Takayoshi Ohkubo

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi Effects of an angiotensin-converting enzyme inhibitor-based regimen on pneumonia risk
    Takayoshi Ohkubo
    Tohoku University Graduate School of Pharmaceutical Science, Sendai, Japan
    Am J Respir Crit Care Med 169:1041-5. 2004
  2. ncbi How many times should blood pressure be measured at home for better prediction of stroke risk? Ten-year follow-up results from the Ohasama study
    Takayoshi Ohkubo
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan and Ohasama Hospital, Iwate, Japan
    J Hypertens 22:1099-104. 2004
  3. ncbi Prognostic significance of morning surge in blood pressure: which definition, which outcome?
    Takayoshi Ohkubo
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Blood Press Monit 13:161-2. 2008
  4. ncbi Control of blood pressure as measured at home and office, and comparison with physicians' assessment of control among treated hypertensive patients in Japan: First Report of the Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) study
    Takayoshi Ohkubo
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Hypertens Res 27:755-63. 2004
  5. ncbi Incorporating self-blood pressure measurements at home in the guideline from the Ohasama study
    Takayoshi Ohkubo
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Blood Press Monit 12:407-9. 2007
  6. ncbi Prognosis of "masked" hypertension and "white-coat" hypertension detected by 24-h ambulatory blood pressure monitoring 10-year follow-up from the Ohasama study
    Takayoshi Ohkubo
    Department of Planning for Drug Development and Clinical Evaluation, Sendai, Japan
    J Am Coll Cardiol 46:508-15. 2005
  7. ncbi Prognostic significance of variability in ambulatory and home blood pressure from the Ohasama study
    Takayoshi Ohkubo
    Department of Planning for Drug Development, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    J Epidemiol 17:109-13. 2007
  8. ncbi [Clinical, epidemiological and pharmacological research on cardiovascular disease based on blood pressure variability]
    Takayoshi Ohkubo
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan
    Yakugaku Zasshi 129:699-708. 2009
  9. ncbi The value of self-measured home blood pressure in predicting stroke
    Takayoshi Ohkubo
    Department of Clinical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences and Medicine, Tohoku University Hospital, Sendai, 980 8574, Japan
    Expert Rev Neurother 6:163-73. 2006
  10. ncbi Prediction of ischaemic and haemorrhagic stroke by self-measured blood pressure at home: the Ohasama study
    Takayoshi Ohkubo
    Departments of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Iwate, Japan
    Blood Press Monit 9:315-20. 2004

Collaborators

Detail Information

Publications111 found, 100 shown here

  1. ncbi Effects of an angiotensin-converting enzyme inhibitor-based regimen on pneumonia risk
    Takayoshi Ohkubo
    Tohoku University Graduate School of Pharmaceutical Science, Sendai, Japan
    Am J Respir Crit Care Med 169:1041-5. 2004
    ....
  2. ncbi How many times should blood pressure be measured at home for better prediction of stroke risk? Ten-year follow-up results from the Ohasama study
    Takayoshi Ohkubo
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan and Ohasama Hospital, Iwate, Japan
    J Hypertens 22:1099-104. 2004
    ..To determine the optimum number of blood pressure self-measurements taken at home (home blood pressure) in relation to their predictive value for stroke risk...
  3. ncbi Prognostic significance of morning surge in blood pressure: which definition, which outcome?
    Takayoshi Ohkubo
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Blood Press Monit 13:161-2. 2008
    ..More prospective studies or meta-analyses are required to better elucidate the prognostic significance of the morning surge in BP...
  4. ncbi Control of blood pressure as measured at home and office, and comparison with physicians' assessment of control among treated hypertensive patients in Japan: First Report of the Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) study
    Takayoshi Ohkubo
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Hypertens Res 27:755-63. 2004
    ..Our findings suggest that an important reason why home and office BP values are not adequately controlled is that physicians approve relatively higher BP levels under treatment, even among middle-aged patients...
  5. ncbi Incorporating self-blood pressure measurements at home in the guideline from the Ohasama study
    Takayoshi Ohkubo
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Blood Press Monit 12:407-9. 2007
    ..We expect that continuous follow-up and further analysis of the Ohasama data would contribute to producing further important findings worth incorporating in future hypertension guidelines...
  6. ncbi Prognosis of "masked" hypertension and "white-coat" hypertension detected by 24-h ambulatory blood pressure monitoring 10-year follow-up from the Ohasama study
    Takayoshi Ohkubo
    Department of Planning for Drug Development and Clinical Evaluation, Sendai, Japan
    J Am Coll Cardiol 46:508-15. 2005
    ..We sought to investigate the prognosis in subjects with "white-coat" hypertension (WCHT) and "masked" hypertension (MHT), in which blood pressure (BP) is lower in clinical measurements than during ambulatory monitoring...
