H Sasano

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. doi request reprint New developments in intracrinology of human breast cancer: estrogen sulfatase and sulfotransferase
    Hironobu Sasano
    Department of Pathology Tohoku University School of Medicine, Sendai, Japan
    Ann N Y Acad Sci 1155:76-9. 2009
  2. ncbi request reprint Discerning malignancy in resected adrenocortical neoplasms
    H Sasano
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryou machi, Aoba ku, Sendai, Japan 980 0872
    Endocr Pathol 12:397-406. 2001
  3. ncbi request reprint Aromatase in colon carcinoma
    Ryuichiro Sato
    Department of Surgery, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8575, Japan
    Anticancer Res 32:3069-75. 2012
  4. ncbi request reprint Activation of AXL and Antitumor Effects of a Monoclonal Antibody to AXL in Lung Adenocarcinoma
    Shinya Iida
    Department of Pathology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Anticancer Res 34:1821-7. 2014
  5. ncbi request reprint Identification of androgen-responsive microRNAs and androgen-related genes in breast cancer
    Kiichiroh Nakano
    2 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8575 Japan
    Anticancer Res 33:4811-9. 2013
  6. pmc Significance of CD133 expression in esophageal squamous cell carcinoma
    Hiroshi Okamoto
    Division of Advanced Surgical Science and Technology, Graduate School of Medicine, Tohoku University, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    World J Surg Oncol 11:51. 2013
  7. pmc An induction of microRNA, miR-7 through estrogen treatment in breast carcinoma
    Mariko Masuda
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Transl Med 10:S2. 2012
  8. pmc Estrogen-producing endometrioid adenocarcinoma resembling sex cord-stromal tumor of the ovary: a review of four postmenopausal cases
    Tomomi Katoh
    Department of Pathology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan
    Diagn Pathol 7:164. 2012
  9. pmc HIF-1α stimulates aromatase expression driven by prostaglandin E2 in breast adipose stroma
    Nirukshi U Samarajeewa
    Prince Henry s Institute, Block E Level 4, Monash Medical Centre, 246 Clayton Rd, Clayton, Melbourne, VIC 3168, Australia
    Breast Cancer Res 15:R30. 2013
  10. pmc Prediction of axillary lymph node metastasis in primary breast cancer patients using a decision tree-based model
    Masahiro Takada
    Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    BMC Med Inform Decis Mak 12:54. 2012

Collaborators

Detail Information

Publications179 found, 100 shown here

  1. doi request reprint New developments in intracrinology of human breast cancer: estrogen sulfatase and sulfotransferase
    Hironobu Sasano
    Department of Pathology Tohoku University School of Medicine, Sendai, Japan
    Ann N Y Acad Sci 1155:76-9. 2009
    ....
  2. ncbi request reprint Discerning malignancy in resected adrenocortical neoplasms
    H Sasano
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryou machi, Aoba ku, Sendai, Japan 980 0872
    Endocr Pathol 12:397-406. 2001
    ....
  3. ncbi request reprint Aromatase in colon carcinoma
    Ryuichiro Sato
    Department of Surgery, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8575, Japan
    Anticancer Res 32:3069-75. 2012
    ..The findings reported here could contribute to a better understanding of the actions of estrogen in colon carcinoma...
  4. ncbi request reprint Activation of AXL and Antitumor Effects of a Monoclonal Antibody to AXL in Lung Adenocarcinoma
    Shinya Iida
    Department of Pathology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Anticancer Res 34:1821-7. 2014
    ..Background/Aim: AXL (anexelekto) has been explored as a potential novel therapeutic target for non-small cell lung carcinoma (NSCLC) but its activation status has not been evaluated in NSCLC...
  5. ncbi request reprint Identification of androgen-responsive microRNAs and androgen-related genes in breast cancer
    Kiichiroh Nakano
    2 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8575 Japan
    Anticancer Res 33:4811-9. 2013
    ..The study of microRNAs has recently provided with important insights into the biology of hormone-dependent cancer...
  6. pmc Significance of CD133 expression in esophageal squamous cell carcinoma
    Hiroshi Okamoto
    Division of Advanced Surgical Science and Technology, Graduate School of Medicine, Tohoku University, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    World J Surg Oncol 11:51. 2013
    ..Therefore, we examined whether CD133 could serve as a prognostic marker of ESCC and investigated the correlation between CD133 expression and the clinicopathological findings of ESCC patients and several markers...
  7. pmc An induction of microRNA, miR-7 through estrogen treatment in breast carcinoma
    Mariko Masuda
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Transl Med 10:S2. 2012
    ..Therefore, in this study, we examined the in vitro effects of estrogen upon miRNA expression profiles in breast carcinoma...
  8. pmc Estrogen-producing endometrioid adenocarcinoma resembling sex cord-stromal tumor of the ovary: a review of four postmenopausal cases
    Tomomi Katoh
    Department of Pathology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan
    Diagn Pathol 7:164. 2012
    ..Due to this, in the histological diagnosis, this variant of ovarian EMA may be challenging and misdiagnosed as SCST because of its wide range in morphology...
