Toshiyuki Takahashi

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. pmc Visual field defects of optic neuritis in neuromyelitis optica compared with multiple sclerosis
    Hideto Nakajima
    Department of Internal Medicine I, Osaka Medical College, Takatsuki, Osaka, Japan
    BMC Neurol 10:45. 2010
  2. ncbi Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre
    Toshiyuki Takahashi
    Department of Neurology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Brain 130:1235-43. 2007
  3. ncbi Establishment of a new sensitive assay for anti-human aquaporin-4 antibody in neuromyelitis optica
    Toshiyuki Takahashi
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 210:307-13. 2006
  4. ncbi Intractable hiccup and nausea in neuromyelitis optica with anti-aquaporin-4 antibody: a herald of acute exacerbations
    T Takahashi
    Department of Neurology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    J Neurol Neurosurg Psychiatry 79:1075-8. 2008
  5. doi Aquaporin-4 antibody-positive cases beyond current diagnostic criteria for NMO spectrum disorders
    Douglas Kazutoshi Sato
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Neurology 80:2210-6. 2013
  6. doi Increase of complement fragment C5a in cerebrospinal fluid during exacerbation of neuromyelitis optica
    Hiroshi Kuroda
    Department of Neurology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    J Neuroimmunol 254:178-82. 2013
  7. ncbi [Neuromyelitis optica and anti-aquaporin 4 antibody--distinct from multiple sclerosis]
    Tatsuro Misu
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Rinsho Byori 57:262-70. 2009
  8. ncbi [NMO spectrum disorders and anti AQP4 antibody]
    Yoshiki Takai
    Departments of Neurology, Tohoku University Graduate School of Medicine, Japan
    Brain Nerve 65:333-43. 2013
  9. ncbi [New insights into the pathogenesis of neuromyelitis optica]
    Tatsuro Misu
    Departments of Neurology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Brain Nerve 62:921-31. 2010
  10. ncbi Efficacy of intravenous cyclophosphamide therapy for neuromyelitis optica spectrum disorder
    Hiroaki Yaguchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Japan
    Intern Med 52:969-72. 2013

Collaborators

Detail Information

Publications46

  1. pmc Visual field defects of optic neuritis in neuromyelitis optica compared with multiple sclerosis
    Hideto Nakajima
    Department of Internal Medicine I, Osaka Medical College, Takatsuki, Osaka, Japan
    BMC Neurol 10:45. 2010
    ..Central scotoma is recognized as a characteristic visual field defect pattern of optic neuritis (ON), however, the differing pathogenic mechanisms of NMO and MS may result in different patterns of visual field defects for ON...
  2. ncbi Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre
    Toshiyuki Takahashi
    Department of Neurology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Brain 130:1235-43. 2007
    ....
  3. ncbi Establishment of a new sensitive assay for anti-human aquaporin-4 antibody in neuromyelitis optica
    Toshiyuki Takahashi
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 210:307-13. 2006
    ..Thus, the newly developed anti-AQP4 antibody assay appears to have a higher sensitivity for NMO than the original NMO-IgG assay and is expected to be useful for the diagnosis of NMO...
  4. ncbi Intractable hiccup and nausea in neuromyelitis optica with anti-aquaporin-4 antibody: a herald of acute exacerbations
    T Takahashi
    Department of Neurology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    J Neurol Neurosurg Psychiatry 79:1075-8. 2008
    ..Recent studies have strongly suggested that the pathogenesis of NMO is closely associated with anti-aquaporin-4 (AQP4) antibody. However, clinical implications of IHN and the relationship with anti-AQP4 antibody remain unknown...
  5. doi Aquaporin-4 antibody-positive cases beyond current diagnostic criteria for NMO spectrum disorders
    Douglas Kazutoshi Sato
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Neurology 80:2210-6. 2013
    ..To analyze aquaporin-4 (AQP4) antibody-positive patients who do not fulfill the current diagnostic criteria of neuromyelitis optica (NMO) and NMO spectrum disorders (NMOSD)...