  7. ncbi Prognostic significance of variability in ambulatory and home blood pressure from the Ohasama study
    Takayoshi Ohkubo
    Department of Planning for Drug Development, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    J Epidemiol 17:109-13. 2007
    ..These variations in BP also bias the diagnosis and treatment of hypertension, which can be managed effectively by considering the phasic, as well as the tonic, component of BP...
  8. ncbi [Clinical, epidemiological and pharmacological research on cardiovascular disease based on blood pressure variability]
    Takayoshi Ohkubo
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan
    Yakugaku Zasshi 129:699-708. 2009
    ..The diagnosis and treatment of hypertension can be managed effectively by considering information from home and ambulatory BP monitoring...
  9. ncbi The value of self-measured home blood pressure in predicting stroke
    Takayoshi Ohkubo
    Department of Clinical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences and Medicine, Tohoku University Hospital, Sendai, 980 8574, Japan
    Expert Rev Neurother 6:163-73. 2006
    ..Home blood pressure measurement increased the predictive power of categorizations of guidelines compared with conventional blood pressure measurement. Home blood pressure measurement is a useful tool to predict future risk of stroke...
  10. ncbi Prediction of ischaemic and haemorrhagic stroke by self-measured blood pressure at home: the Ohasama study
    Takayoshi Ohkubo
    Departments of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Iwate, Japan
    Blood Press Monit 9:315-20. 2004
    ..To examine the predictive value of self-measured blood pressure values taken at home (home blood pressure) for risk of stroke and subtypes...
  11. ncbi Ambulatory versus home versus clinic blood pressure: the association with subclinical cerebrovascular diseases: the Ohasama Study
    Azusa Hara
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Hypertension 59:22-8. 2012
    ....
  12. ncbi Influence of adrenomedullin 2/intermedin gene polymorphism on blood pressure, renal function and silent cerebrovascular lesions in Japanese: the Ohasama study
    Takuo Hirose
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Aoba ku, Sendai, Japan
    Hypertens Res 34:1327-32. 2011
    ..4, P=0.01) and WMH (OR: 2.7, P=0.003), compared with II carriers. The AM2/IMD I/D polymorphism is associated with renal dysfunction, blood pressure regulation and asymptomatic cerebrovascular diseases in the Japanese general population...
  13. ncbi Optimal cutoff point of waist circumference and use of home blood pressure as a definition of metabolic syndrome: the Ohasama study
    Atsushi Sato
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Am J Hypertens 21:514-20. 2008
    ..Eight scientific associations recently defined MS for the Japanese population. However, this definition remains controversial, especially with respect to the cutoff value of waist circumference (WC) being higher in women than in men...
  14. ncbi Factors affecting home-measured resting heart rate in the general population: the Ohasama study
    Junko Yamaguchi
    Departments of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, 1-1 Seiryomachi, Aobaku, Sendai 980-8574, Japan
    Am J Hypertens 18:1218-25. 2005
    ..These results suggest that reduction of home HR through modification of smoking habit or sedentary lifestyle may have a potential to decrease cardiovascular risk in addition to decreasing in these modifiable risk factor per se...
  15. ncbi Plasma renin activity and the aldosterone-to-renin ratio are associated with the development of chronic kidney disease: the Ohasama Study
    Shiho Terata
    Tohoku University Graduate School of Medicine and Pharmaceutical Sciences, Sendai, Japan
    J Hypertens 30:1632-8. 2012
    ..The aldosterone-to-renin ratio (ARR) is used to screen for primary aldosteronism and could be an index for salt sensitivity. The association between ARR and the development of chronic kidney disease (CKD) is completely unknown...
  16. ncbi Electrocardiographic left ventricular hypertrophy and arterial stiffness: the Ohasama study
    Daisuke Watabe
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Aoba, Aramaki, Sendai, Japan
    Am J Hypertens 19:1199-205. 2006
    ..001). CONCLUSIONS: Arterial stiffness is independently related to electrocardiographically determined LVH in the general population...
  17. ncbi Association of kidney dysfunction with silent lacunar infarcts and white matter hyperintensity in the general population: the Ohasama study
    Harunori Otani
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Cerebrovasc Dis 30:43-50. 2010
    ..No previous study has investigated the association of kidney dysfunction with silent lacunar infarcts and white-matter hyperintensity (WMH) independent of ambulatory blood pressure (BP)...
