Nobuyuki Okamura

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi request reprint Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET
    Nobuyuki Okamura
    1 Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Brain 137:1762-71. 2014
  2. doi request reprint Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease
    Nobuyuki Okamura
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    J Nucl Med 54:1420-7. 2013
  3. ncbi request reprint Florbetapir (18F), a PET imaging agent that binds to amyloid plaques for the potential detection of Alzheimer's disease
    Nobuyuki Okamura
    Tohoku University School of Medicine, Department of Pharmacology, 2 1, Seiryo machi, Aoba ku, Sendai 9808575, Japan
    IDrugs 13:890-9. 2010
  4. doi request reprint Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving
    Manabu Tashiro
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hum Psychopharmacol 23:139-50. 2008
  5. doi request reprint Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease
    Masaaki Waragai
    Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Neurol Sci 285:100-8. 2009
  6. doi request reprint Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology
    Ryuichi Harada
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Japan
    Eur J Nucl Med Mol Imaging 40:125-32. 2013
  7. ncbi request reprint Blocking histamine H(1) improves learning and mnemonic dysfunction in mice with social isolation plus repeated methamphetamine injection
    Feiyong Jia
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    J Pharmacol Sci 107:167-74. 2008
  8. doi request reprint Voxel-based analysis of amyloid positron emission tomography probe [C]BF-227 uptake in mild cognitive impairment and alzheimer's disease
    He Shao
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Dement Geriatr Cogn Disord 30:101-11. 2010
  9. doi request reprint A 18F-labeled BF-227 derivative as a potential radioligand for imaging dense amyloid plaques by positron emission tomography
    Shozo Furumoto
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Mol Imaging Biol 15:497-506. 2013
  10. ncbi request reprint 2-(2-[2-Dimethylaminothiazol-5-yl]ethenyl)-6- (2-[fluoro]ethoxy)benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients
    Yukitsuka Kudo
    Tohoku University Biomedical Engineering Research Organization, Sendai, Japan
    J Nucl Med 48:553-61. 2007

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET
    Nobuyuki Okamura
    1 Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Brain 137:1762-71. 2014
    ..This technique would be applicable to the longitudinal evaluation of tau deposition and allow a better understanding of the pathophysiology of Alzheimer's disease. ..
  2. doi request reprint Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease
    Nobuyuki Okamura
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    J Nucl Med 54:1420-7. 2013
    ..After compound optimization, we developed novel (18)F-labeled arylquinoline derivatives, (18)F-THK-5105 and (18)F-THK-5117, for use as tau imaging PET tracers...
  3. ncbi request reprint Florbetapir (18F), a PET imaging agent that binds to amyloid plaques for the potential detection of Alzheimer's disease
    Nobuyuki Okamura
    Tohoku University School of Medicine, Department of Pharmacology, 2 1, Seiryo machi, Aoba ku, Sendai 9808575, Japan
    IDrugs 13:890-9. 2010
    ..This tracer has a potential to serve as an agent for preclinical detection of AD-related pathology in the large elderly population...
  4. doi request reprint Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving
    Manabu Tashiro
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hum Psychopharmacol 23:139-50. 2008
    ....
  5. doi request reprint Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease
    Masaaki Waragai
    Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Neurol Sci 285:100-8. 2009
    ..These findings suggest that amyloid PET using [11C]BF-227 is better suited for the prediction of conversion from MCI to AD, while VBM-MRI appears to be better suited for tracking the severity of dementia...
  6. doi request reprint Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology
    Ryuichi Harada
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Japan
    Eur J Nucl Med Mol Imaging 40:125-32. 2013
    ..The purpose of this study was to compare the binding properties of [(18)F]THK-523 and other amyloid imaging agents, including PiB, BF-227 and FDDNP, to synthetic protein fibrils and human brain tissue...
  7. ncbi request reprint Blocking histamine H(1) improves learning and mnemonic dysfunction in mice with social isolation plus repeated methamphetamine injection
    Feiyong Jia
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    J Pharmacol Sci 107:167-74. 2008
    ....
  8. doi request reprint Voxel-based analysis of amyloid positron emission tomography probe [C]BF-227 uptake in mild cognitive impairment and alzheimer's disease
    He Shao
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Dement Geriatr Cogn Disord 30:101-11. 2010
    ....
