Toshiyuki Takai

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. pmc Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity
    Tomohiro Kubo
    Department of Experimental Immunology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Exp Med 206:1971-82. 2009
  2. pmc Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation
    Ai Masuda
    Department of Experimental Immunology, Japan Science and Technology Agency, Tohoku University, Aoba ku, Sendai shi 980 8575, Japan
    J Exp Med 204:907-20. 2007
  3. pmc Fcgamma receptor IIB-deficient mice develop Goodpasture's syndrome upon immunization with type IV collagen: a novel murine model for autoimmune glomerular basement membrane disease
    A Nakamura
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Exp Med 191:899-906. 2000
  4. pmc Lyn is essential for fcgamma receptor III-mediated systemic anaphylaxis but not for the Arthus reaction
    T Yuasa
    Department of Experimental Immunology and the Core Research for Evolutional Science and Technology CREST Program of Japan Science and Technology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Exp Med 193:563-72. 2001
  5. ncbi request reprint [Immune dysfunctions in Fc receptor-deficient mice]
    Toshiyuki Takai
    Tanpakushitsu Kakusan Koso 47:2375-81. 2002
  6. pmc Paired immunoglobulin-like receptors and their MHC class I recognition
    Toshiyuki Takai
    Department of Experimental Immunology and CREST Program of the Japan Science and Technology Agency, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Immunology 115:433-40. 2005
  7. ncbi request reprint Fc receptors and their role in immune regulation and autoimmunity
    Toshiyuki Takai
    Department of Experimental Immunology and CREST Program of Japan Science and Technology Agency, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Clin Immunol 25:1-18. 2005
  8. pmc Role of PIR-B in autoimmune glomerulonephritis
    Toshiyuki Takai
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Biomed Biotechnol 2011:275302. 2011
  9. ncbi request reprint [Allergy and autoimmunity mediated by IgG and Fcgamma receptors]
    Toshiyuki Takai
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Japan
    Arerugi 54:1183-9. 2005
  10. ncbi request reprint Fc receptors as potential targets for the treatment of allergy, autoimmune disease and cancer
    Toshiyuki Takai
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    Curr Drug Targets Immune Endocr Metabol Disord 3:187-97. 2003

Detail Information

Publications74

  1. pmc Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity
    Tomohiro Kubo
    Department of Experimental Immunology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Exp Med 206:1971-82. 2009
    ....
  2. pmc Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation
    Ai Masuda
    Department of Experimental Immunology, Japan Science and Technology Agency, Tohoku University, Aoba ku, Sendai shi 980 8575, Japan
    J Exp Med 204:907-20. 2007
    ..Thus, the constitutive cis binding between LILRB2 or PIR-B and MHC class I has an essential role in regulating allergic responses...
  3. pmc Fcgamma receptor IIB-deficient mice develop Goodpasture's syndrome upon immunization with type IV collagen: a novel murine model for autoimmune glomerular basement membrane disease
    A Nakamura
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Exp Med 191:899-906. 2000
    ..These results highlight the role of FcgammaRIIB in maintaining tolerance and suggest that it may play a role in the pathogenesis of human GPS...
  4. pmc Lyn is essential for fcgamma receptor III-mediated systemic anaphylaxis but not for the Arthus reaction
    T Yuasa
    Department of Experimental Immunology and the Core Research for Evolutional Science and Technology CREST Program of Japan Science and Technology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Exp Med 193:563-72. 2001
    ..These findings provide us with insight into distinct signaling mechanisms in mast cells underlying the development of diverse pathologies as well as a therapeutic potential for selective treatment of allergic disorders...
  5. ncbi request reprint [Immune dysfunctions in Fc receptor-deficient mice]
    Toshiyuki Takai
    Tanpakushitsu Kakusan Koso 47:2375-81. 2002
  6. pmc Paired immunoglobulin-like receptors and their MHC class I recognition
    Toshiyuki Takai
    Department of Experimental Immunology and CREST Program of the Japan Science and Technology Agency, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Immunology 115:433-40. 2005
    ..Thus, PIR-A and PIR-B constitute a novel and physiologically important MHC class I recognition system...
