Noriko Osumi

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. pmc Patterns of neurogenesis and amplitude of Reelin expression are essential for making a mammalian-type cortex
    Tadashi Nomura
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research CTTAR, Tohoku University School of Medicine, Sendai, Japan
    PLoS ONE 3:e1454. 2008
  2. pmc Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses
    Motoko Maekawa
    Department of Developmental Neurobiology, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 4:e5085. 2009
  3. ncbi request reprint Woman scientists in Japan: their situation and goals
    Noriko Osumi
    EPMEWSE, Science Council of Japan, and Division of Developmental Neuroscience, CTAAR, Tohoku University School of Medicine, Sendai, Japan
    IUBMB Life 58:273-8. 2006
  4. ncbi request reprint [Fatty acid signal, neurogenesis, and psychiatric disorders]
    Noriko Osumi
    Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 30:141-8. 2010
  5. ncbi request reprint Concise review: Pax6 transcription factor contributes to both embryonic and adult neurogenesis as a multifunctional regulator
    Noriko Osumi
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Stem Cells 26:1663-72. 2008
  6. ncbi request reprint Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells
    Hiroshi Tamai
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Genes Cells 12:983-96. 2007
  7. ncbi request reprint Role of Fabp7, a downstream gene of Pax6, in the maintenance of neuroepithelial cells during early embryonic development of the rat cortex
    Yoko Arai
    Division of Developmental Neuroscience, Department of Functional Genomics, Center for Translational and Advanced Animal Research, Tohoku University School of Medicine, Sendai 980 8575, Japan
    J Neurosci 25:9752-61. 2005
  8. doi request reprint Reduced proliferation and excess astrogenesis of Pax6 heterozygous neural stem/progenitor cells
    Nobuyuki Sakayori
    Division of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine ART, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Neurosci Res 74:116-21. 2012
  9. ncbi request reprint The neurogenesis-controlling factor, Pax6, inhibits proliferation and promotes maturation in murine astrocytes
    Katsuyasu Sakurai
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    J Neurosci 28:4604-12. 2008
  10. ncbi request reprint Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin A5
    Tadashi Nomura
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research CTTAR, Seiryo machi, 980 8575, Japan
    Development 133:1335-45. 2006

Detail Information

Publications72

  1. pmc Patterns of neurogenesis and amplitude of Reelin expression are essential for making a mammalian-type cortex
    Tadashi Nomura
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research CTTAR, Tohoku University School of Medicine, Sendai, Japan
    PLoS ONE 3:e1454. 2008
    ..These lines of evidence shed light on the developmental programs underlying the evolution of the mammalian specific laminated cortex...
  2. pmc Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses
    Motoko Maekawa
    Department of Developmental Neurobiology, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 4:e5085. 2009
    ..These results suggest the potential benefit of ARA in ameliorating PPI deficits relevant to psychiatric disorders and suggest that the effect may be correlated with augmented postnatal neurogenesis...
  3. ncbi request reprint Woman scientists in Japan: their situation and goals
    Noriko Osumi
    EPMEWSE, Science Council of Japan, and Division of Developmental Neuroscience, CTAAR, Tohoku University School of Medicine, Sendai, Japan
    IUBMB Life 58:273-8. 2006
  4. ncbi request reprint [Fatty acid signal, neurogenesis, and psychiatric disorders]
    Noriko Osumi
    Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 30:141-8. 2010
    ..Our results suggest a potential benefit of PUFA in ameliorating the PPI relevant to psychiatric disorders through an augmented postnatal neurogenesis...
  5. ncbi request reprint Concise review: Pax6 transcription factor contributes to both embryonic and adult neurogenesis as a multifunctional regulator
    Noriko Osumi
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Stem Cells 26:1663-72. 2008
    ..Pax6 is a multifunctional player regulating proliferation and differentiation through the control of expression of different downstream molecules in a highly context-dependent manner...
  6. ncbi request reprint Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells
    Hiroshi Tamai
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Genes Cells 12:983-96. 2007
    ..Our results suggest the possibility that Pax6 regulates the INM by stabilizing the centrosome at the apical side...
