence of platelet thrombus stability on sustained glycoprotein IIb/IIIa activation through adenosine 5'-diphosphate receptor stimulation and cyclic calcium signaling
    Shinya Goto
    Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan
    J Am Coll Cardiol 47:155-62. 2006

Detail Information

Publications40

  1. ncbi request reprint One-year cardiovascular event rates in Japanese outpatients with myocardial infarction, stroke, and atrial fibrillation. -Results From the Japan Thrombosis Registry for Atrial Fibrillation, Coronary, or Cerebrovascular Events (J-TRACE).-
    Shinya Goto
    Department of Medicine Cardiology, Tokai University School of Medicine, Japan
    Circ J 75:2598-604. 2011
    ..There remains uncertainty about the risk of cardiovascular events in stable outpatients with a history of myocardial infarction (MI), stroke, and atrial fibrillation in Japan...
  2. ncbi request reprint Factor XIa as a possible new target of antithrombotic therapy
    S Goto
    Department of Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1143, Japan
    J Thromb Haemost 4:1494-5. 2006
  3. ncbi request reprint Effects of ticlopidine on von Willebrand factor-mediated shear-induced platelet activation and aggregation
    S Goto
    Division of Cardiology, Department of Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    Platelets 12:406-14. 2001
    ....
  4. doi request reprint Prevalence, clinical profile, and cardiovascular outcomes of atrial fibrillation patients with atherothrombosis
    Shinya Goto
    Department of Medicine and Metabolic Disease Center, Tokai University School of Medicine, Tokai University, Kanagawa, Japan
    Am Heart J 156:855-63, 863.e2. 2008
    ..Atrial fibrillation (AF) is a major risk factor (RF) for ischemic stroke. Its prevalence and prognostic impact in patients with atherothrombosis are unclear...
  5. ncbi request reprint Functional significance of adenosine 5'-diphosphate receptor (P2Y(12)) in platelet activation initiated by binding of von Willebrand factor to platelet GP Ibalpha induced by conditions of high shear rate
    Shinya Goto
    Division of Cardiology, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan
    Circulation 105:2531-6. 2002
    ..The role of the adenosine 5'-diphosphate receptor P2Y(12) in platelet activation initiated by the von Willebrand factor (VWF)-GP Ibalpha interaction under high shear rate was investigated...
  6. ncbi request reprint Involvement of glycoprotein VI in platelet thrombus formation on both collagen and von Willebrand factor surfaces under flow conditions
    Shinya Goto
    Division of Cardiology, Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Circulation 106:266-72. 2002
    ..We studied the role of glycoprotein (GP) VI in platelet adhesion and thrombus formation on the immobilized collagen and von Willebrand factor (vWF) surface under flow conditions...
  7. ncbi request reprint Different effects of various anti-GPIIb-IIIa agents on shear-induced platelet activation and expression of procoagulant activity
    S Goto
    Division of Cardiology, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan
    J Thromb Haemost 1:2022-30. 2003
    ....
  8. ncbi request reprint Understanding the mechanism and prevention of arterial occlusive thrombus formation by anti-platelet agents
    S Goto
    Division of Cardiology, Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Curr Med Chem Cardiovasc Hematol Agents 2:149-56. 2004
    ..We may then expect new antiplatelet agents on the horizon that exert their actions against both thrombus formation under blood flow conditions and against the procoagulant activity appearing on the surface of activated platelets...
  9. ncbi request reprint Understanding the mechanism of platelet thrombus formation under blood flow conditions and the effect of new antiplatelet agents
    Shinya Goto
    Division of Cardiology, Department of Medicine Tokai University School of Medicine Kanagawa, Japan
    Curr Vasc Pharmacol 2:23-32. 2004
    ..We now have new antiplatelet agents on the horizon, targeted against thrombus formation under blood flow conditions...
  10. ncbi request reprint Dependence of platelet thrombus stability on sustained glycoprotein IIb/IIIa activation through adenosine 5'-diphosphate receptor stimulation and cyclic calcium signaling
    Shinya Goto
    Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan
    J Am Coll Cardiol 47:155-62. 2006
    ..We sought to evaluate the mechanisms that support the stability of platelet aggregates on a thrombogenic surface exposed to flowing blood...
