Masahiko Shimura

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi Comparative therapy evaluation of intravitreal bevacizumab and triamcinolone acetonide on persistent diffuse diabetic macular edema
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Sendai, Miyagi, Japan
    Am J Ophthalmol 145:854-61. 2008
  2. ncbi Quantifying alterations of macular thickness before and after panretinal photocoagulation in patients with severe diabetic retinopathy and good vision
    Masahiko Shimura
    Department of Ophthalmology, Tohoku Graduate School of Medicine, Sendai, Japan
    Ophthalmology 110:2386-94. 2003
  3. ncbi Visual prognosis and vitreous cytokine levels after arteriovenous sheathotomy in branch retinal vein occlusion associated with macular oedema
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Sendai, Japan
    Acta Ophthalmol 86:377-84. 2008
  4. ncbi Intraocular hemangiopericytoma. A case report
    M Shimura
    Department of Ophthalmology, School of Medicine, Tohoku University, Sendai, Japan
    Ophthalmologica 215:378-82. 2001
  5. ncbi Effective treatment with topical cyclosporin A of a patient with Cogan syndrome
    M Shimura
    Department of Ophthalmology, School of Medicine, Tohoku University, Sendai, Miyagi, Japan
    Ophthalmologica 214:429-32. 2000
  6. ncbi Visual dysfunction after panretinal photocoagulation in patients with severe diabetic retinopathy and good vision
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Miyagi
    Am J Ophthalmol 140:8-15. 2005
  7. ncbi Clinical course of macular edema in two cases of interferon-associated retinopathy observed by optical coherence tomography
    Masahiko Shimura
    Department of Ophthalmology and Medical Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan
    Jpn J Ophthalmol 49:231-4. 2005
  8. ncbi The effect of unoprostone isopropyl on Ca2+ release-activated Ca2+ currents in cultured monkey trabecular meshwork cells and ciliary muscle cells
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, and Department of Ophthalmology and Medical Sciences, Tohoku University Graduate School of Medicine, Miyagi, Japan
    J Ocul Pharmacol Ther 22:219-26. 2006
  9. ncbi Posterior sub-Tenon's capsule injection of triamcinolone acetonide prevents panretinal photocoagulation-induced visual dysfunction in patients with severe diabetic retinopathy and good vision
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Sendai, Miyagi, Japan
    Ophthalmology 113:381-7. 2006
  10. ncbi Panretinal photocoagulation induces pro-inflammatory cytokines and macular thickening in high-risk proliferative diabetic retinopathy
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, 2 29 1 Yamato, Wakabayashi, Sendai, Miyagi 984 8560, Japan
    Graefes Arch Clin Exp Ophthalmol 247:1617-24. 2009

Collaborators

Detail Information

Publications64

  1. ncbi Comparative therapy evaluation of intravitreal bevacizumab and triamcinolone acetonide on persistent diffuse diabetic macular edema
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Sendai, Miyagi, Japan
    Am J Ophthalmol 145:854-61. 2008
    ..To compare the effect of an intravitreal injection of bevacizumab, an anti-vascular endothelial growth factor (VEGF) antibody, with that of triamcinolone acetonide, a corticosteroid for reduction of diabetic macular edema (DME)...
  2. ncbi Quantifying alterations of macular thickness before and after panretinal photocoagulation in patients with severe diabetic retinopathy and good vision
    Masahiko Shimura
    Department of Ophthalmology, Tohoku Graduate School of Medicine, Sendai, Japan
    Ophthalmology 110:2386-94. 2003
    ..To investigate the alterations of macular thickness during and after panretinal photocoagulation (PRP) in patients with severe diabetic retinopathy and good vision, and to compare the outcomes of weekly and biweekly treatments...
  3. ncbi Visual prognosis and vitreous cytokine levels after arteriovenous sheathotomy in branch retinal vein occlusion associated with macular oedema
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Sendai, Japan
    Acta Ophthalmol 86:377-84. 2008
    ....
