Satoshi Suzuki

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi request reprint Increased expression of 11 beta-hydroxysteroid dehydrogenase type 2 in the lungs of patients with acute respiratory distress syndrome
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University School of Medicine, Sendai, Japan
    Pathol Int 53:751-6. 2003
  2. ncbi request reprint Paclitaxel prevents loss of pulmonary endothelial barrier integrity during cold preservation
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Transplantation 78:524-9. 2004
  3. ncbi request reprint Inflammatory mediators down-regulate 11beta-hydroxysteroid dehydrogenase type 2 in a human lung epithelial cell line BEAS-2B and the rat lung
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Tohoku J Exp Med 207:293-301. 2005
  4. ncbi request reprint Sivelestat reduces reperfusion injury of lungs harvested from endotoxin-primed rats by inhibition of neutrophil-mediated inflammation
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Heart Lung Transplant 26:370-5. 2007
  5. ncbi request reprint Dexamethasone upregulates 11beta-hydroxysteroid dehydrogenase type 2 in BEAS-2B cells
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, Japan 980 8575
    Am J Respir Crit Care Med 167:1244-9. 2003
  6. ncbi request reprint Estrogen inhibits cell proliferation through in situ production in human thymoma
    Hironori Ishibashi
    Department of Pathology, Tohoku University School of Medicine, Japan
    Clin Cancer Res 11:6495-504. 2005
  7. doi request reprint Co-expression of estrogen receptor beta and aromatase in Japanese lung cancer patients: gender-dependent clinical outcome
    Mohit Kumar Verma
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Life Sci 91:800-8. 2012
  8. ncbi request reprint Effects of carbenoxolone on alveolar fluid clearance and lung inflammation in the rat
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, Japan
    Crit Care Med 32:1910-5. 2004
  9. doi request reprint Intratumoral estrogens and estrogen receptors in human non-small cell lung carcinoma
    Hiromichi Niikawa
    Department of Pathology, Tohoku University School of Medicine, Japan
    Clin Cancer Res 14:4417-26. 2008
  10. doi request reprint A novel method for isolating individual cellular components from the adult human distal lung
    Naoya Fujino
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Am J Respir Cell Mol Biol 46:422-30. 2012

Detail Information

Publications82

  1. ncbi request reprint Increased expression of 11 beta-hydroxysteroid dehydrogenase type 2 in the lungs of patients with acute respiratory distress syndrome
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University School of Medicine, Sendai, Japan
    Pathol Int 53:751-6. 2003
    ..Impaired glucocorticoid availability in the lungs of such patients may explain, in part, the fact that glucocorticoid therapy does not always rescue patients with ARDS...
  2. ncbi request reprint Paclitaxel prevents loss of pulmonary endothelial barrier integrity during cold preservation
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Transplantation 78:524-9. 2004
    ..However, rapid cooling may affect pulmonary endothelial function. We examined the effects of microtubule stabilization with paclitaxel on pulmonary endothelial barrier integrity under cold temperature...
  3. ncbi request reprint Inflammatory mediators down-regulate 11beta-hydroxysteroid dehydrogenase type 2 in a human lung epithelial cell line BEAS-2B and the rat lung
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Tohoku J Exp Med 207:293-301. 2005
    ..We conclude that lung inflammation reduces local glucocorticoid breakdown and augments glucocorticoid action in the lung by down-regulating 11beta-HSD2 via multiple mechanisms...
  4. ncbi request reprint Sivelestat reduces reperfusion injury of lungs harvested from endotoxin-primed rats by inhibition of neutrophil-mediated inflammation
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Heart Lung Transplant 26:370-5. 2007
    ..In the present study, we investigated the effect of sivelestat, a neutrophil elastase inhibitor, on reperfusion injury of a donor lung that was harvested from endotoxin-primed animals in a rat lung transplantation model...
  5. ncbi request reprint Dexamethasone upregulates 11beta-hydroxysteroid dehydrogenase type 2 in BEAS-2B cells
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, Japan 980 8575
    Am J Respir Crit Care Med 167:1244-9. 2003
    ....
