Takashi Suzuki

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. doi request reprint Steroid sulfatase and estrogen sulfotransferase in human carcinomas
    Takashi Suzuki
    Department of Pathology and Histotechnology, Tohoku University, Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Mol Cell Endocrinol 340:148-53. 2011
  2. pmc An induction of microRNA, miR-7 through estrogen treatment in breast carcinoma
    Mariko Masuda
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Transl Med 10:S2. 2012
  3. pmc Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue
    Tatsuyuki Takadate
    Division of Gastroenterological Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Miyagi, Japan
    Clin Proteomics 9:8. 2012
  4. ncbi request reprint Immunohistochemical distribution of chicken ovalbumin upstream promoter transcription factor II in human tissues
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Mol Cell Endocrinol 164:69-75. 2000
  5. ncbi request reprint Estrogen-responsive finger protein as a new potential biomarker for breast cancer
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi ken, Japan
    Clin Cancer Res 11:6148-54. 2005
  6. ncbi request reprint 5alpha-reductases in human breast carcinoma: possible modulator of in situ androgenic actions
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Tohoku University Hospital N A, T M, Sendai 980 8575, Japan
    J Clin Endocrinol Metab 86:2250-7. 2001
  7. ncbi request reprint 5Alpha-reductase type 1 and aromatase in breast carcinoma as regulators of in situ androgen production
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Int J Cancer 120:285-91. 2007
  8. ncbi request reprint Early growth responsive gene 3 in human breast carcinoma: a regulator of estrogen-meditated invasion and a potent prognostic factor
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Endocr Relat Cancer 14:279-92. 2007
  9. ncbi request reprint Developmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Clin Endocrinol (Oxf) 53:739-47. 2000
  10. ncbi request reprint Immunohistochemical distribution of 11beta-hydroxysteroid dehydrogenase in human eye
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, 980 8575, Sendai, Japan
    Mol Cell Endocrinol 173:121-5. 2001

Collaborators

Detail Information

Publications171 found, 100 shown here

  1. doi request reprint Steroid sulfatase and estrogen sulfotransferase in human carcinomas
    Takashi Suzuki
    Department of Pathology and Histotechnology, Tohoku University, Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Mol Cell Endocrinol 340:148-53. 2011
    ..Therefore, STS pathway and estrogen actions may play an important role in the development of these carcinomas, and further investigations are required...
  2. pmc An induction of microRNA, miR-7 through estrogen treatment in breast carcinoma
    Mariko Masuda
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Transl Med 10:S2. 2012
    ..Therefore, in this study, we examined the in vitro effects of estrogen upon miRNA expression profiles in breast carcinoma...
  3. pmc Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue
    Tatsuyuki Takadate
    Division of Gastroenterological Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Miyagi, Japan
    Clin Proteomics 9:8. 2012
    ..abstract:..
  4. ncbi request reprint Immunohistochemical distribution of chicken ovalbumin upstream promoter transcription factor II in human tissues
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Mol Cell Endocrinol 164:69-75. 2000
    ..The widespread expression of COUP-TFII suggests that COUP-TFII may play an important role in the function and homeostasis of various human tissues and organs...
  5. ncbi request reprint Estrogen-responsive finger protein as a new potential biomarker for breast cancer
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi ken, Japan
    Clin Cancer Res 11:6148-54. 2005
    ..In this study, we examined expression of Efp in breast carcinoma tissues and correlated these findings with various clinicopathologic variables...
  6. ncbi request reprint 5alpha-reductases in human breast carcinoma: possible modulator of in situ androgenic actions
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Tohoku University Hospital N A, T M, Sendai 980 8575, Japan
    J Clin Endocrinol Metab 86:2250-7. 2001
    ....
  7. ncbi request reprint 5Alpha-reductase type 1 and aromatase in breast carcinoma as regulators of in situ androgen production
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Int J Cancer 120:285-91. 2007
    ..Aromatase inhibitors may be more effective in these patients, possibly due to increasing local DHT concentration with estrogen deprivation...
  8. ncbi request reprint Early growth responsive gene 3 in human breast carcinoma: a regulator of estrogen-meditated invasion and a potent prognostic factor
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Endocr Relat Cancer 14:279-92. 2007
    ..These results suggest that EGR3 plays an important role in estrogen-meditated invasion and is an independent prognostic factor in breast carcinoma...
  9. ncbi request reprint Developmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Clin Endocrinol (Oxf) 53:739-47. 2000
    ..The increased level of P450c17, DHEA-ST, P450 oxidoreductase, and cytochrome b5, and the decreased level of 3betaHSD in the reticularis is likely to contribute to increased C19 steroid production during adrenarche...