  9. pmc HIF-1α stimulates aromatase expression driven by prostaglandin E2 in breast adipose stroma
    Nirukshi U Samarajeewa
    Prince Henry s Institute, Block E Level 4, Monash Medical Centre, 246 Clayton Rd, Clayton, Melbourne, VIC 3168, Australia
    Breast Cancer Res 15:R30. 2013
    ..Together with our on-going studies on the role of AMP-activated protein kinase (AMPK) in the regulation of breast aromatase, this work provides another link between disregulated metabolism and breast cancer...
  10. pmc Prediction of axillary lymph node metastasis in primary breast cancer patients using a decision tree-based model
    Masahiro Takada
    Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    BMC Med Inform Decis Mak 12:54. 2012
    ..The aim of this study was to develop a new data-mining model to predict axillary lymph node (AxLN) metastasis in primary breast cancer. To achieve this, we used a decision tree-based prediction method-the alternating decision tree (ADTree)...
  11. pmc Intratumoral localization and activity of 17β-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer: a potent prognostic factor
    Mohit K Verma
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Transl Med 11:167. 2013
    ..e. 17β-hydroxysteroid dehydrogenases (i.e. 17βHSD1 and 17βHSD2) and others have not been studied. Therefore, in this study, we examined the clinical/ biological significance of 17β-hydroxysteroid dehydrogenases in NSCLCs...
  12. doi request reprint Discerning malignancy in resected adrenocotical tumors
    Sasano Hironobu
    Tohoku University School of Medicine, Department of Pathology, 2 1 Seiryou machi, Aoba ku, Sendai, 980 8575, Japan 81 22 717 7450 81 22 273 5976
    Expert Opin Med Diagn 2:1095-105. 2008
    ..The auxiliary methods that may be of clinical relevance at this juncture include the analysis of the Ki67/MIB-1 labeling index and IGF-II expression in the tumors...
  13. doi request reprint Cytoplasmic estrogen receptor β as a potential marker in human non-small cell lung carcinoma
    Mohit Kumar Verma
    Tohoku University Graduate School of Medicine, Department of Pathology, 2 1 Seriyo machi, Aoba ku, Sendai, Miyagi ken 980 8575, Japan
    Expert Opin Ther Targets 16:S91-102. 2012
    ..Estrogen has been reported to promote an increased susceptibility to lung cancer development. This study focusses on the role of cytoplasmic estrogen receptor β (c-ERβ) in NSCLC...
  14. doi request reprint Effects of estrogen depletion on angiogenesis in estrogen-receptor-positive breast carcinoma--an immunohistochemical study of vasohibin-1 and CD31 with correlation to pathobiological response of the patients in neoadjuvant aromatase inhibitor therapy
    Monica S M Chan
    Tohoku University School of Medicine, Department of Pathology, 2 1 Seiryou machi, Aoba ku, Sendai, Japan
    Expert Opin Ther Targets 16:S69-78. 2012
    ..Vasohibin-1 (VASH-1) is a recently identified endothelium-derived negative feedback regulator of angiogenesis. Vasohibin-1 positive ratio (VPR) is proposed as an indicator of neovascularization of the tissues...
  15. pmc Aromatase expression and outcomes in the P024 neoadjuvant endocrine therapy trial
    Matthew J Ellis
    Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63119, USA
    Breast Cancer Res Treat 116:371-8. 2009
    ..Expression of aromatase by malignant breast epithelial cells and/or the surrounding stroma implies local estrogen production that could influence the outcome of endocrine therapy for breast cancer...
  16. pmc In situ aromatase expression in primary tumor is associated with estrogen receptor expression but is not predictive of response to endocrine therapy in advanced breast cancer
    Anne E Lykkesfeldt
    Department of Tumor Endocrinology, Institute of Cancer Biology, Danish Cancer Society, Copenhagen Ø, Denmark
    BMC Cancer 9:185. 2009
    ..Due to methodological difficulties in the determination of the aromatase protein, COX-2, an enzyme involved in the synthesis of aromatase, has been suggested as a surrogate marker for aromatase expression...
  17. ncbi request reprint 17-beta-hydroxysteroid dehydrogenase in human breast and endometrial carcinoma. A new development in intracrinology
    H Sasano
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Oncology 59:5-12. 2000
    ..02). These results indicate that oxidation of E(2) to E(1) is dominant in endometrial carcinoma, 17 beta-HSD types 1 and 2 play an important role in the regulation of in situ estrogen production in breast and endometrial carcinoma...
  18. doi request reprint Histopathological prognostic factors in early breast carcinoma: an evaluation of cell proliferation in carcinoma cells
    Hironobu Sasano
    Tohoku University School of Medicine, Department of Pathology, Aoba ku, Sendai shi, Miyagi ken, Japan
    Expert Opin Investig Drugs 19:S5-11. 2010
    ....