  4. ncbi Intraocular hemangiopericytoma. A case report
    M Shimura
    Department of Ophthalmology, School of Medicine, Tohoku University, Sendai, Japan
    Ophthalmologica 215:378-82. 2001
    ..To our knowledge, this is only the fourth reported case of intraocular hemangiopericytoma and the first diagnosed in a male patient...
  5. ncbi Effective treatment with topical cyclosporin A of a patient with Cogan syndrome
    M Shimura
    Department of Ophthalmology, School of Medicine, Tohoku University, Sendai, Miyagi, Japan
    Ophthalmologica 214:429-32. 2000
    ..This is the first case exhibiting that topical cyclosporin A is an effective treatment for severe anterior segment inflammation associated with Cogan syndrome...
  6. ncbi Visual dysfunction after panretinal photocoagulation in patients with severe diabetic retinopathy and good vision
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Miyagi
    Am J Ophthalmol 140:8-15. 2005
    ....
  7. ncbi Clinical course of macular edema in two cases of interferon-associated retinopathy observed by optical coherence tomography
    Masahiko Shimura
    Department of Ophthalmology and Medical Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan
    Jpn J Ophthalmol 49:231-4. 2005
    ..With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed...
  8. ncbi The effect of unoprostone isopropyl on Ca2+ release-activated Ca2+ currents in cultured monkey trabecular meshwork cells and ciliary muscle cells
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, and Department of Ophthalmology and Medical Sciences, Tohoku University Graduate School of Medicine, Miyagi, Japan
    J Ocul Pharmacol Ther 22:219-26. 2006
    ....
  9. ncbi Posterior sub-Tenon's capsule injection of triamcinolone acetonide prevents panretinal photocoagulation-induced visual dysfunction in patients with severe diabetic retinopathy and good vision
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Sendai, Miyagi, Japan
    Ophthalmology 113:381-7. 2006
    ....
  10. ncbi Panretinal photocoagulation induces pro-inflammatory cytokines and macular thickening in high-risk proliferative diabetic retinopathy
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, 2 29 1 Yamato, Wakabayashi, Sendai, Miyagi 984 8560, Japan
    Graefes Arch Clin Exp Ophthalmol 247:1617-24. 2009
    ..To investigate whether pan-retinal photocoagulation (PRP) affects vitreous levels of cytokines and macular thickening in patients with high-risk proliferative diabetic retinopathy (PDR)...
  11. ncbi Pretreatment of posterior subtenon injection of triamcinolone acetonide has beneficial effects for grid pattern photocoagulation against diffuse diabetic macular oedema
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, 2 29 1, Yamato, Wakabayashi, Sendai, Miyagi 984 8560, Japan
    Br J Ophthalmol 91:449-54. 2007
    ..To prospectively evaluate the efficacy of subtenon injection of triamcinolone acetonide (TA) before laser grid pattern photocoagulation (G-PC) for the treatment of diffuse diabetic macular oedema (DDME)...
  12. ncbi Diclofenac prevents an early event of macular thickening after cataract surgery in patients with diabetes
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Sendai, Japan
    J Ocul Pharmacol Ther 23:284-91. 2007
    ..This study compares the effect of topical diclofenac with that of betamethasone against postoperative cystoid macular edema (CME) following cataract surgery in patients with non- and mild nonproliferative diabetic retinopathy...
  13. ncbi Neuroprotective effect of latanoprost on rat retinal ganglion cells
    Hideyo Kudo
    Department of Ophthalmology, Tohoku University School of Medicine, 1-1, Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan
    Graefes Arch Clin Exp Ophthalmol 244:1003-9. 2006
    ..CONCLUSIONS: Intravitreal administration of latanoprost has a neuroprotective effect on rat RGC damage induced by either NMDA or optic nerve axotomy, while its pharmacological features are different...