  10. ncbi request reprint Immunohistochemical distribution of 11beta-hydroxysteroid dehydrogenase in human eye
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, 980 8575, Sendai, Japan
    Mol Cell Endocrinol 173:121-5. 2001
    ..The widespread expression of GR suggests that glucocorticoids may play an important role in the function and homeostasis of the human eye...
  11. doi request reprint Intratumoral estrogen production in breast carcinoma: significance of aromatase
    Takashi Suzuki
    Department of Pathology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai 980 8575, Japan
    Breast Cancer 15:270-7. 2008
    ..Therefore, sex steroids are locally produced in noninvasive breast carcinoma as well as invasive carcinoma, and endocrine therapies may be clinically effective in a select group of noninvasive breast carcinoma patients...
  12. ncbi request reprint Retinoid receptors in human breast carcinoma: possible modulators of in situ estrogen metabolism
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Breast Cancer Res Treat 65:31-40. 2001
    ..76-fold (p < 0.001), five days following treatment with 10 nM retinoic acid. These data suggest that retinoid receptors modulate various effects of retinoids, including estrogen metabolism in human breast carcinomas...
  13. ncbi request reprint Peroxisome proliferator-activated receptor gamma in human breast carcinoma: a modulator of estrogenic actions
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Endocr Relat Cancer 13:233-50. 2006
    ..These results suggest that PPARgamma is mainly expressed in well-differentiated and ER-positive breast carcinomas, and modulates estrogenic actions...
  14. ncbi request reprint In situ production of sex steroids in human breast carcinoma
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Med Mol Morphol 40:121-7. 2007
    ....
  15. ncbi request reprint In situ production of estrogens in human breast carcinoma
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Breast Cancer 9:296-302. 2002
    ....
  16. ncbi request reprint Estrogen sulfotransferase and steroid sulfatase in human breast carcinoma
    Takashi Suzuki
    Departments of Pathology, Tohoku University School of Medicine, Sendai, 980 8575, Japan
    Cancer Res 63:2762-70. 2003
    ....
  17. doi request reprint Androgens in human breast carcinoma
    Takashi Suzuki
    Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Med Mol Morphol 43:75-81. 2010
    ..Therefore, androgenic actions may also be involved in apocrine features in breast carcinoma...
  18. ncbi request reprint Intracrine mechanism of estrogen synthesis in breast cancer
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Biomed Pharmacother 57:460-2. 2003
    ....
  19. ncbi request reprint Superoxide dismutase in normal cycling human ovaries: immunohistochemical localization and characterization
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Fertil Steril 72:720-6. 1999
    ..To investigate the expression of manganese (Mn) and copper-zinc (Cu,Zn) superoxide dismutase (SOD) in normal cycling human ovaries throughout the menstrual cycle...
  20. ncbi request reprint Steroid sulfatase and estrogen sulfotransferase in normal human tissue and breast carcinoma
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Steroid Biochem Mol Biol 86:449-54. 2003
    ..In the breast carcinoma, STS and EST are suggested to play important roles in the regulation of in situ estrogen production in the breast carcinomas...
  21. ncbi request reprint Estrogen-related receptor alpha in human breast carcinoma as a potent prognostic factor
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Cancer Res 64:4670-6. 2004
    ..Results from our study suggest that ERRalpha possibly modulates the expression of ERE-containing estrogen-responsive genes, and ERRalpha immunoreactivity is a potent prognostic factor in human breast carcinoma...
  22. ncbi request reprint 11Beta-hydroxysteroid dehydrogenase type 2 in human lung: possible regulator of mineralocorticoid action
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 83:4022-5. 1998
    ..These results indicate that 11betaHSD2 colocalizes with MR in human airway epithelia and suggest that 11betaHSD2 play an important role in pulmonary mineralocorticoid activity such as sodium and fluid transport...
  23. ncbi request reprint Estrogen inhibits cell proliferation through in situ production in human thymoma
    Hironori Ishibashi
    Department of Pathology, Tohoku University School of Medicine, Japan
    Clin Cancer Res 11:6495-504. 2005
    ..Estrogen sulfotransferase (EST), steroid sulfatase (STS), 17beta-hydroxysteroid dehydrogenase (17beta-HSD), and aromatase are considered to play important roles in hormone metabolism of estrogen-dependent tumors...
