Y Sato

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. pmc The vasohibin family: a novel family for angiogenesis regulation
    Yasufumi Sato
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Sendai 980 8575, Japan
    J Biochem 153:5-11. 2013
  2. ncbi request reprint Vasohibin-2 expressed in human serous ovarian adenocarcinoma accelerates tumor growth by promoting angiogenesis
    Yoshifumi Takahashi
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Mol Cancer Res 10:1135-46. 2012
  3. doi request reprint The vasohibin family: Novel regulators of angiogenesis
    Yasufumi Sato
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Sendai 980 8575, Japan
    Vascul Pharmacol 56:262-6. 2012
  4. ncbi request reprint Role of transcription factors in angiogenesis: Ets-1 promotes angiogenesis as well as endothelial apoptosis
    Y Sato
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Ann N Y Acad Sci 947:117-23. 2001
  5. doi request reprint Persistent vascular normalization as an alternative goal of anti-angiogenic cancer therapy
    Yasufumi Sato
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Cancer Sci 102:1253-6. 2011
  6. ncbi request reprint Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction
    Y Sato
    Department of Vascular Biology, Tohoku University, Sendai, Japan
    Ann N Y Acad Sci 902:201-5; discussion 205-7. 2000
  7. ncbi request reprint Molecular mechanism of angiogenesis transcription factors and their therapeutic relevance
    Y Sato
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Pharmacol Ther 87:51-60. 2000
  8. doi request reprint Delta-like 4 and vasohibin 1: two endothelium-produced negative regulators of angiogenesis with distinctive roles
    Yasufumi Sato
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Eur Cytokine Netw 20:220-4. 2009
  9. ncbi request reprint The vasohibin family: a negative regulatory system of angiogenesis genetically programmed in endothelial cells
    Yasufumi Sato
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Arterioscler Thromb Vasc Biol 27:37-41. 2007
  10. ncbi request reprint [Self-regulatory system of angiogenesis programmed in vascular endothelium]
    Yasufumi Sato
    Nihon Yakurigaku Zasshi 129:163-6. 2007

Collaborators

Detail Information

Publications86

  1. pmc The vasohibin family: a novel family for angiogenesis regulation
    Yasufumi Sato
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Sendai 980 8575, Japan
    J Biochem 153:5-11. 2013
    ..This review will focus on the vasohibin family members, which are novel regulators of angiogenesis...
  2. ncbi request reprint Vasohibin-2 expressed in human serous ovarian adenocarcinoma accelerates tumor growth by promoting angiogenesis
    Yoshifumi Takahashi
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Mol Cancer Res 10:1135-46. 2012
    ..These results indicate that VASH2 expressed in serous ovarian carcinoma cells promoted tumor growth and peritoneal dissemination by promoting angiogenesis...
  3. doi request reprint The vasohibin family: Novel regulators of angiogenesis
    Yasufumi Sato
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Sendai 980 8575, Japan
    Vascul Pharmacol 56:262-6. 2012
    ..This mini-review will focus on the vasohibin family in relation to the regulation of angiogenesis...
  4. ncbi request reprint Role of transcription factors in angiogenesis: Ets-1 promotes angiogenesis as well as endothelial apoptosis
    Y Sato
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Ann N Y Acad Sci 947:117-23. 2001
    ..However, there are conflicting reports on the role of Ets-1 in apoptosis. We examined the role of Ets-1 in apoptosis of ECs and found that Ets-1 was pro-apoptotic to ECs by modulating the expression of several apoptosis-related genes...
  5. doi request reprint Persistent vascular normalization as an alternative goal of anti-angiogenic cancer therapy
    Yasufumi Sato
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Cancer Sci 102:1253-6. 2011
    ..Thus, persistent vascular normalization could be an alternative goal of anti-angiogenic cancer treatment...
  6. ncbi request reprint Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction
    Y Sato
    Department of Vascular Biology, Tohoku University, Sendai, Japan
    Ann N Y Acad Sci 902:201-5; discussion 205-7. 2000
    ..The KDR/Flt-1 heterodimer and the KDR homodimer are required for the assembly of vinculin in focal adhesion plaque by regulating the phosphorylation of focal adhesion kinase (FAK) and paxillin...