  19. doi request reprint [Immunohistochemical evaluation of somatostatin receptor subtypes in surgical pathology specimens of neuroendocrine tumors]
    H Sasano
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryou machi, Aoba ku, 980 8575 Sendai, Japan
    Pathologe 31:199-203. 2010
    ....
  20. doi request reprint In situ estrogen production and its regulation in human breast carcinoma: from endocrinology to intracrinology
    Hironobu Sasano
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Pathol Int 59:777-89. 2009
    ....
  21. doi request reprint Aromatase and in situ estrogen production in DCIS (ductal carcinoma in situ) of human breast
    Hironobu Sasano
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryou machi, Aoba ku, Sendai 980 8575, Japan
    J Steroid Biochem Mol Biol 118:242-5. 2010
    ..These findings could provide the scientific rationale as to employing aromatase inhibitors in the management of ER positive DCIS patients...
  22. ncbi request reprint New development in intracrinology of breast carcinoma
    Hironobu Sasano
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Breast Cancer 13:129-36. 2006
    ..Therefore, it will become very important to examine the intratumoral levels of 17beta-HSD type 1 and STS in the resected specimens of human breast carcinoma as potential targets of novel endocrine therapy in the near future...
  23. ncbi request reprint The validation of new aromatase monoclonal antibodies for immunohistochemistry--a correlation with biochemical activities in 46 cases of breast cancer
    H Sasano
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryou machi, Sendai 980 8575, Japan
    J Steroid Biochem Mol Biol 95:35-9. 2005
    ..A methodology and scoring system is recommended whereby staining significantly correlates with aromatase activity of the resected tissue specimens of breast cancer...
  24. ncbi request reprint Pathological evaluation of angiogenesis in human tumor
    H Sasano
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryou machi, Sendai, Japan
    Biomed Pharmacother 59:S334-6. 2005
    ....
  25. ncbi request reprint Chemoprevention of breast cancer among Asian women--its perspective and problems
    Hironobu Sasano
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryou machi, 980 8575 Sendai, Japan
    Biomed Pharmacother 60:266-8. 2006
    ....
  26. ncbi request reprint Recent advances in histopathology and immunohistochemistry of adrenocortical carcinoma
    Hironobu Sasano
    Department of Pathology, Tohoku University School of Medicine and Tohoku University Hospital, Sendai, Japan
    Endocr Pathol 17:345-54. 2006
    ....
  27. ncbi request reprint Analysis of surrogate markers for target-specific therapy in breast carcinomas using archival materials
    Hironobu Sasano
    Department of Pathology, Tohoku University School of Medicine and Tohoku University Hospital, 2 1 Seiryou machi, Sendai 980 8575, Japan
    Biomed Pharmacother 61:543-7. 2007
    ....
  28. ncbi request reprint Angiomyofibroblastoma of the vulva: case report with immunohistochemical, ultrastructural and DNA ploidy studies and a review of the literature
    H Sasano
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Pathol Int 47:647-50. 1997
    ..97). These findings may reflect the quiescent or slow growing features of angiomyofibroblastoma...
  29. ncbi request reprint Proliferative fasciitis of the forearm: case report with immunohistochemical, ultrastructural and DNA ploidy studies and a review of the literature
    H Sasano
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Pathol Int 48:486-90. 1998
    ..DNA content of the cells, which was examined by image cytometry, demonstrated diploidy in both spindle (DNA index=1.01) and giant (DNA index=1.09) cells...
  30. ncbi request reprint Intracrinology of estrogens and androgens in breast carcinoma
    Hironobu Sasano
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryou machi, Aoba ku, Sendai, Japan
    J Steroid Biochem Mol Biol 108:181-5. 2008
    ..However, intracrine mechanisms of androgens as well as their biological or clinical significance in the patients with breast cancer have not been fully elucidated in contrast to those in estrogens...
  31. ncbi request reprint Validation of new aromatase monoclonal antibodies for immunohistochemistry: progress report
    H Sasano
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryou machi, Aoba ku, Sendai 980 8575, Japan
    J Steroid Biochem Mol Biol 86:239-44. 2003
    ..With these two MAbs, interpathologist and intralaboratory variations were minimal in comparison with differences which could be detected between tissue specimens and antibodies...
  32. ncbi request reprint Messenger ribonucleic acid in situ hybridization analysis of estrogen receptors alpha and beta in human breast carcinoma
    H Sasano
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 84:781-5. 1999
    ..The relative ratio of ERalpha and ERbeta expression in carcinoma cells may be related to various estrogen-dependent biological features of human breast cancer...
  33. ncbi request reprint Topoisomerase II alpha expression in esophageal squamous cell carcinoma
    Y Ohashi
    Department of Surgery, Tohoku University School of Medicine, Sendai, Japan
    Anticancer Res 19:1873-80. 1999
    ..Topo II alpha overexpression has been reported in a number of human malignancies and is considered to be related to their biological behaviors...