  7. ncbi request reprint Fc receptors and their role in immune regulation and autoimmunity
    Toshiyuki Takai
    Department of Experimental Immunology and CREST Program of Japan Science and Technology Agency, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Clin Immunol 25:1-18. 2005
    ..This review is aimed at providing a current overview of the mechanism of Fc receptor-based immune regulation and the possible scenario of how autoimmune disease might result from their dysfunction...
  8. pmc Role of PIR-B in autoimmune glomerulonephritis
    Toshiyuki Takai
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Biomed Biotechnol 2011:275302. 2011
    ..Thus, PIR-B is an important regulator of innate immunity mediated by TLR9 in B-1 cells, which can otherwise provoke autoimmunity when overactivated...
  9. ncbi request reprint [Allergy and autoimmunity mediated by IgG and Fcgamma receptors]
    Toshiyuki Takai
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Japan
    Arerugi 54:1183-9. 2005
  10. ncbi request reprint Fc receptors as potential targets for the treatment of allergy, autoimmune disease and cancer
    Toshiyuki Takai
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    Curr Drug Targets Immune Endocr Metabol Disord 3:187-97. 2003
    ..This review summarizes recent advances in Fc receptor biomedicine in light of exploiting them as potential therapeutic targets for allergy, autoimmune disease and cancer...
  11. ncbi request reprint Roles of Fc receptors in autoimmunity
    Toshiyuki Takai
    Department of Experimental Immunology, Japan Science and Technology Corporation, Institute of Development, Ageing and Cancer, Tohoku University, Seiryo, Sendai, Japan
    Nat Rev Immunol 2:580-92. 2002
  12. doi request reprint Transcriptional activation of the Pirb gene in B cells by PU.1 and Runx3
    Kojo Arita
    Department of Experimental Immunology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Immunol 186:7050-9. 2011
    ..1, but not Runx3, knockdown reduced the levels of both the Pirb and Pira transcripts. We conclude that the major promoter of Pirb, and probably Pira as well, is activated dominantly by PU.1 and marginally by Runx3 in B cells...
  13. ncbi request reprint Activating and inhibitory nature of the murine paired immunoglobulin-like receptor family
    T Takai
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Immunol Rev 181:215-22. 2001
    ..Although the ligand for PIR still remains unknown, the transgenics and the gene-targeted mice will provide us with valuable information on their physiological roles in the immune regulation...
  14. doi request reprint The study of allergy by Japanese researchers: a historical perspective
    Toshiyuki Takai
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Int Immunol 21:1311-6. 2009
    ..This article is aimed at introducing such individual work and how these areas have contributed to our understanding of the mechanisms of allergic reactions...
  15. ncbi request reprint Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake
    Ayumi Yada
    Department of Experimental Immunology and the CREST Program of Japan Science and Technology Corporation, Institute of Development, Aging and Cancer, Tohoku University, 980 8575, Sendai, Japan
    Cell Immunol 225:21-32. 2003
    ..These results support the therapeutic benefits of antigen-targeting to FcgammaR on APC in the various inflammatory disorders...
  16. ncbi request reprint Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development
    Yu Mori
    Department of Experimental Immunology, Institute of Development, Aging, and Cancer, and Center of Excellence Program for Innovative Therapeutic Development Towards the Conquest of Signal Transduction Diseases, Tohoku University, Sendai, Japan
    J Immunol 181:4742-51. 2008
    ..Modulation of these regulatory receptors may be a novel way to control various skeletal system disorders and inflammatory arthritis...
  17. ncbi request reprint FcgammaRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease
    Kaori Yajima
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Eur J Immunol 33:1020-9. 2003
    ..Thus, Fc gamma RIIB deletion with Fas mutation is sufficient for the development of systemic autoimmunity in B6 mice. The inhibitory signaling cascade via Fc gamma RIIB may be critical for suppressing SLE in humans...