  7. ncbi request reprint Molecular mechanism of angiogenesis transcription factors and their therapeutic relevance
    Y Sato
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Pharmacol Ther 87:51-60. 2000
    ..This review focuses on transcription factors that may play important roles in angiogenesis...
  8. doi request reprint Delta-like 4 and vasohibin 1: two endothelium-produced negative regulators of angiogenesis with distinctive roles
    Yasufumi Sato
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Eur Cytokine Netw 20:220-4. 2009
    ..These intrinsic factors are thought to regulate angiogenesis by an autoregulatory or negative-feedback mechanism. This review focuses on such negative regulators of angiogenesis produced by endothelial cells...
  9. ncbi request reprint The vasohibin family: a negative regulatory system of angiogenesis genetically programmed in endothelial cells
    Yasufumi Sato
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Arterioscler Thromb Vasc Biol 27:37-41. 2007
    ....
  10. ncbi request reprint [Self-regulatory system of angiogenesis programmed in vascular endothelium]
    Yasufumi Sato
    Nihon Yakurigaku Zasshi 129:163-6. 2007
  11. ncbi request reprint Role of ETS family transcription factors in vascular development and angiogenesis
    Y Sato
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Cell Struct Funct 26:19-24. 2001
    ..This review will summarize the role of ETS family transcription factors in vascular development and angiogenesis...
  12. ncbi request reprint Update on endogenous inhibitors of angiogenesis
    Yasufumi Sato
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Endothelium 13:147-55. 2006
    ..Very few genes encoding molecules that selectively inhibit angiogenesis have been discovered. This review will focus on our current understanding of endogenous inhibitors of angiogenesis...
  13. ncbi request reprint Role of aminopeptidase in angiogenesis
    Yasufumi Sato
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Biol Pharm Bull 27:772-6. 2004
    ..This review will focus on the possible role of these aminopeptidases in angiogenesis...
  14. ncbi request reprint Transcription factor ETS-1 as a molecular target for angiogenesis inhibition
    Y Sato
    Department of Vascular Biology, Tohoku University, Sendai, Japan
    Hum Cell 11:207-14. 1998
    ..The elimination of the expression of ETS-1 in ECs inhibited angiogenesis. These results indicate that ETS-1 can be a molecular target for the regulation of angiogenesis...
  15. ncbi request reprint Molecular diagnosis of tumor angiogenesis and anti-angiogenic cancer therapy
    Yasufumi Sato
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Int J Clin Oncol 8:200-6. 2003
    ..This review focuses on our current understanding of the molecular mechanism of tumor angiogenic and the status of the anti-angiogenesis approach for cancer treatment...
  16. ncbi request reprint Aminopeptidases and angiogenesis
    Yasufumi Sato
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Endothelium 10:287-90. 2003
    ..This review will focus on the possible role of these aminopeptidases in angiogenesis...
  17. ncbi request reprint Role of transcription factor Ets-1 in the apoptosis of human vascular endothelial cells
    K Teruyama
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Cell Physiol 188:243-52. 2001
    ..5 fold in HUVECs. These results indicate that Ets-1 itself is pro-apoptotic to ECs by modulating the expression of apoptosis-related genes...
  18. ncbi request reprint Neurophilin-1 is a downstream target of transcription factor Ets-1 in human umbilical vein endothelial cells
    K Teruyama
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    FEBS Lett 504:1-4. 2001
    ..In contrast, dominant negative ets-1 decreased the levels of neuropilin-1 mRNA and protein. These results indicate that neuropilin-1 is a downstream target of Ets-1 in HUVECs...
  19. ncbi request reprint Vascular smooth muscle cell growth-promoting factor/F-spondin inhibits angiogenesis via the blockade of integrin alphavbeta3 on vascular endothelial cells
    Y Terai
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Cell Physiol 188:394-402. 2001
    ..These results indicate that VSGP/F-spondin inhibits angiogenesis at least in part by the blockade of endothelial integrin alphavbeta3...
  20. ncbi request reprint Inhibition by dexamethasone of antigen-induced c-Jun N-terminal kinase activation in rat basophilic leukemia cells
    N Hirasawa
    Department of Pathophysiological Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    J Immunol 161:4939-43. 1998
    ..These findings indicate that dexamethasone reduces JNK protein level and inhibits the Ag-induced activation of JNK resulting in the inhibition of c-Jun phosphorylation...