  6. ncbi request reprint Estrogen inhibits cell proliferation through in situ production in human thymoma
    Hironori Ishibashi
    Department of Pathology, Tohoku University School of Medicine, Japan
    Clin Cancer Res 11:6495-504. 2005
    ..Estrogen sulfotransferase (EST), steroid sulfatase (STS), 17beta-hydroxysteroid dehydrogenase (17beta-HSD), and aromatase are considered to play important roles in hormone metabolism of estrogen-dependent tumors...
  7. doi request reprint Co-expression of estrogen receptor beta and aromatase in Japanese lung cancer patients: gender-dependent clinical outcome
    Mohit Kumar Verma
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Life Sci 91:800-8. 2012
    ..We aimed to evaluate whether estrogen receptors (ERs) in non-small cell carcinoma (NSCLC) patients may primarily depend upon intratumoral estrogen produced via aromatase pathway...
  8. ncbi request reprint Effects of carbenoxolone on alveolar fluid clearance and lung inflammation in the rat
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, Japan
    Crit Care Med 32:1910-5. 2004
    ..Since 11beta-HSD2 has been detected in lung epithelial cells, we examined whether carbenoxolone, a potent inhibitor of 11beta-HSD, would enhance endogenous glucocorticoid action on lung fluid balance and inflammation...
  9. doi request reprint Intratumoral estrogens and estrogen receptors in human non-small cell lung carcinoma
    Hiromichi Niikawa
    Department of Pathology, Tohoku University School of Medicine, Japan
    Clin Cancer Res 14:4417-26. 2008
    ..Therefore, we examined intratumoral estradiol concentrations in NSCLC to examine local actions of estrogens in NSCLC...
  10. doi request reprint A novel method for isolating individual cellular components from the adult human distal lung
    Naoya Fujino
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Am J Respir Cell Mol Biol 46:422-30. 2012
    ....
  11. doi request reprint Intratumoral localization of aromatase and interaction between stromal and parenchymal cells in the non-small cell lung carcinoma microenvironment
    Yasuhiro Miki
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Res 70:6659-69. 2010
    ....
  12. ncbi request reprint Progesterone receptor in non-small cell lung cancer--a potent prognostic factor and possible target for endocrine therapy
    Hironori Ishibashi
    Departments of Pathology and Molecular Medical Technology, Tohoku University School of Medicine, Sendai, Japan
    Cancer Res 65:6450-8. 2005
    ..Therefore, progesterone therapy may be clinically effective in suppressing development of progesterone receptor-positive NSCLC patients...
  13. ncbi request reprint Effects of rewarming on nuclear factor-kappaB and interleukin 8 expression in cold-preserved alveolar epithelial cells
    Kunihiko Inoue
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Transplantation 76:409-15. 2003
    ....
  14. ncbi request reprint Single dexamethasone injection increases alveolar fluid clearance in adult rats
    Masafumi Noda
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, Japan
    Crit Care Med 31:1183-9. 2003
    ..We examined whether single dexamethasone injection at therapeutic doses would modulate lung epithelial Na+ channels and Na+/K+-ATPase and increase alveolar fluid clearance in adult rats...
  15. ncbi request reprint Sex steroid hormone receptors in human thymoma
    Hironori Ishibashi
    Department of Pathology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    J Clin Endocrinol Metab 88:2309-17. 2003
    ..Results from our study suggest that estrogens may inhibit thymoma growth via ER alpha, and that ER alpha immunoreactivity may act as a prognostic factor in human thymoma...
  16. pmc Intratumoral localization and activity of 17β-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer: a potent prognostic factor
    Mohit K Verma
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Transl Med 11:167. 2013
    ..e. 17β-hydroxysteroid dehydrogenases (i.e. 17βHSD1 and 17βHSD2) and others have not been studied. Therefore, in this study, we examined the clinical/ biological significance of 17β-hydroxysteroid dehydrogenases in NSCLCs...
  17. ncbi request reprint Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism
    Akiko Kikuchi
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Hum Genet 116:354-60. 2005
    ..93, 95% CI 0.4-2.0, P=0.85). These findings suggest that the large size of a (GT)(n) repeat in the HO-1 gene promoter may be associated with the development of lung adenocarcinoma in Japanese male smokers...