  34. ncbi request reprint Characterization of messenger RNA expression of estrogen receptor-alpha and -beta in patients with ovarian endometriosis
    S Matsuzaki
    Tohoku University School of Medicine, Sendai, Japan
    Fertil Steril 73:1219-25. 2000
    ..To evaluate the expression of estrogen receptor (ER)-alpha and ER-beta messenger RNA (mRNA) in ovarian endometriosis...
  35. ncbi request reprint DNA topoisomerase II alpha and Ki-67 in human adrenocortical neoplasms: a possible marker of differentiation between adenomas and carcinomas
    K Iino
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Mod Pathol 10:901-7. 1997
    ..This indicates that immunohistochemical analysis of Ki-67 and topoII alpha could help to differentiate carcinoma from adenoma in resected adrenocortical neoplasms and might predict aggressive biologic behavior in carcinomas...
  36. ncbi request reprint Cell cycle inhibitory protein p27 in esophageal squamous cell carcinoma
    Y Ohashi
    Department of Surgery, Tohoku University School of Medicine, Sendai, Japan
    Anticancer Res 19:1843-8. 1999
    ..p27 protein is one of the cdk inhibitors which regulates the progression from G1 to S phase of the cell cycle. Reduced expression of p27 protein has been reported to be correlated with poor clinical outcome in patients with various cancers...
  37. ncbi request reprint Expression of 5alpha-reductases in human epithelial ovarian cancer: its correlation with androgen receptor status
    J I Akahira
    Department of Pathology, Tohoku University School of Medicine, Sendai 980 8574, Japan
    Jpn J Cancer Res 92:926-32. 2001
    ..The relatively wide distribution of 5alpha-reductase type 1, and its correlation to AR status in human epithelial ovarian malignancies suggest that this isozyme plays important roles in androgen metabolism and actions in these tumors...
  38. ncbi request reprint 5alpha-reductases in human breast carcinoma: possible modulator of in situ androgenic actions
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Tohoku University Hospital N A, T M, Sendai 980 8575, Japan
    J Clin Endocrinol Metab 86:2250-7. 2001
    ....
  39. ncbi request reprint Retinoic acid receptor and retinoid X receptor in ductal carcinoma in situ and intraductal proliferative lesions of the human breast
    N Ariga
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8575, Japan
    Jpn J Cancer Res 91:1169-76. 2000
    ....
  40. pmc Progesterone receptor isoforms A and B in human epithelial ovarian carcinoma: immunohistochemical and RT-PCR studies
    J Akahira
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Br J Cancer 83:1488-94. 2000
    ..Moreover, it is important to examine PRB LI as a prognostic factor in the cases of human epithelial ovarian carcinoma...
  41. ncbi request reprint Urocortin and corticotropin-releasing factor receptor expression in normal cycling human ovaries
    Y Muramatsu
    Department of Pathology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    J Clin Endocrinol Metab 86:1362-9. 2001
    ..These results suggest that urocortin is locally synthesized in steroidogenic luteal cells and acts on them as an autocrine and/or paracrine regulator of ovarian steroidogenesis, especially during luteal regression...
  42. ncbi request reprint Coexpression of mineralocorticoid receptors and 11beta-hydroxysteroid dehydrogenase 2 in human gastric mucosa
    K Kato
    The Department of Medicine III, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 84:2568-73. 1999
    ..Aldosterone may, therefore, regulate biological functions of parietal cells including gastric acid secretion...
  43. ncbi request reprint 11Beta-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor in human fetal development
    G Hirasawa
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 84:1453-8. 1999
    ....
  44. ncbi request reprint Immunohistochemistry of Caspase3/CPP32 in human stomach and its correlation with cell proliferation and apoptosis
    T Hoshi
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Anticancer Res 18:4347-53. 1998
    ..These results also suggest that Caspase3/CPP32 is involved in the development or regulation of apoptotic cell death in cell turnover of normal and neoplastic mucosa of the human stomach...
  45. ncbi request reprint 11Beta-hydroxysteroid dehydrogenase type 2 in human lung: possible regulator of mineralocorticoid action
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 83:4022-5. 1998
    ..These results indicate that 11betaHSD2 colocalizes with MR in human airway epithelia and suggest that 11betaHSD2 play an important role in pulmonary mineralocorticoid activity such as sodium and fluid transport...
  46. ncbi request reprint Spatial and topological distribution of progesterone receptor A and B isoforms during human development
    T Inoue
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Mol Cell Endocrinol 182:83-9. 2001
    ..PR-B was demonstrated as the predominant isoform in comparison to PR-A in all fetal tissues examined. These findings suggest that progesterone may be involved in the development of fetal organs throughout the gestational period...
  47. ncbi request reprint Steroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma
    Hiroki Utsunomiya
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Clin Cancer Res 10:5850-6. 2004
    ..However, the status of steroid sulfatase and/or estrogen sulfotransferase in human endometrial carcinoma has not been examined...