  24. ncbi request reprint Steroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma
    Hiroki Utsunomiya
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Clin Cancer Res 10:5850-6. 2004
    ..However, the status of steroid sulfatase and/or estrogen sulfotransferase in human endometrial carcinoma has not been examined...
  25. ncbi request reprint Identification of androgen-responsive microRNAs and androgen-related genes in breast cancer
    Kiichiroh Nakano
    2 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8575 Japan
    Anticancer Res 33:4811-9. 2013
    ..The study of microRNAs has recently provided with important insights into the biology of hormone-dependent cancer...
  26. doi request reprint Intratumoral localization of aromatase and interaction between stromal and parenchymal cells in the non-small cell lung carcinoma microenvironment
    Yasuhiro Miki
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Res 70:6659-69. 2010
    ....
  27. doi request reprint Aromatase inhibitor treatment of breast cancer cells increases the expression of let-7f, a microRNA targeting CYP19A1
    Yukiko Shibahara
    Department of Pathology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Pathol 227:357-66. 2012
    ..Therefore, AIs may exert tumour-suppressing effects upon breast cancer cells by suppressing aromatase gene expression via restoration of let-7f...
  28. doi request reprint Intratumoral concentration of sex steroids and expression of sex steroid-producing enzymes in ductal carcinoma in situ of human breast
    Rie Shibuya
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Endocr Relat Cancer 15:113-24. 2008
    ..Therefore, estradiol and DHT may play important roles in the development of DCIS of the human breast...
  29. ncbi request reprint Orphan nuclear receptor DAX-1 in human endometrium and its disorders
    Sumika Saito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendia 980 8575, Japan
    Cancer Sci 96:645-52. 2005
    ....
  30. doi request reprint Estrogen signaling ability in human endometrial cancer through the cancer-stromal interaction
    Mitsuyo Matsumoto
    Department of Medical Technology, Tohoku University School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 981 0872, Japan
    Endocr Relat Cancer 15:451-63. 2008
    ..These results suggest that AI may have some therapeutic value in EC; however, the hormonal microenvironment must be assessed prior to initiating therapy...
  31. doi request reprint Nucleobindin 2 in human breast carcinoma as a potent prognostic factor
    Shiho Suzuki
    Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 103:136-43. 2012
    ..These results suggest that NUCB2 is upregulated by estrogens and plays an important role, especially in the process of metastasis, in breast carcinomas. NUCB2 status is considered a potent prognostic factor in human breast cancer...
  32. ncbi request reprint 14-3-3sigma in endometrial cancer--a possible prognostic marker in early-stage cancer
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Cancer Res 11:7384-91. 2005
    ..We examined expression of 14-3-3sigma, a regulator of cell proliferation, and evaluated its clinical significance in endometrioid endometrial carcinoma...
  33. ncbi request reprint Immunolocalization of liver receptor homologue-1 (LRH-1) in human breast carcinoma: possible regulator of insitu steroidogenesis
    Yasuhiro Miki
    Department of Pathology, Tohoku University, Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Cancer Lett 244:24-33. 2006
    ..These results suggest that LRH-1 is frequently detected in breast carcinoma tissues, and plays important roles including the regulation of in situ steroidogenesis...
  34. doi request reprint Intratumoral estrogens and estrogen receptors in human non-small cell lung carcinoma
    Hiromichi Niikawa
    Department of Pathology, Tohoku University School of Medicine, Japan
    Clin Cancer Res 14:4417-26. 2008
    ..Therefore, we examined intratumoral estradiol concentrations in NSCLC to examine local actions of estrogens in NSCLC...
  35. doi request reprint Increased intratumoral androgens in human breast carcinoma following aromatase inhibitor exemestane treatment
    Kiyoshi Takagi
    Department of Pathology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Miyagi ken, Japan
    Endocr Relat Cancer 17:415-30. 2010
    ....
  36. doi request reprint Increased estrogen sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type 1(17beta-HSD1) following neoadjuvant aromatase inhibitor therapy in breast cancer patients
    Niramol Chanplakorn
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi, Japan
    Breast Cancer Res Treat 120:639-48. 2010
    ..This increment may represent the compensatory response of breast carcinoma tissues to estrogen depletion...
  37. doi request reprint TACC2 is an androgen-responsive cell cycle regulator promoting androgen-mediated and castration-resistant growth of prostate cancer
    Ken ichi Takayama
    Department of Anti Aging Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Mol Endocrinol 26:748-61. 2012
    ..Taken together with the critical roles of TACC2 in the cell cycle and the biology of prostate cancer, we infer that the molecule is a potential therapeutic target in CRPC as well as hormone-sensitive prostate cancer...
