H Sakagami

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi request reprint Molecular cloning of the cDNA for rat phosphatase inhibitor-2 and its wide gene expression in the central nervous system
    H Sakagami
    Department of Anatomy, Tohoku University, School of Medicine, Sendai, Japan
    J Chem Neuroanat 8:259-66. 1995
  2. ncbi request reprint Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2
    T Abe
    Department of Neurophysiology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    J Biol Chem 273:22395-401. 1998
  3. pmc Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity
    Sho Kakizawa
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    EMBO J 26:1924-33. 2007
  4. ncbi request reprint Somatodendritic localization of the mRNA for EFA6A, a guanine nucleotide exchange protein for ARF6, in rat hippocampus and its involvement in dendritic formation
    Hiroyuki Sakagami
    Division of Histology, Department of Cell Biology, Tohoku University Graduate School of Medicine, Japan
    Eur J Neurosci 19:863-70. 2004
  5. ncbi request reprint Prominent expression and activity-dependent nuclear translocation of Ca2+/calmodulin-dependent protein kinase Idelta in hippocampal neurons
    Hiroyuki Sakagami
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai 980 8575, Japan
    Eur J Neurosci 22:2697-707. 2005
  6. ncbi request reprint Transient up-regulation of elongation factor-2 kinase (Ca2+/calmodulin-dependent protein kinase III) messenger RNA in developing mouse brain
    Hiroyuki Sakagami
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai 980 8575, Japan
    Neurosci Lett 330:41-4. 2002
  7. ncbi request reprint Localization of the mRNAs for two isoforms of Ca2+/calmodulin-dependent protein kinase kinases in the adult rat brain
    H Sakagami
    Department of Histology, Tohoku University, School of Medicine, Sendai 980, Japan
    Brain Res Mol Brain Res 54:311-5. 1998
  8. ncbi request reprint Distinct immunohistochemical localization of two isoforms of Ca2+/calmodulin-dependent protein kinase kinases in the adult rat brain
    H Sakagami
    Division of Histology, Department of Cell Biology, Graduate School of Medical Sciences, Tohoku University, Sendai 980 0782, Japan
    Eur J Neurosci 12:89-99. 2000
  9. ncbi request reprint Effect of sodium benzylideneascorbate on chemically-induced tumors in rats
    H Sakagami
    First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan
    Anticancer Res 13:65-71. 1993
  10. pmc Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1
    M Yamada
    Department of Microbiology and Immunology, Sendai 980 8575, Japan
    Mol Cell Biol 21:3807-19. 2001

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Molecular cloning of the cDNA for rat phosphatase inhibitor-2 and its wide gene expression in the central nervous system
    H Sakagami
    Department of Anatomy, Tohoku University, School of Medicine, Sendai, Japan
    J Chem Neuroanat 8:259-66. 1995
    ....
  2. ncbi request reprint Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2
    T Abe
    Department of Neurophysiology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    J Biol Chem 273:22395-401. 1998
    ..This suggests that oatp2 and oatp3 are multifunctional transporters involved in the transport of thyroid hormones in the brain, retina, liver, and kidney...
  3. pmc Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity
    Sho Kakizawa
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    EMBO J 26:1924-33. 2007
    ..Therefore, JPs support the Ca(2+)-mediated communication between voltage-gated Ca(2+) channels, RyRs and SK channels, which modulates the excitability of PCs and is fundamental to cerebellar LTD and motor functions...
  4. ncbi request reprint Somatodendritic localization of the mRNA for EFA6A, a guanine nucleotide exchange protein for ARF6, in rat hippocampus and its involvement in dendritic formation
    Hiroyuki Sakagami
    Division of Histology, Department of Cell Biology, Tohoku University Graduate School of Medicine, Japan
    Eur J Neurosci 19:863-70. 2004
    ..The present findings suggest that EFA6A is intimately involved in the regulation of the dendritic development of hippocampal neurons...
  5. ncbi request reprint Prominent expression and activity-dependent nuclear translocation of Ca2+/calmodulin-dependent protein kinase Idelta in hippocampal neurons
    Hiroyuki Sakagami
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai 980 8575, Japan
    Eur J Neurosci 22:2697-707. 2005
    ..Our present study provides the first evidence for the possible involvement of CaMKIdelta in nuclear functions through its nuclear translocation in response to stimuli that trigger intracellular Ca2+ influx...