  7. ncbi request reprint Role of Fabp7, a downstream gene of Pax6, in the maintenance of neuroepithelial cells during early embryonic development of the rat cortex
    Yoko Arai
    Division of Developmental Neuroscience, Department of Functional Genomics, Center for Translational and Advanced Animal Research, Tohoku University School of Medicine, Sendai 980 8575, Japan
    J Neurosci 25:9752-61. 2005
    ..We conclude that Fabp7 is a downstream gene of Pax6 transcription factor in the developing rat cortex and essential for maintenance of neuroepithelial cells during early cortical development...
  8. doi request reprint Reduced proliferation and excess astrogenesis of Pax6 heterozygous neural stem/progenitor cells
    Nobuyuki Sakayori
    Division of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine ART, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Neurosci Res 74:116-21. 2012
    ..We also observed an excess astrogenesis in serially passaged NSPCs from rSey(2)/+ rats. These results show that Pax6 is essential for maintaining NSPCs and determining their differentiation fates...
  9. ncbi request reprint The neurogenesis-controlling factor, Pax6, inhibits proliferation and promotes maturation in murine astrocytes
    Katsuyasu Sakurai
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    J Neurosci 28:4604-12. 2008
    ..These phenotypes of Pax6-deficient astrocytes putatively occur via higher Akt activity. Thus, the breakdown of Pax6 function induces the retention of neural stem-like characteristics and inhibits astrocyte maturation...
  10. ncbi request reprint Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin A5
    Tadashi Nomura
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research CTTAR, Seiryo machi, 980 8575, Japan
    Development 133:1335-45. 2006
    ..Our results suggest that Pax6-regulated ephrin A5 acts as a repulsive molecule for olfactory cortex neurons in the developing telencephalon...
  11. doi request reprint FilaminB is required for the directed localization of cell-cell adhesion molecules in embryonic epithelial development
    Yoshio Wakamatsu
    Tohoku University, Graduate School of Medicine, Center for Translational and Advanced Animal Research on Human Diseases, Division of Developmental Neuroscience, Sendai, Miyagi, Japan
    Dev Dyn 240:149-61. 2011
    ..We further suggest that the reduction of structural integrity of the neural epithelium caused by the loss of Filamin function may also result in formation of the neuronal nodules found in PH patients...
  12. ncbi request reprint Pax6 is required for production and maintenance of progenitor cells in postnatal hippocampal neurogenesis
    Motoko Maekawa
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research CTAAR, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Genes Cells 10:1001-14. 2005
    ..Taken all together, an appropriate dosage of Pax6 is essential for production and maintenance of the GFAP+ early progenitor cells in the postnatal hippocampal neurogenesis...
  13. pmc Downstream genes of Pax6 revealed by comprehensive transcriptome profiling in the developing rat hindbrain
    Keiko Numayama-Tsuruta
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    BMC Dev Biol 10:6. 2010
    ..To screen for genes downstream of Pax6, we performed comprehensive transcriptome profiling analyses in the early hindbrain of Pax6 homozygous mutant and wild-type rats using microarrays...
  14. doi request reprint Subtype-specific reduction of olfactory bulb interneurons in Pax6 heterozygous mutant mice
    Hasumi Haba
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Neurosci Res 65:116-21. 2009
    ..The number of these interneuron subtypes was dramatically decreased in Pax6 heterozygous mutant mice. These results indicate that Pax6 is required for differentiation and/or maintenance of EPL interneurons in the adult mouse OB...
  15. doi request reprint Dmrta1 regulates proneural gene expression downstream of Pax6 in the mammalian telencephalon
    Takako Kikkawa
    Division of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8575, Japan
    Genes Cells 18:636-49. 2013
    ..Our novel findings suggest that dual regulation of proneural genes mediated by Pax6 and Dmrt family members is crucial for cortical neurogenesis. ..