  21. ncbi request reprint cDNA microarray analysis of the gene expression profile of VEGF-activated human umbilical vein endothelial cells
    M Abe
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Seiryou-machi, Aoba-ku, Sendai, 980-8575, Japan
    Angiogenesis 4:289-98. 2001
    ..Further analysis of these genes may aid in the elucidation of the molecular mechanisms of angiogenesis or vascular permeability stimulated by VEGF...
  22. ncbi request reprint Antitumor effects due to irreversible stoppage of tumor tissue blood flow: evaluation of a novel combretastatin A-4 derivative, AC7700
    K Hori
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai
    Jpn J Cancer Res 90:1026-38. 1999
    ..AC7700 has been demonstrated to be a promising anticancer compound which has such an action...
  23. ncbi request reprint TGF-beta attenuates the transactivation activity of Ets-1 despite its induction via the inhibition of DNA binding
    C Iwasaka-Yagi
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Tohoku J Exp Med 193:311-8. 2001
    ..These results suggest the possibility that TGF-beta attenuates the transactivation activity of Ets-1 by inducing a protein that interferes with the binding of Ets-1 to the DNA binding site...
  24. ncbi request reprint Heterogeneity of the signal transduction pathways for VEGF-induced MAPKs activation in human vascular endothelial cells
    R Yashima
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Cell Physiol 188:201-10. 2001
    ..The activation of Ras by VEGF appeared to be most prominent in HMVECs. These results indicate that intracellular signal transduction pathways for VEGF-induced activation of MAPKs are heterogeneous and vary depending on the origin of ECs...
  25. ncbi request reprint Expression of the 37-kDa laminin binding protein in murine lung tumor cell correlates with tumor angiogenesis
    M Tanaka
    Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, Japan
    Cancer Lett 153:161-8. 2000
    ..These results suggest that decreased expression of 37LBP in antisense-RNA transfectant may relate to its low tumorigenicity, and that this effect may be partly caused by the diminished tumor angiogenesis of murine lung cancer...
  26. ncbi request reprint Diffusion-weighted MRI abnormalities as an early diagnostic marker for Creutzfeldt-Jakob disease
    Y Shiga
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Neurology 63:443-9. 2004
    ..To evaluate the usefulness of diffusion-weighted MRI (DWI) for the early diagnosis of Creutzfeldt-Jakob disease (CJD)...
  27. ncbi request reprint Retinoic acids repress the expression of ETS-1 in endothelial cells
    T Igarashi
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Tohoku J Exp Med 194:35-43. 2001
    ..These results indicate that the anti-angiogenic effect of retinoic acids is mediated at least in part by the transcriptional repression of ets-1 mRNA in ECs...
  28. ncbi request reprint ETS-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin beta3
    N Oda
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Cell Physiol 178:121-32. 1999
    ..These results indicate that ETS-1 is a principal regulator that converts ECs to the angiogenic phenotype...
  29. ncbi request reprint Critical role of the neuronal nitric-oxide synthase heme proximal side residue, Arg418, in catalysis and electron transfer
    Y Sato
    Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, 980-8577, Sendai, Japan
    J Inorg Biochem 87:261-6. 2001
    ..The results suggest that Arg418 is critical in preserving the heme proximal structure and thus, is indirectly involved in both catalysis and electron transfer from the reductase domain to the heme...
  30. doi request reprint A potent anti-angiogenic factor, vasohibin-1, ameliorates experimental bronchiolitis obliterans
    T Watanabe
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Transplant Proc 44:1155-7. 2012
    ..Vasohibin-1 (VASH1) has been isolated as a vascular endothelial growth factor-inducible gene in endothelial cells (ECs) that inhibits migration and proliferation of ECs and exhibits anti-angiogenic activity in vivo...
  31. ncbi request reprint Augmented binding and activation of latent transforming growth factor-beta by a tryptic fragment of latency associated peptide
    M Abe
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, 980 8575, Japan
    Endothelium 9:25-36. 2002
    ..These results suggest a unique mechanism for the activation of latent TGF-beta by proteolytic fragments of LAP. The mechanism may arise from degradation by elevated levels of proteases under certain conditions...