  18. ncbi Isolated uncontrolled hypertension at home and in the office among treated hypertensive patients from the J-HOME study
    Taku Obara
    Department of Clinical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Science and Medicine, Tohoku University, 980-8574 Sendai, Japan
    J Hypertens 23:1653-60. 2005
    ..CONCLUSIONS: The use of all four, three of four, or all three predictive factors might be useful for the clinician to suspect isolated uncontrolled home or office hypertension...
  19. ncbi The current status of home and office blood pressure control among hypertensive patients with diabetes mellitus: the Japan Home Versus Office Blood Pressure Measurement Evaluation (J-HOME) study
    Taku Obara
    Department of Clinical Pharmacology, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Tohoku University Hospital, Sendai, Japan
    Diabetes Res Clin Pract 73:276-83. 2006
    ..The main reason for this would appear to be a lack of intensive treatment and a lack of recognition by physicians that their patients' BP was insufficiently controlled...
  20. ncbi Stroke risk in systolic and combined systolic and diastolic hypertension determined using ambulatory blood pressure. The Ohasama study
    Ryusuke Inoue
    21st Century COE Program Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation, Tohoku University, Sendai, Japan
    Am J Hypertens 20:1125-31. 2007
    ....
  21. ncbi Blood pressure-lowering effect and duration of action of bedtime administration of doxazosin determined by home blood pressure measurement
    Kenta Gonokami
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Clin Exp Hypertens 32:311-7. 2010
    ..The results suggest that bedtime administration of doxazosin effectively suppresses morning HBP in uncontrolled morning hypertensives and lowers evening HBP in uncontrolled evening hypertensives...
  22. ncbi Predictive value for mortality of the double product at rest obtained by home blood pressure measurement: the Ohasama study
    Ryusuke Inoue
    Medical Informatics Center of Tohoku University Hospital, Sendai, Japan
    Am J Hypertens 25:568-75. 2012
    ..To clarify whether the double product (DP) (product of systolic blood pressure (SBP) and pulse rate (PR)) at rest based on home blood pressure (HBP) measurement has prognostic value for mortality...
  23. ncbi Prediction of stroke by home "morning" versus "evening" blood pressure values: the Ohasama study
    Kei Asayama
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University 21st Century Center of Excellence Program, Sendai, Japan
    Hypertension 48:737-43. 2006
    ....
  24. ncbi Diagnostic thresholds for ambulatory blood pressure monitoring based on 10-year cardiovascular risk
    Masahiro Kikuya
    Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Circulation 115:2145-52. 2007
    ..Current diagnostic thresholds for ambulatory blood pressure (ABP) mainly rely on statistical parameters derived from reference populations. We determined an outcome-driven reference frame for ABP measurement...
  25. ncbi Association of arterial stiffness with silent cerebrovascular lesions: the Ohasama study
    Rieko Hatanaka
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Cerebrovasc Dis 31:329-37. 2011
    ..Hence, we hypothesized that arterial stiffness would be a significant determinant of silent cerebrovascular lesions...
  26. ncbi Diagnostic thresholds for ambulatory blood pressure monitoring based on 10-year cardiovascular risk
    Masahiro Kikuya
    The Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Blood Press Monit 12:393-5. 2007
    ..In conclusion, population-based outcome-driven thresholds for optimal and normal ABP are lower than those currently proposed by hypertension guidelines...
  27. ncbi Masked hypertension determined by self-measured blood pressure at home and chronic kidney disease in the Japanese general population: the Ohasama study
    Hiroyuki Terawaki
    Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine and Pharmaceutical Sciences, Sendai, Japan
    Hypertens Res 31:2129-35. 2008
    ..56) and SHT (3.60) groups compared with the SNBP group (reference). MHT, like SHT, is closely related to CKD, and HBP measurement could be a useful screening strategy to detect CKD in the general population...
  28. ncbi Uncontrolled hypertension based on morning and evening home blood pressure measurements from the J-HOME study
    Taku Obara
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Hypertens Res 32:1072-8. 2009
    ..Physicians should also consider evening BP measuring condition for adequate evaluation of evening BP values...
  29. ncbi Prevalence of Masked Hypertension in Subjects Treated with Antihypertensive Drugs as Assessed by Morning versus Evening Home Blood Pressure Measurements: the J-HOME study
    Taku Obara
    Department of Clinical Pharmacology, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Clin Exp Hypertens 30:277-87. 2008
    ..9% for diastolic BP (kappa coefficient = 0.43). The present study showed that the prevalence of masked hypertension was underestimated when the diagnosis of masked hypertension was made on the basis of evening home BP...
