Tadao Saito

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. doi request reprint Antihypertensive peptides derived from bovine casein and whey proteins
    Tadao Saito
    Graduate School of Agricultural Science, Tohoku University, Tsutsumidori Amamiyamachi, Aoba ku, 981 8555, Sendai, Japan
    Adv Exp Med Biol 606:295-317. 2008
  2. ncbi request reprint Application of two-dimensional mapping for an analysis of galactosyllactoses in yogurt
    T Saito
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 62:1445-7. 1998
  3. ncbi request reprint Molecular cloning and sequencing of two phospho-beta-galactosidase I and II genes of Lactobacillus gasseri JCM1031 isolated from human intestine
    T Saito
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 62:2318-27. 1998
  4. ncbi request reprint Isolation and structural analysis of antihypertensive peptides that exist naturally in Gouda cheese
    T Saito
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    J Dairy Sci 83:1434-40. 2000
  5. ncbi request reprint Purification and characterization of two phospho-β-galactosidases, LacG1 and LacG2, from Lactobacillus gasseri ATCC33323(T)
    Hiroyuki Honda
    Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Gen Appl Microbiol 58:11-7. 2012
  6. ncbi request reprint Strong immunostimulatory activity of AT-oligodeoxynucleotide requires a six-base loop with a self-stabilized 5'-C...G-3' stem structure
    Takeshi Shimosato
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai 981 8555, Japan
    Cell Microbiol 8:485-95. 2006
  7. pmc Immunobiotic Lactobacillus jensenii elicits anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the Toll-like receptor signaling pathway
    Tomoyuki Shimazu
    Food Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Infect Immun 80:276-88. 2012
  8. pmc Immunoregulatory effect of bifidobacteria strains in porcine intestinal epithelial cells through modulation of ubiquitin-editing enzyme A20 expression
    Yohsuke Tomosada
    Food and Feed Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    PLoS ONE 8:e59259. 2013
  9. pmc DNA sequencing and homologous expression of a small peptide conferring immunity to gassericin A, a circular bacteriocin produced by Lactobacillus gasseri LA39
    Yasushi Kawai
    Laboratory of Animal Products Chemistry, Biological Resource Science, Graduate School of Agricultural Science, Tohoku University, Aoba ku, Sendai, Japan
    Appl Environ Microbiol 75:1324-30. 2009
  10. doi request reprint A newly established bovine intestinal epithelial cell line is effective for in vitro screening of potential antiviral immunobiotic microorganisms for cattle
    Eriko Chiba
    Food Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Res Vet Sci 93:688-94. 2012

Collaborators

Detail Information

Publications50

  1. doi request reprint Antihypertensive peptides derived from bovine casein and whey proteins
    Tadao Saito
    Graduate School of Agricultural Science, Tohoku University, Tsutsumidori Amamiyamachi, Aoba ku, 981 8555, Sendai, Japan
    Adv Exp Med Biol 606:295-317. 2008
    ..We discuss the isolation, utilization, and application of bioactive peptides, especially ACE inhibitory peptides and antihypertensive peptides including our recent human studies on their use as a functional food material...
  2. ncbi request reprint Application of two-dimensional mapping for an analysis of galactosyllactoses in yogurt
    T Saito
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 62:1445-7. 1998
    ..This two-dimensional mapping method was found useful for a rapid qualitative evaluation of the chemical structure of trisaccharides formed in yogurt...
  3. ncbi request reprint Molecular cloning and sequencing of two phospho-beta-galactosidase I and II genes of Lactobacillus gasseri JCM1031 isolated from human intestine
    T Saito
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 62:2318-27. 1998
    ....
  4. ncbi request reprint Isolation and structural analysis of antihypertensive peptides that exist naturally in Gouda cheese
    T Saito
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    J Dairy Sci 83:1434-40. 2000
    ..Peptides A and F, which were chemically synthesized, showed potent angiotensin I-converting enzyme inhibitory activity with little antihypertensive effects...
  5. ncbi request reprint Purification and characterization of two phospho-β-galactosidases, LacG1 and LacG2, from Lactobacillus gasseri ATCC33323(T)
    Hiroyuki Honda
    Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Gen Appl Microbiol 58:11-7. 2012
    ..Our data suggest two phospho-β-galactosidase, LacG1 and LacG2, are the primary enzymes for lactose utilization in Lb. gasseri ATCC33323(T). We propose a reclassification of Pbg1 and Pbg2 as phospho-β-glucosidase...