  6. ncbi request reprint Transient up-regulation of elongation factor-2 kinase (Ca2+/calmodulin-dependent protein kinase III) messenger RNA in developing mouse brain
    Hiroyuki Sakagami
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai 980 8575, Japan
    Neurosci Lett 330:41-4. 2002
    ..These findings suggest that eEF-2K may be involved in early neuronal events such as proliferation, differentiation, and establishment of synaptic connections...
  7. ncbi request reprint Localization of the mRNAs for two isoforms of Ca2+/calmodulin-dependent protein kinase kinases in the adult rat brain
    H Sakagami
    Department of Histology, Tohoku University, School of Medicine, Sendai 980, Japan
    Brain Res Mol Brain Res 54:311-5. 1998
    ..In the adult rat brain, CaMKK alpha mRNAs are widely distributed throughout the brain, whereas CaMKK beta mRNAs are restricted to some neuronal populations, particularly the cerebellar granule cells...
  8. ncbi request reprint Distinct immunohistochemical localization of two isoforms of Ca2+/calmodulin-dependent protein kinase kinases in the adult rat brain
    H Sakagami
    Division of Histology, Department of Cell Biology, Graduate School of Medical Sciences, Tohoku University, Sendai 980 0782, Japan
    Eur J Neurosci 12:89-99. 2000
    ..The distinct localization of two isoforms of CaM-KKs suggests that the complicated mechanisms for activation of CaM-KIV by CaM-KKs may be exerted in region-specific manners as well as intracellularly...
  9. ncbi request reprint Effect of sodium benzylideneascorbate on chemically-induced tumors in rats
    H Sakagami
    First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan
    Anticancer Res 13:65-71. 1993
    ..These data suggest that the conditions of SBA administration should be re-established for each tumor sample to produce maximum antitumor activity...
  10. pmc Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1
    M Yamada
    Department of Microbiology and Immunology, Sendai 980 8575, Japan
    Mol Cell Biol 21:3807-19. 2001
    ..These data suggest that STAM1 is dispensable for cytokine-mediated signaling in lymphocytes but may be involved in the survival of hippocampal CA3 pyramidal neurons...
  11. ncbi request reprint Localization of mRNAs for synaptojanin isoforms in the brain of developing and mature rats
    M Kudo
    Division of Histology, Department of Cell Biology, Graduate School of Medical Science, Tohoku University, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Brain Res Mol Brain Res 64:179-85. 1999
    ....
  12. ncbi request reprint Localization of PDK-1 mRNA in the brain of developing and adult rats
    S Yoshida
    Department of Cell Biology, Graduate School of Medical Sciences, Tohoku University, Sendai, Japan
    Tohoku J Exp Med 187:249-55. 1999
    ..The pattern of this gene expression is similar to those of for protein kinase B and class I phosphoinositide 3-kinases...
  13. ncbi request reprint Distribution and intracellular localization of a mouse homologue of Ca2+/calmodulin-dependent protein kinase Ibeta2 in the nervous system
    T Ueda
    Department of Biochemistry, Kobe University, School of Medicine, Japan
    J Neurochem 73:2119-29. 1999
    ..In addition, mCaMKI/beta2 proteins are localized to the cytoplasm and nuclei, but not to nucleoli, suggesting that mCaMKIbeta2 proteins might be involved in the cytoplasmic and nuclear signal transduction of the nervous system...
  14. ncbi request reprint A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration
    F Ono
    Department of Histology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 77, Japan
    J Biol Chem 273:7731-6. 1998
    ..In addition, its expression increases during liver regeneration after partial hepatectomy with maximal expression after the growth period, suggesting that PI3K-IIgamma may function mainly in highly differentiated hepatic cells...
  15. ncbi request reprint Localization of epidermal-type fatty acid binding protein in alveolar macrophages and some alveolar type II epithelial cells in mouse lung
    Y Owada
    Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai, Japan
    Histochem J 33:453-7. 2001
    ..No immunoreactive interstitial fibroblasts were encountered. Based on the present findings, possible roles of epidermal-type fatty acid binding protein in the host-defence mechanism played by alveolar macrophages are suggested...