  16. doi request reprint The effects of Fabp7 and Fabp5 on postnatal hippocampal neurogenesis in the mouse
    Miho Matsumata
    Division of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine ART, Tohoku University School of Medicine, Sendai, Japan
    Stem Cells 30:1532-43. 2012
    ..These data suggest that Fabp7 and Fabp5 have differential roles for proliferation and survival of the NSCs/NPCs during postnatal DG neurogenesis...
  17. doi request reprint Pax6 regulates boundary-cell specification in the rat hindbrain
    Masanori Takahashi
    Division of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine ART, Graduate School of Medicine, Tohoku University, Seiryo machi, Aoba ku, Sendai, Miyagi, Japan
    Mech Dev 128:289-302. 2011
    ..Taken together, Pax6 seems to be required for coordinating boundary-cell specification and reducing neurogenesis within the hindbrain boundary region...
  18. ncbi request reprint Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development
    Daisuke Sakai
    Center for Translational and Advanced Animal Research on Human Diseases, Division of Developmental Neuroscience, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980 8575, Japan
    Development 133:1323-33. 2006
    ..Consistently, Sox9 directly activates the Snail2 promoter in synergy with, and through a direct binding to, Snail2. Finally, functions of these transcription factors in neural crest cells are enhanced by PKA signaling...
  19. pmc Evaluation of Pax6 mutant rat as a model for autism
    Toshiko Umeda
    Division of Developmental Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 5:e15500. 2010
    ..Taken together with our prior human genetic data and results in other literatures, rSey(2)/+ rats likely have some phenotypic components of autism...
  20. doi request reprint Penetration and differentiation of cephalic neural crest-derived cells in the developing mouse telencephalon
    Emiko Yamanishi
    Division of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine ART, Graduate School of Medicine, Tohoku University, 2 1, Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8575
    Dev Growth Differ 54:785-800. 2012
    ....
  21. ncbi request reprint Abnormal migration and distribution of neural crest cells in Pax6 heterozygous mutant eye, a model for human eye diseases
    Sachiko Kanakubo
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Sendai, 980 8575, Japan
    Genes Cells 11:919-33. 2006
    ....
  22. ncbi request reprint Sox genes regulate type 2 collagen expression in avian neural crest cells
    Takashi Suzuki
    Center for Translational and Advanced Animal Research on Human Diseases, Division of Developmental Neuroscience, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980 8575, Japan
    Dev Growth Differ 48:477-86. 2006
    ..Our study suggests that the regulatory mechanisms are similar in cartilage and neural crest differentiation...
  23. pmc Dynamic expression of Six family genes in the dental mesenchyme and the epithelial ameloblast stem/progenitor cells during murine tooth development
    Koji Nonomura
    Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, Sendai, Japan
    J Anat 216:80-91. 2010
    ....
  24. ncbi request reprint [Role of Pax6 in the developing central nervous system]
    Yoko Matsumoto
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Brain Nerve 60:365-74. 2008
    ..In this review, we introduce multiple functions of Pax6 in the developing central nervous system and in postnatal neurogenesis...
  25. ncbi request reprint Identification of a novel type II classical cadherin: rat cadherin19 is expressed in the cranial ganglia and Schwann cell precursors during development
    Masanori Takahashi
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research on Human Diseases, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai, Japan
    Dev Dyn 232:200-8. 2005
    ..These results suggest that cad19 is an evolutionarily conserved cadherin and may be involved in the early development of Schwann cells in the peripheral nervous system...
  26. ncbi request reprint The germinal matrices in the developing dentate gyrus are composed of neuronal progenitors at distinct differentiation stages
    Taku Sugiyama
    Division of Developmental Neuroscience, Tohoku University Graduate School of Medicine, Miyagi, Japan
    Dev Dyn 242:1442-53. 2013
    ..The proliferative area in the developing DG was divided into the three germinal matrices (GMs). However, the stage of the progenitor cells in each GM along the GC differentiation process is not clear...
  27. ncbi request reprint Manipulating gene expressions by electroporation in the developing brain of mammalian embryos
    Masanori Takahashi
    Department of Developmental Neurobiology, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Differentiation 70:155-62. 2002
    ..The combination of these techniques in addition to analysis of genetic mutants will clarify functions of individual genes, gene interactions, and the molecular mechanisms underlying the brain development...