  18. ncbi request reprint Immortalized dendritic cell line with efficient cross-priming ability established from transgenic mice harboring the temperature-sensitive SV40 large T-antigen gene
    Shin Ebihara
    Department of Experimental Immunology, and the CREST Program of Japan Science and Techonology Agency JST, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Biochem 136:321-8. 2004
    ....
  19. pmc Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12
    Masanori Inui
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Seiryo 4 1, Sendai 980 8575, Japan
    Proc Natl Acad Sci U S A 106:4816-21. 2009
    ....
  20. pmc Regulation of cytotoxic T lymphocyte triggering by PIR-B on dendritic cells
    Shota Endo
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    Proc Natl Acad Sci U S A 105:14515-20. 2008
    ..On surface plasmon resonance analysis, PIR-B and CD8alpha alpha were revealed to compete in binding to MHC-I. Our results may provide a novel strategy for regulating CTL-mediated immunity and diseases in a sterical manner...
  21. ncbi request reprint Activating Fc gamma receptors participate in the development of autoimmune diabetes in NOD mice
    Yoshihiro Inoue
    Department of Experimental Immunology, Tohoku University, Sendai, Japan
    J Immunol 179:764-74. 2007
    ..These findings highlight the critical roles of activating Fc gammaRs in the development of T1D, and indicate that Fc gammaRs are novel targets for therapies for T1D...
  22. ncbi request reprint Deregulation of peripheral B-cell development in enhanced severity of collagen-induced arthritis in FcgammaRIIB-deficient mice
    Akira Nakamura
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Seiryo machi 4 1, Sendai 980 8575, Japan
    J Autoimmun 20:227-36. 2003
    ..IIB-/-. These findings suggest that the FcgammaRIIB-dependent triple regulation in the peripheral T2 B cells, in the antibody production, and in the effector cell responses is crucial for suppressing CIA...
  23. doi request reprint A novel regulatory role of gp49B on dendritic cells in T-cell priming
    Satoshi Kasai
    Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Eur J Immunol 38:2426-37. 2008
    ..These findings demonstrate a novel regulatory role of gp49B in the function of DC...
  24. ncbi request reprint Exacerbated graft-versus-host disease in Pirb-/- mice
    Akira Nakamura
    Department of Experimental Immunology and Core Research for Evolutional Science and Technology Program, Japan Science and Technology Agency, Institute of Development, Aging and Cancer, Tohoku University, Seiryo 4 1, Sendai 980 8575, Japan
    Nat Immunol 5:623-9. 2004
    ..Thus, PIR-A and PIR-B are counteracting receptors that are essential for successful tissue transplantation and may regulate irrelevant reaction to autologous tissues in a constitutive way in physiological conditions...
  25. ncbi request reprint Establishment and functional characterization of novel natural killer cell lines derived from a temperature-sensitive SV40 large T antigen transgenic mouse
    Satoru Iizuka
    Department of Experimental Immunology and the CREST Program of the Japan Science and Technology Corporation JST and Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575
    J Biochem 140:255-65. 2006
    ..In addition, one clone could serve as a host for transient as well as stable gene transfection. Taken together, these findings indicate that the cell lines could constitute useful tools for detailed analysis of murine NK cell biology...
  26. doi request reprint Ectopically expressed PIR-B on T cells constitutively binds to MHC class I and attenuates T helper type 1 responses
    Michiyo Imada
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Int Immunol 21:1151-61. 2009
    ..Our findings suggest that T cell expression of PIR-B with the cis-interacting MHC class I is strictly prohibited in periphery so as to secure prompt immune responses...
  27. doi request reprint Regulation of plasmacytoid dendritic cell responses by PIR-B
    Yoshiya Mitsuhashi
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Blood 120:3256-9. 2012
    ..These results demonstrate a novel regulatory role for PIR-B in PDCs...