  18. doi request reprint Highly concordant coexpression of aromatase and estrogen receptor beta in non-small cell lung cancer
    Keiko Abe
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hum Pathol 41:190-8. 2010
    ....
  19. ncbi request reprint Endogenous secretory receptor for advanced glycation end products in non-small cell lung carcinoma
    Seiichi Kobayashi
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryoumachi, Aobaku, Sendai, Japan
    Am J Respir Crit Care Med 175:184-9. 2007
    ..A recently discovered novel splice variant, the endogenous secretory receptor for advanced glycation end products, mediates the receptor for advanced glycation end-product-associated cell responses by functioning as a decoy receptor...
  20. ncbi request reprint Expression of 11 beta-hydroxysteroid dehydrogenase type 1 in alveolar epithelial cells in rats
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Endocr J 50:445-51. 2003
    ..Our results suggest that alveolar type II cells enhance intracellular glucocorticoid availability via 11beta-HSD1. 11beta-HSD1 in alveolar type II cells is thought of as an autocrine amplifier of glucocorticoid action in the lung...
  21. ncbi request reprint Early changes in alveolar fluid clearance by nitric oxide after endotoxin instillation in rats
    Hiroyoshi Tsubochi
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Am J Respir Crit Care Med 167:205-10. 2003
    ..NO is produced via inducible NO synthase in endotoxin-stimulated alveolar macrophages and was also shown to increase alveolar fluid clearance at 24 hours...
  22. pmc Isolation of alveolar epithelial type II progenitor cells from adult human lungs
    Naoya Fujino
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Lab Invest 91:363-78. 2011
    ..Our findings demonstrated that adult human lungs contain a progenitor population for ATII cells. This study is a first step toward better understanding of stem cell biology in adult human lung alveoli...
  23. ncbi request reprint Osteopontin may be responsible for pulmonary vascular remodeling
    Yasushi Hoshikawa
    Department of Thoracic Surgery, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Chest 128:621S. 2005
  24. pmc Vasohibin-1 expression in endothelium of tumor blood vessels regulates angiogenesis
    Tomoko Hosaka
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Am J Pathol 175:430-9. 2009
    ....
  25. ncbi request reprint Clinical significance of heparanase activity in primary resected non-small cell lung cancer
    Hidenori Takahashi
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Seiryo machi 1 1, Aoba ku, Sendai 980 8574, Japan
    Lung Cancer 45:207-14. 2004
    ..These results suggest that heparanase activity could be used as a prognostic indicator for postoperative patients with NSCLC and heparanase might be a promising molecular target for treatment of NSCLC...
  26. ncbi request reprint Nitroglycerin treatment may enhance chemosensitivity to docetaxel and carboplatin in patients with lung adenocarcinoma
    Hiroyasu Yasuda
    Department of Translational Clinical Oncology, Kyoto University Graduate School of Medicine, Kyoto, and Department of Internal Medicine, Sendai City Hospital, Sendai, Japan
    Clin Cancer Res 12:6748-57. 2006
    ..The effects and mechanisms of nitroglycerin on the enhancement of chemosensitivity to docetaxel and carboplatin regimen (DCb) in patients with lung adenocarcinoma have not been reported...
  27. doi request reprint Suppression of estrogen actions in human lung cancer
    Yasuhiro Miki
    Department of Pathology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Mol Cell Endocrinol 340:168-74. 2011
    ..Therefore, in this review, we focused on the potential of an endocrine therapy in NSCLC using clinically available inhibitors of estrogen and aromatase actions...
  28. ncbi request reprint Hypoxia diminishes toll-like receptor 4 expression through reactive oxygen species generated by mitochondria in endothelial cells
    Itaru Ishida
    Department of Thoracic Surgery, Tohoku University, Sendai, Japan
    J Immunol 169:2069-75. 2002
    ..We conclude that hypoxia decreases TLR4 expression in endothelial cells and that this change is mediated by mitochondrial ROS leading to attenuation of AP-1 transcriptional activity...
  29. ncbi request reprint Rapidly growing endobronchial hamartoma with bone marrow tissue
    Hisashi Oishi
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Ann Thorac Surg 81:2287-9. 2006
    ..An extremely rare case of pulmonary hamartoma showing rapid growth and involving bone marrow tissue is presented...