  38. doi request reprint MicroRNA-34b functions as a potential tumor suppressor in endometrial serous adenocarcinoma
    Eri Hiroki
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int J Cancer 131:E395-404. 2012
    ..The expression of MET was reduced following the restoration of miR-34b in cell lines. In summary, our data suggest that miR-34b plays a role in the molecular pathogenesis of endometrial cancer...
  39. ncbi request reprint Aromatase localization in human breast cancer tissues: possible interactions between intratumoral stromal and parenchymal cells
    Yasuhiro Miki
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Res 67:3945-54. 2007
    ....
  40. ncbi request reprint Sex steroid hormone receptors in human thymoma
    Hironori Ishibashi
    Department of Pathology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    J Clin Endocrinol Metab 88:2309-17. 2003
    ..Results from our study suggest that estrogens may inhibit thymoma growth via ER alpha, and that ER alpha immunoreactivity may act as a prognostic factor in human thymoma...
  41. ncbi request reprint Sex steroid receptors expression and hormone-induced cell proliferation in human osteosarcoma
    Osamu Dohi
    Department of Orthopaedic Surgery, Tohoku Kosai Hospital, 2 3 11 Kokubuncho, Aoba ku, Sendai, Japan
    Cancer Sci 99:518-23. 2008
    ..In addition, these data suggest the potential for a novel endocrine therapy in osteosarcoma using clinically available inhibitors of progesterone and estrogen actions...
  42. ncbi request reprint Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues
    Norihiro Shimada
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Mol Cell Endocrinol 218:147-53. 2004
    ..Therefore, these results indicate that Efp is widely expressed and may play important roles in various human tissues possibly through ERs...
  43. ncbi request reprint Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane
    Yasuhiro Miki
    Department of Pathology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8575, Japan
    Bone 40:876-87. 2007
    ..These results indicated that the steroidal aromatase inhibitor, EXE, stimulated hFOB cell proliferation via both AR dependent and independent pathways...
  44. ncbi request reprint Nuclear receptor DAX-1 in human common epithelial ovarian carcinoma: an independent prognostic factor of clinical outcome
    Manar Abd-Elaziz
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8575
    Cancer Sci 94:980-5. 2003
    ..In conclusion, DAX-1 immunoreactivity is considered to be a new independent marker of poor prognosis or adverse clinical outcome in patients with epithelial ovarian carcinoma, possibly through altering in situ steroids production...
  45. ncbi request reprint Expression of estrogen-responsive finger protein (Efp) is associated with advanced disease in human epithelial ovarian cancer
    Michiko Sakuma
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Gynecol Oncol 99:664-70. 2005
    ..To understand the estrogenic action on ovarian cancer, we studied the relationships between Efp and ERs expressions and the correlations of Efp expression with clinicopathological parameters in epithelial ovarian cancer...
  46. ncbi request reprint Progesterone receptor isoforms as a prognostic marker in human endometrial carcinoma
    Sumika Saito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Cancer Sci 97:1308-14. 2006
    ..0258). The results of our study demonstrated that loss or absence of PR isoform expression determined by immunohistochemistry could become an important prognostic indicator in patients with endometrioid endometrial carcinoma...
  47. doi request reprint 17Beta-hydroxysteroid dehydrogenase type 12 in human breast carcinoma: a prognostic factor via potential regulation of fatty acid synthesis
    Shuji Nagasaki
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Res 69:1392-9. 2009
    ....
  48. ncbi request reprint Aldosterone enhances 11beta-hydroxysteroid dehydrogenase type 2 expression in colonic epithelial cells in vivo
    Kouhei Fukushima
    Department of Surgery, Tohoku University, Graduate School of Medicine, Sendai, Japan
    Scand J Gastroenterol 40:850-7. 2005
    ..However, little is known about the regulatory mechanism of epithelial 11beta-HSD2 expression in the gut...
  49. ncbi request reprint Progesterone receptor in non-small cell lung cancer--a potent prognostic factor and possible target for endocrine therapy
    Hironori Ishibashi
    Departments of Pathology and Molecular Medical Technology, Tohoku University School of Medicine, Sendai, Japan
    Cancer Res 65:6450-8. 2005
    ..Therefore, progesterone therapy may be clinically effective in suppressing development of progesterone receptor-positive NSCLC patients...