  28. pmc Differential but competitive binding of Nogo protein and class i major histocompatibility complex (MHCI) to the PIR-B ectodomain provides an inhibition of cells
    Haruka Matsushita
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Biol Chem 286:25739-47. 2011
    ..Thus, we propose a novel mechanism by which PIR-B-mediated regulation is achieved differentially but competitively via MHCI and Nogo in cells of the immune system...
  29. ncbi request reprint Targeting apoptotic tumor cells to Fc gamma R provides efficient and versatile vaccination against tumors by dendritic cells
    Kenichi Akiyama
    Department of Experimental Immunology and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Sendai, Japan
    J Immunol 170:1641-8. 2003
    ..These results show that using ATC-ICs may overcome the limitations and may enhance the immune response of current ATC-based DC vaccination therapy...
  30. ncbi request reprint [Immune regulation by Fc receptors]
    Toshiyuki Takai
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University
    Nihon Rinsho 63:420-7. 2005
  31. ncbi request reprint Impaired dendritic cell maturation and increased T(H)2 responses in PIR-B(-/-) mice
    Azusa Ujike
    Department of Experimental Immunology and CREST Program of JST, Institute of Development, Aging and Cancer, Tohoku University, Seiryo 4 1, Sendai 980 8575, Japan
    Nat Immunol 3:542-8. 2002
    ..Thus, PIR-B is critical for B cell suppression, DC maturation and for balancing T(H)1 and T(H)2 immune responses...
  32. pmc Increased susceptibility to LPS-induced endotoxin shock in secretory leukoprotease inhibitor (SLPI)-deficient mice
    Akira Nakamura
    Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Exp Med 197:669-74. 2003
    ..SLPI(-/-) B cells show more proliferation and IgM production after LPS treatment than SLPI(+/+) B cells. Our results suggest that SLPI attenuates excessive inflammatory responses and thus assures balanced functioning of innate immunity...
  33. ncbi request reprint [Regulatory mechanisms of osteoclast development and bone disorders]
    Masanori Inui
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Seiryo 4 1, Aoba ku, Sendai 980 8575, Japan
    Seikagaku 78:250-6. 2006
  34. doi request reprint Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells
    Won Fen Wong
    Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Immunol 188:5408-20. 2012
    ..Our data indicate that Runx1 plays an essential role in repressing the transcription of cytokine genes in naive CD4(+) T cells and, thereby, maintains cell quiescence...
  35. doi request reprint Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals
    Masahiro Shinohara
    Department of Cell Signaling, Graduate School, Tohoku University, Seiryo machi 4 1, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Cell 132:794-806. 2008
    ..Thus, this study reveals the importance of the osteoclastogenic signaling complex composed of tyrosine kinases, which may provide the molecular basis for a new therapeutic strategy...
  36. ncbi request reprint A role of FcgammaRIIB in the development of collagen-induced arthritis
    Akira Nakamura
    Department of Experimental Immunology and CREST Program of Japan Science and Technology Agency, Institute of Development, Aging and Cancer, Tohoku University, Seiryo 4 1, Sendai 980 8575, Japan
    Biomed Pharmacother 58:292-8. 2004
    ..This review provides an overview of FcgammaRIIB-mediated immune regulation, highlighting the implication of FcgammaRIIB in the selection of peripheral B cell development during the CIA course...
  37. ncbi request reprint Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer
    Akira Nakamura
    Tohoku University, Department of Experimental Immunology and CREST programme of Japan Science and Technology Agency, Institute of Development, Ageing and Cancer, Seiryo 4 1, Sendai 980 8575, Japan
    Expert Opin Ther Targets 9:169-90. 2005
    ..This review summarises recent advances of FcR, which were mainly obtained by murine studies, and highlights novel antibodies as possible FcR-targeting therapies for allergy, autoimmune diseases and cancer...
  38. ncbi request reprint Increased susceptibility of MER5 (peroxiredoxin III) knockout mice to LPS-induced oxidative stress
    Lianqin Li
    Department of Cell Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seriyo machi, Aoba ku, Sendai 980 8575, Japan
    Biochem Biophys Res Commun 355:715-21. 2007
    ....