  11. ncbi request reprint Antiplatelet therapy after coronary intervention in Asia and Japan: the Asian perspective of antiplatelet intervention
    S Goto
    Department of Medicine Cardiology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Hamostaseologie 29:321-5. 2009
    ....
  12. ncbi request reprint Role of von Willebrand factor for the onset of arterial thrombosis
    S Goto
    Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Clin Lab 47:327-34. 2001
    ....
  13. ncbi request reprint Synergistic effect of epinephrine and shearing on platelet activation
    S Goto
    First Dept Intern Med, Tokai Univ School of Med, Isehara, Japan
    Thromb Res 84:351-9. 1996
    ..Our findings suggested that epinephrine and shearing synergistically activated platelets through vWF interaction to GP Ib, which might suggest the role of sympathetic stimulation for the onset of acute arterial thrombosis...
  14. pmc Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary artery disease
    Shinya Goto
    Department of Medicine Cardiology, Tokai University School of Medicine, Isehara, Kanagawa 259 1143, Japan
    Eur Heart J 31:2601-13. 2010
    ....
  15. ncbi request reprint Platelet surface P-selectin molecules increased after exposing platelet to a high shear flow
    S Goto
    Division of Cardiology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Int Angiol 19:147-51. 2000
    ....
  16. ncbi request reprint Functional compensation of the low platelet count by increased individual platelet size in a patient with May-Hegglin anomaly presenting with acute myocardial infarction
    S Goto
    Department of Medicine, Tokai University, School of Medicine, Isehara, Japan
    Int J Cardiol 64:171-7. 1998
    ....
  17. ncbi request reprint Specific inhibiting characteristics of tetramethylpyrazine, one of the active ingredients of the Chinese herbal medicine 'Chuanxiong,' on platelet thrombus formation under high shear rates
    M Li
    Division of Cardiology, Department of Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan
    Thromb Res 104:15-28. 2001
    ....
  18. ncbi request reprint Platelet aggregability under shear is enhanced in patients with unstable angina pectoris who developed acute myocardial infarction
    K Eto
    Department of Medicine, Teikyo University School of Medicine, Japan
    Jpn Circ J 65:279-82. 2001
    ....
  19. ncbi request reprint Two distinct mechanisms are involved in stent thrombosis under flow conditions
    K Eto
    Division of Cardiology, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan
    Platelets 12:228-35. 2001
    ....
  20. ncbi request reprint Platelet aggregation induced by ADP or epinephrine is enhanced in habitual smokers
    Y Fusegawa
    Department of Internal Medicine, School of Medicine, Tokai University, Isehara, Kanagawa, Japan
    Thromb Res 97:287-95. 2000
    ..These results confirmed that platelet aggregability is enhanced in smokers, and we speculate that long-term smoking might enhance the sensitivity of platelets to epinephrine or ADP...
  21. ncbi request reprint Estimation of left ventricular systolic pressure by the left ventricular volume-time curve obtained from electrocardiograph gated 99m Tc-tetrofosmin single photon emission tomography using quantitative gated SPECT
    K Ban
    Division of Cardiology, Department of Medicine, School of Medicine, Tokai University, Japan
    Nucl Med Commun 23:175-9. 2002
    ..69, P<0.01). Using QGS, LVSP and the systolic LV pressure-volume relationship could be estimated by the LV volume-time curve...
  22. ncbi request reprint Co-localization of von Willebrand factor with platelet thrombi, tissue factor and platelets with fibrin, and consistent presence of inflammatory cells in coronary thrombi obtained by an aspiration device from patients with acute myocardial infarction
    Y Hoshiba
    Department of Medicine, Tokai University School of Medicine, Shimokasuya, Isehara, Kanagawa, Japan
    J Thromb Haemost 4:114-20. 2006
    ..Detailed histochemical analysis of coronary thrombi obtained freshly from acute phase of myocardial infarction patients may provide information necessary to understand the mechanism of coronary occlusive thrombus formation...