  50. ncbi request reprint Retinoid receptors in the developing human lung
    Yuichiro Kimura
    Department of Pathology, Tohoku University School of Medicine, Tohoku University, Sendai, Japan
    Clin Sci (Lond) 103:613-21. 2002
    ..4+/-0.05-fold and 3.1+/-0.03-fold respectively; P <0.01), RAR-beta at distal sites (2.4+/-0.01-fold; P <0.05) and RAR-gamma at proximal sites (2.2+/-0.11-fold; P <0.05) were significantly higher in the fetus than in the adult...
  51. doi request reprint Nudix-type motif 2 in human breast carcinoma: a potent prognostic factor associated with cell proliferation
    Kimako Oka
    Department of Anatomic Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int J Cancer 128:1770-82. 2011
    ..NUDT2 promotes proliferation of breast carcinoma cells and is a potent prognostic factor in human breast carcinomas...
  52. doi request reprint Immunolocalization of estrogen-producing and metabolizing enzymes in benign breast disease: comparison with normal breast and breast carcinoma
    Yoshie Sasaki
    Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 101:2286-92. 2010
    ....
  53. ncbi request reprint Hepatocyte growth factor induces angiogenesis in injured lungs through mobilizing endothelial progenitor cells
    Kota Ishizawa
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Miyagi 980 8574, Japan
    Biochem Biophys Res Commun 324:276-80. 2004
    ..These complex effects induced by HGF orchestrate pulmonary regeneration in emphysematous lung parenchyma...
  54. pmc MDM2: a novel mineralocorticoid-responsive gene involved in aldosterone-induced human vascular structural remodeling
    Yasuhiro Nakamura
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Am J Pathol 169:362-71. 2006
    ....
  55. doi request reprint Loss of estrogen receptor beta isoform expression and its correlation with aberrant DNA methylation of the 5'-untranslated region in human epithelial ovarian carcinoma
    Fumihiko Suzuki
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Cancer Sci 99:2365-72. 2008
    ..The results of our present study suggest that ERbeta is inactivated mainly through aberrant DNA methylation. This process may play an important role in the pathogenesis of epithelial ovarian cancer...
  56. ncbi request reprint Immunolocalization of nuclear transcription factors, DAX-1 and Ad4BP/SF-1, in human common epithelial ovarian tumors: correlations with StAR and steroidogenic enzymes in epithelial ovarian carcinoma
    Manar Abd-Elaziz
    Department of Pathology, Tohoku University School of Medicine and Tohoku University Hospital, Sendai, Japan
    Int J Gynecol Pathol 24:153-63. 2005
    ..The status of intratumoral DAX-1, Ad4BP/SF-1, and StAR and steroidogenic enzymes in epithelial cells and intratumoral stromal cells of epithelial ovarian carcinoma may contribute in the progression and/or aggressiveness of these tumors...
  57. ncbi request reprint Decreased expression of RIZ1 and its clinicopathological significance in epithelial ovarian carcinoma: correlation with epigenetic inactivation by aberrant DNA methylation
    Jun ichi Akahira
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pathol Int 57:725-33. 2007
    ..Reduced expression of RIZ1 may play an important role in the pathogenesis and/or development of epithelial ovarian carcinoma, and is considered to be caused in part by aberrant DNA methylation...
  58. ncbi request reprint Nuclear cyclin B1 in human breast carcinoma as a potent prognostic factor
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi ken, 980 8575, Japan
    Cancer Sci 98:644-51. 2007
    ..Nuclear cyclin B1-positive breast carcinoma is resistant to adjuvant therapy, and nuclear cyclin B1 immunoreactivity is a potent prognostic factor in breast carcinoma patients...
  59. doi request reprint Expression of retinoic acid receptors in human endometrial carcinoma
    Kojiro Tanabe
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Cancer Sci 99:267-71. 2008
    ..AM580 might therefore be considered as a potential treatment for endometrial carcinoma...
  60. doi request reprint Runt-related transcription factor 2 in human colon carcinoma: a potent prognostic factor associated with estrogen receptor
    Tomohiko Sase
    Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int J Cancer 131:2284-93. 2012
    ....
  61. doi request reprint A novel method for isolating individual cellular components from the adult human distal lung
    Naoya Fujino
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Am J Respir Cell Mol Biol 46:422-30. 2012
    ....
  62. ncbi request reprint Nuclear receptor DAX1 in human prostate cancer: a novel independent biological modulator
    Yasuhiro Nakamura
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Endocr J 56:39-44. 2009
    ..DAX1 immunoreactivity is considered a new biological modulator of human prostate cancer, but independent to the status of sex steroid receptors in human prostate cancer tissues...