  30. ncbi request reprint Analysis of intrapulmonary vessels and epithelial-endothelial interactions in the human developing lung
    Sumiko Maeda
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Lab Invest 82:293-301. 2002
    ..Epithelial-endothelial interactions during lung development are considered very important in the establishment of the functional blood-gas interface...
  31. doi request reprint Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma
    Daisuke Inoue
    Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 103:760-6. 2012
    ..The prognostic impact of p62 status was pronounced in adenocarcinoma patients, suggesting that molecular mechanisms underlying cancer evolution differ between adenocarcinoma and squamous cell carcinoma...
  32. ncbi request reprint A rare case of a pulmonary granular cell tumor presenting as a coin lesion
    Tomoko Hosaka
    Department of Surgery, Sendai Kosei Hospital, Sendai, Japan
    Jpn J Thorac Cardiovasc Surg 51:107-9. 2003
    ..Although this was a very rare case presenting as an asymptomatic coin lesion, the histological features were the same as those demonstrated for granular cell tumor at common sites...
  33. ncbi request reprint [Effects of peroxisome proliferator-activated receptor gamma ligands on monocrotaline-induced pulmonary hypertension in rats]
    Yasushi Matsuda
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University
    Nihon Kokyuki Gakkai Zasshi 43:283-8. 2005
    ..We conclude that PPARgamma ligands reduce MCT-induced pulmonary hypertension and pulmonary vascular wall thickening in rats. Inhibition of MCT-induced cell proliferation in the pulmonary arterial walls may account for this effect..
  34. ncbi request reprint Retinoid receptors in the developing human lung
    Yuichiro Kimura
    Department of Pathology, Tohoku University School of Medicine, Tohoku University, Sendai, Japan
    Clin Sci (Lond) 103:613-21. 2002
    ..4+/-0.05-fold and 3.1+/-0.03-fold respectively; P <0.01), RAR-beta at distal sites (2.4+/-0.01-fold; P <0.05) and RAR-gamma at proximal sites (2.2+/-0.11-fold; P <0.05) were significantly higher in the fetus than in the adult...
  35. ncbi request reprint Successful closure of an empyema space associated with persistent bronchopleural fistula: Muscle transposition combined with endobronchial plug
    Hisashi Oishi
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Thorac Cardiovasc Surg 129:692-3. 2005
  36. ncbi request reprint Primary intrapulmonary thymoma successfully resected with vascular reconstruction
    Hironori Ishibashi
    Department of Thoracic Surgery, Sendai Kousei Hospital, Sendai, Japan
    Ann Thorac Surg 76:1735-7. 2003
    ..There has been no evidence of recurrence in 6 years. Complete resection of the tumor with vascular reconstruction and adjuvant radiation should be considered in invasive intrapulmonary thymoma...
  37. ncbi request reprint Left-side catamenial pneumothorax with endometrial tissue on the visceral pleura
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan
    Jpn J Thorac Cardiovasc Surg 54:225-7. 2006
    ....
  38. doi request reprint Chest injuries and the 2011 Great East Japan Earthquake
    Kimiaki Sato
    Department of Thoracic Surgery, Japanese Red Cross Ishinomaki Hospital, 71 Nishimichi Shita, Hebita, Ishinomaki, Miyagi 986 8522, Japan
    Respir Investig 51:24-7. 2013
    ..Chest injuries caused during a major earthquake remain unclear. We have described profiles of patients with chest injuries who were diagnosed and treated at the area that was most affected by the Great East Japan Earthquake in 2011...
  39. ncbi request reprint Nano-sized fluorescent particles as new tracers for sentinel node detection: experimental model for decision of appropriate size and wavelength
    Morio Nakajima
    Division of Surgical Oncology, Graduate School of Medicine, Tohoku University, 1 1 Seiryo machi, Sendai 980 8574, Japan
    Cancer Sci 96:353-6. 2005
    ....
  40. ncbi request reprint Right lung cancer with right aortic arch
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan
    Jpn J Thorac Cardiovasc Surg 51:469-71. 2003
    ..Although a unique operative view required particular attention in identifying nodes in the mediastinum, we were able to perform the operation without specific techniques...
