Affiliation: Tohoku University
Location: Sendai, Japan
Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, et al
. Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes. Mol Cell Biol. 2015;35:2658-72 pubmed publisher
..These results demonstrate that the total amount of PHD activity is more important than the specific function of each isoform for hepatic Epo expression regulated by a PHD-HIF2Î±-EpoHE cascade in vivo. ..
Suzuki N, Yamamoto M. Roles of renal erythropoietin-producing (REP) cells in the maintenance of systemic oxygen homeostasis. Pflugers Arch. 2016;468:3-12 pubmed publisher
..To further analyze REP cells, we introduce a newly established mouse line in which REP cells are efficiently labeled with fluorescent protein. ..
Nezu M, Souma T, Yu L, Suzuki T, Saigusa D, Ito S, et al
. Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression. Kidney Int. 2017;91:387-401 pubmed publisher
..Thus, Nrf2 may be a promising therapeutic target for preventing acute kidney injury to chronic kidney disease transition. ..
Suzuki N, Gradin K, Poellinger L, Yamamoto M. Regulation of hypoxia-inducible gene expression after HIF activation. Exp Cell Res. 2017;356:182-186 pubmed publisher
..Since epigenetic mechanisms contribute to stress-inducible and cell-type specific gene regulation, the HIF-dependent reorganization of nucleosome structures in hypoxia-inducible gene promoters is also discussed. ..
Nezu M, Souma T, Yu L, Sekine H, Takahashi N, Wei A, et al
. Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes. Sci Signal. 2017;10: pubmed publisher