  9. doi request reprint A 18F-labeled BF-227 derivative as a potential radioligand for imaging dense amyloid plaques by positron emission tomography
    Shozo Furumoto
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Mol Imaging Biol 15:497-506. 2013
    ..e., [18F] fluorinated amyloid imaging compound of Tohoku university ([18F]FACT)) as amyloid positron emission tomography (PET) tracers and to assess [18F]FACT efficacy in imaging of Alzheimer's disease (AD)...
  10. ncbi request reprint 2-(2-[2-Dimethylaminothiazol-5-yl]ethenyl)-6- (2-[fluoro]ethoxy)benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients
    Yukitsuka Kudo
    Tohoku University Biomedical Engineering Research Organization, Sendai, Japan
    J Nucl Med 48:553-61. 2007
    ..This study reports a novel compound, 2-(2-[2-dimethylaminothiazol-5-yl]ethenyl)-6-(2-[fluoro]ethoxy)benzoxazole (BF-227), for in vivo detection of dense amyloid deposits using PET...
  11. doi request reprint In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET
    Nobuyuki Okamura
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Eur J Nucl Med Mol Imaging 37:934-41. 2010
    ..The purpose of this study is to evaluate the amyloid imaging tracer BF-227 with positron emission tomography (PET) for the non-invasive detection of PrP amyloid in the brain...
  12. ncbi request reprint Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia
    Kotaro Hiraoka
    Division of Cyclotron Nuclear Medicin, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
    Eur Neurol 68:137-43. 2012
    ....
  13. doi request reprint Greater responsiveness to donepezil in Alzheimer patients with higher levels of acetylcholinesterase based on attention task scores and a donepezil PET study
    Masashi Kasuya
    Departments of Geriatric Behavioral Neurology, Tohoku University, Sendai, Japan
    Alzheimer Dis Assoc Disord 26:113-8. 2012
    ..Higher baseline attention may predict responsiveness to donepezil in patients with AD, and higher acetylcholinesterase levels result in a greater clinical effect...
  14. pmc In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease
    Nobuyuki Okamura
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Br J Clin Pharmacol 65:472-9. 2008
    ..The biodistribution of donepezil in the brain after administration is not precisely understood in vivo. * There is no method to measure the amount of binding of orally administered donepezil to AChE...
  15. doi request reprint Brain accumulation of amyloid β protein visualized by positron emission tomography and BF-227 in Alzheimer's disease patients with or without diabetes mellitus
    Naoki Tomita
    Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan
    Geriatr Gerontol Int 13:215-21. 2013
    ..To discover the mechanism of developing dementia in AD patients with DM in a living state, we studied the distribution of amyloid β (Αβ) protein of diabetic AD patients...
  16. ncbi request reprint Methamphetamine- and 3,4-methylenedioxymethamphetamine-induced behavioral changes in histamine H3-receptor knockout mice
    Tomohiro Okuda
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    J Pharmacol Sci 111:167-74. 2009
    ..These findings suggest that deficiency in histamine H(3) receptors may have inhibitory effects on psychostimulant-induced increase in locomotion, but insignificant effects on the reward...
  17. doi request reprint Synthesis of [11C]interleukin 8 using a cell-free translation system and L-[11C]methionine
    Ryuichi Harada
    Department of Pharmacology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Nucl Med Biol 39:155-60. 2012
    ..This study clearly demonstrates that cell-free protein production system combined with positron emitter-labeled amino acid holds great promise as a novel approach to prepare radiolabeled proteins and peptides for PET imaging...
  18. doi request reprint Positron emission tomography evaluation of sedative properties of antihistamines
    Kazuhiko Yanai
    Tohoku University Graduate School of Medicine, Department of Pharmacology, Sendai, Japan
    Expert Opin Drug Saf 10:613-22. 2011
    ..These sedative properties have been evaluated using the incidence of subjective sleepiness, objective cognitive and psychomotor functions, and positron emission tomography (PET) measurement of H(1) receptor occupancy...
  19. doi request reprint Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging
    Tetsuro Tago
    Cyclotron and Radioisotope Center CYRIC, Tohoku University, Sendai, 980 8578, Japan
    J Labelled Comp Radiopharm 57:18-24. 2014
    ..15% ID/g at 30 min postinjection) and showed the labeling of NFTs in an AD brain section by autoradiography assay. These findings indicate the availability of [(11) C]THK-951 for in vivo PET imaging of tau pathology in AD...