  28. ncbi request reprint Multiple roles of Sox2, an HMG-box transcription factor in avian neural crest development
    Yoshio Wakamatsu
    Department of Developmental Neurobiology, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan
    Dev Dyn 229:74-86. 2004
    ..Developmental Dynamics 229:74-86, 2004...
  29. ncbi request reprint [Molecular mechanism and mental function of postnatal neurogenesis]
    Kaichi Yoshizaki
    Division of Developmental Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Brain Nerve 62:1315-22. 2010
    ..In this review, we describe the molecular mechanisms and functional significance of postnatal neurogenesis...
  30. ncbi request reprint Impaired hippocampal neurogenesis and vascular formation in ephrin-A5-deficient mice
    Yoshinobu Hara
    Division of Developmental Neuroscience, Core Center for Neuroscience, Art, Tohoku University School of Medicine, Sendai, Japan
    Stem Cells 28:974-83. 2010
    ..EphA/ephrin-A signaling thus plays crucial roles in the establishment and/or maintenance of the brain vascular system, as an essential constituent of the adult neurogenic niche...
  31. doi request reprint Stabilization of ATF4 protein is required for the regulation of epithelial-mesenchymal transition of the avian neural crest
    Takashi Suzuki
    Center for Translational and Advanced Animal Research on Human Diseases, Division of Developmental Neuroscience, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980 8575, Japan
    Dev Biol 344:658-68. 2010
    ..Thus, our results emphasize the importance of the regulation of protein stability in the neural crest EMT...
  32. ncbi request reprint Expression of a novel secreted factor, Seraf indicates an early segregation of Schwann cell precursors from neural crest during avian development
    Yoshio Wakamatsu
    Center for Translational and Advanced Animal Research on Human Diseases, Division of Developmental Neuroscience, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980 8575, Japan
    Dev Biol 268:162-73. 2004
    ..Our results suggest an autocrine function of Seraf and provide a significant step to understand the developmental processes of Schwann cell lineage...
  33. doi request reprint A sensitive period for GABAergic interneurons in the dentate gyrus in modulating sensorimotor gating
    Nannan Guo
    Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8575, Japan
    J Neurosci 33:6691-704. 2013
    ..It is plausible that changes in neurogenesis during this window may affect the survival of GABAergic interneurons, although this link needs to be causally addressed...
  34. pmc Differential proliferation rhythm of neural progenitor and oligodendrocyte precursor cells in the young adult hippocampus
    Yoko Matsumoto
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Graduate School of Medicine, Tohoku University, Sendai, Japan
    PLoS ONE 6:e27628. 2011
    ..These data suggest an intriguing control of OPC proliferation in the hippocampus...
  35. pmc Expression study of cadherin7 and cadherin20 in the embryonic and adult rat central nervous system
    Masanori Takahashi
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    BMC Dev Biol 8:87. 2008
    ..In this study, we identified rat cad7 and cad20 and analyzed their expression patterns in embryonic and adult rat brains...
  36. ncbi request reprint Misrouting of mitral cell progenitors in the Pax6/small eye rat telencephalon
    Tadashi Nomura
    Division of Developmental Neuroscience, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Development 131:787-96. 2004
    ..These results provide evidence that Pax6 is required to position the mitral cell progenitors at the rostral end of the telencephalon...
  37. ncbi request reprint Regulation of Slug transcription in embryonic ectoderm by beta-catenin-Lef/Tcf and BMP-Smad signaling
    Daisuke Sakai
    Center for Translational and Advanced Animal Research on Human Diseases, Division of Developmental Neuroscience, Tohoku University, Sendai, Miyagi 980 8575, Japan
    Dev Growth Differ 47:471-82. 2005
    ..These observations indicated that in the anterior ectoderm BMP signal has a predominant role for Slug expression...
  38. ncbi request reprint Transitin, a nestin-like intermediate filament protein, mediates cortical localization and the lateral transport of Numb in mitotic avian neuroepithelial cells
    Yoshio Wakamatsu
    Department of Developmental Neurobiology, Tohoku University, Graduate School of Medicine, Seiryo machi 2 1, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Development 134:2425-33. 2007
    ..These results indicate that transitin has important roles in determining the intracellular localization of Numb, which regulates neurogenesis in the developing nervous system of avian embryos...