  14. ncbi Calpain-mediated degradation of G-substrate plays a critical role in retinal excitotoxicity for amacrine cells
    Toru Nakazawa
    Department of Ophthalmology, Tohoku Graduate School of Medicine, Sendai, Japan
    J Neurosci Res 87:1412-23. 2009
    ..ALLN did not have a neuroprotective effect in G-substrate(-/-) mice. These data strongly suggest that calpain-mediated loss of G-substrate represents an important mechanism contributing to NMDA-induced amacrine cell death...
  15. ncbi Drug reflux during posterior subtenon infusion of triamcinolone acetonide in diffuse diabetic macular edema not only brings insufficient reduction but also causes elevation of intraocular pressure
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Sendai, Miyagi, Japan
    Graefes Arch Clin Exp Ophthalmol 247:907-12. 2009
    ..We investigated the influence of this reflux on regression of DME and postoperative intraocular pressure (IOP)...
  16. ncbi ERK1 plays a critical protective role against N-methyl-D-aspartate-induced retinal injury
    Toru Nakazawa
    Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan
    J Neurosci Res 86:136-44. 2008
    ..ERK1 appears to play a major role in this process. These new findings on retinal glial cell response during NMDA injury offer an important new therapeutic target for preventing many retinal disorders associated with excitotoxicity...
  17. ncbi Pitavastatin prevents NMDA-induced retinal ganglion cell death by suppressing leukocyte recruitment
    Toru Nakazawa
    Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan
    J Neurochem 100:1018-31. 2007
    ..Statins or other anti-inflammatory agents may thus have therapeutic benefits in excitotoxicity-associated neuronal diseases through blockade of leukocyte recruitment...
  18. ncbi Estrogen has a neuroprotective effect on axotomized RGCs through ERK signal transduction pathway
    Toru Nakazawa
    Department of Ophthalmology and Visual Science, Tohoku University Graduate School of Medicine, Sendai, 980 8574 Miyagi, Japan
    Brain Res 1093:141-9. 2006
    ..The neuroprotective effect of estrogen may have therapeutic benefits in retinal diseases associated with RGC death such as glaucoma...
  19. ncbi Early change of central macular thickness after intravitreous triamcinolone or bevacizumab in diabetic macular edema or retinal vein occlusion
    Yasushi Sonoda
    Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, Japan
    Retina 31:290-7. 2011
    ..To evaluate the immediate changes after intravitreous triamcinolone acetonide or intravitreous bevacizumab in diabetic macular edema (DME)...
  20. ncbi A comparison of preservative-free diclofenac and preserved diclofenac eye drops after cataract surgery in patients with diabetic retinopathy
    Kanako Yasuda
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Sendai, Miyagi, Japan
    J Ocul Pharmacol Ther 28:283-9. 2012
    ..1% diclofenac eye drops for the management of postoperative inflammation after cataract surgery in patients with nonproliferative diabetic retinopathy and in normal controls...
  21. ncbi Effective treatment of diffuse diabetic macular edema by temporal grid pattern photocoagulation
    Masahiko Shimura
    Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Ophthalmic Surg Lasers Imaging 35:270-80. 2004
    ..CONCLUSION: Grid pattern photocoagulation without treatment to the papillomacular bundle area was effective in treating diffuse diabetic macular edema, especially in eyes with an initial mean deviation showing moderate dysfunction...
  22. ncbi Presence of mitogen-activated protein kinase in retinal Müller cells and its neuroprotective effect ischemia-reperfusion injury
    Hiroshi Akiyama
    Department of Ophthalmology, Tohoku University School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan
    Neuroreport 13:2103-7. 2002
    ..We conclude that the MAPK activated in the RMCs protects ganglion cells against the ischemia-reperfusion injury through glia-neuronal interaction...
  23. ncbi Intrinsic activation of PI3K/Akt signaling pathway and its neuroprotective effect against retinal injury
    Toru Nakazawa
    Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan
    Curr Eye Res 26:55-63. 2003
    ..The aim of this study was to determine whether the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway can function as a neuroprotective pathway following induced retinal injury...