  41. ncbi request reprint Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines
    Hisao Hirai
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Blood 102:1619-21. 2003
    ..These findings suggested that the polymorphism of the HO-1 gene is associated with the strength of antiapoptotic effects of HO-1, resulting in an association with susceptibility to oxidative stress-mediated diseases...
  42. ncbi request reprint Analysis of edema fluids and histologic features of the lung in reexpansion pulmonary edema during video-assisted thoracoscopic surgery
    Satoshi Suzuki
    Department of Surgery, Sendai Kosei Hospital, Sendai, Japan
    J Thorac Cardiovasc Surg 123:387-9. 2002
  43. doi request reprint Delayed cardiac rupture occurring two months after blunt chest trauma
    Shinsaku Ueda
    Department of Thoracic Surgery, Ishinomaki Red Cross Hospital, 71 Hebita Nishimichisita, Ishinomaki, Miyagi 986 8522, Japan
    Gen Thorac Cardiovasc Surg 59:45-7. 2011
    ..The cardiac rupture and the pericardial defect did not induce life-threatening cardiac tamponade; however, the cardiac rupture did induce hemothorax, which could be successfully treated...
  44. ncbi request reprint Biophoton detection as a novel technique for cancer imaging
    Motohiro Takeda
    Division of Surgical Oncology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai 980 8574, Japan
    Cancer Sci 95:656-61. 2004
    ..73). This non-invasive and simple technique has the potential to be used as an optical biopsy to detect tumor viability...
  45. ncbi request reprint High prevalence of deep vein thrombosis in tsunami-flooded shelters established after the great East-Japan earthquake
    Shinsaku Ueda
    Department of Thoracic Surgery, Japanese Red Cross Ishinomaki Hospital, Miyagi, Japan
    Tohoku J Exp Med 227:199-202. 2012
    ..Those deteriorated and crowded shelters were observed in tsunami-flooded areas. Therefore, long-term shelters should not be set up in flooded areas after tsunami...
  46. ncbi request reprint Utilization of human liver microsomes to explain individual differences in paclitaxel metabolism by CYP2C8 and CYP3A4
    Ryoko Taniguchi
    Department of Pharmacology, St Marianna University School of Medicine, Kawasaki, Japan
    J Pharmacol Sci 97:83-90. 2005
    ..CYP2C8 is the primary metabolic pathway of paclitaxel, but there is a "shifting phenomenon" in the metabolic pathway of paclitaxel in the liver of some human subjects...
  47. ncbi request reprint Transplantation of human hepatocytes cultured with deleted variant of hepatocyte growth factor prolongs the survival of mice with acute liver failure
    Yong Chen
    Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Transplantation 79:1378-85. 2005
    ..As a tool for maintaining hepatocyte functions in vitro, dHGF, a variant of HGF (hepatocyte growth factor) with a deletion of five amino acids, attracted our attention because it is less cytotoxic compared with HGF...
  48. doi request reprint Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascade
    Takeshi Niizeki
    Dept of Cardiology, Pulmonology, and Nephrology, Yamagata Univ School of Medicine, Yamagata, Japan
    Am J Physiol Heart Circ Physiol 295:H245-55. 2008
    ..DGKepsilon may be a novel therapeutic target to prevent cardiac hypertrophy and progression to heart failure...
  49. ncbi request reprint Expression of CYP3A4 mRNA is correlated with CYP3A4 protein level and metabolic activity in human liver
    Minoru Watanabe
    Department of Pharmacology, St Marianna University School of Medicine, Kanagawa, Japan
    J Pharmacol Sci 94:459-62. 2004
    ..Our results suggest that CYP3A4 protein and activity levels can be predicted from CYP3A4 mRNA levels determined by RT-PCR and using a very small amount of liver tissue...
  50. ncbi request reprint Overexpression of CYP2A6 in human colorectal tumors
    Yoko Matsuda
    Onco Pathology, Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, Kita gun, Kagawa 761 0793, Japan
    Cancer Sci 98:1582-5. 2007
    ..The data indicate that CYP2A6 may have important roles in human colorectal tumorigenesis and progression, so that it could be a candidate therapeutic and chemopreventive target for colorectal cancers...