  39. ncbi request reprint Pax6 regulates specification of ventral neurone subtypes in the hindbrain by establishing progenitor domains
    Masanori Takahashi
    Department of Developmental Neurobiology, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Development 129:1327-38. 2002
    ..Taken together, we conclude that Pax6 regulates specification of the ventral neurone subtypes by establishing the correct progenitor domains...
  40. doi request reprint Neural crest-derived horizontal basal cells as tissue stem cells in the adult olfactory epithelium
    Jun Suzuki
    Division of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine ART, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Neurosci Res 75:112-20. 2013
    ..These results suggest that NCDCs contribute greatly to the adult HBC population and that they are important for the maintenance of the OE...
  41. ncbi request reprint Role of a transcription factor Pax6 in the developing vertebrate olfactory system
    Tadashi Nomura
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi Aoba ku, Sendai, 980 8575, Japan
    Dev Growth Differ 49:683-90. 2007
    ....
  42. pmc Molecular and cellular features of murine craniofacial and trunk neural crest cells as stem cell-like cells
    Kunie Hagiwara
    Department of Ophthalmology, Tohoku University Graduate School of Medicine, Seiryo cho, Aoba ku, Sendai, Japan Department of Ophthalmology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Japan
    PLoS ONE 9:e84072. 2014
    ..Furthermore, these newly-identified genes up-regulated in cNCC would provide helpful information on NC-originating tumors, developmental disorders in NCC derivatives, and potential applications of NCCs in regenerative medicine. ..
  43. pmc Cyclin D2 in the basal process of neural progenitors is linked to non-equivalent cell fates
    Yuji Tsunekawa
    Division of Developmental Neuroscience, United Core Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    EMBO J 31:1879-92. 2012
    ..We demonstrate that Cyclin D2 is also expressed in the developing human cortex within similar domains, thus indicating that its role as a fate determinant is ancient and conserved...
  44. doi request reprint Transferring genes into cultured mammalian embryos by electroporation
    Masanori Takahashi
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University Graduate School of Medicine, Sendai, Japan
    Dev Growth Differ 50:485-97. 2008
    ..In this review, we introduce combinatorial methods of WEC and EP, and summarize various applications in developmental neurobiology...
  45. ncbi request reprint Preservation of cochlear function in Fabp3 (H-Fabp) knockout mice
    Jun Suzuki
    Department of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine ART, Tohoku University Graduate School of Medicine, Sendai, Japan Department of Otorhinolaryngology Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Neurosci Res 81:64-8. 2014
    ..Compared with the wild-type mice, the adult mutant mice demonstrated no differences in their vulnerability to acoustic overexposure. These results suggest that Fabp3 deficiency alone does not adversely affect hearing function. ..
  46. ncbi request reprint Deltex/Dtx mediates NOTCH signaling in regulation of Bmp4 expression in cranial neural crest formation during avian development
    Yukinori Endo
    Center for Translational and Advanced Animal Research on Human Diseases, Division of Developmental Neuroscience, Graduate School of Medicine, Tohoku University, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Dev Growth Differ 45:241-8. 2003
    ..In parallel, Hairy2 expression in the epidermis was regulated by a Su(H)-dependent pathway. These results indicate that NOTCH signaling has dual functions mediated by either Su(H) or Deltex in the avian embryonic ectoderm...
  47. doi request reprint Distinctive effects of arachidonic acid and docosahexaenoic acid on neural stem /progenitor cells
    Nobuyuki Sakayori
    Division of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine ART, Tohoku University School of Medicine, Seiryo machi, Aoba ku, Sendai, Japan
    Genes Cells 16:778-90. 2011
    ....
  48. doi request reprint Neural crest-derived multipotent cells in the adult mouse iris stroma
    Miki Kikuchi
    Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan
    Genes Cells 16:273-81. 2011
    ..These data indicate that neural crest-derived multipotent cells can be isolated from the murine IS and expanded in sphere culture...