  6. doi Increase of complement fragment C5a in cerebrospinal fluid during exacerbation of neuromyelitis optica
    Hiroshi Kuroda
    Department of Neurology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    J Neuroimmunol 254:178-82. 2013
    ..The CSF-C5a levels correlated with the severity of exacerbation. Our results may provide a rationale for anti-complement therapies of NMO...
  7. ncbi [Neuromyelitis optica and anti-aquaporin 4 antibody--distinct from multiple sclerosis]
    Tatsuro Misu
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Rinsho Byori 57:262-70. 2009
    ..Therefore, AQP4 antibody is indispensable in the diagnosis and treatment of NMO...
  8. ncbi [NMO spectrum disorders and anti AQP4 antibody]
    Yoshiki Takai
    Departments of Neurology, Tohoku University Graduate School of Medicine, Japan
    Brain Nerve 65:333-43. 2013
    ..Further studies are warranted to clarify disease pathogenesis and develop a molecular target treatment for NMO...
  9. ncbi [New insights into the pathogenesis of neuromyelitis optica]
    Tatsuro Misu
    Departments of Neurology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Brain Nerve 62:921-31. 2010
    ..These evidences suggested the pathogenic role of AQP4 antibody with astrocytopathy in NMO. Now it is indispensable to check the AQP4 antibody,and is important to reconsider the role of astrocyte in demyelinating disorders...
  10. ncbi Efficacy of intravenous cyclophosphamide therapy for neuromyelitis optica spectrum disorder
    Hiroaki Yaguchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Japan
    Intern Med 52:969-72. 2013
    ..In this study, we report the efficacy of intravenous cyclophosphamide (IVCY) therapy for NMOSD...
  11. ncbi [Biomarkers in neuromyelitis optica]
    Tatsuro Misu
    Department of Neurology, Tohoku University Graduate School of Medicine, Japan
    Brain Nerve 64:525-35. 2012
    ..Therefore, the assessment of such useful biomarkers may become a supportive criterion for diagnosing NMO and NMO spectrum disorders...
  12. ncbi Therapeutic efficacy of interferon β-1b in Japanese patients with optic-spinal multiple sclerosis
    Yuko Shimizu
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Tohoku J Exp Med 223:211-4. 2011
    ..59 ± 0.34 → 0.13 ± 0.15) (P = 0.027) after IFNβ-1b therapy. These results suggest that IFNβ is therapeutically effective in inhibiting functional worsening and reducing relapse rate in "genuine" OSMS...
  13. doi Pathological study of subacute autoimmune encephalopathy with anti-AQP4 antibodies in a pregnant woman
    Hiroaki Yaguchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
    Mult Scler 18:683-7. 2012
    ..Moreover, loss of AQP4 was observed in the gray matter. The presence of anti-AQP4 antibodies, and the pathology, led to the diagnosis of anti-AQP4 antibodies-related encephalopathy...
  14. ncbi A prominent elevation of glial fibrillary acidic protein in the cerebrospinal fluid during relapse in neuromyelitis optica
    Rina Takano
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 215:55-9. 2008
    ..CSF-GFAP may be useful as a biomarker of NMO...
  15. doi Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders
    Douglas Kazutoshi Sato
    From the Departments of Neurology D K S, T T, I N, M A and Multiple Sclerosis Therapeutics T M, K F, Tohoku University Graduate School of Medicine, Sendai, Japan Department of Neurology D C, F M d H J, S L A P, R F S, A M M L, Faculty of Medicine, University of Sao Paulo, Brazil CIEM MS Research Center M A L P, N T, Federal University of Minas Gerais Medical School, Belo Horizonte, Brazil Neuroimmunology Group P J W, M I L, Nuffield Department of Clinical Neurosciences, Oxford University, UK
    Neurology 82:474-81. 2014
    ..To evaluate clinical features among patients with neuromyelitis optica spectrum disorders (NMOSD) who have myelin oligodendrocyte glycoprotein (MOG) antibodies, aquaporin-4 (AQP4) antibodies, or seronegativity for both antibodies...