  51. ncbi request reprint Nitric oxide further attenuates pulmonary hypertension in magnesium-treated piglets
    Kelly Mullins Haas
    Department of Pediatrics, Nagoya City University Medical School, Nagoya, Japan
    Pediatr Int 44:670-4. 2002
    ..However, magnesium (Mg2+) is an antagonist of Ca2+. We studied the effect of magnesium sulfate on the treatment of hypoxia-induced pulmonary hypertension and compared to the site of action of nitric oxide (NO)...
  52. ncbi request reprint Pentraxin 3, a new marker for vascular inflammation, predicts adverse clinical outcomes in patients with heart failure
    Satoshi Suzuki
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Am Heart J 155:75-81. 2008
    ..The purpose of the present study was to examine the clinical significance of plasma PTX3 levels in patients with heart failure...
  53. doi request reprint Soluble Receptor for advanced glycation end products (RAGE) is a prognostic factor for heart failure
    Yo Koyama
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    J Card Fail 14:133-9. 2008
    ..In the present study, we measured serum soluble RAGE levels in patients and examined whether serum soluble RAGE predicts prognosis in patients with heart failure...
  54. ncbi request reprint Late circulatory dysfunction and decreased cerebral blood flow volume in infants with periventricular leukomalacia
    Sumio Fukuda
    Nagoya City University, Graduate School of Medical Sciences, Department of Pediatrics, Neonatology and Congenital Disorders, Kawasumi, Mizuho, Nagoya, Aichi 467 8601, Japan
    Brain Dev 30:589-94. 2008
    ..The results of the present study suggest that a dip in the blood flow volume in the few days after birth might result in subsequent PVL...
  55. ncbi request reprint Lung toxicity of 16 fine particles on intratracheal instillation in a bioassay model using f344 male rats
    Masanao Yokohira
    Onco Pathology, Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Toxicol Pathol 36:620-31. 2008
    ....
  56. ncbi request reprint [Guidelines for the management of rapidly progressive glomerulonephritis]
    Hideto Sakai
    Nihon Jinzo Gakkai Shi 44:55-82. 2002
  57. ncbi request reprint Relation of serum heat shock protein 60 level to severity and prognosis in chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    Takeshi Niizeki
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Am J Cardiol 102:606-10. 2008
    ..In conclusion, serum HSP 60 level was related to the severity of CHF and associated with a high risk for adverse cardiac events in patients CHF...
  58. ncbi request reprint Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J female mice
    Toshiya Kuno
    Onco Pathology, Department of Pathology and Host Defence, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Oncol Rep 20:767-72. 2008
    ..It can be concluded from the present data that 8-MOP at 100 ppm in the diet does not prevent mouse lung carcinogenesis when administered in the post-initiation phase...
  59. ncbi request reprint The Tei index permits evaluation of cardiopulmonary function during inhaled nitric oxide therapy in the hypoxic newborn piglet
    Takahiro Sugiura
    Department of Pediatrics, Neonatology, and Congenital Disorders, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan
    Biol Neonate 86:176-82. 2004
    ..These results suggest that the Tei index provides an objective assessment of persistent pulmonary hypertension of the newborn...
  60. ncbi request reprint Dengue hemorrhagic shock and disseminated candidiasis
    Satoshi Suzuki
    Department of Infectious Diseases, Graduate School of Medicine, The University of Tokyo
    Intern Med 46:1043-6. 2007
    ..The patient developed a disseminated Candida tropicalis infection, which may have been due to translocation of the fungus from the intestine damaged by the dengue virus...
  61. ncbi request reprint The sex differences of cerebrospinal fluid levels of interleukin 8 and antioxidants in asphyxiated newborns
    Mohamed Hamed Hussein
    Department of Pediatrics, Neonatology and Congenital Disorders, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Misuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Shock 28:154-9. 2007
    ....
  62. ncbi request reprint [An intra-pulmonary lymphnode resembling typical pulmonary primary adenocarcinoma on high-resolution computed tomographic (HR-CT) chest images]
    Rieko Hatta
    Department of Respiratory Medicine, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Kahoku gun, Ishikawa, Japan
    Nihon Kokyuki Gakkai Zasshi 40:980-3. 2002
    ..In cases with such radiographic findings, careful attention should be paid in the differential diagnosis to distinguish intrapulmonary lymph nodes from primary pulmonary adenocarcinoma...