  30. ncbi Association of (pro)renin receptor gene polymorphism with blood pressure in Japanese men: the Ohasama study
    Takuo Hirose
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Am J Hypertens 22:294-9. 2009
    ..However, there is no information on (P)RR in humans. We investigated the association of (P)RR gene polymorphisms with blood pressure in a Japanese population...
  31. ncbi Day-by-day variability of blood pressure and heart rate at home as a novel predictor of prognosis: the Ohasama study
    Masahiro Kikuya
    Department of Clinical Pharmacology and Therapeutics, Graduate School of Medicine and Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Hypertension 52:1045-50. 2008
    ..In conclusion, day-by-day blood pressure variability and heart rate variability by self-measurement at home make up a simple method of providing useful clinical information for assessing cardiovascular risk...
  32. ncbi Progress report on the HOMED-BP Study: hypertension objective treatment based on measurement by electrical devices of blood pressure study
    Yohei Aoki
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Clin Exp Hypertens 26:119-27. 2004
    ..At the end of March 2002, 546 patients were recruited. Of these, 412 (202 men and 210 women, aged 58.4 +/- 10.2 y) were randomized. Patients will be recruited until February, 2006 and followed for 7 years...
  33. ncbi Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women: the Ohasama study
    Takuo Hirose
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Hypertens Res 34:530-5. 2011
    ..The polymorphism of the (P)RR gene +1513A>G is associated with lacunar infarction and LVH in Japanese women. These results suggest that (P)RR has a role in organ damage in humans...
  34. ncbi Ambulatory blood pressure and 10-year risk of cardiovascular and noncardiovascular mortality: the Ohasama study
    Masahiro Kikuya
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai, Japan
    Hypertension 45:240-5. 2005
    ..We conclude that the relationship between ambulatory systolic blood pressure and cardiovascular mortality is not U-shaped or J-shaped, and that nighttime blood pressure has better prognostic value than daytime blood pressure...
  35. ncbi Prognostic significance for stroke of a morning pressor surge and a nocturnal blood pressure decline: the Ohasama study
    Hirohito Metoki
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science, Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation, Sendai, Japan
    Hypertension 47:149-54. 2006
    ....
  36. ncbi Predictive value of ambulatory heart rate in the Japanese general population: the Ohasama study
    Atsushi Hozawa
    Department of Health Science, Shiga University of Medical Science, Otsu, Japan
    J Hypertens 26:1571-6. 2008
    ..However, only a few studies have described the relationship between heart rate measured by ambulatory blood pressure monitoring devices and cardiovascular disease prediction...
  37. ncbi Gene expression of (pro)renin receptor is upregulated in hearts and kidneys of rats with congestive heart failure
    Takuo Hirose
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai 980 8578, Japan
    Peptides 30:2316-22. 2009
    ..These findings suggest that the expression of (P)RR is increased in the hearts and kidneys of rats with heart failure, and that (P)RR may contribute to heart failure...
  38. ncbi Factors associated with day-by-day variability of self-measured blood pressure at home: the Ohasama study
    Tetsuo Kato
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Am J Hypertens 23:980-6. 2010
    ..The objective of this study is to clarify the determinants of the day-by-day home-BP variability...
  39. ncbi Individual assessment of inherent arterial stiffness using nomogram and pulse wave velocity index: the Ohasama study
    Rieko Hatanaka
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Clin Exp Hypertens 33:147-52. 2011
    ..53). The calculated PWV index was significantly higher in 13 smokers than 70 nonsmokers among controlled hypertensives. The calculated PWV index might provide more precise information about inherent arterial stiffness...
  40. ncbi Association of microalbuminuria with brachial-ankle pulse wave velocity: the Ohasama study
    Tomofumi Ishikawa
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Am J Hypertens 21:413-8. 2008
    ..However, the associations between microalbuminuria and pulse wave velocity (PWV), carotid intima-media thickness (IMT), and ambulatory blood pressure (ABP), respectively, have not been investigated...
  41. ncbi Use of 2003 European Society of Hypertension-European Society of Cardiology guidelines for predicting stroke using self-measured blood pressure at home: the Ohasama study
    Kei Asayama
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, 1-1 Seiryo-cho, Aoba-ku, Sendai 980-8574, Japan
    Eur Heart J 26:2026-31. 2005
    ..The results indicate the usefulness of HBP for the prediction of stroke risk in individuals...