  6. ncbi request reprint Strong immunostimulatory activity of AT-oligodeoxynucleotide requires a six-base loop with a self-stabilized 5'-C...G-3' stem structure
    Takeshi Shimosato
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai 981 8555, Japan
    Cell Microbiol 8:485-95. 2006
    ..Finally, we found that novel strong immunostimulatory non-CpG AT-ODNs exist in the genome of probiotic lactic acid bacteria...
  7. pmc Immunobiotic Lactobacillus jensenii elicits anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the Toll-like receptor signaling pathway
    Tomoyuki Shimazu
    Food Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Infect Immun 80:276-88. 2012
    ....
  8. pmc Immunoregulatory effect of bifidobacteria strains in porcine intestinal epithelial cells through modulation of ubiquitin-editing enzyme A20 expression
    Yohsuke Tomosada
    Food and Feed Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    PLoS ONE 8:e59259. 2013
    ..We previously showed that evaluation of anti-inflammatory activities of lactic acid bacteria in porcine intestinal epithelial (PIE) cells is useful for selecting potentially immunobiotic strains...
  9. pmc DNA sequencing and homologous expression of a small peptide conferring immunity to gassericin A, a circular bacteriocin produced by Lactobacillus gasseri LA39
    Yasushi Kawai
    Laboratory of Animal Products Chemistry, Biological Resource Science, Graduate School of Agricultural Science, Tohoku University, Aoba ku, Sendai, Japan
    Appl Environ Microbiol 75:1324-30. 2009
    ..Comparison of GaaI to peptides with similar characteristics found in the circular bacteriocin gene loci is discussed...
  10. doi request reprint A newly established bovine intestinal epithelial cell line is effective for in vitro screening of potential antiviral immunobiotic microorganisms for cattle
    Eriko Chiba
    Food Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Res Vet Sci 93:688-94. 2012
    ....
  11. ncbi request reprint Toll-like receptor 2 is expressed on the intestinal M cells in swine
    Masanori Tohno
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Aobaku, Sendai 981 8555, Japan
    Biochem Biophys Res Commun 330:547-54. 2005
    ..Furthermore, the potential function of TLR2 as a pattern recognition receptor and its cellular distribution suggest that TLR2 plays an important role in ligand-specific transcytosis and transport in M cells...
  12. ncbi request reprint An adhesin-like protein, Lam29, from Lactobacillus mucosae ME-340 binds to histone H3 and blood group antigens in human colonic mucus
    Masamichi Watanabe
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi 981 8555, Japan
    Biosci Biotechnol Biochem 76:1655-60. 2012
    ..This is the first report to indicate that lactobacilli expressing Lam29 adhere to histone H3 on gastrointestinal mucosa...
  13. pmc Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells
    Shoichi Hosoya
    Food Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Vet Res 42:111. 2011
    ..casei MEP221106 modulates the interaction between IEC and immune cells during the generation of a TLR3-mediated immune response...
  14. ncbi request reprint Lactic acid bacteria (LAB) bind to human B- or H-antigens expressed on intestinal mucosa
    Hideaki Uchida
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University
    Biosci Biotechnol Biochem 70:3073-6. 2006
    ..We found two strains, L. gasseri OLL2755 and L. gasseri OLL2877 that firmly adhere to human B-antigen, and we found L. gasseri OLL2827 bound to the H-antigen...
  15. pmc Advanced application of bovine intestinal epithelial cell line for evaluating regulatory effect of lactobacilli against heat-killed enterotoxigenic Escherichia coli-mediated inflammation
    Naoya Takanashi
    Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Aoba ku, 981 8555, Japan
    BMC Microbiol 13:54. 2013
    ....
  16. ncbi request reprint Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-2 (NOD2)
    Masanori Tohno
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Mol Immunol 45:194-203. 2008
    ..Our results implicate NOD2 as an important immunoregulator in the swine intestinal immunity...
  17. ncbi request reprint Lactobacilli binding human A-antigen expressed in intestinal mucosa
    Hideaki Uchida
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori Amamiyamachi 1 1, Aoba ku, Sendai 981 8555, Miyagi, Japan
    Res Microbiol 157:659-65. 2006
    ..brevis ATCC8287T. The probiotic LAB binds to human blood type-A antigen expressed in the intestinal mucosa which may aid in colonization of the gut...
  18. ncbi request reprint Augmentation of T(H)-1 type response by immunoactive AT oligonucleotide from lactic acid bacteria via Toll-like receptor 9 signaling
    Takeshi Shimosato
    Graduate School of Agricultural Science, Tohoku University, Tsutsumidori Amamiyamachi 1 1, Aoba ku, Sendai shi 981 8555, Japan
    Biochem Biophys Res Commun 326:782-7. 2005
    ..Moreover, the swine TLR9 transfectant demonstrated its usefulness for evaluation of immunostimulation by bacterial DNA through the detection of T(H)-1, T(H)-2 type cytokine induction via TLR9 signaling...
