Tohru Yamakuni

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi request reprint Expression of V-1, a novel catecholamine biosynthesis regulatory protein, is enhanced by hypertension in atrial myocytes of Dahl salt-sensitive rats
    Tohru Yamakuni
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Biochem Biophys Res Commun 298:793-7. 2002
  2. ncbi request reprint [Preventive action of nobiletin, a constituent of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, against amyloid-beta peptide-induced neurotoxicity expression and memory impairment]
    Tohru Yamakuni
    Tohoku University, Sendai, Japan
    Yakugaku Zasshi 130:517-20. 2010
  3. ncbi request reprint Pharmacological action of nobiletin, a component of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, and its application for development of functional foods
    Tohru Yamakuni
    Nihon Yakurigaku Zasshi 132:155-9. 2008
  4. ncbi request reprint V-1, a catecholamine biosynthesis regulatory protein, positively controls catecholamine secretion in PC12D cells
    Tohru Yamakuni
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba ku, Sendai 980 8578, Japan
    FEBS Lett 530:94-8. 2002
  5. doi request reprint 4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade
    Md Al Rahim
    Laboratory of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba ku, Sendai 980 8578, Japan
    Biochemistry 48:7713-21. 2009
  6. doi request reprint Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action
    Ichiro Kawahata
    Department of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3 Aoba, Aramaki Aoba ku, Sendai, 980 8578, Japan
    J Neural Transm 120:1397-409. 2013
  7. ncbi request reprint Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice
    Akira Nakajima
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
    J Pharmacol Sci 105:122-6. 2007
  8. doi request reprint Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation
    Yui Yamamoto
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki Aoba Aoba ku, Sendai 980 8578, Japan
    Brain Res 1295:218-29. 2009
  9. ncbi request reprint Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus
    Kentaro Matsuzaki
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3 Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Eur J Pharmacol 578:194-200. 2008
  10. ncbi request reprint Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's disease
    Hiroshi Onozuka
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3 Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    J Pharmacol Exp Ther 326:739-44. 2008

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Expression of V-1, a novel catecholamine biosynthesis regulatory protein, is enhanced by hypertension in atrial myocytes of Dahl salt-sensitive rats
    Tohru Yamakuni
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Biochem Biophys Res Commun 298:793-7. 2002
    ..It is also suggested that V-1 expression is increased by hypertension in DS rat atrium...
  2. ncbi request reprint [Preventive action of nobiletin, a constituent of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, against amyloid-beta peptide-induced neurotoxicity expression and memory impairment]
    Tohru Yamakuni
    Tohoku University, Sendai, Japan
    Yakugaku Zasshi 130:517-20. 2010
    ..The natural compound with these unique actions has thus potential to become a novel drug for fundamental treatment of AD...
  3. ncbi request reprint Pharmacological action of nobiletin, a component of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, and its application for development of functional foods
    Tohru Yamakuni
    Nihon Yakurigaku Zasshi 132:155-9. 2008
  4. ncbi request reprint V-1, a catecholamine biosynthesis regulatory protein, positively controls catecholamine secretion in PC12D cells
    Tohru Yamakuni
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba ku, Sendai 980 8578, Japan
    FEBS Lett 530:94-8. 2002
    ..These results suggest that the enhancement of high K(+)-induced dopamine secretion by V-1 overexpression results from the potentiation of high K(+)-induced [Ca(2+)](i) elevation and the increase in the number of dense-cored vesicles...
  5. doi request reprint 4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade
    Md Al Rahim
    Laboratory of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba ku, Sendai 980 8578, Japan
    Biochemistry 48:7713-21. 2009
    ....
  6. doi request reprint Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action
    Ichiro Kawahata
    Department of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3 Aoba, Aramaki Aoba ku, Sendai, 980 8578, Japan
    J Neural Transm 120:1397-409. 2013
    ..These findings suggest that above four compounds and nobiletin in the Nchinpi extract mainly cooperated to facilitate potently CRE-mediated transcription linked to the upstream cAMP/PKA/ERK/CREB pathway in hippocampal neurons...
  7. ncbi request reprint Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice
    Akira Nakajima
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
    J Pharmacol Sci 105:122-6. 2007
    ..These results suggest that nobiletin rescues OBX-induced cholinergic neurodegeneration, accompanied by improvement of impaired memory in OBX mice...