  39. doi request reprint Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer
    Akira Nakamura
    Department of Experimental Immunology and CREST Program of Japan Science and Technology Agency, Institute of Development, Aging and Cancer, Tohoku University, Seiryo 4 1, Sendai 980 8575, Japan
    Adv Exp Med Biol 640:220-33. 2008
    ..This review summarizes FcR functions and highlights possible FcR-targeting therapies including mAb therapies for allergy, autoimmune diseases and cancer...
  40. ncbi request reprint The control effect of histamine on body temperature and respiratory function in IgE-dependent systemic anaphylaxis
    Yoko Makabe-Kobayashi
    Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine, Seiryo cho 2 1, Aoba ku, Sendai 980 8575, Japan
    J Allergy Clin Immunol 110:298-303. 2002
    ..The systemic anaphylaxis reaction comprises various symptoms, including hypotension, changes in respiration pattern, and hypothermia...
  41. doi request reprint Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence
    Masafumi Nakayama
    Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Immunol 189:5903-11. 2012
    ..These results provide direct evidence that bacteria exploit the inhibitory receptor for virulence, and host immune system counterbalances the infection...
  42. doi request reprint [Regulation of osteoclast development by immunoglobulin-like receptors]
    Masanori Inui
    Department of Experimental Immunology, Tohoku University, Japan
    Clin Calcium 22:1651-7. 2012
    ..On the other hand, ITIM signals induced by inhibitory IgLR regulate osteoclast development and activation. Thus, ITAM and ITIM play important roles in the maintenance of bone homeostasis...
  43. pmc Natural killer (NK)-dendritic cell interactions generate MHC class II-dressed NK cells that regulate CD4+ T cells
    Masafumi Nakayama
    Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    Proc Natl Acad Sci U S A 108:18360-5. 2011
    ..These results suggest that MHCII-dressed NK cells generated through NK-DC interactions regulate T cell-mediated immune responses...
  44. ncbi request reprint [Regulation of osteoclast development by immunoglobulin-like receptors]
    Toshiyuki Takai
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University
    Nihon Rinsho 63:1562-8. 2005
    ..Thus, activation signals initiated by multiple IgLR associating with DAP12 and FcRgamma are indispensable for the development of osteoclast in concert with RANKL and M-CSF...
  45. pmc Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice
    Tomonori Kaifu
    Department of Experimental Immunology and Core Research for Evolutional Science and Technology CREST Program of the Japan Science and Technology Corporation JST, Tohoku University, Sendai, Japan
    J Clin Invest 111:323-32. 2003
    ..These results provide a molecular basis for a unique combination of skeletal and psychotic characteristics of Nasu-Hakola disease as well as for schizophrenia and presenile dementia...
  46. ncbi request reprint [Role of Fcgamma receptors in immune regulation and diseases]
    Toshiyuki Takai
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University
    Nihon Rinsho Meneki Gakkai Kaishi 28:318-26. 2005
    ..This review is aimed at providing a current overview of the mechanism of Fc receptor-based immune regulation and the possible scenario of how immunological disorders might result from their dysfunction...
  47. ncbi request reprint [Role of Fc receptor in the development of collagen-induced arthritis]
    Akira Nakamura
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University CREST, Japan Science and Technology Corporation JST, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 25:56-61. 2002
  48. ncbi request reprint Comparison of 30 immunity-related genes from the common marmoset with orthologues from human and mouse
    Kazuyoshi Kohu
    Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Tohoku J Exp Med 215:167-80. 2008
    ..This suggests that these immunity-related genes do not evolve at a uniform rate. Interestingly, however, ligand/receptor pairs such as interleukin-6 and interleukin-6 receptor appear to have evolved simultaneously...
  49. pmc Deletion of fcgamma receptor IIB renders H-2(b) mice susceptible to collagen-induced arthritis
    T Yuasa
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Exp Med 189:187-94. 1999
    ..These results indicate that a nonpermissive H-2(b) haplotype can be rendered permissive to CIA induction through deletion of FcgammaRIIB, suggesting that FcgammaRIIB plays a critical role in suppressing the induction of CIA...