  42. ncbi Increased expression of urotensin II, urotensin II-related peptide and urotensin II receptor mRNAs in the cardiovascular organs of hypertensive rats: comparison with endothelin-1
    Takuo Hirose
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Peptides 30:1124-9. 2009
    ....
  43. ncbi Home blood pressure level, blood pressure variability, smoking, and stroke risk in Japanese men: the Ohasama study
    Takanao Hashimoto
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Am J Hypertens 25:883-91. 2012
    ..Hypertension and smoking independently contribute to the risk of stroke. Our objective was to investigate home blood pressure (HBP) levels, day-by-day BP variability, and smoking in the prediction of stroke in Japanese men...
  44. ncbi Insufficient duration of action of antihypertensive drugs mediates high blood pressure in the morning in hypertensive population: the Ohasama study
    Kenichi Chonan
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Clin Exp Hypertens 24:261-75. 2002
    ..The high morning BP accompanies so-called non-dipper pattern of circadian BP variation. An insufficient duration of action of drugs may partly mediate non-dipping in subjects with antihypertensive medication...
  45. ncbi White-coat hypertension as a risk factor for the development of home hypertension: the Ohasama study
    Takashi Ugajin
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Medicine and Pharmaceutical Sciences, Sendai, Japan
    Arch Intern Med 165:1541-6. 2005
    ....
  46. ncbi Associated factors of home versus ambulatory heart rate variability in the general population: the Ohasama study
    Kenta Gonokami
    Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai, Japan
    Clin Exp Hypertens 33:404-10. 2011
    ..018). Associated factors of daytime ambulatory HR variability and day-by-day home HR variability were different. Our findings suggest that HR variabilities by different intervals of measurements might be mediated by different mechanisms...
  47. ncbi Enhanced radial late systolic pressure augmentation in hypertensive patients with left ventricular hypertrophy
    Junichiro Hashimoto
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Science and Medicine, 6 3 Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Am J Hypertens 19:27-32. 2006
    ..We examined the relationship between late systolic pressure augmentation in the peripheral radial artery pulse wave and the existence of left ventricular hypertrophy (LVH) in hypertension...
  48. ncbi Factors affecting heart rate as measured at home among treated hypertensive patients: the Japan home versus office blood pressure measurement evaluation (J-HOME) study
    Rie Komai
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Hypertens Res 30:1051-7. 2007
    ..These results suggest that adequate control of risk factors for cardiovascular disease such as smoking and diabetes mellitus or use of heart rate-lowering agents might help to decrease home HR in treated hypertensive patients...
  49. ncbi Time-dependent effects of imidapril administration in patients with morning hypertension measured as home blood pressure
    Takako Shibasaki
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Clin Exp Hypertens 30:243-54. 2008
    ..3 +/- 0.5 and 1.0 +/- 0.7, respectively. One daily dose of imidapril taken either in the morning or at bedtime lowered morning HBP, indicating that imidapril is useful for controlling morning hypertension...
  50. ncbi Prognostic value of home heart rate for cardiovascular mortality in the general population: the Ohasama study
    Atsushi Hozawa
    Department of Public Health, Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai, Japan
    Am J Hypertens 17:1005-10. 2004
    ..We therefore investigated the usefulness of HR values in predicting cardiovascular mortality using a device that allowed self-measurement of BP and HR at home...
  51. ncbi Therapeutic effects of evening administration of guanabenz and clonidine on morning hypertension: evaluation using home-based blood pressure measurements
    Junichiro Hashimoto
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai, Japan
    J Hypertens 21:805-11. 2003
    ..To clarify the effects of bedtime administration of the centrally acting alpha(2)-agonists, guanabenz and clonidine, on morning hypertension...
  52. ncbi Parental longevity and offspring's home blood pressure: the Ohasama study
    Yumiko Watanabe
    Department of Clinical Pharmacology and Therapeutics, Japan
    J Hypertens 28:272-7. 2010
    ..No study has used self-measurement of BP at home (home BP). We examined the association between parental longevity and home BP values of adult Japanese offspring...
  53. ncbi Aldosterone-to-renin ratio and nocturnal blood pressure decline in a general population: the Ohasama study
    Michihiro Satoh
    Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai, Japan
    J Hypertens 29:1940-7. 2011
    ....
  54. ncbi Control of home heart rate and home blood pressure levels in treated patients with hypertension: the J-HOME study
    Taku Obara
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan
    Blood Press Monit 12:289-95. 2007
    ..The objective of this study was to examine the current status of home HR control and home BP control among treated patients with hypertension...