  8. doi request reprint Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation
    Yui Yamamoto
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki Aoba Aoba ku, Sendai 980 8578, Japan
    Brain Res 1295:218-29. 2009
    ..These findings suggest that the activation of CaMKII and ERK signaling in part mediates improvement of ischemia-induced learning and memory deficits by nobiletin...
  9. ncbi request reprint Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus
    Kentaro Matsuzaki
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3 Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Eur J Pharmacol 578:194-200. 2008
    ..These findings suggest that nobiletin probably up-regulates synaptic transmission via the postsynaptic AMPA receptors at least partially by stimulation of PKA-mediated phosphorylation of GluR1 receptor in the hippocampus...
  10. ncbi request reprint Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's disease
    Hiroshi Onozuka
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3 Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    J Pharmacol Exp Ther 326:739-44. 2008
    ..These findings suggest that this natural compound has potential to become a novel drug for fundamental treatment of AD...
  11. ncbi request reprint Nobiletin restoring beta-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats
    Kentaro Matsuzaki
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Neurosci Lett 400:230-4. 2006
    ..In the AD model rats, nobiletin showed protective effects on Abeta(1-40)-induced impairment of learning ability. These results suggest that nobiletin has the potential for becoming a novel lead compound for drug development for AD...
  12. ncbi request reprint Three-membered ring sesquiterpenoids with NGF-potentiating activity from the roots of Valeriana fauriei
    Yuanqiang Guo
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Planta Med 72:373-5. 2006
    ..Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2 and 3 showed enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC 12D cells...
  13. doi request reprint A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Abeta-inhibition of the cascade in cultured rat CNS neurons
    Md Al Rahim
    Department of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Sendai, Japan
    Eur J Pharmacol 600:10-7. 2008
    ....
  14. ncbi request reprint Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells
    Ping Li
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Sendai, Aoba 980 8578, Japan
    Brain Res Dev Brain Res 145:177-83. 2003
    ..Nardosinone is the first enhancer of the neuritogenic action of dbcAMP and staurosporine and may become a useful pharmacological tool for studying the mechanism of action of not only NGF but also both the neuritogenic substances...
  15. ncbi request reprint Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana
    Yuanqiang Guo
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
    J Nat Prod 69:274-6. 2006
    ..A known compound, 7-oxo-ent-clerod-3-en-15,16:18,19-diolide, was also identified. Compounds 1 and 2 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells...
  16. ncbi request reprint Garcinone B reduces prostaglandin E2 release and NF-kappaB-mediated transcription in C6 rat glioma cells
    Tohru Yamakuni
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Neurosci Lett 394:206-10. 2006
    ..These results suggest that garcinone B becomes a unique pharmacological tool to investigate intracellular signaling pathways involved in inflammation...
  17. ncbi request reprint Nobiletin, a citrus flavonoid, reverses learning impairment associated with N-methyl-D-aspartate receptor antagonism by activation of extracellular signal-regulated kinase signaling
    Akira Nakajima
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6 6 11 404 Aoba, Aramaki, Aoba ku, Sendai 980 8579, Japan
    J Pharmacol Exp Ther 321:784-90. 2007
    ....
  18. doi request reprint High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound
    Daisuke Saigusa
    Laboratory of Oncology Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Science, Tohoku University, Aoba ku, Sendai, Japan
    Anal Bioanal Chem 400:3635-41. 2011
    ..025-10 ng, with coefficient of variation of less than 6.76%. This method enabled us to determine pharmacokinetic parameters of nobiletin given intraperitoneally or per os in the brain of mice...
  19. ncbi request reprint Ca2+ channel activating action of maitotoxin in cultured brainstem neurons
    Atsushi Kakizaki
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Eur J Pharmacol 536:223-31. 2006
    ....
  20. ncbi request reprint Evidence for the involvement of protein kinase C in acidic pH-induced contraction in spontaneously hypertensive rat aorta
    Dileep Kumar Rohra
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Pharmacology 71:10-6. 2004
    ..Furthermore, PKC- and tyrosine kinase-dependent pathways underlying the APIC are independent of each other...
  21. ncbi request reprint Proinsulin C-peptide stimulates a PKC/IkappaB/NF-kappaB signaling pathway to activate COX-2 gene transcription in Swiss 3T3 fibroblasts
    Masashi Kitazawa
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578
    J Biochem 139:1083-8. 2006
    ..These results suggest that C-peptide stimulates the transcription of inflammatory genes via activation of a PKC/IkappaB/NF-kappaB signaling pathway...