  19. doi request reprint Utilization of the porcine system to study lymphotoxin-beta regulation in intestinal lymphoid tissue
    Tomoyuki Shimazu
    Food Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai, 981 8555, Japan
    Biochem Genet 47:126-36. 2009
    ..LT-beta may therefore be useful for studying the development of the intestinal immune system at parturition in both swine and humans...
  20. ncbi request reprint Molecular cloning, tissue expression, and subcellular localization of porcine peptidoglycan recognition proteins 3 and 4
    Wataru Ueda
    Food Immunology Group, Graduate School of Agricultural Science, Tohoku University, Aobaku, Sendai 981 8555, Japan
    Vet Immunol Immunopathol 143:148-54. 2011
    ..These results should help contribute to the understanding of PGLYRP3- and 4-mediated immune responses via their recognition of intestinal microorganisms in newborn and adult swine...
  21. ncbi request reprint Toll-like receptor 2 and 9 are expressed and functional in gut-associated lymphoid tissues of presuckling newborn swine
    Masanori Tohno
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Aobaku, Sendai, 981 8555, Japan
    Vet Res 37:791-812. 2006
    ..These results indicate that TLR2 and TLR9 allow MLN and ileal Pps to respond to a variety of bacterial components immediately after birth, thereby providing newborns with a host defense system...
  22. doi request reprint Food preservative potential of gassericin A-containing concentrate prepared from a cheese whey culture supernatant from Lactobacillus gasseri LA39
    Kiyoshi Nakamura
    Graduate School of Agricultural Science, Tohoku University, Aoba ku, Sendai, Japan
    Anim Sci J 84:144-9. 2013
    ..5% (w/w) glycine. This is the first highly practical application of GA to foods as a biopreservative, and the concentration method and the bacteriocin concentrate would contribute to biopreservation of several foods...
  23. ncbi request reprint Cell surface glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of Lactobacillus plantarum LA 318 recognizes human A and B blood group antigens
    Hideki Kinoshita
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori Amamiyamachi 1 1, Aoba ku, Sendai, Miyagi 981 8555, Japan
    Res Microbiol 159:685-91. 2008
    ..The binding of GAPDH to HCM significantly decreased after incubation with NAD+. This suggests that the NAD binding domain on GAPDH may be related to binding to HCM...
  24. ncbi request reprint Molecular cloning and functional characterization of porcine MyD88 essential for TLR signaling
    Masanori Tohno
    Food Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Aobaku, Sendai 981 8555, Japan
    Cell Mol Immunol 4:369-76. 2007
    ..These results suggest that an MyD88-dependent signaling pathway is present in newborn as well as in adult swine and that it is involved in the innate immune system of these animals...
  25. ncbi request reprint Molecular cloning of porcine RP105/MD-1 involved in recognition of extracellular phosphopolysaccharides from Lactococcus lactis ssp. cremoris
    Masanori Tohno
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Aobaku, Sendai 981 8555, Japan
    Mol Immunol 44:2566-77. 2007
    ..These effects were mediated by phosphatidylinositol 3-kinase and Bruton's tyrosine kinase. Thus, we identified extracellular polysaccharide from Lc.cremoris as an active substance that can induce immune activation via RP105 and MD-1...
  26. ncbi request reprint Immunostimulatory oligonucleotide, CpG-like motif exists in Lactobacillus delbrueckii ssp. bulgaricus NIAI B6
    Haruki Kitazawa
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aobaku, 981 8555, Sendai, Japan
    Int J Food Microbiol 85:11-21. 2003
    ..This study demonstrated that L. bulgaricus NIAI B6 was a good candidate of a starter culture for the production of new functional foods, "Bio-Defense Foods"...
  27. pmc Immunobiotic Lactobacillus jensenii modulates the Toll-like receptor 4-induced inflammatory response via negative regulation in porcine antigen-presenting cells
    Julio Villena
    Food Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Clin Vaccine Immunol 19:1038-53. 2012
    ....
  28. doi request reprint Toll-like receptor-2-activating bifidobacteria strains differentially regulate inflammatory cytokines in the porcine intestinal epithelial cell culture system: finding new anti-inflammatory immunobiotics
    Hitomi Fujie
    Food Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    FEMS Immunol Med Microbiol 63:129-39. 2011
    ..Although our findings should be proven in appropriate experiments in vivo, the results of the present work provide a scientific rationale for the use of B. breve MCC-117 to prevent ETEC-induced intestinal inflammation...