  63. ncbi request reprint Estrogen receptors in atherosclerotic human aorta: inhibition of human vascular smooth muscle cell proliferation by estrogens
    Yasuhiro Nakamura
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Mol Cell Endocrinol 219:17-26. 2004
    ..Our study also indicates that decreased levels of ER, especially ERalpha, in the female atherosclerotic neointima may be associated with progression of atherosclerotic changes...
  64. ncbi request reprint Aromatase in human breast carcinoma as a key regulator of intratumoral sex steroid concentrations
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Health Sciences, Sendai, Japan
    Endocr J 55:455-63. 2008
    ..Aromatase inhibitors may thus have additional antiproliferative effects through increasing local DHT concentration with estrogen deprivation...
  65. ncbi request reprint 3beta-Hydroxysteroid dehydrogenase in human aorta
    Yasuhiro Nakamura
    Department of Pathology, Tohoku University School of Medicine, Seiryo machi, Sendai, Japan
    Endocr J 52:111-5. 2005
    ..These findings all indicated that steroidogenesis via 3beta-HSD may occur in VSMCs of human aorta, possibly related to gender differences and/or the degree of atherosclerosis...
  66. ncbi request reprint Expression of androgen receptor and 5alpha-reductases in the human normal endometrium and its disorders
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Int J Cancer 99:652-7. 2002
    ..Androgenic actions may be also regulated predominantly by serum testosterone and not by DHT in endometrial hyperplasia because of the absence of 5alpha-reductases in the site of its actions...
  67. ncbi request reprint StAR and progesterone producing enzymes (3beta-hydroxysteroid dehydrogenase and cholesterol side-chain cleavage cytochromes P450) in human epithelial ovarian carcinoma: immunohistochemical and real-time PCR studies
    Manar Abd-Elaziz
    Department of Pathology, Tohoku University School of Medicine and Tohoku University Hospital, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Cancer Sci 96:232-9. 2005
    ....
  68. ncbi request reprint Differential expression of progesterone receptor isoforms A and B in the normal ovary, and in benign, borderline, and malignant ovarian tumors
    Jun ichi Akahira
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8574, Japan
    Jpn J Cancer Res 93:807-15. 2002
    ..These results suggest that down-regulation of PRA is associated with the development of ovarian epithelial carcinoma...
  69. ncbi request reprint Expression of urocortin 3/stresscopin in human adrenal glands and adrenal tumors
    Kazuhiro Takahashi
    Department of Analytical Medical Technology, Tohoku University School of Health Sciences, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Peptides 27:178-82. 2006
    ....
  70. doi request reprint Comparative effects of raloxifene, tamoxifen and estradiol on human osteoblasts in vitro: estrogen receptor dependent or independent pathways of raloxifene
    Yasuhiro Miki
    Department of Pathology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi, Japan
    J Steroid Biochem Mol Biol 113:281-9. 2009
    ..Results of our present study demonstrated that raloxifene exerted direct protective effects on human osteoblasts in both estrogen receptor dependent and independent manners...
  71. ncbi request reprint Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma
    Mitsuhisa Muto
    Division of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Sendai 2980 8574, Japan
    Cancer Sci 98:1570-6. 2007
    ..The results of our present study demonstrate that LST-2 immunoreactivity is a potent prognostic factor in human breast cancer...
  72. ncbi request reprint Intracrinology of sex steroids in ductal carcinoma in situ (DCIS) of human breast: comparison to invasive ductal carcinoma (IDC) and non-neoplastic breast
    Yasuhiro Miki
    Department of Pathology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi ken 980 8575, Japan
    J Steroid Biochem Mol Biol 114:68-71. 2009
    ..Therefore, in this review, we also focused on the importance of key intracrine enzymes such as 17beta-hydroxysteroid dehydrogenases, steroid sulfatase,estrogen sulfotransferase, 5alpha-reductases in both IDC and DCIS...
  73. ncbi request reprint Urocortin and corticotropin-releasing factor receptor expression in the human colonic mucosa
    Y Muramatsu
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Peptides 21:1799-809. 2000
    ..The appearance of urocortin after birth indicates that the exposure to dietary intake and/or luminal bacteria after birth may contribute to the initiation of urocortin expression in human gastrointestinal tract mucosa...
  74. ncbi request reprint Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation
    Jun ichi Akahira
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Cancer Res 10:2687-93. 2004
    ..In this study, we examined the promoter methylation status and expression of 14-3-3 sigma and evaluated its clinical significance in epithelial ovarian cancer...
