Genomes and Genes


Norio Suzuki


Affiliation: Tohoku University
Location: Sendai, Japan


  1. Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, et al. Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes. Mol Cell Biol. 2015;35:2658-72 pubmed publisher
    ..These results demonstrate that the total amount of PHD activity is more important than the specific function of each isoform for hepatic Epo expression regulated by a PHD-HIF2α-EpoHE cascade in vivo. ..
  2. Suzuki N, Yamamoto M. Roles of renal erythropoietin-producing (REP) cells in the maintenance of systemic oxygen homeostasis. Pflugers Arch. 2016;468:3-12 pubmed publisher
    ..To further analyze REP cells, we introduce a newly established mouse line in which REP cells are efficiently labeled with fluorescent protein. ..
  3. Nezu M, Souma T, Yu L, Suzuki T, Saigusa D, Ito S, et al. Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression. Kidney Int. 2017;91:387-401 pubmed publisher
    ..Thus, Nrf2 may be a promising therapeutic target for preventing acute kidney injury to chronic kidney disease transition. ..
  4. Suzuki N, Gradin K, Poellinger L, Yamamoto M. Regulation of hypoxia-inducible gene expression after HIF activation. Exp Cell Res. 2017;356:182-186 pubmed publisher
    ..Since epigenetic mechanisms contribute to stress-inducible and cell-type specific gene regulation, the HIF-dependent reorganization of nucleosome structures in hypoxia-inducible gene promoters is also discussed. ..
  5. Nezu M, Souma T, Yu L, Sekine H, Takahashi N, Wei A, et al. Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes. Sci Signal. 2017;10: pubmed publisher


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