  23. doi request reprint Disturbed blood flow induces erosive injury to smooth muscle cell-rich neointima and promotes thrombus formation in rabbit femoral arteries
    T Sumi
    Department of Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    J Thromb Haemost 8:1394-402. 2010
    ..Plaque erosion is a cause of atherothrombosis that preferentially occurs on smooth muscle cell (SMC)- and proteoglycan-rich rather than lipid-rich plaques. However, its underlying mechanisms remain unknown...
  24. ncbi request reprint On the mechanism of the failure of mitochondrial function in isolated guinea-pig myocytes subjected to a Ca2+ overload
    K Ban
    Department of Medicine, School of Medicine, Tokai University, Kanagawa, Japan
    Cardiovasc Res 44:556-67. 1999
    ..The influence of agents that inhibit the movement of Ca2+ across the mitochondrial membrane or Ca2+ dependent changes to this membrane upon the response of isolated ventricular myocytes to a Ca2+ overload has been investigated...
  25. ncbi request reprint Effects of pranlukast, a leukotriene receptor antagonist, on airway inflammation in mild asthmatics
    K Yamauchi
    The Third Department of Internal Medicine, Iwate Medical University, School of Medicine, Morioka, Japan
    J Asthma 38:51-7. 2001
    ..Pranlukast also increased values of peak expiratory flow significantly (p < 0.05). Pranlukast may be useful for mild asthmatics, in part through its ability to suppress eosinophilic airway infiltration...
  26. ncbi request reprint Longer longitudinal atrial dimension in patients with idiopathic paroxysmal atrial fibrillation: A possible cause of atrial fibrillation
    T Tanabe
    Department of Cardiology and the Laboratory of Echocardiography, School of Medicine, Tokai University, Isehara, Japan
    Am Heart J 142:669-78. 2001
    ..The structural details of the atria in patients with idiopathic PAF, however, remain unknown...
  27. ncbi request reprint Early reduction of neurohumoral factors plays a key role in mediating the efficacy of beta-blocker therapy for congestive heart failure
    T Yoshikawa
    Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Am Heart J 131:329-36. 1996
    ..Thus early reduction of neurohumoral factor levels preceded the late improvement of left ventricular contractile function and may therefore be partly responsible for the efficacy of beta-blocker therapy for congestive heart failure...
  28. ncbi request reprint Characterization of a patient with glycoprotein (GP) VI deficiency possessing neither anti-GPVI autoantibody nor genetic aberration
    H Kojima
    Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Thromb Haemost 4:2433-42. 2006
    ..There have been only seven reported cases of glycoprotein (GP) VI deficiency. However, the pathogenesis of this disorder has not been well-elucidated...
  29. ncbi request reprint A role for glycosphingolipid-enriched microdomains in platelet glycoprotein Ib-mediated platelet activation
    W Jin
    Department of Laboratory and Clinical Medicine, University of Yamanashi, Yamanashi, Japan
    J Thromb Haemost 5:1034-40. 2007
    ..As recent reports have suggested that GPIb partially locates in a particular region, designated as glycosphingolipid-enriched microdomains (GEMs), we hypothesized that GEMs play a central role in GPIb-mediated platelet activation...
  30. doi request reprint Sarpogrelate-Aspirin Comparative Clinical Study for Efficacy and Safety in Secondary Prevention of Cerebral Infarction (S-ACCESS): A randomized, double-blind, aspirin-controlled trial
    Yukito Shinohara
    Department of Neurology, Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, 4 2 22 Nishikicho, Tachikawa, Tokyo 190 8531, Japan
    Stroke 39:1827-33. 2008
    ..The antiplatelet agent sarpogrelate is a selective inhibitor of 5-hydroxytryptamine receptors. The purpose of this study was to compare the efficacy and safety of sarpogrelate with those of aspirin in Japanese ischemic stroke patients...
  31. ncbi request reprint Aberrant quality control in the endoplasmic reticulum impairs the biosynthesis of pulmonary surfactant in mice expressing mutant BiP
    N Mimura
    Department of Anesthesiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba City, Chiba, Japan
    Cell Death Differ 14:1475-85. 2007
    ..Moreover, failure of this adaptive mechanism may increase pulmonary susceptibility to environmental insults, such as hypoxia and ischemia, ultimately leading to neonatal respiratory failure...