  48. ncbi request reprint Estrogen inhibits cell proliferation through in situ production in human thymoma
    Hironori Ishibashi
    Department of Pathology, Tohoku University School of Medicine, Japan
    Clin Cancer Res 11:6495-504. 2005
    ..Estrogen sulfotransferase (EST), steroid sulfatase (STS), 17beta-hydroxysteroid dehydrogenase (17beta-HSD), and aromatase are considered to play important roles in hormone metabolism of estrogen-dependent tumors...
  49. ncbi request reprint Regional distribution of urocortin-like immunoreactivity and expression of urocortin mRNA in the human brain
    K Takahashi
    Department of Molecular Biology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Peptides 19:643-7. 1998
    ..RT-PCR showed that UCN mRNA was expressed in every region of brain examined. These findings indicated that UCN and UCN mRNA were widely expressed in the human brain...
  50. ncbi request reprint Progesterone receptor A and B isoforms in the human breast and its disorders
    N Ariga
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8575, Japan
    Jpn J Cancer Res 92:302-8. 2001
    ..These results suggest that both PRA and PRB are strongly associated with ERalpha in human breast and this relation may be disturbed in breast cancer...
  51. ncbi request reprint Urocortin and corticotropin-releasing factor receptor expression in the human colonic mucosa
    Y Muramatsu
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Peptides 21:1799-809. 2000
    ..The appearance of urocortin after birth indicates that the exposure to dietary intake and/or luminal bacteria after birth may contribute to the initiation of urocortin expression in human gastrointestinal tract mucosa...
  52. ncbi request reprint Peroxisome proliferator-activated receptor gamma in human breast carcinoma: a modulator of estrogenic actions
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Endocr Relat Cancer 13:233-50. 2006
    ..These results suggest that PPARgamma is mainly expressed in well-differentiated and ER-positive breast carcinomas, and modulates estrogenic actions...
  53. ncbi request reprint Retinoid receptors in the human endometrium and its disorders: a possible modulator of 17 beta-hydroxysteroid dehydrogenase
    K Ito
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai 980 8557, Japan
    J Clin Endocrinol Metab 86:2721-7. 2001
    ..These results all suggest that retinoic acids may be involved in modulation of in situ estrogen metabolism in both normal and neoplastic human endometrium possibly through RXR gamma by stimulating the expression of 17 beta-HSD type 2...
  54. ncbi request reprint Urocortin expression in the human central nervous system
    K Iino
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Clin Endocrinol (Oxf) 50:107-14. 1999
    ..In this study, we first examined urocortin expression in the hypothalamus (20 cases) and pituitary stalks (17 cases) of human brain obtained from autopsy using immunohistochemistry and mRNA in situ hybridization...
  55. pmc Aromatase cytochrome P450 gene expression in endometrial carcinoma
    H Sasano
    Department of Pathology, Tohoku School of Medicine, Sendai, Japan
    Br J Cancer 74:1541-4. 1996
    ..Further studies are required, but alternative splicing as well as use of multiple exons 1 transcripts may result in increased aromatase expression in stromal cells observed in endometrial carcinoma...
  56. ncbi request reprint Cytokeratin subtypes in biliary atresia: immunohistochemical study
    H Sasaki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Pathol Int 51:511-8. 2001
    ..These findings suggest that the expression patterns of CK subtypes in bile-duct cells in BA are similar to that in developing bile-duct cells, which is indicative of bile-duct cell immaturity...
  57. ncbi request reprint 17Beta-hydroxysteroid dehydrogenase types 1 and 2 in human placenta: an immunohistochemical study with correlation to placental development
    J Takeyama
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 83:3710-5. 1998
    ..17BetaHSD type 2, therefore, is considered to prevent the passage of excessive estrogens into the fetal circulation at endothelial cells of the intravillous fetal capillaries by catalyzing the inactivation ofE2 to E1...
  58. ncbi request reprint Sex steroid receptors expression and hormone-induced cell proliferation in human osteosarcoma
    Osamu Dohi
    Department of Orthopaedic Surgery, Tohoku Kosai Hospital, 2 3 11 Kokubuncho, Aoba ku, Sendai, Japan
    Cancer Sci 99:518-23. 2008
    ..In addition, these data suggest the potential for a novel endocrine therapy in osteosarcoma using clinically available inhibitors of progesterone and estrogen actions...
  59. doi request reprint Increased estrogen sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type 1(17beta-HSD1) following neoadjuvant aromatase inhibitor therapy in breast cancer patients
    Niramol Chanplakorn
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi, Japan
    Breast Cancer Res Treat 120:639-48. 2010
    ..This increment may represent the compensatory response of breast carcinoma tissues to estrogen depletion...
  60. ncbi request reprint Expression of melanin-concentrating hormone receptor messenger ribonucleic acid in tumor tissues of pheochromocytoma, ganglioneuroblastoma, and neuroblastoma
    K Takahashi
    Department of Molecular Biology, Health Administration Center, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    J Clin Endocrinol Metab 86:369-74. 2001
    ..These findings raised the possibility that MCH or MCH-like peptides may be related to the pathophysiology of these neural crest-derived tumors...
