Research Topics
Genomes and Genes | Kenshi YamasakiSummaryAffiliation: Tohoku University Country: Japan Publications
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Detail Information
Publications
TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytesKenshi Yamasaki
Division of Dermatology, Department of Medicine, University of California, San Diego, VA San Diego Health Care System, San Diego, California, USA
J Invest Dermatol 131:688-97. 2011..These observations show that abnormal TLR2 function may explain enhanced inflammatory responses to environmental stimuli and can act as a critical element in the pathogenesis of rosacea...
Increased serine protease activity and cathelicidin promotes skin inflammation in rosaceaKenshi Yamasaki
Division of Dermatology, University of California, San Diego, and VA San Diego Health Care System, 3350 La Jolla Village Drive, San Diego, California 92161, USA
Nat Med 13:975-80. 2007..These findings confirm the role of cathelicidin in skin inflammatory responses and suggest an explanation for the pathogenesis of rosacea by demonstrating that an exacerbated innate immune response can reproduce elements of this disease...- Staphylococcus epidermidis antimicrobial delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A StreptococcusAnna L Cogen
Division of Dermatology, University of California San Diego, San Diego, California, United States of America
PLoS ONE 5:e8557. 2010..Thus, these data suggest that S. epidermidis-derived delta-toxin cooperates with the host-derived antimicrobial peptides in the innate immune system to reduce survival of an important human bacterial pathogen... - NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injuryKenshi Yamasaki
Division of Dermatology, University of California, and Veterans Affairs San Diego Health Care System, San Diego, CA 92161, USA
J Biol Chem 284:12762-71. 2009..These findings support the hypothesis that hyaluronan works through IL-1beta and the cryopyrin system to signal sterile inflammation... - Cathelicidin antimicrobial peptides inhibit hyaluronan-induced cytokine release and modulate chronic allergic dermatitisYasuhide Morioka
Division of Dermatology, University of California, San Diego, and Veterans Affairs San Diego Health Care System, San Diego, California 92161, USA
J Immunol 181:3915-22. 2008..These results suggest that cathelicidin has anti-inflammatory activity in skin that may be mediated in part by inhibition of HA-mediated processes... - Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skinAnna L Cogen
Division of Dermatology, Department of Medicine, University of California San Diego, VA San Diego Health Care System, San Diego, California, USA
J Invest Dermatol 130:192-200. 2010..Thus, these data suggest that the production of PSMgamma and PSMdelta by S. epidermidis can benefit cutaneous immune defense by selectively inhibiting the survival of skin pathogens while maintaining the normal skin microbiome... - Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPSJun Muto
Division of Dermatology, University of California, San Diego and VA San Diego Health Care System, San Diego, CA 92161, USA
Mol Immunol 47:449-56. 2009..Therefore, our results show that hyaluronan acts through TLR4, CD44 and A20 to stimulate a unique cellular response that can protect against the septic response to LPS... - Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acidShin Morizane
Division of Dermatology, Department of Medicine, University of California, San Diego, San Diego, CA, USA
J Invest Dermatol 130:1297-306. 2010..Thus, these variables may further control the functions of antimicrobial peptides in the skin... - Cathelicidin antimicrobial peptide LL-37 in psoriasis enables keratinocyte reactivity against TLR9 ligandsShin Morizane
Division of Dermatology, Department of Medicine, University of California, San Diego and VA San Diego Healthcare System, San Diego, California, USA
J Invest Dermatol 132:135-43. 2012..These findings suggest that keratinocytes recognize and respond to DNA and can actively participate in contributing to the immunological environment that characterizes psoriasis... - Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skinKenshi Yamasaki
Division of Dermatology, University of California, San Diego, and VA San Diego Health Care System, San Diego, California, USA
FASEB J 20:2068-80. 2006..These observations demonstrate that the balance of proteolytic activity at an epithelial interface will control innate immune defense... - Mast cell cathelicidin antimicrobial peptide prevents invasive group A Streptococcus infection of the skinAnna Di Nardo
Department of Medicine, Division of Dermatology, University of California, San Diego and Veteran s Affairs Medical Center San Diego, CA 92161, USA
J Immunol 180:7565-73. 2008..Combined, these results show that MC confer defense against Gram-positive bacterial infection in the skin, a function mediated in part by the expression of a unique cathelicidin peptide... - CC chemokine ligand 3 overcomes the bacteriocidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- miceAnke Leichtle
Division of Otolaryngology, Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA
J Immunol 184:3087-97. 2010..Manipulation of CCL3 and/or TNF may prove to be effective therapeutic approaches in OM or other conditions associated with defective TNF generation... - The molecular pathology of rosaceaKenshi Yamasaki
Division of Dermatology, University of California, San Diego, CA 92161, USA
J Dermatol Sci 55:77-81. 2009..This article discusses the possible molecular mechanisms for the pathogenesis of rosacea from current clinical observations and laboratory research... - Exogenous addition of a C-xylopyranoside derivative stimulates keratinocyte dermatan sulfate synthesis and promotes migrationJun Muto
Division of Dermatology, University of California, San Diego and Veterans Affairs San Diego Health Care System, San Diego, California, United States of America
PLoS ONE 6:e25480. 2011..These results indicate that C-Xyloside may enhance epithelial repair by serving as an initiator of DS synthesis... - Antimicrobial peptides in human skin diseaseKenshi Yamasaki
Division of Dermatology, University of California, San Diego MC 9111B, San Diego, California 92161, USA
Eur J Dermatol 18:11-21. 2008.... - Control of the innate epithelial antimicrobial response is cell-type specific and dependent on relevant microenvironmental stimuliJürgen Schauber
Division of Dermatology, University of California, San Diego and VA San Diego Healthcare System, San Diego, CA, USA
Immunology 118:509-19. 2006.... - Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2Kristen R Taylor
Division of Dermatology, University of California, San Diego and Veterans Affairs Medical Center, San Diego, California 92161, USA
J Biol Chem 282:18265-75. 2007..Taken together, our results define a previously unknown mechanism for initiation of sterile inflammation that involves recognition of released hyaluronan fragments as an endogenous signal of tissue injury... - Anti-fungal activity of cathelicidins and their potential role in Candida albicans skin infectionBelen Lopez-Garcia
Division of Dermatology, University of California San Diego, and VA San Diego Healthcare Center, San Diego, California 92161, USA
J Invest Dermatol 125:108-15. 2005..albicans in blood-killing assays or in an intradermal infection model. Therefore, cathelicidins appear active against C. albicans, but may be most effective as a superficial barrier to infection...