  32. ncbi request reprint A novel wx mutation caused by insertion of a retrotransposon-like sequence in a glutinous cultivar of rice (Oryza sativa)
    Y Hori
    Graduate School of Agricultural Science, Tohoku University, Tsutsumidori Amamiyamachi 1 1, Aoba ku, Sendai, 981 8555, Japan
    Theor Appl Genet 115:217-24. 2007
    ..Furthermore, it had a structure similar to Dasheng and may be a member of Dasheng...
  33. ncbi request reprint Tumor-selective blood flow decrease induced by an angiotensin converting enzyme inhibitor, temocapril hydrochloride
    K Hori
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai
    Jpn J Cancer Res 91:261-9. 2000
    ..Using this technique, it should be possible to trap anticancer drugs selectively in tumor tissue for an extended period of time...
  34. ncbi request reprint Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-inducible factor-1
    M Oikawa
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
    Biochem Biophys Res Commun 289:39-43. 2001
    ..Double-stranded synthetic oligonucleotides of this sequence as a decoy inhibited the hypoxia-mediated inducibility. These results indicate that hypoxia induces ETS-1 via the activity of HIF-1...
  35. ncbi request reprint Visually based path-planning by Japanese monkeys
    H Mushiake
    Department of Physiology, Tohoku University School of Medicine, 980 8575, Sendai, Japan
    Brain Res Cogn Brain Res 11:165-9. 2001
    ..The animals then developed a strategy of solving the problem by planning a novel shortest path from the start to the goal and rerouting the path to bypass the obstacle...
  36. ncbi request reprint Sinorhizobium meliloti RpoH1 is required for effective nitrogen-fixing symbiosis with alfalfa
    H Mitsui
    Graduate School of Life Sciences, Tohoku University, Katahira, Aoba ku, 980 8577 Sendai, Japan
    Mol Genet Genomics 271:416-25. 2004
    ..Although groESL(5) expression is almost completely dependent on RpoH(1), we found that a groESL(5) mutant strain is still capable of normal symbiotic nitrogen fixation on alfalfa...
  37. ncbi request reprint An increased ratio of interleukin-1 receptor antagonist to interleukin-1alpha in inflammatory skin diseases
    T Terui
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    Exp Dermatol 7:327-34. 1998
    ....
  38. pmc Functions of two types of NADH oxidases in energy metabolism and oxidative stress of Streptococcus mutans
    M Higuchi
    Department of Molecular and Cell Biology, Division of Life Science, Graduate School of Agriculture, Tohoku University, Aoba ku, Sendai 981 8555, Japan
    J Bacteriol 181:5940-7. 1999
    ..mutans to cumene hydroperoxide and H(2)O(2), implying that the existence of some other antioxidant system(s) independent of Nox-1 in S. mutans compensates for the deficiency...
  39. ncbi request reprint Involvement of a phosphatidylinositol 3-kinase-p38 mitogen activated protein kinase pathway in antigen-induced IL-4 production in mast cells
    N Hirasawa
    Department of Pathophysiological Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan
    Biochim Biophys Acta 1456:45-55. 2000
    ..These findings suggest that the activation of PI3-kinase and p38 MAPK is partially responsible for the antigen-induced IL-4 production in RBL-2H3 cells...
  40. ncbi request reprint Stoppage of blood flow in 3-methylcholanthrene-induced autochthonous primary tumor due to a novel combretastatin A-4 derivative, AC7700, and its antitumor effect
    K Hori
    Department of Vascular Biology, Division of Cancer Control, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryomachi Aoba ku, Sendai 980 8575, Japan
    Med Sci Monit 7:26-33. 2001
    ..In this study, the antivascular and antitumor effects of AC7700 were tested on primary autochthonous tumor...
  41. pmc Increased growth and incidence of lymph node metastases due to the angiogenesis inhibitor AGM-1470
    K Hori
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Br J Cancer 75:1730-4. 1997
    ..From the present experiment, it is concluded that application of AGM-1470 alone to patients should be carried out with great caution...
  42. doi request reprint Genetic analysis of interspecific incompatibility in Brassica rapa
    H Udagawa
    Laboratory of Plant Breeding and Genetics, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai, Miyagi, 981 8555, Japan
    Theor Appl Genet 121:689-96. 2010
    ..Based on synteny of this QTL region with Arabidopsis thaliana chromosome 5, a possible candidate gene, which might be involved in interspecific incompatibility, is discussed...