  61. ncbi request reprint Regional distribution of immunoreactive prolactin-releasing peptide in the human brain
    K Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Miyagi, Japan
    Peptides 21:1551-5. 2000
    ..The immunoreactive-PrRP levels in the human hypothalamus were, however, lower than the levels of other neuropeptides with prolactin-releasing activity, such as thyrotropin-releasing hormone and vasoactive intestinal polypeptide...
  62. ncbi request reprint Expression of 11 beta-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor in primary lung carcinomas
    S Suzuki
    Department of Thoracic Surgery, Tohoku University, Sendai, Japan
    Anticancer Res 20:323-8. 2000
    ..These data suggest that the patterns of 11 beta HSD2 and MR expression may reflect cellular origin and differentiation status of primary lung adenocarcinomas and serve as a new useful marker of differentiation...
  63. ncbi request reprint A novel acyl-CoA synthetase, ACS5, expressed in intestinal epithelial cells and proliferating preadipocytes
    E Oikawa
    Tohoku University Gene Research Center School of Medicine, Tohoku University, Sendai, 981 8555, Japan
    J Biochem 124:679-85. 1998
    ....
  64. ncbi request reprint A case of ruptured dissecting aneurysm 5 years after pituitary microsurgical treatment of Cushing's disease: autopsy findings in the hypothalamic-pituitary-adrenal axis
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Endocr J 40:613-8. 1993
    ..Periodic cardiovascular re-evaluations should therefore be performed when there is clinical remission of Cushing's syndrome...
  65. ncbi request reprint Adrenal rest tumor of the broad ligament: case report with immunohistochemical study of steroidogenic enzymes
    H Sasano
    Department of Pathology, Tohoku University School of Medicine, Sendia, Japan
    Pathol Int 47:493-6. 1997
    ..A relatively low Ki-67 labelling index (3.20 +/- 1.15 per 100 tumor cells) and an absence of necrosis and vascular and/or capsular invasion suggest benignity of the lesion...
  66. ncbi request reprint 17beta-hydroxysteroid dehydrogenase type 1 and 2 expression in the human fetus
    J Takeyama
    Department of Pathology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    J Clin Endocrinol Metab 85:410-6. 2000
    ..17betaHSD2 in these tissues may be functioning in the prevention of in utero exposure of the fetus to excessive estradiol from the maternal circulation and amniotic fluids...
  67. ncbi request reprint Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist
    M Murakami
    Department of Molecular Pharmacology, Tohoku University School of Medicine, Seiryomachi, Aobaku, 980 8575, Sendai, Japan
    Brain Res 868:123-7. 2000
    ..Our findings apparently support the idea that cilnidipine attenuates synaptic neurotransmission by inhibiting N-type calcium channels in DRG neurons...
  68. ncbi request reprint Expression and cellular localization of estrogen receptors alpha and beta in the human fetus
    J Takeyama
    Department of Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    J Clin Endocrinol Metab 86:2258-62. 2001
    ....
  69. pmc EBAG9/RCAS1 in human breast carcinoma: a possible factor in endocrine-immune interactions
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Br J Cancer 85:1731-7. 2001
    ..0025). This study suggests that EBAG9 is produced via ER in carcinoma cells and inhibits the intratumoural infiltration of T lymphocytes in the context of a possible endocrine-immune interaction in human breast carcinomas...
  70. ncbi request reprint Biological roles of estrogen and progesterone in human endometrial carcinoma--new developments in potential endocrine therapy for endometrial cancer
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Endocr J 54:667-79. 2007
    ....
  71. ncbi request reprint Sex steroid hormone receptors in human thymoma
    Hironori Ishibashi
    Department of Pathology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    J Clin Endocrinol Metab 88:2309-17. 2003
    ..Results from our study suggest that estrogens may inhibit thymoma growth via ER alpha, and that ER alpha immunoreactivity may act as a prognostic factor in human thymoma...
  72. ncbi request reprint Nuclear receptor DAX1 in human prostate cancer: a novel independent biological modulator
    Yasuhiro Nakamura
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Endocr J 56:39-44. 2009
    ..DAX1 immunoreactivity is considered a new biological modulator of human prostate cancer, but independent to the status of sex steroid receptors in human prostate cancer tissues...
  73. ncbi request reprint Intracrinology of sex steroids in ductal carcinoma in situ (DCIS) of human breast: comparison to invasive ductal carcinoma (IDC) and non-neoplastic breast
    Yasuhiro Miki
    Department of Pathology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi ken 980 8575, Japan
    J Steroid Biochem Mol Biol 114:68-71. 2009
    ..Therefore, in this review, we also focused on the importance of key intracrine enzymes such as 17beta-hydroxysteroid dehydrogenases, steroid sulfatase,estrogen sulfotransferase, 5alpha-reductases in both IDC and DCIS...
  74. ncbi request reprint Immunohistochemical analysis of gastrin-releasing peptide receptor (GRPR) and possible regulation by estrogen receptor βcx in human prostate carcinoma
    S Nagasaki
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Neoplasma 59:224-32. 2012
    ..These results also suggest that ERβcx contributes to prostate cancer development possibly through mediating GRPR expression in carcinoma cells...