  24. ncbi Retinal G-substrate, potential downstream component of NO/cGMP/PKG pathway, is located in subtype of retinal ganglion cells and amacrine cells with protein phosphatases
    Toru Nakazawa
    Department of Ophthalmology and Visual Science, Tohoku Graduate School of Medicine, 980 8574, Seiryo 1 1, Aoba, Sendai, Japan
    Brain Res Mol Brain Res 135:58-68. 2005
    ..The co-localization of retinal G-substrate with protein Ser/Thr phosphatases suggests that it acts as an endogenous protein phosphatase inhibitor as in the cerebellum...
  25. ncbi Visual outcome after intravitreal triamcinolone acetonide depends on optical coherence tomographic patterns in patients with diffuse diabetic macular edema
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Sendai, Miyagi, Japan
    Retina 31:748-54. 2011
    ..To evaluate the effectiveness of intravitreal triamcinolone acetonide (IVTA) on the reduction of diffuse diabetic macular edema with different optical coherence tomographic patterns...
  26. ncbi N-Methyl-D-Aspartic acid suppresses Akt activity through protein phosphatase in retinal ganglion cells
    Toru Nakazawa
    Department of Ophthalmology and Visual Science, Tohoku University Graduate School of Medicine, Seiryo, Aoba, Sendai, Miyagi, Japan
    Mol Vis 11:1173-82. 2005
    ..To investigate the relationship between Akt activity and retinal ganglion cell (RGC) death induced by N-Methyl-D-Aspartic acid (NMDA) in the rat retina...
  27. ncbi Gliclazide attenuates the intracellular Ca2+ changes induced in vitro by ischemia in the retinal slices of rats with streptozotocin-induced diabetes
    Jiro Kinukawa
    Department of Ophthalmology and Medical Science, Tohoku University Graduate School of Medicine, Sendai Miyagi, Japan
    Curr Eye Res 30:789-98. 2005
    ....
  28. ncbi Chemokines in aqueous humour before and after intravitreal triamcinolone acetonide in eyes with macular oedema associated with branch retinal vein occlusion
    Hiroshi Kunikata
    Department of Ophthalmology and Visual Science, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Acta Ophthalmol 90:162-7. 2012
    ..To determine the aqueous humour levels of chemokines before and after an intravitreal injection of triamcinolone acetonide (IVTA) in eyes with macular oedema associated with a branch retinal vein occlusion (ME-BRVO)...
  29. ncbi Choroiditis in systemic lupus erythematosus: systemic steroid therapy and focal laser treatment
    Masahiko Shimura
    Department of Ophthalmology, Tohoku University, School of Medicine, Sendai, Japan
    Jpn J Ophthalmol 47:312-5. 2003
    ..Thus, in SLE choroiditis, laser photocoagulation at a leakage point, in addition to systemic steroid therapy, may be helpful for the prompt restoration of vision in patients with serous retinal detachment...
  30. ncbi Clinical features of bilateral acute idiopathic maculopathy
    Toru Nakazawa
    Department of Ophthalmology, Katta General Hospital, Shiroishi, Japan
    Jpn J Ophthalmol 47:385-91. 2003
    ..However, the physiological dysfunction detected by mfERGs remained. CONCLUSIONS: We conclude that the major abnormality in BAIM is an alteration of the retinal pigment epithelium causing severe edema...
  31. ncbi Progression of visual field defects in eyes with different optic disc appearances in patients with normal tension glaucoma
    Toru Nakazawa
    Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8574, Japan
    J Glaucoma 21:426-30. 2012
    ..To investigate the relationship between the optic disc appearance and the progression of visual field defects in eyes with normal tension glaucoma (NTG)...
  32. ncbi Vitrectomy for exudative age-related macular degeneration with vitreous hemorrhage
    Taiji Sakamoto
    Department of Ophthalmology, Kagoshima University School of Dental and Medical Sciences, Kagoshima, Japan
    Retina 30:856-64. 2010
    ..The purpose of this study was to study the effect of pars plana vitrectomy (PPV) for age-related macular degeneration with vitreous hemorrhage on choroidal neo-vascularization (CNV)...