  32. ncbi request reprint Indoleamine 2,3-dioxygenase is necessary for cytolytic activity of natural killer cells
    S Kai
    Department of Surgery I, Oita University, Hazama machi, Oita, Japan
    Scand J Immunol 59:177-82. 2004
    ..The cytotoxicity of NK cells against K562 and HepG2 cells was reduced by IDO inhibitor. These results suggest that IDO in NK cells is essential for NK cells to generate killing activity against cancer cells...
  33. ncbi request reprint Involvement of FGF-2 in the action of Emdogain on normal human osteoblastic activity
    S Mizutani
    Department of Pharmacology, School of Dentistry, Aichi Gakuin University, Nagoya, Japan
    Oral Dis 9:210-7. 2003
    ..The present study was designed to evaluate the pharmacological characteristics of Emdogain (EMD) on cell growth and cell activity in human osteoblasts...
  34. ncbi request reprint Activation of ribosomal S6 kinase (RSK) during porcine oocyte maturation
    K Sugiura
    Department of Animal Resource Sciences, Graduate School of Agricultural Sciences, University of Tokyo, Japan
    Zygote 10:31-6. 2002
    ..These results suggest that the activation of RSK is involved in the regulation of meiotic maturation of porcine oocytes...
  35. ncbi request reprint Effects of Sn, Ga, and In additives on properties of Ag-Pd-Au-Cu alloy for ultra-low fusing ceramics
    T Shimizu
    Department of Dental Materials Science, School of Dentistry at Niigata, Nippon Dental University, 1-8 Hamaura cho, Niigata City, Niigata 951-8580, Japan
    Dent Mater J 20:286-304. 2001
    ..Based on the evaluated properties three experimental alloys (2% Sn-added alloy, 4% Ga-added alloy and 2% In-added alloy) can be recommended as a suitable alloy for ceramic-metal restorations using ultra-low fusing ceramics...
  36. ncbi request reprint A resin veneer for enamel protection during orthodontic treatment
    H Miwa
    Department of Orthodontics, School of Dentistry, Aichi-Gakuin, University Nagoya, Japan
    Eur J Orthod 23:759-67. 2001
    ..It is suggested that application of a resin veneer prior to bracket bonding is suitable for clinical application to protect the teeth and to prevent decalcification and caries...
  37. ncbi request reprint UDP-sugar transporter implicated in glycosylation and processing of Notch
    S Goto
    Genetic Strain Research Center, National Institute of Genetics, Mishima, Shizuoka ken 411 8540, Japan
    Nat Cell Biol 3:816-22. 2001
    ..The results suggest that changes in nucleotide-sugar levels can differently affect Wingless and two distinct aspects of Notch signalling...
  38. ncbi request reprint Development of Ag-Pd-Au-Cu alloys for multiple dental applications. Part 2. Mechanical properties of experimental Ag-Pd-Au-Cu alloys containing Sn or Ga for ceramic-metal restorations
    S Goto
    Department of Dental Materials Science, Advanced Research Center, School of Dentistry at Niigata, The Nippon Dental University, Japan
    Dent Mater J 20:135-47. 2001
    ..Between the Ga- and Sn-added alloys, differences in tensile strength, proof stress, elongation and hardness were found at several Ag-Pd-Au-Cu compositions...
  39. ncbi request reprint Specification of the embryonic limb primordium by graded activity of Decapentaplegic
    S Goto
    Genetic Stock Research Center, National Institute of Genetics, Mishima, Japan
    Development 124:125-32. 1997
    ..We propose that Wingless and Decapentaplegic act sequentially to initiate the proximodistal axis...
  40. ncbi request reprint Calcineurin and synaptophysin in the human spinal cord of normal individuals and patients with familial dysautonomia
    S Goto
    Division of Neuropathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467
    Acta Neuropathol 79:647-52. 1990
    ..By contrast, there was a significant depletion of synaptophysin-positive axon terminals in the substantia gelatinosa and in the dorsal nucleus of Clarke of patients with familial dysautonomia...