  29. ncbi request reprint Strong immunostimulation in murine immune cells by Lactobacillus rhamnosus GG DNA containing novel oligodeoxynucleotide pattern
    Iliyan D Iliev
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai 981 8555, Japan
    Cell Microbiol 7:403-14. 2005
    ..In this study we demonstrate for a first time that, DNA from LGG is a factor of immunobiotic activity. Furthermore, ODN ID35 is the first ODN, with such a strong immunostimulatory activity to be found in immunobiotic bacterial DNA...
  30. ncbi request reprint Toll-like receptor 9 is expressed on follicle-associated epithelia containing M cells in swine Peyer's patches
    Takeshi Shimosato
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Japan
    Immunol Lett 98:83-9. 2005
    ..These results suggest that Pps and MLNs provide the host defense with the ability to respond to a variety of bioactive oligonucleotides (ODNs) from bacteria at a conductive site of initial immune responses...
  31. ncbi request reprint A swine toll-like receptor 2-expressing transfectant as a potential primary screening system for immunobiotic microorganisms
    Masanori Tohno
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aobaku, Sendai 981 8555, Japan
    FEMS Immunol Med Microbiol 44:283-8. 2005
    ..These findings suggest that the swine TLR2-expressing transfectant can be very useful for the primary screening of immunobiotic microorganisms...
  32. doi request reprint Biosorption of heavy metals by lactic acid bacteria and identification of mercury binding protein
    Hideki Kinoshita
    School of Food, Agricultural and Environmental Sciences, Miyagi University, 2 2 1, Hatatate, Taihaku ku, Sendai, Miyagi 982 0215, Japan
    Res Microbiol 164:701-9. 2013
    ..Having a CXXC motif, a ∼14 kDa protein may be one of the Hg (II) binding proteins. LAB biosorption may aid the detoxification of people exposed to heavy metals...
  33. ncbi request reprint Toll-like receptor 4 and cytokine expression involved in functional immune response in an originally established porcine intestinal epitheliocyte cell line
    Masayuki Moue
    Food Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Aobaku, Sendai 981 8555, Japan
    Biochim Biophys Acta 1780:134-44. 2008
    ....
  34. ncbi request reprint Identification of five phospho-beta-glycosidases from Lactobacillus gasseri ATCC33323T cultured in lactose medium
    Seiji Nagaoka
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi, Japan
    Biosci Biotechnol Biochem 72:1954-7. 2008
    ..To our knowledge, this is the first report indicating that five glycosidases are induced from a single bacterial strain using a single carbon source, lactose...
  35. ncbi request reprint Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-1 (NOD1) recognizing minimum agonists, meso-diaminopimelic acid and meso-lanthionine
    Masanori Tohno
    Food Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Aobaku, Sendai 981 8555, Japan
    Mol Immunol 45:1807-17. 2008
    ..Our results should help clarify how the intestinal immune system is modulated by low-molecular weight peptidoglycan fragments through NOD1...
  36. ncbi request reprint Cloning and characterization of Swine interleukin-17, preferentially expressed in the intestines
    Shinichiro Katoh
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Aobaku, Sendai 981 8555, Japan
    J Interferon Cytokine Res 24:553-9. 2004
    ..The gene sequence and biologically active recombinat protein for PoIL-17 will be useful for elucidation of the role of IL-17 in the regulation of intestinal immune responses...
  37. doi request reprint Advanced application of porcine intestinal epithelial cells for the selection of immunobiotics modulating toll-like receptor 3-mediated inflammation
    Shoichi Hosoya
    Food Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Microbiol Immunol Infect 46:474-81. 2013
    ....
  38. pmc Enzymatic digestion of the milk protein beta-casein releases potent chemotactic peptide(s) for monocytes and macrophages
    Haruki Kitazawa
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, USA
    Int Immunopharmacol 7:1150-9. 2007
    ..Our study suggests that biologically active peptides released by actinase-digested milk beta-casein may promote innate host immune responses by inducing macrophage migration and activation...
  39. ncbi request reprint Swine Toll-like receptor 9(1) recognizes CpG motifs of human cell stimulant
    Takeshi Shimosato
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aobaku, 981 8555, Sendai, Japan
    Biochim Biophys Acta 1627:56-61. 2003
    ..The strong expression of sTLR9 in Pps and MLNs and its recognizing CpG DNA for human cell stimulant are shown first in this study, which may help in understanding the intestinal immune system mediated by a bacterial DNA through TLR9...
  40. pmc Structural and functional differences in two cyclic bacteriocins with the same sequences produced by lactobacilli
    Yasushi Kawai
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori Amamiyamachi, Aoba ku, Sendai 981 8555, Japan
    Appl Environ Microbiol 70:2906-11. 2004
    ..This is the first report that characteristics of native bacteriocins produced by wild lactobacillus strains having the same structural genes are influenced by a difference in D-amino acid contents in the molecules...