  20. doi request reprint In vivo detection of amyloid plaques in the mouse brain using the near-infrared fluorescence probe THK-265
    Nobuyuki Okamura
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan Innovation of New Biomedical Engineering Center, Tohoku University, Sendai, Japan
    J Alzheimers Dis 23:37-48. 2011
    ..These findings strongly support the usefulness of THK-265 as an NIRF imaging probe for the noninvasive measurement of brain amyloid load...
  21. ncbi request reprint Neuroanatomical correlates of low body weight in Alzheimer's disease: a PET study
    XiaSheng Hu
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Miyagi 980 8574, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 26:1285-9. 2002
    ....
  22. doi request reprint Quantitative analysis of donepezil binding to acetylcholinesterase using positron emission tomography and [5-(11)C-methoxy]donepezil
    Kotaro Hiraoka
    Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Neuroimage 46:616-23. 2009
    ..In conclusion, this method enables quantitative analysis of AChE and direct investigation of the pharmacokinetics of donepezil in the human brain...
  23. ncbi request reprint Next-day residual sedative effect after nighttime administration of an over-the-counter antihistamine sleep aid, diphenhydramine, measured by positron emission tomography
    Dongying Zhang
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    J Clin Psychopharmacol 30:694-701. 2010
    ..Taking into account the possible hangover effect of OTC antihistamine sleep aids, care needs to be taken during their administration...
  24. doi request reprint Advances in molecular imaging for the diagnosis of dementia
    Nobuyuki Okamura
    Tohoku University, Pharmacology, Sendai, Japan
    Expert Opin Med Diagn 3:705-16. 2009
    ..New targets for molecular imaging are focusing on protein misfolding diseases associated with the neurotoxic deposition of aggregated tau, α-synuclein and prion proteins...
  25. ncbi request reprint The neural correlates of driving performance identified using positron emission tomography
    Etsuo Horikawa
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Japan
    Brain Cogn 58:166-71. 2005
    ..These brain regions may thus play roles in the maintenance of driving performance...
  26. ncbi request reprint Mechanism of the histamine H(3) receptor-mediated increase in exploratory locomotor activity and anxiety-like behaviours in mice
    Attayeb Mohsen
    Department of Pharmacology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Neuropharmacology 81:188-94. 2014
    ..These results suggest that H(3)R blockade induces histamine release, activates H(2)R and elicits exploratory locomotor activity and anxiety-like behaviours...
  27. ncbi request reprint Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors
    Hongmei Dai
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Sendai, Japan
    Neurosci Res 57:306-13. 2007
    ..In conclusion, our results demonstrate that both H1 and H2 receptors are involved in learning and memory processes for which the frontal cortex, amygdala and hippocampus interact...
  28. doi request reprint Use of a benzimidazole derivative BF-188 in fluorescence multispectral imaging for selective visualization of tau protein fibrils in the Alzheimer's disease brain
    Ryuichi Harada
    Department of Pharmacology, Tohoku University School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Mol Imaging Biol 16:19-27. 2014
    ..Here, we introduce a novel fluorescent probe that can distinguish between these two deposits by multispectral fluorescence imaging technique...
  29. ncbi request reprint [Molecular PET imaging for in vivo detection of amyloid in the human brain]
    Nobuyuki Okamura
    Department of Pharmacology, Tohoku University School of Medicine
    Rinsho Shinkeigaku 49:922-4. 2009
    ..Molecular PET imaging using beta-sheet binding agents has the potential to be extended to these wide spectrums of protein misfolding diseases...
  30. pmc Evaluation of the biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe [18F]FACT in humans
    Miho Shidahara
    Division of Medical Physics, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    EJNMMI Res 3:32. 2013
    ..The biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe ([18F] FACT) was investigated in humans...
  31. ncbi request reprint The effects of a sedative antihistamine, d-chlorpheniramine, on visuomotor spatial discrimination and regional brain activity as measured by positron emission tomography (PET)
    Hideki Mochizuki
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Hum Psychopharmacol 17:413-8. 2002
    ..These findings clearly suggest that the alteration in the cortical and subcortical activity contributes to impaired spatial cognition caused by treatment with d-chlorpheniramine...