  75. ncbi request reprint PTOV1: a novel testosterone-induced atherogenic gene in human aorta
    Y Nakamura
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Pathol 209:522-31. 2006
    ....
  76. ncbi request reprint Adrenal adenoma with bilateral adrenocortical nodular change in a patient with Cushing's syndrome
    K Iino
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Clin Endocrinol (Oxf) 47:371-5. 1997
    ..When examining patients with Cushing's syndrome and bilateral adrenal enlargement, the possibility of concomitant adenoma and adrenocortical nodule formation should also be considered in the differential diagnosis..
  77. ncbi request reprint Immunohistochemical distribution of 11beta-hydroxysteroid dehydrogenase in human eye
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, 980 8575, Sendai, Japan
    Mol Cell Endocrinol 173:121-5. 2001
    ..The widespread expression of GR suggests that glucocorticoids may play an important role in the function and homeostasis of the human eye...
  78. ncbi request reprint Retinoid receptors in human breast carcinoma: possible modulators of in situ estrogen metabolism
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Breast Cancer Res Treat 65:31-40. 2001
    ..76-fold (p < 0.001), five days following treatment with 10 nM retinoic acid. These data suggest that retinoid receptors modulate various effects of retinoids, including estrogen metabolism in human breast carcinomas...
  79. ncbi request reprint Malignant rhabdoid tumor of the vulva: case report with cytological, immunohistochemical, ultrastructural and DNA ploidy studies and a review of the literature
    T Igarashi
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Pathol Int 48:887-91. 1998
    ..No cytokeratin and desmin immunoreactivity were detected in the tumor cells. The Ki-67 labeling index was 36% and the DNA content of the tumor cells, which was examined by image cytometry, demonstrated diploidy (DNA index = 0.95)...
  80. ncbi request reprint Immunohistochemical analysis of Ki-67, p53, p21, and p27 in benign and malignant apocrine lesions of the breast: its correlation to histologic findings in 43 cases
    T Moriya
    Department of Pathology, Tohoku University Hospital, Sendai, Japan
    Mod Pathol 13:13-8. 2000
    ..Results of these studies suggest that Ki-67 and p53 may be good markers for differentiation between benign and malignant breast apocrine lesions...
  81. pmc Difficult-to-control hypertension due to bilateral aldosterone-producing adrenocortical microadenomas associated with a cortisol-producing adrenal macroadenoma
    R Morimoto
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    J Hum Hypertens 25:114-21. 2011
    ..Two microAPAs with paradoxical hyperplasia were revealed within the apparently atrophic left adrenal gland. Soon after the second surgery, her blood pressure normalized without requiring any anti-hypertensive medication...
  82. ncbi request reprint Ad4BP in the human adrenal cortex and its disorders
    H Sasano
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 80:2378-80. 1995
    ..Ad4BP therefore seems to play important roles in the induction and maintenance of the transcription of all steroidogenic P450 genes in human adrenocortical cells, even after malignant transformation...
  83. doi request reprint Intratumoral localization of aromatase and interaction between stromal and parenchymal cells in the non-small cell lung carcinoma microenvironment
    Yasuhiro Miki
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Res 70:6659-69. 2010
    ....
  84. doi request reprint Intratumoral concentration of sex steroids and expression of sex steroid-producing enzymes in ductal carcinoma in situ of human breast
    Rie Shibuya
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Endocr Relat Cancer 15:113-24. 2008
    ..Therefore, estradiol and DHT may play important roles in the development of DCIS of the human breast...
  85. ncbi request reprint Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation
    Jun ichi Akahira
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Cancer Res 10:2687-93. 2004
    ..In this study, we examined the promoter methylation status and expression of 14-3-3 sigma and evaluated its clinical significance in epithelial ovarian cancer...
  86. ncbi request reprint Immunohistochemical expression of gonadotropin releasing hormone receptor in human breast carcinoma
    T Moriya
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Pathol Int 51:333-7. 2001
    ..Breast carcinomas positive for GnRH-R maintain some hormonal regulatory mechanisms, and GnRH actions may lead to a low proliferative rate in human breast carcinoma...
  87. ncbi request reprint Immunohistochemical distribution of chicken ovalbumin upstream promoter transcription factor II in human tissues
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Mol Cell Endocrinol 164:69-75. 2000
    ..The widespread expression of COUP-TFII suggests that COUP-TFII may play an important role in the function and homeostasis of various human tissues and organs...
  88. ncbi request reprint Aromatase in atherosclerotic lesions of human aorta
    H Murakami
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryou machi, Aoba ku, 980 8575, Sendai, Japan
    J Steroid Biochem Mol Biol 79:67-74. 2001
    ..Moreover, it was suggested that aromatase overexpression, possibly as a result of alternative splicing, may play some roles in the development of atherosclerosis...