  50. ncbi request reprint Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses
    Yan Xiu
    Department of Pathology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Immunol 169:4340-6. 2002
    ....
  51. pmc PIR-B-deficient mice are susceptible to Salmonella infection
    Ikuko Torii
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    J Immunol 181:4229-39. 2008
    ..These findings suggest that the disruption of PIR-A and PIR-B balance affects their regulatory roles in host defense to bacterial infection...
  52. ncbi request reprint The pre-B cell receptor signaling for apoptosis is negatively regulated by Fc gamma RIIB
    Ibuki Kato
    Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
    J Immunol 168:629-34. 2002
    ..The results demonstrate that FcgammaRIIB negatively regulates pre-BCR-mediated signaling for apoptosis...
  53. ncbi request reprint Transient neutrophil infiltration after allergen challenge is dependent on specific antibodies and Fc gamma III receptors
    Christian Taube
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 170:4301-9. 2003
    ..These results demonstrate that neutrophil influx after allergen challenge requires prior sensitization, is allergen-specific, is mediated through FcgammaRIII, and is dependent on the presence of Ab...
  54. ncbi request reprint The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling
    Shalini Pereira
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    J Immunol 173:5757-65. 2004
    ..These observations point to a nonredundant role for PIR-B in the regulation of leukocyte integrin signaling...
  55. ncbi request reprint The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B
    Hong Zhang
    Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    Immunity 22:235-46. 2005
    ..These data support a model in which the Src family kinases Hck and Fgr function as negative regulators of myeloid cell chemokine signaling by maintaining the tonic phosphorylation of PIR-B...
  56. ncbi request reprint Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine production
    Masafumi Nakayama
    Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA
    J Immunol 178:4250-9. 2007
    ..aureus and enhanced TLR-mediated inflammatory responses to the bacteria. These data suggest a novel mechanism for innate immune regulation by paired Ig-like receptor family members...
  57. ncbi request reprint Functional analysis of activating receptor LMIR4 as a counterpart of inhibitory receptor LMIR3
    Kumi Izawa
    Division of Cellular Therapy, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 282:17997-8008. 2007
    ..Collectively, these results suggest that the innate immune system is at least in part regulated by the qualitative and quantitative balance of the paired receptors LMIR3 and LMIR4...
  58. ncbi request reprint Targeting of platelet integrin alphaIIbbeta3 determines systemic reaction and bleeding in murine thrombocytopenia regulated by activating and inhibitory FcgammaR
    Bernhard Nieswandt
    Department of Vascular Biology, Rudolf Virchow Zentrum, Universitat Wurzburg, 97078 Wurzburg, Germany
    Int Immunol 15:341-9. 2003
    ....
  59. pmc Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse
    Emanuele Giurisato
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Biol 27:8583-99. 2007
    ..These results provide new insights into the mechanism of immunological synapse formation and also demonstrate how multiple mechanisms can be used to recruit the same signaling proteins to the plasma membrane...
  60. ncbi request reprint Signaling via immunoglobulin Fc receptors induces oligodendrocyte precursor cell differentiation
    Jin Nakahara
    Glial Cell Research Group, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi, 173 0015, Tokyo, Japan
    Dev Cell 4:841-52. 2003
    ..Our findings indicate that the FcRgamma-Fyn-MBP cascade is pivotal during the differentiation of OPCs into myelinating oligodendrocytes, revealing an unexpected involvement of immunological molecules...
  61. ncbi request reprint Roles of FcgammaRIIB in nasal eosinophilia and IgE production in murine allergic rhinitis
    Tohru Watanabe
    Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Am J Respir Crit Care Med 169:105-12. 2004
    ..These results suggest that FcgammaRIIB plays a regulatory role in the initiation of allergic rhinitis that is independent of either mouse strain or type of sensitization...
  62. ncbi request reprint Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
    Takako Koga
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 428:758-63. 2004
    ..These results reveal that RANKL and M-CSF are not sufficient to activate the signals required for osteoclastogenesis...