  16. ncbi Acute combined central and peripheral demyelination showing anti-aquaporin 4 antibody positivity
    Mari Kitada
    Department of Neurology, Kinki University School of Medicine, Japan
    Intern Med 51:2443-7. 2012
    ..There have been no previous reports of NMO or NMOSD associated with neuropathy. The HCV infection or undetermined humoral factors other than the anti-AQP4 antibodies may have caused her peripheral neuropathy...
  17. doi Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica
    Masahiko Nakamura
    Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8574, Japan
    Graefes Arch Clin Exp Ophthalmol 248:1777-85. 2010
    ....
  18. ncbi Recurrent spinal cord attacks in a patient with a limited form of neuromyelitis optica
    Hideyuki Matsumoto
    Department of Neurology, Japanese Red Cross Medical Center, Japan
    Intern Med 50:509-13. 2011
    ..Recurrence within the same spinal cord area might be a characteristic clinical finding in NMO spectrum disorders. For such patients, examination for anti-AQP4 antibody might be necessary for the diagnosis and therapy of this disorder...
  19. doi Transient increases in anti-aquaporin-4 antibody titers following rituximab treatment in neuromyelitis optica, in association with elevated serum BAFF levels
    Ichiro Nakashima
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Clin Neurosci 18:997-8. 2011
    ..Although anti-AQP4 antibodies appear to decrease overall following rituximab treatment, our findings raise concern over the potential for an early BAFF-mediated worsening of patients with NMO receiving rituximab...
  20. ncbi Surgical treatment of spinal intradural arachnoid cysts using endoscopy
    Toshiki Endo
    Department of Neurosurgery, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    J Neurosurg Spine 12:641-6. 2010
    ..They evaluated the usefulness and reliability of endoscopic treatment for this clinical entity based on long-term follow-up results...
  21. ncbi Cervical cord compression with myelopathy caused by bilateral persistence of the first intersegmental arteries: case report
    Toshiyuki Takahashi
    Department of Neurosurgery, Kohnan Hospital, Sendai, Japan
    Neurosurgery 53:234-7; discussion 237. 2003
    ..We report a case caused by bilateral persistence of the first intersegmental arteries (a vertebral artery anomaly). Myelopathy was successfully treated with vascular decompression...
  22. ncbi Spinal granulocytic sarcoma manifesting as radiculopathy in a nonleukemic patient
    Tomoo Inoue
    Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Neurol Med Chir (Tokyo) 48:131-6. 2008
    ..The importance of immunohistochemical staining in the differential diagnosis from other types of spinal tumor, and the efficacy of FDG-PET for evaluation of the treatment are also emphasized...
  23. ncbi Quantitative assessment of surgical decompression of the cervical spine with cine phase contrast magnetic resonance imaging
    Teiji Tominaga
    Department of Neurosurgery, Kohnan Hospital, Tohoku University School of Medicine, Sendai, Japan
    Neurosurgery 50:791-5; discussion 796. 2002
    ..We measured cerebrospinal fluid flow velocity by use of cine phase contrast magnetic resonance imaging to quantitate the effectiveness of surgical decompression in patients with cervical myelopathy...
  24. ncbi Intraoperative angiography to prevent vertebral artery injury during reduction of a dislocated hangman fracture. Case report
    Toshiyuki Takahashi
    Department of Neurosurgery, Kohnan Hospital, Sendai, Japan
    J Neurosurg 97:355-8. 2002
    ..In this case, intraoperative angiography was particularly useful for preventing brain-related ischemic complications during reduction...
  25. ncbi Rotational vertebral artery occlusion from occipital bone anomaly: a rare cause of embolic stroke. Case report
    Teiji Tominaga
    Department of Neurosurgery, Kohnan Hospital, Sendai, Japan
    J Neurosurg 97:1456-9. 2002
    ..An occipital bone anomaly can cause rotational VA occlusion at the craniovertebral junction in patients who present with repeated embolic strokes resulting from injury to the arterial wall...
  26. ncbi HyperCKemia related to the initial and recurrent attacks of neuromyelitis optica
    Shoko Deguchi
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan
    Intern Med 51:2617-20. 2012
    ..This case suggests that hyperCKemia is partly involved in the pathogenesis of NMO in both the central nervous system and myofiber surface, which is usually difficult to detect by clinical imaging modalities alone...