  55. ncbi Ambulatory arterial stiffness index and 24-hour ambulatory pulse pressure as predictors of mortality in Ohasama, Japan
    Masahiro Kikuya
    Tohoku University Graduate School of Medicine and Pharmaceutical Science, 1 1 Seiryomachi, Sendai, Japan
    Stroke 38:1161-6. 2007
    ..We investigated the prognostic value of AASI and PP in relation to fatal outcomes...
  56. ncbi Introversion associated with large differences between screening blood pressure and home blood pressure measurement: The Ohasama study
    Atsushi Hozawa
    Department of Health Science, Shiga University of Medical Science, Shiga, Japan
    J Hypertens 24:2183-9. 2006
    ..To explore the effect of personality on screening blood pressures measured in clinical settings and home blood pressure measurements...
  57. ncbi Predicting stroke using 4 ambulatory blood pressure monitoring-derived blood pressure indices: the Ohasama Study
    Ryusuke Inoue
    Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Science, 1-1 Seiryo-cho, Aoba-ku, Sendai, 980-8574, Japan
    Hypertension 48:877-82. 2006
    ..In conclusion, PP was the weakest predictor of stroke. Exclusion of age from covariates increased the predictive power of PP, suggesting that the stroke risk associated with PP reflected the risk of aging per se...
  58. ncbi Prognostic significance of night-time, early morning, and daytime blood pressures on the risk of cerebrovascular and cardiovascular mortality: the Ohasama Study
    Hirohito Metoki
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    J Hypertens 24:1841-8. 2006
    ..CONCLUSION: High BP at different times of day were associated with different subtypes of cerebrovascular and cardiovascular mortality risk...
  59. ncbi Reproducibility of nocturnal blood pressure assessed by self-measurement of blood pressure at home
    Keiko Hosohata
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Hypertens Res 30:707-12. 2007
    ..To evaluate nocturnal BP using a self-measurement device, estimation of quality of sleep is indispensable...
  60. ncbi Prognostic significance of home arterial stiffness index derived from self-measurement of blood pressure: the Ohasama Study
    Masahiro Kikuya
    Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai, Japan
    Am J Hypertens 25:67-73. 2012
    ..Arterial stiffness is a stroke risk factor. The home arterial stiffness index (HASI) can be calculated from self-measured blood pressure using the same formula as the calculation of ambulatory arterial stiffness index (AASI)...
  61. ncbi Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study
    Takayoshi Ohkubo
    Departments of Public Health, Clinical Pharmacology and Therapeutics, and Environmental Health Science, Tohoku University School of Medicine and Pharmaceutical Science, Sendai and Ohasama Hospital, Iwate, Japan
    J Hypertens 20:2183-9. 2002
    ..To examine the relationship between the normal nocturnal decline in blood pressure and the risk of cardiovascular mortality in individuals with and without high 24-h blood pressure values...
  62. ncbi Prediction of stroke by self-measurement of blood pressure at home versus casual screening blood pressure measurement in relation to the Joint National Committee 7 classification: the Ohasama study
    Kei Asayama
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Stroke 35:2356-61. 2004
    ..CONCLUSIONS: The JNC-7 classification had a stronger predictive power using HBP-based classification compared with CBP-based classification, suggesting the usefulness of HBP in the management of hypertension...
  63. ncbi The association between masked hypertension and waist circumference as an obesity-related anthropometric index for metabolic syndrome: the Ohasama study
    Kei Asayama
    Tohoku University 21st Century COE Program Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation, Sendai, Japan
    Hypertens Res 32:438-43. 2009
    ..Our results suggest that HBP measurements might be particularly important in abdominally obese people for the early detection of masked hypertension...
  64. ncbi Efficacy of combination antihypertensive therapy with low-dose indapamide: assessment by blood pressure self-monitoring at home
    Junichiro Hashimoto
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Science and Medicine, 6 3 Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Clin Exp Hypertens 27:331-41. 2005
    ..95 for SBP and 0.85 for DBP. Low-dose indapamide used in combination can provide additional anti-hypertensive efficacy lasting for 24 h. The added effect of indapamide may be more prominent on ARBs than on CCBs...
  65. ncbi Progress report on The Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study: status at February 2004
    Keiko Hosohata
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Miyagi, Japan
    Clin Exp Hypertens 29:69-81. 2007
    ..These results indicate the necessity of additional interventional strategies to improve the achievement of target BP levels, especially in the more intensive BP-lowering group...
  66. ncbi The second progress report on the Hypertension Objective treatment based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study
    Shin Saito
    Departments of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, 1-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8574, Japan
    Blood Press Monit 9:243-7. 2004
    ..CONCLUSIONS: Good quality of randomization was observed at the end of March 2003, but rate of achievement for target BPs was insufficient...