  63. ncbi request reprint Analysis by comparative genomic hybridization of gastric cancer with peritoneal dissemination and/or positive peritoneal cytology
    Koji Morohara
    Department of Surgery, Division of General and Gastroenterological Surgery, School of Medicine, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Cancer Genet Cytogenet 161:57-62. 2005
    ..In this study, gain/amplification of 5p14, 7q21.3, 7q31, and 7q36, and loss of 22q11.2 were significant in gastric cancer cases with peritoneal dissemination and/or positive peritoneal cytology...
  64. ncbi request reprint Anti-monocyte chemoattractant protein-1 gene therapy attenuates renal injury induced by protein-overload proteinuria
    Hideaki Shimizu
    Division of Clinical Immunology, Department of Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Am Soc Nephrol 14:1496-505. 2003
    ..The fact that 7ND gene therapy had little effect on the contralateral kidney indicates that 7ND acted locally. This strategy may have a potential usefulness as a gene therapy against tubulointerstitial renal injury...
  65. ncbi request reprint Molecular evaluation of endothelial progenitor cells in patients with ischemic limbs: therapeutic effect by stem cell transplantation
    Koji Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya 466 8550, Japan
    Arterioscler Thromb Vasc Biol 24:e192-6. 2004
    ..It is also important to evaluate endothelial progenitor cell (EPC) contents in different stem cell sources to choose the best material for therapeutic angiogenesis...
  66. ncbi request reprint Fibrillary glomerulonephritis with hypocomplementemia
    Satoshi Suzuki
    First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata
    Intern Med 42:719-22. 2003
    ..Immunosuppressive therapy did not attenuate the nephrotic-range proteinuria. Such a case of fibrillary glomerulonephritis with hypocomplementemia is rare...
  67. ncbi request reprint Reduction of MDR3 mRNA levels by forskolin in Chang liver cells
    Satoshi Suzuki
    Department of Medicine, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3, Kanagawa machi, Kanazawa 920 1181, Japan
    Anticancer Res 23:3373-8. 2003
    ..To clarify the regulatory system for the expression of MDR3 mRNA in comparison with MDR1 mRNA, we examined the effect of cyclic AMP using forskolin...
  68. ncbi request reprint Long-term treatment with probucol improves endothelial function in patients with coronary artery disease
    Tatsuya Tagawa
    Department of Clinical Pharmacology and Therapeutics, University of the Ryukyus, School of Medicine, Okinawa, Japan
    Hypertens Res 27:311-8. 2004
    ....
  69. ncbi request reprint Development and characterization of a novel porcine model of neonatal sepsis
    Takenori Kato
    Department of Pediatrics, Neonatology and Congenital Disorders, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Shock 21:329-35. 2004
    ..These results suggested that this model mimics the clinical state of neonatal sepsis and hence may have significant implications for the treatment of sepsis, including its use as a model in further investigations...
  70. ncbi request reprint Effect of PSK on the maturation of dendritic cells derived from human peripheral blood monocytes
    Masashi Kanazawa
    Department of Surgery II, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, 960 1295, Japan
    Immunol Lett 91:229-38. 2004
    ..The clinical significance of the combined use of PSK in DC vaccine therapy remains for study...
  71. ncbi request reprint Usefulness of a new Doppler index for assessing both ventricular functions and pulmonary circulation in newborn piglet with hypoxic pulmonary hypertension
    Takahiro Sugiura
    Department of Pediatrics, Nagoya City University Medical School and Department of Pediatrics, Nagoya City Johoku Hospital, Japan
    Pediatr Res 53:927-32. 2003
    ..These results suggest that the Tei index will become an objective method of assessing patients with persistent pulmonary hypertension of the newborn...
  72. ncbi request reprint [A case of recurrent gastric cancer effectively treated by combination chemotherapy of weekly paclitaxel and 5'- DFUR after showing resistance to weekly paclitaxel]
    Satoshi Suzuki
    Dept of Surgery II, Fukushima Medical University
    Gan To Kagaku Ryoho 33:385-7. 2006
    ..This case suggests that combination chemotherapy of weekly paclitaxel and 5'-DFUR might be a promising regimen for recurrent gastric cancer even for patients who show no effect with only paclitaxel administration...