  27. ncbi Elderly-onset neuromyelitis optica which developed after the diagnosis of prostate adenocarcinoma and relapsed after a 23-valent pneumococcal polysaccharide vaccination
    Yu Kitazawa
    Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan
    Intern Med 51:103-7. 2012
    ....
  28. ncbi [A case of neuromyelitis optica associated with anti-aquaporin 4 antibody and other autoantibodies]
    Kyoko Maruta
    Department of Neurology, National Hospital Organization Minamikyushu National Hospital, Japan
    Nihon Ronen Igakkai Zasshi 49:491-5. 2012
    ..The possibility of NMO should be considered in similar patients with autoimmune disease, and anti-AQP4 antibody should be assessed...
  29. doi Anti-aquaporin-4 antibody-positive definite neuromyelitis optica in a patient with thymectomy for myasthenia gravis
    Kotaro Ogaki
    Department of Neurology, Juntendo University Shizuoka Hospital, Izunokuni, Japan
    Neurologist 18:76-9. 2012
    ..Recently, a rare coexistence of NMO and myasthenia gravis (MG) has been documented. Here, we provide further evidence of the association of these 2 immunologic disorders and review the literature...
  30. ncbi Congestive myelopathy due to cervical perimedullary arteriovenous fistula evaluated by apparent diffusion coefficient values - case report
    Tomoo Inoue
    Department of Neurosurgery, Kohnan Hospital, Sendai, Miyagi, Japan
    Neurol Med Chir (Tokyo) 46:559-62. 2006
    ..The high preoperative ADC value probably indicated reversible vasogenic edema and immediate normalization of the ADC value suggests a good clinical outcome...
  31. ncbi Thoracic intradural arachnoid cyst associated with surgical removal of epidural hematoma--case report
    Hidenori Endo
    Department of Neurosurgery, Kohnan Hospital, Sendai, Japan
    Neurol Med Chir (Tokyo) 44:607-10. 2004
    ..This case of intradural arachnoid cyst of the thoracic spine which appeared after surgical removal of an epidural hematoma at the same spinal level indicates some association between the epidural hematoma and the arachnoid cyst...
  32. ncbi Optic neuritis following aseptic meningitis associated with modified measles: a case report
    Nobuhito Nakajima
    Department of Neurology, Kitamurayama Public Hospital, Yamagata, Japan
    Jpn J Infect Dis 66:320-2. 2013
    ..In general, modified measles is believed to be associated with mild symptoms and few neurological complications; however, our present observations demonstrated that modified measles can cause rapid neurological complications. ..
  33. ncbi Intercostal arteriovenous fistula associated with neurofibromatosis manifesting as congestive myelopathy: case report
    Atsushi Saito
    Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Neurosurgery 61:E656-7; discussion E657. 2007
    ..A case of intercostal AVF associated with NF-1 and manifesting as congestive myelopathy is described...
  34. ncbi Seizure-induced thoracic spine compression fracture: case report
    Toshiyuki Takahashi
    Department of Neurosurgery, Kohnan Hospital, Sendai, Japan
    Surg Neurol 58:214-6; discussion 216-7. 2002
    ..Vertebral fracture caused solely by a convulsive seizure has rarely been reported in the neurosurgical literature...
  35. ncbi Intramedullary spinal tuberculoma--case report
    Hiroaki Torii
    Department of Neurosurgery, Kohnan Hospital, Sendai, Miyagi, Japan
    Neurol Med Chir (Tokyo) 44:266-8. 2004
    ..Intramedullary spinal tuberculoma is rare, but must be considered in the differential diagnosis of spinal cord compression...
  36. ncbi Dissection of the superior cerebellar artery: a report of two cases and review of the literature
    Hisaharu Gotoh
    Department of Neurosurgery, Kohnan Hospital, Sendai, Japan
    J Clin Neurosci 11:196-9. 2004
    ..The patient's condition improved sufficiently to return to daily life. In our search only four reported cases involved the SCA. Clinical manifestation and treatment for patients with cerebellar arterial dissections are discussed...