  67. ncbi Relationship of dysregulation of glucose metabolism with white-coat hypertension: the Ohasama study
    Miki Hosaka
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan
    Hypertens Res 33:937-43. 2010
    ..Our results suggest that dysregulation of glucose metabolism in WCHT might contribute to the increase in the long-term cardiovascular risk among the general population...
  68. ncbi Plasma fibrinogen, ambulatory blood pressure, and silent cerebrovascular lesions: the Ohasama study
    Yoko Aono
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, 980 8574, Japan
    Arterioscler Thromb Vasc Biol 27:963-8. 2007
    ..We evaluated the association of 24-hour ABP and plasma fibrinogen levels with the risk of silent cerebrovascular lesions (white matter hyperintensity and lacunar infarct) detected by MRI...
  69. ncbi Low-dose and very low-dose spironolactone in combination therapy for essential hypertension: evaluation by self-measurement of blood pressure at home
    Tomohiro Hanazawa
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Clin Exp Hypertens 33:427-36. 2011
    ..1 mmHg) groups. An increase in serum potassium correlated positively with the decline in morning systolic BP. Even very low-dose (12.5 mg) spironolactone is clinically effective, although serum potassium should be carefully monitored...
  70. ncbi Detection of silent cerebrovascular lesions in individuals with 'masked' and 'white-coat' hypertension by home blood pressure measurement: the Ohasama study
    Azusa Hara
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    J Hypertens 27:1049-55. 2009
    ..Conclusion The present study is the first to demonstrate that the risk of silent cerebrovascular lesions is higher with MHT than with SNBP and similar to that of sustained hypertension...
  71. ncbi Influence of alcohol intake on circadian blood pressure variation in Japanese men: the Ohasama study
    Manami Nakashita
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Am J Hypertens 22:1171-6. 2009
    ..Therefore, the association between these two factors was examined...
  72. ncbi Association of environmental tobacco smoke exposure with elevated home blood pressure in Japanese women: the Ohasama study
    Mami Seki
    Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Department of Clinical Pharmacology, Sendai, Japan
    J Hypertens 28:1814-20. 2010
    ..The association between home blood pressure (HBP) and ETS exposure was investigated in the general population...
  73. ncbi Detection of carotid atherosclerosis in individuals with masked hypertension and white-coat hypertension by self-measured blood pressure at home: the Ohasama study
    Azusa Hara
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    J Hypertens 25:321-7. 2007
    ..To investigate carotid atherosclerosis in individuals with masked hypertension (MHT) and white-coat hypertension (WCHT) in a general population...
  74. ncbi Difference between home and office blood pressures among treated hypertensive patients from the Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) study
    Tsuyoshi Horikawa
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Aoba ku, Sendai, Japan
    Hypertens Res 31:1115-23. 2008
    ..These predictive factors might be useful clinically to help identify patients who may have a large difference between home and office blood pressures...
  75. ncbi Characteristics of resistant hypertension determined by self-measured blood pressure at home and office blood pressure measurements: the J-HOME study
    Takuya Oikawa
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    J Hypertens 24:1737-43. 2006
    ....
  76. ncbi Electrocardiographic abnormalities and home blood pressure in treated elderly hypertensive patients: Japan home versus office blood pressure measurement evaluation in the elderly (J-HOME-Elderly) study
    Taku Shibamiya
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai 980 8578, Japan
    Hypertens Res 33:670-7. 2010
    ..Morning home BP was more closely associated with ECG-LVH and abnormal T waves than either office or evening home BP among treated hypertensive Japanese patients...
  77. ncbi [The Ohasama Study]
    Takayoshi Ohkubo
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Science
    Nippon Rinsho 62:18-21. 2004
  78. ncbi Study design of HOMED-BP: hypertension objective treatment based on measurement by electrical devices of blood pressure
    Tohru Fujiwara
    Department of Clinical Pharmacology and Therapeutics, and Public Health, Tohoku University School of Medicine and Pharmaceutical Science, Sendai, Japan
    Clin Exp Hypertens 25:143-4. 2003
    ..However, no large-scale interventional trial has been conducted to show which of these three initial medication can give the greatest benefit in terms of reduced cardiovascular disease risk in the Japanese hypertensive patients...
  79. ncbi Influence of home blood pressure measuring conditions in the evening on the morning-evening home blood pressure difference in treated hypertensive patients: the J-HOME study
    Kie Ito
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Blood Press Monit 14:160-5. 2009
    ....