  22. ncbi request reprint Nobiletin induces inhibitions of Ras activity and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling to suppress cell proliferation in C6 rat glioma cells
    Koichi Aoki
    Department of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Tohoku University
    Biol Pharm Bull 36:540-7. 2013
    ..Thus, the natural compound has potential to be a therapeutic agent for glioma...
  23. ncbi request reprint Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities
    Hiroyuki Nagase
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Biochem Biophys Res Commun 337:1330-6. 2005
    ..These results suggest that nobiletin with the activity to improve impaired memory may become a potential leading compound for drug development for neurodegenerative disorders exhibiting the dysregulated CRE-dependent transcription...
  24. ncbi request reprint Mechanism of neurotrophic action of nobiletin in PC12D cells
    Hiroyuki Nagase
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Biochemistry 44:13683-91. 2005
    ....
  25. ncbi request reprint Acidosis-induced protein tyrosine phosphorylation depends on Ca2+ influx via voltage-dependent Ca2+ channels in SHR aorta
    Dileep Kumar Rohra
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Eur J Pharmacol 504:105-11. 2004
    ..These findings suggest that acidosis-induced Ca2+ influx through VDCC is the upstream event leading to the tyrosine phosphorylation of PI3-kinase, which in turn contributes to the enhancement of Ca2+ entry to some extent in SHR aorta...
  26. ncbi request reprint Honeybee royal jelly and nobiletin stimulate CRE-mediated transcription in ERK-independent and -dependent fashions, respectively, in PC12D cells
    Hironori Fujiwara
    Department of Anti dementia Functional Food Development, Graduate School of Engineering, Tohoku University, Japan
    J Pharmacol Sci 116:384-7. 2011
    ..Combining RJ plus nobiletin may activate effectively neuronal functions via enhancement of CRE-mediated transcription...
  27. ncbi request reprint Ephedorae herba decreases lipopolysaccharide-induced cyclooxgenase-2 protein expression and NF-kappaB-dependent transcription in C6 rat glioma cells
    Kohichi Aoki
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    J Pharmacol Sci 98:327-30. 2005
    ..These results suggest that Mao prevents LPS-induced NF-kappaB-dependent transcription by inhibiting IkappaB degradation and suppresses an increase in COX-2 protein expression in C6 cells...
  28. ncbi request reprint Glucocorticoid inhibits expression of V-1, a catecholamine biosynthesis regulatory protein, in cultured adrenal medullary cells
    Yusuke Hiwatashi
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba ku, Sendai 980 8578, Japan
    FEBS Lett 528:166-70. 2002
    ....
  29. ncbi request reprint Nardosinone enhances nerve growth factor-induced neurite outgrowth in a mitogen-activated protein kinase- and protein kinase C-dependent manner in PC12D cells
    Ping Li
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    J Pharmacol Sci 93:122-5. 2003
    ..These results suggest that the enhancement of NGF-induced neurite outgrowth from PC12D cells by nardosinone involves activation of a down-stream step of the MAP kinase-dependent cascade of NGF coupled with PKC...
  30. ncbi request reprint Stimulated tyrosine phosphorylation of phosphatidylinositol 3-kinase causes acidic pH-induced contraction in spontaneously hypertensive rat aorta
    Dileep Kumar Rohra
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    J Pharmacol Exp Ther 303:1255-64. 2002
    ..These results suggest that acidic pH induces an increase in tyrosine phosphorylation of PI3-kinase, resulting in the MLC phosphorylation-dependent contraction of SHR aorta...
  31. ncbi request reprint Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei
    Yuanqiang Guo
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Chem Pharm Bull (Tokyo) 54:123-5. 2006
    ..Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2 and 4 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells...
  32. ncbi request reprint Intracellular cAMP controls a physical association of V-1 with CapZ in cultured mammalian endocrine cells
    Masashi Kitazawa
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Biochem Biophys Res Commun 331:181-6. 2005
    ....
  33. doi request reprint Repeated treatment with nicotine induces phosphorylation of NMDA receptor NR2B subunit in the brain regions involved in behavioral sensitization
    Akira Nakajima
    Department of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Neurosci Lett 524:133-8. 2012
    ....
  34. ncbi request reprint Neurobehavioral effects of tetrabromobisphenol A, a brominated flame retardant, in mice
    Akira Nakajima
    Laboratory of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Toxicol Lett 189:78-83. 2009
    ..Together, the possibility of widespread human exposure to TBBPA warrants further studies to characterize its neurotoxicity...