  43. pmc Changes in the activity and mRNA of cinnamyl alcohol dehydrogenase during tracheary element differentiation in zinnia
    Y Sato
    Biological Institute, Faculty of Science, Tohoku University, Sendai, Japan
    Plant Physiol 113:425-30. 1997
    ..No such increases were observed in control cultures. These results indicated that both the gene expression and the activity of CAD are strictly regulated, in association with lignification, during TE differentiation in Z. elegans...
  44. ncbi request reprint Aromatic residues and neighboring Arg414 in the (6R)-5,6,7, 8-tetrahydro-L-biopterin binding site of full-length neuronal nitric-oxide synthase are crucial in catalysis and heme reduction with NADPH
    I Sagami
    Institute for Chemical Reaction Science, Tohoku University, Sendai 980 8577, Japan
    J Biol Chem 275:26150-7. 2000
    ..Thus, hydrogen bond networks consisting of the heme carboxylate, Tyr(706), and Arg(414) are crucial in stabilizing the appropriate conformation(s) of the heme active site for H4B/l-Arg binding and/or efficient electron transfer to occur...
  45. ncbi request reprint Unusual role of Tyr588 of neuronal nitric oxide synthase in controlling substrate specificity and electron transfer
    Y Sato
    Institute for Chemical Reaction Science, Tohoku University, Sendai, 980 8577, Japan
    Biochem Biophys Res Commun 281:621-6. 2001
    ..12 for the Tyr588Ser mutant, compared with 1.07 for the wild-type enzyme. Intriguingly, heme reduction rates for the Tyr588 mutants were much lower than for wild type by two orders of magnitude...
  46. ncbi request reprint A new type-II membrane protein in erythropoietic organs enhances erythropoiesis
    N Yanai
    Department of Cell Biology, Tohoku University, Sendal, Japan
    Leukemia 11:484-5. 1997
    ..Over expression of its antisense cDNA in a stroma cell line caused a decrease in the erythropoietic supporting activity. Thus, SMAP-1 may play an important role in the erythropoietic stimulatory activity of the stromal cells...
  47. ncbi request reprint Clinical features of Creutzfeldt-Jakob disease with V180I mutation
    K Jin
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Neurology 62:502-5. 2004
    ..MRI demonstrated remarkable high-intensity areas with swelling in the cerebral cortex except for the medial occipital and cerebellar cortices. These characteristic MRI findings are an important clue for an accurate premortem diagnosis...
  48. ncbi request reprint Preferential X-chromosome inactivation in women with idiopathic recurrent pregnancy loss
    S Uehara
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Fertil Steril 76:908-14. 2001
    ..To determine whether preferential X-chromosome inactivation (P-XCI) relates to idiopathic recurrent pregnancy loss...
  49. ncbi request reprint Mutation detection in rice waxy mutants by PCR-RF-SSCP
    Y Sato
    Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Theor Appl Genet 107:560-7. 2003
    ..Two mutations found at a splice site were considered to inhibit normal splicing of mRNA. These results show that PRS is a useful technique for detecting point mutations in large plant genes...
  50. doi request reprint Assessment of synchronization measures for effective ventricular support by using the shape memory alloy fibred artificial myocardium in goats
    Y Shiraishi
    Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    Conf Proc IEEE Eng Med Biol Soc 2009:3047-50. 2009
    ..Therefore, it was suggested that the synchronization measures should be examined in order to achieve sophisticated ventricular passive/active support on physiological demand...
  51. ncbi request reprint Mechanism of free radical-induced hemolysis of human erythrocytes: comparison of calculated rate constants for hemolysis with experimental rate constants
    Y Sato
    Faculty of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai, Aoba ku, 980 8578, Japan
    Arch Biochem Biophys 366:61-9. 1999
    ..These results indicate that the competitive reaction model may be useful for analyzing radical-induced hemolysis...
  52. ncbi request reprint Differential relationship between changes in tumour size and microcirculatory functions induced by therapy with an antivascular drug and with cytotoxic drugs. implications for the evaluation of therapeutic efficacy of AC7700 (AVE8062)
    K Hori
    Aging and Cancer, Tohoku University, 4 1 Seiryomachi, Aoba ku, 980 8575 Sendai, Japan
    Eur J Cancer 39:1957-66. 2003
    ..When both tumour cells and the tumour vasculature are destroyed, the effectiveness of therapy can not be determined from changes in tumour size alone...