  41. ncbi request reprint A new assay using surface plasmon resonance (SPR) to determine binding of the Lactobacillus acidophilus group to human colonic mucin
    Hideaki Uchida
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 68:1004-10. 2004
    ..The results indicated that some strains of the L. acidophilus group could recognize and bind the sugar chain of A-antigen structure on HCM...
  42. ncbi request reprint The circular bacteriocins gassericin A and circularin A
    Yasushi Kawai
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Curr Protein Pept Sci 5:393-8. 2004
    ..Gassericin A and circularin A have limited mutual similarity in their primary sequences. Unlike most bacteriocins, including gassericin A, circularin A has a three-amino-acid-leader sequence...
  43. ncbi request reprint A novel immunostimulating aspect of Lactobacillus gasseri: induction of "Gasserokine" as chemoattractants for macrophages
    Haruki Kitazawa
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Int J Food Microbiol 77:29-38. 2002
    ..Therefore, the activity is expected to be used for one of the functional parameters in the immunomodulating properties of probiotic lactic acid bacteria...
  44. ncbi request reprint Trans fatty acids promote the growth of some Lactobacillus strains
    Yasushi Endo
    Graduate School of Agricultural Science, Tohoku University, Aoba, Sendai, Japan
    J Gen Appl Microbiol 52:29-35. 2006
    ..These results showed that octadecenoic acid and trans FAs had strong promotion activities for the Lactobacillus growth due to their incorporation into membrane lipids...
  45. ncbi request reprint Dextran from Leuconostoc mesenteroides augments immunostimulatory effects by the introduction of phosphate groups
    Toshihiro Sato
    NOF Corporation, Yebisu Garden Place Tower, 20 3 Ebisu 4 chome, Shibuya ku, Tokyo 150 6019, Japan
    J Food Prot 67:1719-24. 2004
    ..The levels of mRNA expression of gamma interferon and interleukin-10 on murine splenocytes were also increased by the stimulation. These results demonstrate that dextran exerts immunostimulation by the introduction of phosphate groups...
  46. ncbi request reprint Composition and oligosaccharides of a milk sample of the giant panda, Ailuropoda melanoleuca
    Tadashi Nakamura
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido, 080 8555, Japan
    Comp Biochem Physiol B Biochem Mol Biol 135:439-48. 2003
    ....
  47. ncbi request reprint An immunostimulatory DNA sequence from a probiotic strain of Bifidobacterium longum inhibits IgE production in vitro
    Noritoshi Takahashi
    Food Research and Development Laboratory, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa, Japan
    FEMS Immunol Med Microbiol 46:461-9. 2006
    ..The results suggest the potential of ODNs BL07 and BL07S in preventing IgE-related immune responses and the possible involvement of ODN BL07 in the antiallergic efficacy of B. longum BB536...
  48. ncbi request reprint Chemical characterization of sialyl oligosaccharides in milk of the Japanese black bear, Ursus thibetanus japonicus
    Tadasu Urashima
    Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido, 080 8555, Japan
    Comp Biochem Physiol B Biochem Mol Biol 139:587-95. 2004
    ..Neu5Ac(alpha2-6)Gal(beta1-4)GlcNAc(beta1-3)[Gal(alpha1-3)[Fuc(alpha1-2)]Gal(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-6)]Gal(beta1-4)Glc. Neu5Ac(alpha2-6)Gal(beta1-4)GlcNAc(beta1-3)[Neu5Ac(alpha2-6)Gal(beta1-4)GlcNAc(beta1-6)Gal(beta1-4)Glc...
  49. ncbi request reprint Determination of each neutral oligosaccharide in the milk of Japanese women during the course of lactation
    Wataru Sumiyoshi
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Hokkaido, 080 8555, Japan
    Br J Nutr 89:61-9. 2003
    ..These differences may be caused by different assay methodology, although racial differences cannot be ruled out...
  50. ncbi request reprint Oral administration of an immunostimulatory DNA sequence from Bifidobacterium longum improves Th1/Th2 balance in a murine model
    Noritoshi Takahashi
    Food Research and Development Laboratory, Morinaga Milk Industry Co, Ltd, Zama, Japan
    Biosci Biotechnol Biochem 70:2013-7. 2006
    ..ODN BL07S increased Th1 cytokine and decreased Th2 cytokine production in splenocytes. These results suggest that immunostimulatory ODNs are potentially associated with the antiallergic effects of probiotics...