  16. ncbi request reprint Structure of the mouse glutamate decarboxylase 65 gene and its promoter: preferential expression of its promoter in the GABAergic neurons of transgenic mice
    K Makinae
    Department of Biochemistry, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    J Neurochem 75:1429-37. 2000
    ....
  17. ncbi request reprint Differentiation-dependent enhanced expression of protein phosphatase 2Cbeta in germ cells of mouse seminiferous tubules
    S Kato
    Department of Biochemistry, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    FEBS Lett 396:293-7. 1996
    ....
  18. ncbi request reprint Rat hepatocellular carcinogenesis and proliferating cell nuclear antigen expression induced by 3'-methyl-4-dimethylaminoazobenzene
    H Ota
    Second Department of Pathology, School of Medicine, Showa University, Tokyo, Japan
    In Vivo 8:289-94. 1994
    ..The present study confirms the previously reported usefulness of the PCNA immunostaining method for prognosis and assessment of the malignancy of carcinoma...
  19. ncbi request reprint Tumor-specific action of sodium 5,6-benzylidene-L-ascorbate in N-nitrosodiethylamine-administered mouse model
    K Asano
    Department of Physiology, School of Medicine, Showa University, Tokyo, Japan
    Anticancer Res 21:281-4. 2001
    ..The antitumor activity of SBA might be due to the long-term production of radicals in tumor tissues by its prooxidant action...
  20. ncbi request reprint Functional assay of EFA6A, a guanine nucleotide exchange factor for ADP-ribosylation factor 6 (ARF6), in dendritic formation of hippocampal neurons
    Hiroyuki Sakagami
    Department of Cell Biology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Methods Enzymol 404:232-42. 2005
    ..This reliable and consistent neuronal transfection method will also be applicable for the vector-based RNA interference method...
  21. ncbi request reprint Distinct spatiotemporal expression of EFA6D, a guanine nucleotide exchange factor for ARF6, among the EFA6 family in mouse brain
    Hiroyuki Sakagami
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai 980 8574, Japan
    Brain Res 1093:1-11. 2006
    ..Furthermore, immunoblot analysis revealed that EFA6D was highly concentrated in the postsynaptic density fraction. These findings suggest differential spatiotemporal regulation of ARF6 by three members of the EFA6 family in the brain...
  22. pmc Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins
    Shigeki Moriguchi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Graduate School of Medicine, Tohoku University, Sendai 980, Japan
    Proc Natl Acad Sci U S A 103:10811-6. 2006
    ..Therefore, JPs seem to have an essential role in neural excitability fundamental to plasticity and integrated functions...
  23. ncbi request reprint Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family
    Taisuke Miyazaki
    Department of Anatomy, Hokkaido University, School of Medicine, Sapporo, Japan
    FEBS Lett 580:4057-64. 2006
    ..Because cerebellar maturation and plasticity require metabotropic glutamate receptor signaling and resulting PKC activation, BSRPs are likely involved in ER functions supporting PKCalpha activation in PCs...
  24. ncbi request reprint Interaction of LDL receptor-related protein 4 (LRP4) with postsynaptic scaffold proteins via its C-terminal PDZ domain-binding motif, and its regulation by Ca/calmodulin-dependent protein kinase II
    Qing Bao Tian
    Department of Neuroplasticity, Institute on Ageing and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Eur J Neurosci 23:2864-76. 2006
    ..These findings suggest a postsynaptic role for LRP4, a putative endocytic multiligand receptor, and a mechanism in which CaMKII regulates PDZ-dependent protein-protein interactions and receptor dynamics...
  25. ncbi request reprint Altered emotional behavioral responses in mice lacking brain-type fatty acid-binding protein gene
    Yuji Owada
    Division of Histology, Graduate School of Medical Science, Tohoku University, 2 1 Seiryo machi, Aobaku, Sendai 980 8575, Japan
    Eur J Neurosci 24:175-87. 2006
    ..These data indicate that B-FABP is crucially involved in the fear memory and anxiety through its binding with FAs and/or its own direct effects on pertinent metabolism/signaling of FAs...