  49. doi request reprint Life science must go on: standing up after the 311 disaster
    Noriko Osumi
    Division of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine ART, Tohoku University School of Medicine, Seiryo machi, Aoba ku, Sendai, Japan
    Genes Cells 16:741-4. 2011
    ..As one of the persons present in the area at the time of the earthquake, I would like to report how I experienced the 311 disaster in our laboratory in Tohoku University and how this experience has changed my outlook on many things...
  50. ncbi request reprint Bimodal functions of Notch-mediated signaling are involved in neural crest formation during avian ectoderm development
    Yukinori Endo
    Department of Developmental Neurobiology, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980 8575, Japan
    Development 129:863-73. 2002
    ..Notch activation in the epidermis additionally inhibits neural crest formation in this tissue, so that neural crest generation by BMP4 is restricted to the junction...
  51. ncbi request reprint Comparative gene expression analyses reveal heterochrony for Sox9 expression in the cranial neural crest during marsupial development
    Yoshio Wakamatsu
    Department of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine ART, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980 8575, Japan
    Evol Dev 16:197-206. 2014
    ..This study provides the first clue for understanding the molecular basis for the heterochronic development of the CNC cells and jaw elements in marsupials. ..
  52. ncbi request reprint [The function of fatty acid signals in neurogenesis]
    Nobuyuki Sakayori
    Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 31:111-6. 2011
    ....
  53. doi request reprint Competent stripes for diverse positions of limbs/fins in gnathostome embryos
    Sayuri Yonei-Tamura
    Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba ku, Sendai 980 8578, Japan
    Evol Dev 10:737-45. 2008
    ..This schema would have permitted subsequent divergence into various levels of limbs/fins in each animal group...
  54. ncbi request reprint Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb
    Minoree Kohwi
    Department of Neurological Surgery, Program in Developmental and Stem Cell Biology, University of California, San Francisco, California 94143, USA
    J Neurosci 25:6997-7003. 2005
    ..Our data show that SVZ neuroblasts are heterogeneous and that Pax6 is required in a cell-autonomous manner for the production of cells in the dopaminergic lineage...
  55. ncbi request reprint Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation
    Jason E Long
    Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:3230-43. 2007
    ....
  56. ncbi request reprint Cell-autonomous involvement of Mab21l1 is essential for lens placode development
    Ryuichi Yamada
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0101, Japan
    Development 130:1759-70. 2003
    ..We conclude that Mab21l1 expression dependent on PAX6 is essential for lens placode growth and for formation of the lens vesicle; lack of Mab21l1 expression causes reduced expression of Foxe3 in a cell-autonomous manner...
  57. ncbi request reprint Gliogenic radial glial cells show heterogeneity in the developing mouse spinal cord
    Yasuhiro Ogawa
    Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, 5 1 Higashiyama, Myodaiji, Okazaki, Japan
    Dev Neurosci 27:364-77. 2005
    ..This raises the idea that astrocytes generated from different domains along the dorsoventral axis in the mouse spinal cord have distinct characteristics...
  58. ncbi request reprint Subpial neuronal migration in the medulla oblongata of Pax-6-deficient rats
    Masao Horie
    Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, Fuchu 183 8526, Japan
    Eur J Neurosci 17:49-57. 2003
    ....
  59. pmc Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart
    Yuichi Tomita
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    J Cell Biol 170:1135-46. 2005
    ....
  60. ncbi request reprint Altered whisker patterns induced by ectopic expression of Shh are topographically represented by barrels
    Kanae Ohsaki
    Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, 187 8502, Tokyo, Japan
    Brain Res Dev Brain Res 137:159-70. 2002
    ....
  61. ncbi request reprint Craniofacial anomalies of the cultured mouse embryo induced by inhibition of sonic hedgehog signaling: an animal model of holoprosencephaly
    Takashi Nagase
    Department of Plastic and Reconstructive Surgery, University Hospital, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Craniofac Surg 16:80-8. 2005
    ..The authors consider that these facial anomalies represent milder phenotypes of holoprosencephaly...