  33. ncbi Expression and functional properties of unique inward rectifier K+ channel Kir7.1 in the porcine iris and retinal pigment epithelium
    Kanako Yasuda
    Department of Ophthalmology, Tohoku University, School of Medicine, Sendai Miyagi, Aoba, Japan
    Curr Eye Res 27:279-87. 2003
    ..1 subunit was predominantly expressed in the acutely dissociated porcine IPE and its functional properties are similar to those in the RPE. However, the current density seems too small to fulfill the task of the Kir function of RPE...
  34. ncbi Stromal-derived factor-1 and inflammatory cytokines in retinal vein occlusion
    Yuya Ki i
    Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Curr Eye Res 32:1065-72. 2007
    ..To identify the roles of stromal-derived factor (SDF-1) and inflammatory cytokines in retinal vein occlusion (RVO)...
  35. ncbi Platelet-derived growth factor and its receptors are expressed in areas of both active inflammation and active fibrosis in inflammatory bowel disease
    S Kumagai
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 195:21-33. 2001
    ..Our results suggest that PDGF is not only important as an inducer of fibrosis in the repair phase but also it is involved in the active inflammatory phase possibly as a chemoattractant for mononuclear inflammatory cells...
  36. ncbi Diclofenac prevents temporal increase of intraocular pressure after uneventful cataract surgery with longer operation time
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Sendai, Japan
    Clin Ophthalmol 3:95-101. 2009
    ....
  37. ncbi Networking possibilities for waste recycling in Miyagi prefecture, Japan
    M Omura
    Graduate School of Agricultural Science, Tohoku University, 1 1 Amemiya Aoba ku, Sendai, Miyagi, Japan
    Waste Manag 27:711-9. 2007
    ..Materials are difficult to circulate among manufacturing industries even if a waste-exchange network exists, and resources are consumed during transportation and recycling...
  38. ncbi Increased expression of TGF-beta1 but not of its receptors contributes to human obstructive nephropathy
    H Kaneto
    Department of Urology and Pathology, Tohoku University School of Medicine, Sendai, Japan
    Kidney Int 56:2137-46. 1999
    ..Increased expression of TGF-beta1 but not of its receptors contributes to human obstructive nephropathy...
  39. ncbi Macrophage-derived chemokine (MDC/CCL22) and CCR4 are involved in the formation of T lymphocyte-dendritic cell clusters in human inflamed skin and secondary lymphoid tissue
    F Katou
    Departments of Oral and Maxillofacial Surgery I, Tohoku University School of Dentistry, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Am J Pathol 158:1263-70. 2001
    ..Our data suggest that the MDC-CCR4 system plays an important role in the formation of T cell-DC clusters both in inflamed skin and LNs...
  40. ncbi Stromal reaction in cancer tissue: pathophysiologic significance of the expression of matrix-degrading enzymes in relation to matrix turnover and immune/inflammatory reactions
    H Ohtani
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Pathol Int 48:1-9. 1998
    ....
  41. ncbi Malignant rhabdoid tumor of the vulva: case report with cytological, immunohistochemical, ultrastructural and DNA ploidy studies and a review of the literature
    T Igarashi
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Pathol Int 48:887-91. 1998
    ..No cytokeratin and desmin immunoreactivity were detected in the tumor cells. The Ki-67 labeling index was 36% and the DNA content of the tumor cells, which was examined by image cytometry, demonstrated diploidy (DNA index = 0.95)...
  42. ncbi Procollagen-positive fibroblasts predominantly express fibrogenic growth factors and their receptors in human encapsulation process against foreign body
    F Katou
    Department of Oral and Maxillofacial Surgery 1, School of Dentistry, Tohoku University, Sendai, Japan
    J Pathol 186:201-8. 1998
    ....