  75. ncbi request reprint Retinoid receptors in the human endometrium and its disorders: a possible modulator of 17 beta-hydroxysteroid dehydrogenase
    K Ito
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai 980 8557, Japan
    J Clin Endocrinol Metab 86:2721-7. 2001
    ..These results all suggest that retinoic acids may be involved in modulation of in situ estrogen metabolism in both normal and neoplastic human endometrium possibly through RXR gamma by stimulating the expression of 17 beta-HSD type 2...
  76. ncbi request reprint Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle
    Yoko Sato
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 88:3415-20. 2003
    ..These results indicated that DAX-1 and COUP-TFII may play a role in the modulation of Ad4BP/SF-1-dependent transcription of steroidogenic enzymes in different cell types and follicular stages in normal cycling human ovaries...
  77. ncbi request reprint 14-3-3sigma is down-regulated in human prostate cancer
    Tomohiko Urano
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 319:795-800. 2004
    ..These data suggest that 14-3-3sigma expression is down-regulated during the neoplastic transition of prostate epithelial cells...
  78. ncbi request reprint Ad4BP in the human adrenal cortex and its disorders
    H Sasano
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 80:2378-80. 1995
    ..Ad4BP therefore seems to play important roles in the induction and maintenance of the transcription of all steroidogenic P450 genes in human adrenocortical cells, even after malignant transformation...
  79. ncbi request reprint Sex steroid receptors in rheumatoid arthritis
    Masato Ishizuka
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Clin Sci (Lond) 106:293-300. 2004
    ....
  80. ncbi request reprint Induction of 11beta-hydroxysteroid dehydrogenase type 2 and hyperaldosteronism are essential for enhanced sodium absorption after total colectomy in rats
    Shun Sato
    Departments of Surgery and Pathology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aoba ku, Sendai 980 9574, Japan
    Surgery 137:75-84. 2005
    ..Analysis of the intestinal adaptation after total colectomy may lead to developing novel therapies for postoperative diarrhea...
  81. ncbi request reprint A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E
    D H Kim
    Tohoku University Gene Research Center, Sendai, 981 8555, Japan
    J Biochem 124:1072-6. 1998
    ..In LDLR-deficient Watanabe heritable hyperlipidemic rabbits, LRP5 mRNA was increased in the liver and accumulated in cholesterol-laden foam cells of atherosclerotic lesions...
  82. ncbi request reprint Expression of adrenomedullin2/intermedin in human brain, heart, and kidney
    Ryo Morimoto
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Sendai, Miyagi 980 8574, Japan
    Peptides 28:1095-103. 2007
    ..The present study has shown expression of AM2/IMD in various types of cells in the central nervous system and the cardiovascular system, and suggested possible (patho)physiological roles of AM2/IMD in these systems...
  83. ncbi request reprint Analysis for localization of steroid sulfatase in human tissues
    Takashi Suzuki
    Departmen of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Methods Enzymol 400:303-16. 2005
    ....
  84. ncbi request reprint Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma
    Yasuhiro Miki
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi ken, Japan
    Cancer Res 66:535-42. 2006
    ..These results suggest that SXR/hPXR and its target gene, such as OATP-A, may play important roles in the biology of human breast cancers...
  85. ncbi request reprint Intracellular elasticity and viscosity in the body, leading, and trailing regions of locomoting neutrophils
    M Yanai
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai 980 8574, Japan
    Am J Physiol 277:C432-40. 1999
    ..This is consistent with the contraction/solation hypothesis of pseudopodial formation...
  86. ncbi request reprint Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma and seminoma/dysgerminoma in human: immunohistochemical study on formalin-fixed, paraffin-embedded tissues
    Y Tsuura
    Department of Pathology, Fukushima Medical College, Japan
    Virchows Arch 424:135-41. 1994
    ..The c-kit product may be a useful marker in diagnostic pathology of seminoma/dysgerminoma and SCLC among human solid tumours, and in distinction of SCLC from non-pulmonary small cell carcinoma...
  87. ncbi request reprint PTOV1: a novel testosterone-induced atherogenic gene in human aorta
    Y Nakamura
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Pathol 209:522-31. 2006
    ....
  88. ncbi request reprint Adrenal cortical diseases: international case conference
    Hironobu Sasano
    Department of Pathology, Tohoku University School of Medicine, Seiryou machi, Sendai, Japan
    Endocr Pathol 13:141-8. 2002
    ..In this article, we provide a clinical summary, macroscopic and histologic findings, and histologic diagnosis of these four adrenocortical cases...