  37. ncbi Development of extensive brain lesions following interferon beta therapy in relapsing neuromyelitis optica and longitudinally extensive myelitis
    Yuko Shimizu
    J Neurol 255:305-7. 2008
  38. ncbi The association between microalbuminuria and metabolic syndrome in the general population in Japan: the Takahata study
    Zhimei Hao
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Intern Med 46:341-6. 2007
    ..Therefore, we undertook a population-based study to examine the association between microalbuminuria and the metabolic syndrome in Takahata, Japan...
  39. ncbi Usefulness of 11C-methionine for differentiating tumors from granulomas in experimental rat models: a comparison with 18F-FDG and 18F-FLT
    Songji Zhao
    Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    J Nucl Med 49:135-41. 2008
    ..In this study, the potentials of (18)F-FLT and (11)C-methionine in differentiating malignant tumors from granulomas were compared with (18)F-FDG using experimental rat models...
  40. ncbi Reactive lymphoid hyperplasia of the liver: a case report and review of literature
    Takuro Machida
    Department of Internal Medicine, Hokkaido Gastroenterology Hospital, Sapporo, Hokkaido 065 0041, Japan
    World J Gastroenterol 13:5403-7. 2007
    ..Although their pathology resembles malignant lymphoma, the clinical course is completely benign. The authors propose that RLH of the liver can be discriminated from HCC by its clinical features...
  41. ncbi Extensive FDG uptake and its modification with corticosteroid in a granuloma rat model: an experimental study for differentiating granuloma from tumors
    Songji Zhao
    Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Kita 15 Nishi 7, Kita ku, Sapporo, Japan
    Eur J Nucl Med Mol Imaging 34:2096-105. 2007
    ..Here, we developed a rat granuloma model and examined FDG uptake in the granuloma. The effects of corticosteroid on FDG uptake in the granuloma were compared with those in a malignant tumor...
  42. ncbi [The points of differential diagnosis for heart failure]
    Toshiyuki Takahashi
    Department of Cardiology, JR Tokyo General Hospital
    Nihon Rinsho 65:467-71. 2007
  43. ncbi Hypoglossal neurinoma presenting with intratumoral hemorrhage
    Toshiyuki Takahashi
    Department of Neurosurgery, Kohnan Hospital, Sendai, Japan
    J Clin Neurosci 9:716-9. 2002
    ..Extensive hemorrhage was present, as was necrosis. Thickening and hyalinization of arterial walls, a common occurrence in neurinomas, may have contributed to symptomatic intratumoral hemorrhage...
  44. ncbi [Clinical feature and surgical treatment of spontaneous spinal epidural hematoma]
    Tomomi Kimiwada
    Department of Neurosurgery, Kohnan Hospital, 4 20 1 Nagamachi minami, Taihaku ku, Sendai 982 8574, Japan
    No Shinkei Geka 32:333-8. 2004
    ..To obtain good prognosis for patients with SSEH, early diagnosis and immediate treatment are important...
  45. ncbi Tumor-associated antigen recognized by the 22-1-1 monoclonal antibody encourages colorectal cancer progression under the scanty CD8+ T cells
    Taro Oshikiri
    Department of Surgery, Hokkaido Gastroenterology Hospital and Surgical Oncology, Hokkaido University Hospital, Honcho 1jo, 1chome, Higashi, Sapporo 065 0014, Hokkaido, Japan
    Clin Cancer Res 12:411-6. 2006
    ..The objective of this study is to examine Tn glycan antigen function in colorectal cancer and to determine its relationship to CD8+ T cells and prognosis...
  46. doi Relationship between antinuclear antibody and microalbuminuria in the general population: the Takahata study
    Mizue Ishikawa
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, 990 9585, Japan
    Clin Exp Nephrol 12:200-6. 2008
    ..However, the relationship between antinuclear antibody (ANA) and microalbuminuria in the general population is unknown. Thus, we conducted a cross-sectional study to examine the relationship between ANA and microalbuminuria...