  26. ncbi request reprint Developmental expression of the SRF co-activator MAL in brain: role in regulating dendritic morphology
    Jun Shiota
    Department of Biological Chemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama City, Japan
    J Neurochem 98:1778-88. 2006
    ..Taken together, these findings indicate that the MAL-SRF signaling pathway plays a key role in regulating dendritic morphology...
  27. ncbi request reprint Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth
    Akifumi Kamata
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Japan
    Neurosci Res 57:86-97. 2007
    ....
  28. ncbi request reprint Somatodendritic localization of EFA6A, a guanine nucleotide exchange factor for ADP-ribosylation factor 6, and its possible interaction with alpha-actinin in dendritic spines
    Hiroyuki Sakagami
    Division of Histology, Department of Cell Biology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Sendai 980 8575, Japan
    Eur J Neurosci 25:618-28. 2007
    ..Our present findings suggest that EFA6A may form a protein complex with alpha-actinin and activate ARF6 in close proximity of the actin cytoskeleton and membrane proteins in the dendritic spines...
  29. ncbi request reprint Rat leucine-rich protein binds and activates the promoter of the beta isoform of Ca2+/calmodulin-dependent protein kinase II gene
    Nagahiro Ochiai
    Department of Biochemistry, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
    Neurosci Res 58:67-76. 2007
    ..These results indicate that rLRP157 is one of the proteins binding to, and regulating the activity of, the promoter of beta CaM kinase II...
  30. ncbi request reprint Distinct developmental expression of two isoforms of Ca2+/calmodulin-dependent protein kinase kinases and their involvement in hippocampal dendritic formation
    Akifumi Kamata
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai 980 8575, Japan
    Neurosci Lett 423:143-8. 2007
    ..Our present findings provide the detailed anatomical information on the developmental expression of CaMKKs and the functional involvement of CaMKK in the formation of primary dendrites...
  31. ncbi request reprint Synaptic vesicle dynamics in the mossy fiber-CA3 presynaptic terminals of mouse hippocampus
    Shigetomo Suyama
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University, Tochigi, Japan
    Neurosci Res 59:481-90. 2007
    ..Therefore, the fidelity of transmission is suggested to be ensured by the rapid refilling rate of RRP...
  32. doi request reprint IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses
    Hiroyuki Sakagami
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara 228 8555, Japan
    Neurosci Res 60:199-212. 2008
    ..Taken together, IQ-ArfGEF/BRAG1 forms a postsynaptic protein complex containing PSD-95 and NMDA receptors at excitatory synapses, where it may function as a GEF for Arf6...
  33. ncbi request reprint The EFA6 family: guanine nucleotide exchange factors for ADP ribosylation factor 6 at neuronal synapses
    Hiroyuki Sakagami
    Department of Anatomy, Kitasato University School of Medicine
    Tohoku J Exp Med 214:191-8. 2008
    ..Here, I will review the recent advances in the expression and functions of the EFA6 family in the nervous system...
  34. ncbi request reprint Transgenic mouse lines expressing synaptopHluorin in hippocampus and cerebellar cortex
    Rikita Araki
    Department of Developmental Biology and Neurosciences, Tohoku University Graduate School of Life Sciences, and CREST, JST, Sendai, Japan
    Genesis 42:53-60. 2005
    ..These transgenic lines are expected to facilitate morphological and physiological studies of presynaptic terminals in a variety of regions of the brain...
  35. ncbi request reprint p55 protein is a member of PSD scaffold proteins in the rat brain and interacts with various PSD proteins
    Zhang Jing-Ping
    Department of Neuroplasticity, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Brain Res Mol Brain Res 135:204-16. 2005
    ..r-p55 protein may form a basic structure, which interlinks diverse functional molecules of the PSD necessary for postsynaptic signaling and synaptic adhesion...
  36. ncbi request reprint NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity
    Fuminori Saitoh
    Department of Neuroplasticity Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Biol Chem 279:29461-8. 2004
    ..These results suggested that NIDD plays an important role in the regulation of the NO signaling pathway at postsynaptic sites through targeting of nNOS to the postsynaptic membrane...