  32. doi request reprint Analysis of early phase [11C]BF-227 PET, and its application for anatomical standardization of late-phase images for 3D-SSP analysis
    Tomohiro Kaneta
    Department of Diagnostic Radiology, Tohoku University, 1 1 Seiryomachi, Aobaku, Sendai, 980 8574, Japan
    Jpn J Radiol 32:138-44. 2014
    ....
  33. doi request reprint Roles of the histaminergic neurotransmission on methamphetamine-induced locomotor sensitization and reward: a study of receptors gene knockout mice
    Naoko Takino
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    Int Rev Neurobiol 85:109-16. 2009
    ..Our results suggest that the neuronal histamine could inhibit the METH-induced abnormal behaviors through the interactions of H1, H2, and H3 receptors...
  34. ncbi request reprint [Introduction to and general remarks on molecular imaging]
    Hiroshi Fukuda
    Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Brain Nerve 59:203-7. 2007
    ..The goal of this project is to detect AD at pre-clinical stage...
  35. ncbi request reprint Discrete cortical regions associated with the musical beauty of major and minor chords
    Miho Suzuki
    Department of Pharmacology, School of Medicine, Tohoku University, Sendai, Japan
    Cogn Affect Behav Neurosci 8:126-31. 2008
    ..These results suggest that major and minor keys, both of which are perceived as beautiful, are processed differently in the brain...
  36. ncbi request reprint Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain
    Nobuyuki Okamura
    BF Research Institute, Suita 565 0873, Japan
    J Neurosci 24:2535-41. 2004
    ..These findings strongly suggest that styrylbenzoxazole derivatives are promising candidate probes for positron emission tomography and single-photon emission computed tomography imaging for early detection of amyloid plaque formation...
  37. ncbi request reprint A novel imaging probe for in vivo detection of neuritic and diffuse amyloid plaques in the brain
    Nobuyuki Okamura
    BF Research Institute, c o National Cardiovascular Center, Fujishiro dai, Suita, Osaka, Japan
    J Mol Neurosci 24:247-55. 2004
    ..These findings suggest that BF-145 is a potential candidate as a probe for imaging early brain pathology in AD patients...
  38. ncbi request reprint [Molecular imaging techniques for research on brain function using PET]
    Nobuyuki Okamura
    Nihon Yakurigaku Zasshi 126:347-52. 2005
  39. ncbi request reprint Recent advances in the development of amyloid imaging agents
    Shozo Furumoto
    Biomedical Engineering Research Organization, Tohoku University, Sendai 980 8575, Japan
    Curr Top Med Chem 7:1773-89. 2007
    ....
  40. ncbi request reprint [In-vivo imaging of amyloid plaques]
    Nobuyuki Okamura
    Nihon Yakurigaku Zasshi 131:333-7. 2008
  41. pmc Differential cognitive effects of ebastine and (+)-chlorpheniramine in healthy subjects: correlation between cognitive impairment and plasma drug concentration
    Masaaki Tagawa
    Department of Pharmacology, Tohoku University School of Medicine, Cyclotron and Radioisotope Center, Tohoku University, Japan
    Br J Clin Pharmacol 53:296-304. 2002
    ..In order to evaluate the sedative properties of ebastine, a second-generation antihistamine, its effect on cognitive performance in healthy subjects was compared with placebo and (+)-chlorpheniramine...
  42. ncbi request reprint Combined Analysis of CSF Tau Levels and [(123)I]Iodoamphetamine SPECT in Mild Cognitive Impairment: Implications for a Novel Predictor of Alzheimer's Disease
    Nobuyuki Okamura
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Am J Psychiatry 159:474-6. 2002
    ..The aim of this study was to establish an objective and reliable index to predict the development of Alzheimer's disease in a large pool of elderly patients with mild cognitive impairment...
  43. ncbi request reprint Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice
    Feiyong Jia
    Department of Pharmacology, Tohoku University School of Medicine, Aoba ku, Sendai, Japan
    Neuropharmacology 50:404-11. 2006
    ....
  44. ncbi request reprint Arg(184)His mutant GTP cyclohydrolase I, causing recessive hyperphenylalaninemia, is responsible for dopa-responsive dystonia with parkinsonism: a case report
    Akio Kikuchi
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Mov Disord 19:590-3. 2004
    ..This is the first mutation in the GCH-I gene that has been proven to be responsible for both recessive and dominant phenotypes...