  53. ncbi request reprint Pulsed laser-induced liquid jet microcatheter system for rapid and reliable fibrinolysis in acute cerebral embolisms: experiments on safety and preliminary application in porcine cranial vessels
    Y Sato
    Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Minim Invasive Neurosurg 50:212-8. 2007
    ..The purpose of this study is to evaluate an appropriate operation mode to minimize debris size and to apply the system in in vivo experiments using a porcine cranial artery model...
  54. pmc Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis
    Takahiro Heishi
    Department of Vascular Biology, Institute of Development, Tohoku University, Aoba ku, Sendai 980 8575, Japan
    Am J Pathol 176:1950-8. 2010
    ..These results suggest vasohibin1 to be the first known intrinsic factor having broad-spectrum antilymphangiogenic activity and indicate that it suppresses lymph node metastasis...
  55. doi request reprint Expression of vasohibin, an antiangiogenic factor, in human choroidal neovascular membranes
    Ryosuke Wakusawa
    Department of Ophthalmology and Visual Science, Tohoku University Graduate School of Medicine, Miyagi, Japan
    Am J Ophthalmol 146:235-243. 2008
    ....
  56. ncbi request reprint [Vascular regeneration]
    Yasufumi Sato
    Nihon Ronen Igakkai Zasshi 39:42-3. 2002
  57. ncbi request reprint Goniodomin A, an antifungal polyether macrolide, exhibits antiangiogenic activities via inhibition of actin reorganization in endothelial cells
    Mayumi Abe
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryou machi, Aoba ku, Sendai 980 8575, Japan
    J Cell Physiol 190:109-16. 2002
    ..Our results indicated that GDA suppressed angiogenic properties of ECs at least in part through the inhibition of actin reorganization and inhibited angiogenesis in vivo...
  58. ncbi request reprint Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) is required for the development of vascular as well as hematopoietic system in embryoid bodies
    Mayumi Abe
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Genes Cells 11:719-29. 2006
    ....
  59. ncbi request reprint VEGFR1 for lymphangiogenesis: an alternative signaling pathway?
    Yasufumi Sato
    Arterioscler Thromb Vasc Biol 28:604-5. 2008
  60. ncbi request reprint Vasohibin prevents arterial neointimal formation through angiogenesis inhibition
    Hiroshi Yamashita
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Biochem Biophys Res Commun 345:919-25. 2006
    ..Vasohibin exhibited no direct effect on migration and proliferation of smooth muscle cells. Thus, vasohibin has an activity to prevent neointimal formation by inhibiting adventitial angiogenesis...
  61. ncbi request reprint Multiple processing forms and their biological activities of a novel angiogenesis inhibitor vasohibin
    Hikaru Sonoda
    Diagnostics Science Division, Shionogi and Co Ltd, Osaka 553 0002, Japan
    Biochem Biophys Res Commun 342:640-6. 2006
    ..Processing patterns and biological activities of the processed forms of this novel antiangiogenic factor are discussed...
  62. ncbi request reprint Neovascularization; its molecular mechanism and biology
    Yasufumi Sato
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai
    Intern Med 42:295-7. 2003
  63. ncbi request reprint A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis
    Hiroki Miyashita
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Blood 99:3241-9. 2002
    ..Moreover, AS-ODN to mPILSAP inhibited angiogenesis in vivo. These results suggest a novel function of mPILSAP, which is expressed in ECs and plays an important role in angiogenesis...
  64. ncbi request reprint In vivo evidence of angiogenesis induced by transcription factor Ets-1: Ets-1 is located upstream of angiogenesis cascade
    Naotaka Hashiya
    Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Circulation 109:3035-41. 2004
    ..Thus, we examined (1) the effects of overexpression of the ets-1 gene on angiogenesis in a rat hindlimb ischemia model, and (2) how ets-1 induced angiogenesis...
  65. pmc Transcription factor Ets-1 mediates ischemia- and vascular endothelial growth factor-dependent retinal neovascularization
    Daisuke Watanabe
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Pathol 164:1827-35. 2004
    ..Ets-1 up-regulation is involved in the development of retinal neovascularization, and inhibition of Ets-1 may be beneficial in the treatment of ischemic ocular diseases...