  37. ncbi request reprint Localization of mRNAs for phosphatidylinositol phosphate kinases in the mouse brain during development
    Yosuke Akiba
    Division of Histology, Department of Cell Biology, Graduate School of Medical Sciences, Tohoku University, 2 1 Seiryo machi, Aobaku, Sendai 980 8575, Japan
    Brain Res Gene Expr Patterns 1:123-33. 2002
    ..The distinct expression for the gene encoding PIPK IIalpha was detected in the postnatal white matter such as the cerebellar medulla, the corpus callosum, the hippocampal fimbriae, and the internal capsule...
  38. ncbi request reprint Coexpression of junctophilin type 3 and type 4 in brain
    Miyuki Nishi
    Department of Medical Chemistry, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Brain Res Mol Brain Res 118:102-10. 2003
    ..The results obtained suggest the collaborative contribution of JP-3 and JP-4 to the subsurface cistern formation in neurons...
  39. ncbi request reprint Localization of epidermal-type fatty acid binding protein in macrophages in advanced atretic follicles of adult mice
    Mohammad Reza Nourani
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Aoba ku, Sendai, Japan
    J Mol Histol 36:391-400. 2005
    ....
  40. pmc ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons
    Lidong Liu
    Department of Environmental Health, University of Washington, Seattle, WA 98195 7234, USA
    Proc Natl Acad Sci U S A 100:8532-7. 2003
    ..These data suggest that ERK5 activation of myocyte enhancer factor 2-induced gene expression may play an important and novel role in the development of the CNS by mediating NT-promoted survival of embryonic neurons...
  41. ncbi request reprint Localization of brain-type fatty acid-binding protein in Kupffer cells of mice and its transient decrease in response to lipopolysaccharide
    Soha Abdelkawi Abdelwahab
    Division of Histology, Department of Cell Biology, Graduate School of Medical Science, Tohoku University, 980 8575 Sendai, Japan
    Histochem Cell Biol 119:469-75. 2003
    ....
  42. ncbi request reprint Cloning, characterization and expression of two alternatively splicing isoforms of Ca2+/calmodulin-dependent protein kinase I gamma in the rat brain
    Hideki Nishimura
    Division of Histology, Department of Cell Biology, Graduate School of Medical Sciences, Tohoku University, Sendai, Japan
    J Neurochem 85:1216-27. 2003
    ..These findings suggest that both isoforms of CaMKI gamma may be involved in Ca2+ signal transduction in the cytoplasmic compartment of certain neuronal population...
  43. ncbi request reprint Cloning and characterization of a novel variant (mM-rdgBbeta1) of mouse M-rdgBs, mammalian homologs of Drosophila retinal degeneration B gene proteins, and its mRNA localization in mouse brain in comparison with other M-rdgBs
    Nobuo Takano
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Neurochem 84:829-39. 2003
    ..Taken together, mM-rdgBbeta1 is suggested to play a role in the phosphoinositide-mediated signaling in the neural development...
  44. ncbi request reprint Brain-specific potential guanine nucleotide exchange factor for Arf, synArfGEF (Po), is localized to postsynaptic density
    Yuji Inaba
    Department of Neuroplasticity, Research Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Neurochem 89:1347-57. 2004
    ..Thus, both the mRNA and the protein were localized in the postsynaptic compartments. These results suggest a postsynaptic role of synArfGEF in the brain...
  45. ncbi request reprint BAALC 1-6-8 protein is targeted to postsynaptic lipid rafts by its N-terminal myristoylation and palmitoylation, and interacts with alpha, but not beta, subunit of Ca/calmodulin-dependent protein kinase II
    Xin Wang
    Department of Neuroplasticity, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Neurochem 92:647-59. 2005
    ..These findings suggest that BAALC 1-6-8 protein play a synaptic role at the postsynaptic lipid raft possibly through interaction with CaMKIIalpha...
  46. ncbi request reprint Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells
    Shigetsune Matsuya
    Division of Histology, Department of Cell Biology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Neurochem 93:674-85. 2005
    ..These findings suggest that EFA6C may be involved in the regulation of the membrane dynamics of the somatodendritic compartments of Purkinje cells through the activation of ARF6...