  73. ncbi request reprint Hair follicle regeneration using grafted rodent and human cells
    Ritsuko Ehama
    Life Science Research Center, Shiseido Research Center, Yokohama, Kanagawa, Japan
    J Invest Dermatol 127:2106-15. 2007
    ..This study emphasizes the importance of EMI in follicular generation and the differentiation potential of epidermal keratinocytes...
  74. ncbi request reprint Heart-type fatty acid-binding protein is more sensitive than troponin T to detect the ongoing myocardial damage in chronic heart failure patients
    Takeshi Niizeki
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    J Card Fail 13:120-7. 2007
    ..We hypothesized that a cytosolic marker (H-FABP) is more sensitive than a myofibrillar component (TnT) in the detection of OMD in CHF...
  75. ncbi request reprint Azelnidipine inhibits H2O2-induced cell death in neonatal rat cardiomyocytes
    Yo Koyama
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, 990 9585, Japan
    Cardiovasc Drugs Ther 21:69-72. 2007
    ..We evaluated the antioxidant effects of azelnidipine compared to another dihyropyridine calcium channel blocker, nifedipine, in neonatal rat cardiomyocytes...
  76. ncbi request reprint Improvement of hepatocyte viability after cryopreservation by supplementation of long-chain oligosaccharide in the freezing medium in rats and humans
    Yoshitaka Miyamoto
    Department of Innovative Surgery, National Research Institute for Child Health and Development, Tokyo 157 8535, Japan
    Cell Transplant 15:911-9. 2006
    ..Possible reasons for these differences may be prior cell damage during extended cold ischemia of the human liver, donor age, or cell degradation caused by progression of fatty liver in humans, and/or species differences...
  77. ncbi request reprint High-throughput genotyping of filamentous fungus Aspergillus oryzae based on colony direct polymerase chain reaction
    Satoshi Suzuki
    National Food Research Institute, 2 1 12 Kannondai, Tsukuba, Ibaraki 305 8642, Japan
    J Biosci Bioeng 102:572-4. 2006
    ..This method was then applied to detect other fungal species from agar slants and food materials. This method offers a convenient tool for the genotyping of filamentous fungi without using an organic solvent or specialized equipment...
  78. ncbi request reprint Total hydroperoxide and biological antioxidant potentials in a neonatal sepsis model
    Hiroki Kakita
    Department of Pediatrics, Neonatology and Congenital Disorders, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Pediatr Res 60:675-9. 2006
    ..This is the first study to reveal that the presence of oxidant/antioxidant imbalance in sepsis and septic shock changes during the disease course...
  79. ncbi request reprint An incidentally found case of multiple localized segmented painless dissections of the descending aorta like gnarled tree
    Satoshi Suzuki
    Department of General Internal Medicine, Omiya Medical Center, Jichi Medical University, 1 847 Amanuma cho, Omiya ku, Saitama shi, Saitama
    Intern Med 45:1075-6. 2006
  80. ncbi request reprint Protein kinase Cbeta isoform down-regulates the expression of MDR3 P-glycoprotein in human Chang liver cells
    Satoshi Suzuki
    Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3, Kanagawa machi, Kanazawa 920 1181, Japan
    Biochim Biophys Acta 1760:1552-7. 2006
    ..These suggested that PKCbeta plays a regulatory role in the expression of MDR3...
  81. ncbi request reprint Assessment of induction of cytochrome P450 by NO-1886 (ibrolipim), a lipoprotein lipase-promoting agent, in primary cultures of human hepatocytes and in female rat liver
    Yujiro Morioka
    Department of Drug Metabolism, Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc, Naruto, Tokushima, Japan
    Drug Metab Pharmacokinet 21:19-28. 2006
    ....
  82. ncbi request reprint [Effect of DC therapy combined with chemotherapy in advanced cancer cases]
    Masashi Kanazawa
    Dept of Surgery 2, Fukushima Medical University
    Gan To Kagaku Ryoho 30:1655-60. 2003
    ..The results indicate this method can be useful in advanced cancer patients...