  63. ncbi request reprint Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells
    Yoshinori Yamanishi
    Institute of Medical Science, University of Tokyo, Japan
    Blood 111:688-98. 2008
    ..Collectively, although both mouse and human LMIR5 play activatory roles in innate immunity cells, the functions of LMIR5 were differentially regulated in mouse versus human cells...
  64. pmc Fcgamma receptor regulation of Citrobacter rodentium infection
    Atsuhiro Masuda
    Department of Gastroenterology, Kobe University School of Medicine, 7 5 1, Chu o ku, Kusunoki cho, Kobe, Hyogo 650 0017, Japan
    Infect Immun 76:1728-37. 2008
    ..rodentium infection, indicating that the critical role played by IgG in this infection is not mediated by IgG alone but is dependent upon this class of receptors...
  65. ncbi request reprint Pathways participating in activation of mouse uterine natural killer cells during pregnancy
    Xuemei Xie
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Biol Reprod 73:510-8. 2005
    ..These data reveal key importance of FcRgamma-/-/CD3zeta-/- and thus maternal IgG during activation of mouse uNK cells and assign DAP12 but not DAP10 signaling contributions...
  66. pmc DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis
    Isaiah R Turnbull
    Department of Pathology and Immunology, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110
    J Exp Med 202:363-9. 2005
    ..These data demonstrate that, during sepsis, DAP12 signaling augments the response to microbial products, amplifying inflammation and contributing to mortality...
  67. pmc Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12
    Amanda L Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 107:2474-6. 2006
    ..Moreover, it supports a model in which engagement of DNAX-activation protein 12 (DAP12)-associated receptors with antibodies or low avidity endogenous ligands interferes with TLR-mediated cellular activation...
  68. ncbi request reprint The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
    Hiromitsu Hara
    Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    Nat Immunol 8:619-29. 2007
    ..Thus, the activation of lymphoid and myeloid cells through ITAM-associated receptors or Toll-like receptors is regulated by CARMA1-Bcl-10 and CARD9-Bcl-10, respectively...
  69. ncbi request reprint Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis
    Noriko Takegahara
    Department of Molecular Immunology and CREST Program of JST, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 8:615-22. 2006
    ..These findings reveal an unexpected role for plexin-A1 and present a novel signalling mechanism for exerting the pleiotropic functions of semaphorins...
  70. ncbi request reprint Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics
    Daniel B Graham
    Department of Pathology and Immunology, Washington University School of Medicine and Siteman Cancer Center, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Immunol 177:2349-55. 2006
    ..Based on these findings, we propose a novel model of ITAM-independent signaling by Vav downstream of DAP10 in NK cells...
  71. ncbi request reprint Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation
    Kenichi Kitamura
    Department of Medicine II, Faculty of Medicine, Okayama University Medical School, Okayama, Japan
    J Immunol 178:480-8. 2007
    ..These results demonstrate that expression of FcRgamma, most likely FcgammaRI, on APCs is important during the sensitization phase for the development of allergic airway inflammation and AHR...
  72. ncbi request reprint Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adapters DAP12 and FcRgamma chain on peritoneal macrophages
    Chigusa Nakahashi
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    J Immunol 178:765-70. 2007
    ..The FcRgamma chain may provide cooperation with and/or compensation for DAP12 in MAIR-II-mediated inflammatory responses by peritoneal macrophages...
  73. pmc Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice
    Taku Okazaki
    Department of Medical Chemistry and Molecular Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Exp Med 202:1643-8. 2005
    ..These observations suggest cross talk between two immunoinhibitory receptors, FcgammaRIIB and PD-1, on the regulation of autoimmune diseases...
  74. pmc Pathological role of osteoclast costimulation in arthritis-induced bone loss
    Sae Ochi
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8549, Japan
    Proc Natl Acad Sci U S A 104:11394-9. 2007
    ..These results establish the pathological role of costimulatory receptors for RANK in bone loss in arthritis and may provide a molecular basis for the future therapy of inflammatory diseases...