  66. pmc Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis
    Kazuhide Watanabe
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    J Clin Invest 114:898-907. 2004
    ..We propose vasohibin to be an endothelium-derived negative feedback regulator of angiogenesis...
  67. ncbi request reprint Vascular endothelial zinc finger 1 is involved in the regulation of angiogenesis: possible contribution of stathmin/OP18 as a downstream target gene
    Hiroki Miyashita
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Arterioscler Thromb Vasc Biol 24:878-84. 2004
    ..Here, we present that Vezf1 was expressed in ECs at the site of postnatal angiogenesis. We therefore examined whether Vezf1 was involved in the regulation of angiogenesis...
  68. ncbi request reprint Transcriptional regulation of angiogenesis-related puromycin-insensitive leucyl-specific aminopeptidase in endothelial cells
    Osamu Niizeki
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Arch Biochem Biophys 424:63-71. 2004
    ..AML1/Runx1/PEBP2alphaB increased PILSAP mRNA in mouse ECs, whereas dominant interfering chimerical PEBP2beta-MYH11 decreased it. These results indicate that the expression of PILSAP in mouse ECs is regulated, at least in part, by PEBP2...
  69. ncbi request reprint Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) is involved in the activation of endothelial integrins
    Tetsuya Akada
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Cell Physiol 193:253-62. 2002
    ..This inhibition of cell spreading and of tyrosine phosphorylation of FAK could be negated by Mg(2+). These results suggest that mPILSAP is involved in the activation of endothelial integrins...
  70. ncbi request reprint Gene regulation of a novel angiogenesis inhibitor, vasohibin, in endothelial cells
    Kazue Shimizu
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980 575, Japan
    Biochem Biophys Res Commun 327:700-6. 2005
    ..These results indicate that the expression of vasohibin in endothelial cells is regulated either positively or negatively by certain factors at the transcriptional level...
  71. ncbi request reprint Transcriptional regulation of human angiopoietin-2 by transcription factor Ets-1
    Yasuhiro Hasegawa
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Biochem Biophys Res Commun 316:52-8. 2004
    ..Moreover, synthetic double-strand oligonucleotides containing corresponding EBS8 abrogated the induction of Ang-2 by VEGF in HUVECs. These results indicate that Ets-1 and the corresponding EBS are critical for the induction of Ang-2...
  72. ncbi request reprint [Vasohibin, a novel angiogenesis inhibitor ]
    Yasufumi Sato
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Seikagaku 78:763-7. 2006
  73. ncbi request reprint HEX acts as a negative regulator of angiogenesis by modulating the expression of angiogenesis-related gene in endothelial cells in vitro
    Tomowaki Nakagawa
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Arterioscler Thromb Vasc Biol 23:231-7. 2003
    ..The hematopoietically expressed homeobox (HEX) is transiently expressed in endothelial cells (ECs) during vascular formation in embryo. Here, we investigated whether HEX played any role in angiogenesis-related properties of ECs in vitro...
  74. ncbi request reprint Metallothionein 1 is a downstream target of vascular endothelial zinc finger 1 (VEZF1) in endothelial cells and participates in the regulation of angiogenesis
    Hiroki Miyashita
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Endothelium 12:163-70. 2005
    ..Moreover, down-regulation of MT1 resulted in the cell cycle arrest at G1 phase. These results indicate that MT1 is a downstream target of VEZF1 in endothelial cells and is involved in the regulation of angiogenesis...
  75. ncbi request reprint Vasohibin is up-regulated by VEGF in the retina and suppresses VEGF receptor 2 and retinal neovascularization
    Jikui Shen
    The Departments of Ophthalmology and Neuroscience The Johns Hopkins University School of Medicine Baltimore, Maryland 21287 9277, USA
    FASEB J 20:723-5. 2006
    ..These data support the hypothesis that vasohibin acts as a negative feedback regulator of neovascularization in the retina and suggest that suppression of VEGF receptor 2 may play some role in mediating its activity...