  89. ncbi request reprint Progesterone receptor subtypes in vascular smooth muscle cells of human aorta
    Yasuhiro Nakamura
    Department of Pathology, Tohoku University School of Medicine, Seiryomachi, Sendai, Japan
    Endocr J 52:245-52. 2005
    ..PR-B was equally expressed between male and female aorta, but PR-A was more abundant in female than in male aorta. This finding demonstrated that the status of PR subtype expression was associated with the difference of genders...
  90. ncbi request reprint IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis
    Muneo Numasaki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    J Immunol 175:6177-89. 2005
    ....
  91. ncbi request reprint 17Beta-hydroxysteroid dehydrogenases in human endometrium and its disorders
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Mol Cell Endocrinol 248:136-40. 2006
    ..These results indicated that 17-HSD types 2 and 5 play an important role in the regulation of in situ estrogen production in endometrial carcinoma...
  92. ncbi request reprint Distribution of organic anion-transporting polypeptide 2 (oatp2) and oatp3 in the rat retina
    Aki Ito
    Department of Ophthalmology, Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    Invest Ophthalmol Vis Sci 43:858-63. 2002
    ..To examine the expression of multifunctional Na(+)-independent organic anion-transporting polypeptides, termed oatp1, oatp2, and oatp3, involving the transport of thyroid hormone in the rat retina at the protein and mRNA levels...
  93. ncbi request reprint Endogenous secretory receptor for advanced glycation end products in non-small cell lung carcinoma
    Seiichi Kobayashi
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryoumachi, Aobaku, Sendai, Japan
    Am J Respir Crit Care Med 175:184-9. 2007
    ..A recently discovered novel splice variant, the endogenous secretory receptor for advanced glycation end products, mediates the receptor for advanced glycation end-product-associated cell responses by functioning as a decoy receptor...
  94. ncbi request reprint Immunohistochemistry of a proliferation marker Ki67/MIB1 in adrenocortical carcinomas: Ki67/MIB1 labeling index is a predictor for recurrence of adrenocortical carcinomas
    Ryo Morimoto
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Endocr J 55:49-55. 2008
    ..0001) and overall survival (P = 0.0063). The present study has suggested that Ki67/MIB1LI, as well as Weiss score, is a useful predictor for tumor recurrence after resection of the primary tumors in patients with ACC...
  95. ncbi request reprint Estrogen actions and in situ synthesis in human vascular smooth muscle cells and their correlation with atherosclerosis
    Yasuhiro Nakamura
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Steroid Biochem Mol Biol 93:263-8. 2005
    ..They indicate that both abundance of these estrogen-metabolizing enzymes in female aorta and relative levels of ER in VSMCs of female neointima may be associated with the status of atherosclerotic changes...
  96. ncbi request reprint Nur-related factor 1 and nerve growth factor-induced clone B in human adrenal cortex and its disorders
    Liangying Lu
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Clin Endocrinol Metab 89:4113-8. 2004
    ..0001) associated with that of CYP11B2. These results suggest that the expression of Nurr1 and NGFI-B plays an important role in human adrenal cortex and its neoplasms, including possible regulation of steroidogenesis...
  97. doi request reprint Amyloid precursor protein is a primary androgen target gene that promotes prostate cancer growth
    Ken ichi Takayama
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Cancer Res 69:137-42. 2009
    ..Our findings will indicate that APP could be a potential molecular target for the diagnosis and treatment of prostate cancer...
  98. doi request reprint Runx2 in human breast carcinoma: its potential roles in cancer progression
    Yoshiaki Onodera
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Cancer Sci 101:2670-5. 2010
    ..Results of our present study demonstrated that Runx2 plays very important roles in the progression of breast cancer, especially in those of ER-negative cases...
  99. ncbi request reprint Urocortin 1 in colonic mucosa in patients with ulcerative colitis
    Masayuki Saruta
    Department of Pathology, Tohoku University School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Clin Endocrinol Metab 89:5352-61. 2004
    ..Ucn1 therefore may act as a possible local immune-inflammatory mediator in UC...
  100. ncbi request reprint Expression of 11 beta-hydroxysteroid dehydrogenase type 1 in alveolar epithelial cells in rats
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Endocr J 50:445-51. 2003
    ..Our results suggest that alveolar type II cells enhance intracellular glucocorticoid availability via 11beta-HSD1. 11beta-HSD1 in alveolar type II cells is thought of as an autocrine amplifier of glucocorticoid action in the lung...
  101. ncbi request reprint Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate
    T Nishio
    Department of Neurophysiology, Tohoku University School of Medicine, Sendai, 980 8575, Japan
    Biochem Biophys Res Commun 275:831-8. 2000
    ....