  43. ncbi Pathophysiologic significance of host reactions in human cancer tissue: desmoplasia and tumor immunity
    H Ohtani
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 187:193-202. 1999
    ..These data suggest that various host reactions take place in the stroma of cancer tissue, which modulate the biologic behavior of cancer...
  44. ncbi Immunological activation of dermal Langerhans cells in contact with lymphocytes in a model of human inflamed skin
    F Katou
    Departments of Oral and Maxillofacial Surgery I, Tohoku University, Sendai, Japan
    Am J Pathol 156:519-27. 2000
    ..Our observations indicate that dermal Langerhans cells in the inflamed skin are activated to express common phenotypes to mature dendritic cells so that they could stimulate neighboring memory CD4(+) T cells...
  45. ncbi A case of extramedullary plasmacytoma arising from the nasal septum
    H Hidaka
    Department of Otorhinolaryngology, Tohoku University School of Medicine, Sendai, Japan
    J Laryngol Otol 114:53-5. 2000
    ..The clinical presentation, pathological features and surgical procedures are described with a review of the literature...
  46. ncbi The immuno-inflammatory mechanism for tissue injury in inflammatory bowel disease and Helicobacter pylori-infected chronic active gastritis. Roles of the mucosal immune system
    H Nagura
    Department of Pathology, Tohoku University Graduate School of Medical Science, Sendai, Japan
    Digestion 63:12-21. 2001
    ..pylori infection, respectively...
  47. ncbi Synchronous multifocal osteosarcoma with lymphatic spread in the lung: an autopsy case report
    M Hatori
    Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Jpn J Clin Oncol 31:562-6. 2001
    ..Immunohistochemistry revealed that p53 protein was positive in most of the tumor cells. In summary, the present case was characterized by multiple bone involvement and prominent lymphatic spread of sarcoma cells in the lungs...
  48. ncbi Gene and protein expressions of type I collagen are regulated tissue-specifically in rat hyaline cartilages in vivo
    Y Sasano
    Second Department of Oral Anatomy, Tohoku University School of Dentistry, Sendai, Japan
    Eur J Morphol 39:149-54. 2001
    ..The present study suggested that expression of type I collagen in hyaline cartilages may be regulated tissue-specifically at gene and/or protein levels...
  49. ncbi LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers
    T Abe
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University School of Medicine, Sendai, Japan
    Gastroenterology 120:1689-99. 2001
    ..The aim of this study was to isolate an organic anion transporter that is weak in normal cells, but abundantly expressed in cancer cells, to deliver the anticancer drugs to the cells...
  50. ncbi Proliferative activity of CD8(+) T cells as an important clue to analyze T cell-mediated inflammatory dermatoses
    M Deguchi
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    Arch Dermatol Res 293:442-7. 2001
    ..In conclusion, the proliferative status of T cells could be an important clue in the elucidation of the pathophysiology of T cell-mediated inflammatory dermatoses...
  51. ncbi Pre-seasonal treatment with topical olopatadine suppresses the clinical symptoms of seasonal allergic conjunctivitis
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Sendai, Miyagi, Japan
    Am J Ophthalmol 151:697-702.e2. 2011
    ..To evaluate the effectiveness of pre-seasonal treatment with topical olopatadine on the reduction of clinical symptoms of seasonal allergic conjunctivitis (SAC)...
  52. ncbi Over 10 years follow-up of Coats' disease in adulthood
    Tatsuro Otani
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Sendai, Miyagi, Japan
    Clin Ophthalmol 5:1729-32. 2011
    ..Even with adult Coats' disease, conventional therapies of retinal photocoagulation and cryotherapy are effective and are the initial choice for improving or maintaining visual function...
  53. ncbi Mesodermal- vs. neuronal-specific expression of MafK is elicited by different promoters
    H Motohashi
    Department of Biochemistry, Tohoku University School of Medicine, Aoba ku, Sendai, Japan
    Genes Cells 1:223-38. 1996
    ....