  35. ncbi request reprint gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells
    Keigo Nakatani
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Mol Pharmacol 66:667-74. 2004
    ....
  36. ncbi request reprint IC101 induces apoptosis by Akt dephosphorylation via an inhibition of heat shock protein 90-ATP binding activity accompanied by preventing the interaction with Akt in L1210 cells
    Hironori Fujiwara
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    J Pharmacol Exp Ther 310:1288-95. 2004
    ..These results suggest that IC101 dephosphorylates Akt through an inhibition of HSP90 functions, resulting in the interaction with Akt to induce apoptotic cell death of L1210 cells...
  37. ncbi request reprint [V-1, a catecholamine biosynthesis regulatory protein, enhances GTP cyclohydrolase I gene transcription in a cAMP-responsive element dependent manner]
    Tohru Yamakuni
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
    Nihon Yakurigaku Zasshi 120:82P-84P. 2002
    ..These results suggest that V-1 promotes GCH gene expression via a CRE-dependent transcription to positively control the BH4 biosynthesis in catecholaminergic cells...
  38. doi request reprint SLC10A4 is a protease-activated transporter that transports bile acids
    Takuya Abe
    Laboratory of Oncology, Pharmacy Practice and Sciences, Department of Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    J Biochem 154:93-101. 2013
    ..Therefore, SLC10A4 may have low activity but becomes activated by proteases, including thrombin, following cleavage. We have demonstrated that SLC10A4 appears to be a protease-activated transporter and transports bile acids. ..
  39. ncbi request reprint Metronomic scheduling of a cyclic hexapeptide Ra-VII for anti-angiogenesis, tumor vessel maturation and anti-tumor activity
    Takayuki Koizumi
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 857, Japan
    Cancer Sci 97:665-74. 2006
    ..A careful dose setting of RA-VII is crucial to obtain therapeutic superiority, possibly through tumor vessel maturation and a better distribution of the compound in the tumor tissue...
  40. ncbi request reprint Picrosides I and II, selective enhancers of the mitogen-activated protein kinase-dependent signaling pathway in the action of neuritogenic substances on PC12D cells
    Ping Li
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Life Sci 71:1821-35. 2002
    ..Picrosides I and II may become selective pharmacological tools for studying the MAP kinase-dependent signaling pathway in outgrowth of neurites induced by many kinds of neuritogenic substances including bFGF...
  41. ncbi request reprint Down-regulation of an ankyrin repeat-containing protein, V-1, during skeletal muscle differentiation and its re-expression in the regenerative process of muscular dystrophy
    Yuko Furukawa
    Mitsubishi Kagaku Institute of Life Sciences, Minamiooya 11, Machida, 194 8511, Tokyo, Japan
    Neuromuscul Disord 13:32-41. 2003
    ..Thus, it seems that V-1 is a good marker for early stage of muscle regeneration and changes of its expression suggest that V-1 plays a role in prenatal muscle differentiation and postnatal muscle regeneration...
  42. ncbi request reprint Enhanced expression of GTP cyclohydrolase I in V-1-overexpressing PC12D cells
    Takahiro Suzuki
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Biochem Biophys Res Commun 293:962-8. 2002
    ..Promoter analysis showed increased reporter activity in the construct with 150 bp of the promoter region of the human GCH gene, suggesting the involvement of cAMP-responsive element-mediated transcriptional regulation...
  43. ncbi request reprint Overexpression of V-1 prevents nitric oxide-induced cell death: involvement of enhanced tetrahydrobiopterin biosynthesis
    Kohei Yuyama
    Laboratory of Molecular Recognition, Graduate School of Integrated Science, Yokohama City University, Yokohama, Japan
    J Neurosci Res 72:716-25. 2003
    ..Moreover, these findings suggest the up-regulation of V1 expression as a possible therapeutic target for protection against the insult of NO-induced oxidative stress...
  44. ncbi request reprint Clerodane diterpenoids and flavonoids with NGF-potentiating activity from the aerial parts of Baccharis gaudichaudiana
    Yuanqiang Guo
    Department of Pharmaceutical Sciences, Nankai University, Tianjin, P R China
    Chem Pharm Bull (Tokyo) 55:1532-4. 2007
    ..Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2, 3, and 5 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells...
  45. ncbi request reprint Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene
    Takahiro Suzuki
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    J Biol Chem 277:40768-74. 2002
    ....