  62. ncbi request reprint Mosaic development of the olfactory cortex with Pax6-dependent and -independent components
    Tatsumi Hirata
    Division of Brain Function, National Institute of Genetics, Graduate University for Advanced Studies, Yata 1111, Mishima 411 8540, Japan
    Brain Res Dev Brain Res 136:17-26. 2002
    ....
  63. ncbi request reprint Pax6 controls the expression of Lewis x epitope in the embryonic forebrain by regulating alpha 1,3-fucosyltransferase IX expression
    Yasushi Shimoda
    Department of Biochemical Cell Research, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    J Biol Chem 277:2033-9. 2002
    ..These results strongly suggest that Pax6 controls Lewis x expression in the embryonic brain by regulating FucT-IX gene expression...
  64. ncbi request reprint Disappearance of epidermal growth factor receptor is essential in the fusion of the nasal epithelium
    Masako Fujino
    Section of Molecular Craniofacial Embryology, Graduate School, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Japan
    Anat Sci Int 78:25-35. 2003
    ..These results suggest that temporal disappearance of the EGF/EGF-R signaling from presumptive fusion of the nasal prominences is required for morphological change of the epithelial cells leading to the fusion of MNP and LNP...
  65. pmc Roles of HNK-1 carbohydrate epitope and its synthetic glucuronyltransferase genes on migration of rat neural crest cells
    Takashi Nagase
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Anat 203:77-88. 2003
    ..Our data suggest that the HNK-1 epitope synthesized by different GlcATs is involved in migration in the sublineages of the NCCs in the rat embryo, and that GlcAT-P and GlcAT-D mediate different effects on the NCC migration...
  66. ncbi request reprint The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signalling
    Kenji Kasai
    Department of Pathology, Aichi Medical University School of Medicine, Nagakute, Aichi 480 1195, Japan
    Genes Cells 9:49-58. 2004
    ..The participation of RhoA, a pivotal molecular switch in many signal transduction pathways, may help explain how Shh can trigger a variety of cellular responses...
  67. pmc Human mesenchymal stem cells in rodent whole-embryo culture are reprogrammed to contribute to kidney tissues
    Takashi Yokoo
    Department of Internal Medicine and Gene Therapy and Pediatrics, Institute of DNA Medicine, Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Minato ku, Tokyo 105 8461, Japan
    Proc Natl Acad Sci U S A 102:3296-300. 2005
    ..We show that a combination of whole-embryo culture, followed by organ culture, encourages exogenous human mesenchymal stem cells to differentiate and contribute to functional complex structures of the new kidney...
  68. ncbi request reprint NSSRs/TASRs/SRp38s function as splicing modulators via binding to pre-mRNAs
    Kazuo Fushimi
    Center for Nano Materials and Technology, Japan Advanced Institute of Science and Technology, Nomi City, Ishikawa 923 1292, Japan
    Genes Cells 10:531-41. 2005
    ..5, all containing undifferentiated neural stem cells. Taken together, our results showed that NSSRs modulate alternative splicing via binding to premRNAs during neural differentiation...
  69. ncbi request reprint Single-cell detection of microRNAs in developing vertebrate embryos after acute administration of a dual-fluorescence reporter/sensor plasmid
    Davide De Pietri Tonelli
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Biotechniques 41:727-32. 2006
    ....
  70. ncbi request reprint A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Neuropsychopharmacology 32:1727-37. 2007
    ..In conclusion, the present study suggests that a promoter haplotype of IMPA2 possibly contributes to risk for bipolar disorder by elevating IMPA2 levels in the brain, albeit the genetic effect varies among populations...
  71. ncbi request reprint Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation
    Noriaki Nakatani
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Hum Mol Genet 15:1949-62. 2006
    ..Finally, gene network analysis using the currently obtained expression data highlighted cellular growth and nervous system development pathways as potential targets in the molecular pathophysiology of bipolar disorder...
  72. pmc Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype
    Akiko Watanabe
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    PLoS Biol 5:e297. 2007
    ..We also discuss the results from the perspective of fetal programming...