  89. ncbi request reprint Genotype analysis of prepro-vasopressin signal peptide in vasopressin-producing and -non-producing lung tumors
    M Shoji
    The Second Department of Internal Medicine, Tohoku University, Sendai, Japan
    Life Sci 61:2561-6. 1997
    ..These results suggest that similar to the hypothalamus the normal signal peptide is functional in tumor cells and that the variant signal peptide is not a prerequisite for AVP secretion from SCLC cells...
  90. ncbi request reprint Endomyometriosis arising in the uterosacral ligament: a case report including a literature review and immunohistochemical analysis
    S Matsuzaki
    Departments of Obstetrics and Gynecology andPathology, Tohoku University School of Medicine, Sendai, Japan
    Pathol Int 50:493-6. 2000
    ..A relatively high proliferating activity was also demonstrated in these cells by Ki-67 immunostaining. These findings suggest that the mass was hormone dependent and had a relatively rapid evolution...
  91. ncbi request reprint Apoptosis of human endometrium mediated by perforin and granzyme B of NK cells and cytotoxic T lymphocytes
    R Konno
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 187:149-55. 1999
    ..This finding suggests that the cytotoxic granules released from EGs, which are derived from cytotoxic T lymphocytes and natural killer cells, are initiators of the apoptotic pathway that induces endometrial menstruation...
  92. ncbi request reprint Uterine angiomyolipoma: case report and review of the literature
    H Yaegashi
    Department of Pathology, Mitokyodo General Hospital, Mito, Japan
    Pathol Int 51:896-901. 2001
    ..It is of particular interest that non-vascular smooth muscle cells were negative for HMB45, in contrast to renal and other extrarenal AML in which HMB45 immunoreactivity has been demonstrated in these cells...
  93. ncbi request reprint Urocortin expression in human pituitary gland and pituitary adenoma
    K Iino
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 82:3842-50. 1997
    ..The results described above indicated that urocortin is synthesized in human anterior pituitary cells and may play an important role in biological features of normal pituitary gland, possibly as an autocrine or a paracrine regulator..
  94. ncbi request reprint StAR and progesterone producing enzymes (3beta-hydroxysteroid dehydrogenase and cholesterol side-chain cleavage cytochromes P450) in human epithelial ovarian carcinoma: immunohistochemical and real-time PCR studies
    Manar Abd-Elaziz
    Department of Pathology, Tohoku University School of Medicine and Tohoku University Hospital, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Cancer Sci 96:232-9. 2005
    ....
  95. ncbi request reprint Expression of adrenomedullin2/intermedin in human brain, heart, and kidney
    Ryo Morimoto
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Sendai, Miyagi 980 8574, Japan
    Peptides 28:1095-103. 2007
    ..The present study has shown expression of AM2/IMD in various types of cells in the central nervous system and the cardiovascular system, and suggested possible (patho)physiological roles of AM2/IMD in these systems...
  96. ncbi request reprint Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle
    Yoko Sato
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 88:3415-20. 2003
    ..These results indicated that DAX-1 and COUP-TFII may play a role in the modulation of Ad4BP/SF-1-dependent transcription of steroidogenic enzymes in different cell types and follicular stages in normal cycling human ovaries...
  97. doi request reprint Intratumoral estrogens and estrogen receptors in human non-small cell lung carcinoma
    Hiromichi Niikawa
    Department of Pathology, Tohoku University School of Medicine, Japan
    Clin Cancer Res 14:4417-26. 2008
    ..Therefore, we examined intratumoral estradiol concentrations in NSCLC to examine local actions of estrogens in NSCLC...
  98. doi request reprint Comparative effects of raloxifene, tamoxifen and estradiol on human osteoblasts in vitro: estrogen receptor dependent or independent pathways of raloxifene
    Yasuhiro Miki
    Department of Pathology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi, Japan
    J Steroid Biochem Mol Biol 113:281-9. 2009
    ..Results of our present study demonstrated that raloxifene exerted direct protective effects on human osteoblasts in both estrogen receptor dependent and independent manners...
  99. doi request reprint Increased intratumoral androgens in human breast carcinoma following aromatase inhibitor exemestane treatment
    Kiyoshi Takagi
    Department of Pathology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Miyagi ken, Japan
    Endocr Relat Cancer 17:415-30. 2010
    ....
  100. ncbi request reprint Expression of estrogen receptor alpha and beta in peritoneal and ovarian endometriosis
    S Matsuzaki
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Fertil Steril 75:1198-205. 2001
    ..To quantify and compare messenger RNA (mRNA) levels of ER-alpha and ER-beta among ovarian endometriotic cysts and red and black peritoneal endometriotic lesions...
  101. ncbi request reprint Melanin-concentrating hormone in human and rat
    K Takahashi
    Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Sendai, Japan
    Neuroendocrinology 61:493-8. 1995
    ..5 pmol/g wet weight, n = 9) or adrenal tumors including pheochromocytomas. Immunoreactive MCH were not detected in plasma obtained from human healthy subjects (< 0.25 pmol/l) and rat (< 0.25 pmol/l).(ABSTRACT TRUNCATED AT 250 WORDS)..