  76. ncbi request reprint Puromycin-insensitive leucyl-specific aminopeptidase (PILSAP) binds and catalyzes PDK1, allowing VEGF-stimulated activation of S6K for endothelial cell proliferation and angiogenesis
    Tohru Yamazaki
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aobaku, Sendai 980 8575, Japan
    Blood 104:2345-52. 2004
    ..These results indicate that PILSAP plays a crucial role in the cell cycle progression of ECs and angiogenesis via the binding and modification of PDK1...
  77. ncbi request reprint [Molecular mechanism and biology of neovascularization]
    Yasufumi Sato
    Nihon Naika Gakkai Zasshi 91:102-5. 2002
  78. doi request reprint Expression of vasohibin as a novel endothelium-derived angiogenesis inhibitor in endometrial cancer
    Kousuke Yoshinaga
    Department of Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 99:914-9. 2008
    ..0001, r(2) = 0.591). This is the first study to elucidate the correlation between expression of vasohibin in the stromal endothelial cells and that of VEGFR-2 in human carcinomas...
  79. ncbi request reprint Down syndrome candidate region 1,a downstream target of VEGF, participates in endothelial cell migration and angiogenesis
    Masashi Iizuka
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Vasc Res 41:334-44. 2004
    ..These results suggest that DSCR1 is involved in angiogenesis by regulating adhesion and migration of ECs via the interaction with integrin alphavbeta3...
  80. ncbi request reprint Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) affects RhoA activation in endothelial cells
    Takahiro Suzuki
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Cell Physiol 211:708-15. 2007
    ..These results indicate that PILSAP affects RhoA activation and that influences the proper function of ECs...
  81. ncbi request reprint Expression and function of Ets-1 during experimental acute renal failure in rats
    Hiroyuki Tanaka
    Homeostasis Medicine and Nephrology, Tokyo Medical and Dental University, 5 45 Yushima 1 chome, Bunkyo ku, Tokyo 113 8519, Japan
    J Am Soc Nephrol 15:3083-92. 2004
    ..Taken together, these data suggest that Ets-1 plays a key role in the cell-cycle progression of renal tubules in ARF. The Ets-1 pathway may regulate the transcription of cyclin D1 and control the regeneration of renal tubules in ARF...
  82. ncbi request reprint All-trans retinoic acid induces in vitro angiogenesis via retinoic acid receptor: possible involvement of paracrine effects of endogenous vascular endothelial growth factor signaling
    Akiko Saito
    Department of Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    Endocrinology 148:1412-23. 2007
    ..Retinoids may therefore be potential candidates for therapeutic angiogenesis against ischemic vascular disorders...
  83. ncbi request reprint MS-818 accelerates mobilization of endothelial progenitor cells and differentiation to endothelial cells
    Masanori Kanemura
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Seiryo machi, Sendai, Japan
    Endothelium 11:221-30. 2004
    ..MS-818 activates the mitogen-activated protein kinase (MAPK) pathway but not the phosphoinositol 3-kinase (PI3K)-Akt pathway in ECs. These results indicate that MS-818, a synthetic compound, promotes both angiogenesis and vasculogenesis...
  84. ncbi request reprint Metronomic scheduling of a cyclic hexapeptide Ra-VII for anti-angiogenesis, tumor vessel maturation and anti-tumor activity
    Takayuki Koizumi
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 857, Japan
    Cancer Sci 97:665-74. 2006
    ..A careful dose setting of RA-VII is crucial to obtain therapeutic superiority, possibly through tumor vessel maturation and a better distribution of the compound in the tumor tissue...
  85. ncbi request reprint Effect of low-voltage electrical stimulation on angiogenic growth factors in ischaemic rat skeletal muscle
    Makoto Nagasaka
    Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Exp Pharmacol Physiol 33:623-7. 2006
    ..4. These results suggest that LVES in a hindlimb ischaemia model of rats increases not only VEGF, but also HGF, production, which may be the main mechanism responsible for the angiogenesis produced by LVES...
  86. ncbi request reprint Isolation and characterization of vasohibin-2 as a homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin
    Takumi Shibuya
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980 8575, Japan
    Arterioscler Thromb Vasc Biol 26:1051-7. 2006
    ..We recently isolated vasohibin, a novel vascular endothelial growth factor (VEGF)-inducible endothelium-derived angiogenesis inhibitor. Our aim is to find DNA sequences homologous to vasohibin and determine their expression profile...