  47. ncbi request reprint Expression of V-1, a novel catecholamine biosynthesis regulatory protein, is enhanced by hypertension in atrial myocytes of Dahl salt-sensitive rats
    Tohru Yamakuni
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Biochem Biophys Res Commun 298:793-7. 2002
    ..It is also suggested that V-1 expression is increased by hypertension in DS rat atrium...
  48. ncbi request reprint A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins
    Tatsuo Suzuki
    Department of Neuroplasticity, Institute on Ageing and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Eur J Neurosci 21:339-50. 2005
    ..These results suggest that TANC protein may work as a postsynaptic scaffold component by forming a multiprotein complex with various postsynaptic density proteins...
  49. ncbi request reprint Specific localization of epidermal-type fatty acid binding protein in dendritic cells of splenic white pulp
    Noriko Kitanaka
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, 2 1 Seiryo cho Aoba ku, 980 8575 Sendai, Japan
    Histochem Cell Biol 120:465-73. 2003
    ..Taken together, E-FABP is useful as a marker for dendritic cells in the splenic white pulp, and may be involved through combination with fatty acids in antigen presentation and retention as well as in cytokine production...
  50. doi request reprint CLIC4 interacts with histamine H3 receptor and enhances the receptor cell surface expression
    Kay Maeda
    Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    Biochem Biophys Res Commun 369:603-8. 2008
    ..These results indicate that, by binding to the C-terminus of H3R, CLIC4 plays a critical role in regulation of the receptor cell surface expression...
  51. pmc Extracellular signal-regulated kinase (ERK) 5 is necessary and sufficient to specify cortical neuronal fate
    Lidong Liu
    Toxicology Program, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 103:9697-702. 2006
    ....
  52. ncbi request reprint Structural and functional characterization of mouse glutamate decarboxylase 67 gene promoter
    Takashi Kobayashi
    Department of Biochemistry, Institute of Development, Aging and Cancer, Tohoku University, Seiryomachi, Aoba ku, Sendai 980 8575, Japan
    Biochim Biophys Acta 1628:156-68. 2003
    ..These results suggest that the 10.2 kb DNA fragment of the mGAD67 gene contains regulatory elements essential for its targeted expression in GABAergic neurons, islet cells and spermatocytes...
  53. pmc Importin alpha transports CaMKIV to the nucleus without utilizing importin beta
    Ippei Kotera
    Department of Cell Biology and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    EMBO J 24:942-51. 2005
    ..This is the first report to demonstrate definitely that mammalian importin alpha solely carries a cargo protein into the nucleus without utilizing the classical importin beta-dependent transport system...
  54. ncbi request reprint Occurrence of immunoreactivity for adipocyte-type fatty acid binding protein in degenerating granulosa cells in atretic antral follicles of mouse ovary
    Mohammad Reza Nourani
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai, Japan
    J Mol Histol 36:491-7. 2005
    ..The present findings suggest that A-FABP is involved in the apoptosis of ovarian granulosa cells, probably through its interaction with peroxisome proliferator activated receptors...
  55. ncbi request reprint Epidermal-type fatty acid binding protein as a negative regulator of IL-12 production in dendritic cells
    Noriko Kitanaka
    Department of Histology, Graduate School of Medicine, Tohoku University, Japan
    Biochem Biophys Res Commun 345:459-66. 2006
    ..Collectively, it is suggested that E-FABP may be a novel negative regulator of IL-12 production in DCs, and this regulation may be exerted via its involvement in the p38MAPK-mediated transcription of IL-12p35...
  56. ncbi request reprint Enhanced expression of adipocyte-type fatty acid binding protein in murine lymphocytes in response to dexamethasone treatment
    Soha Abdelkawi Abdelwahab
    Division of Histology, Department of Cell Biology, Graduate School of Medical Science, Tohoku University, Tohoku, Sendai, 980 8575, Japan
    Mol Cell Biochem 299:99-107. 2007
    ..The present findings altogether suggest that A-FABP and its ligands, fatty acids, play an important role in the process of apoptosis and the immune modulation induced by DEX...
  57. ncbi request reprint Localization of Ca/calmodulin-dependent protein kinase I in the carotid body chief cells and the ganglionic small intensely fluorescent (SIF) cells of adult rats
    Hisae Hoshi
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai, Japan
    Adv Exp Med Biol 580:87-92; discussion 351-9. 2006