  54. ncbi Vascular smooth muscle cells and pericytes express MMP-1, MMP-9, TIMP-1 and type I procollagen in inflammatory bowel disease
    S Arihiro
    Department of Pathology, Tohoku University Graduate School of Medical Science, Sendai, Japan
    Histopathology 39:50-9. 2001
    ..MMP-1 expression in the mucosa may be related to the initial step of ulceration in UC. Therapeutic manipulation of extracellular matrix turnover would be an effective therapy to alleviate active inflammation and accelerate ulcer healing...
  55. ncbi Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate
    T Nishio
    Department of Neurophysiology, Tohoku University School of Medicine, Sendai, 980 8575, Japan
    Biochem Biophys Res Commun 275:831-8. 2000
    ....
  56. ncbi Stromal expression of fibroblast activation protein/seprase, a cell membrane serine proteinase and gelatinase, is associated with longer survival in patients with invasive ductal carcinoma of breast
    N Ariga
    Department of Pathology, Tohoku University Hospital, Sendai, Japan
    Int J Cancer 95:67-72. 2001
    ..FAP/seprase expression is one of the manifestations of the stromal reaction (i.e., matrix turnover); thus, invasive ductal carcinomas with fewer stromal reactions expressing FAP/seprase may be more aggressive...
  57. ncbi Visual outcome after intravitreal bevacizumab depends on the optical coherence tomographic patterns of patients with diffuse diabetic macular edema
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Sendai, Japan
    Retina 33:740-7. 2013
    ..The purpose of this study was to evaluate the effectiveness of intravitreal bevacizumab (IVB) on the reduction of diffuse diabetic macular edema in patients with different optical coherence tomography patterns...
  58. ncbi A case of unilateral optic disc swelling with chronic active Epstein-Barr virus infection
    Naoko Aizawa
    Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Clin Ophthalmol 4:977-9. 2010
    ..Antibody titers to EBV were markedly elevated. Treatment with immunosuppressants and corticosteroids dramatically relieved all his symptoms, including unilateral optic swelling and visual field abnormalities...
  59. ncbi Neuroprotective effect of nipradilol on axotomized rat retinal ganglion cells
    Toru Nakazawa
    Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan
    Curr Eye Res 24:114-22. 2002
    ..To determine whether nipradilol, a new anti-glaucoma drug, can protect retinal ganglion cells (RGCs) from secondary cell death caused by transection of the optic nerve (ON)...
  60. ncbi Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: possible association with suppression of micrometastasis
    T Chiba
    Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Br J Cancer 91:1711-7. 2004
    ..In conclusion, our data support a hypothesis on the presence of systemic immunosurveillance against micrometastasis of cancer cells...
  61. ncbi Ultrastructural characterization of enterochromaffin-type cells in human gastric carcinoma
    H Ohtani
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 160:333-42. 1990
    ..It is speculated that they are derived from neoplastic precursor cells with a special differentiation...
  62. ncbi Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome 16: an animal model of Down's syndrome
    M Ema
    Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980 8578, Japan
    Hum Mol Genet 8:1409-15. 1999
    ..Taken together, our data show that overdosage of Sim2 may be important for the pathogenesis of Down's syndrome, especially mental retardation...
  63. ncbi In situ expression of the cell adhesion molecules in bronchial tissues from asthmatics with air flow limitation: in vivo evidence of VCAM-1/VLA-4 interaction in selective eosinophil infiltration
    Y Ohkawara
    First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    Am J Respir Cell Mol Biol 12:4-12. 1995
    ....
  64. ncbi In situ CD14 expression in biliary atresia: comparison between early and late stages
    A F Ahmed
    Department of Pediatric Surgery, Tohoku University School of Medicine, Sendai, Japan
    J Pediatr Surg 36:240-3. 2001
    ..CONCLUSION: These results suggest that CD14 expression in BA is a dynamic phenomenon having time-related change with overexpression in the early stage and reduced expression in the late stage...