  80. ncbi Angiotensin-converting enzyme I/D polymorphism and hypertension: the Ohasama study
    Mitsunobu Matsubara
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai, Japan
    J Hypertens 20:1121-6. 2002
    ....
  81. ncbi Heart rate measurement and outcome
    Yutaka Imai
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, 1 1 Seiryomachi Aobaku, Japan, 980 8574
    Blood Press Monit 8:53-5. 2003
    ..In conclusion, heart rate and heart rate variability must not be overlooked when evaluating hypertension...
  82. ncbi The economic impact of the introduction of home blood pressure measurement for the diagnosis and treatment of hypertension
    Jin Funahashi
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Tokyo, Japan
    Blood Press Monit 11:257-67. 2006
    ..CONCLUSIONS: The introduction of home blood pressure measurement for the diagnosis and treatment of hypertension would be very effective to save costs...
  83. ncbi Attributable risk fraction of prehypertension on cardiovascular disease mortality in the Japanese population: the Ohsaki Study
    Atsushi Hozawa
    Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Am J Hypertens 22:267-72. 2009
    ..However, no studies have reported the fraction...
  84. ncbi Patient characteristics and factors associated with inter-arm difference of blood pressure measurements in a general population in Ohasama, Japan
    Atsushi Kimura
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    J Hypertens 22:2277-83. 2004
    ....
  85. ncbi Seasonal trends of blood pressure during pregnancy in Japan: the babies and their parents' longitudinal observation in Suzuki Memorial Hospital in Intrauterine Period study
    Hirohito Metoki
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    J Hypertens 26:2406-13. 2008
    ..Some interaction seems to exist between season and gestational age. The present study observed home BP values during pregnancy with adjustment for seasonal variation and gestational age...
  86. ncbi [HOMED-BP]
    Kei Asayama
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine
    Nippon Rinsho 64:459-64. 2006
  87. ncbi T+31C polymorphism of angiotensinogen gene and nocturnal blood pressure decline: the Ohasama study
    Tohru Fujiwara
    Department of Clinical Pharmacology, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Am J Hypertens 15:628-32. 2002
    ..We assessed the association between several polymorphisms of angiotensinogen gene (AGT) and essential hypertension using ambulatory blood pressure (BP)...
  88. ncbi [The Ohasama study]
    Takayoshi Ohkubo
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Science
    Nippon Rinsho 64:100-3. 2006
  89. ncbi Stroke risk and antihypertensive drug treatment in the general population: the Japan arteriosclerosis longitudinal study
    Kei Asayama
    Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation, Tohoku University 21st Century COE Program, Sendai, Japan
    J Hypertens 27:357-64. 2009
    ..To evaluate the association between stroke risk and blood pressure (BP) levels with regard to the usage of antihypertensive medications...
  90. ncbi Impact of walking upon medical care expenditure in Japan: the Ohsaki Cohort Study
    Ichiro Tsuji
    Department of Public Health, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Int J Epidemiol 32:809-14. 2003
    ..We attempted to quantify the association between time spent walking and medical care costs, based on a 4-year prospective observation of National Health Insurance (NHI) beneficiaries in rural Japan...
  91. ncbi Expression of adrenomedullin 2/intermedin, a possible reno-protective peptide, is decreased in the kidneys of rats with hypertension or renal failure
    Takuo Hirose
    Dept of Clinical Pharmacology and Therapeutics, Tohoku Univ Graduate School of Pharmaceutical Sciences and Medicine, 6 3 Aramaki Aza Aoba, Aoba ku, Sendai 980 8578, Japan
    Am J Physiol Renal Physiol 299:F128-34. 2010
    ..Given the organ-protective effects of AM2/IMD, the downregulation of AM2/IMD as an endogenous regulatory peptide may have a role in the progression of renal impairment...
  92. ncbi Kidney dysfunction as a risk factor for first symptomatic stroke events in a general Japanese population--the Ohasama study
    Masaaki Nakayama
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, and Ohasama Hospital, Iwate, Japan
    Nephrol Dial Transplant 22:1910-5. 2007
    ..Although a high prevalence of stroke is a characteristic feature in Japanese populations, it is unclear whether CKD constitutes a risk for stroke events...
  93. ncbi Relationship between personality and self-measured blood pressure value at home: the Ohasama study
    Atsushi Hozawa
    Department of Public Health, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Exp Hypertens 24:115-23. 2002
    ..When physicians investigate the pathogenesis of essential hypertension, they should take psychological factors into consideration, as well as the many environmental and genetic factors...
  94. ncbi Blood pressure control assessed by home, ambulatory and conventional blood pressure measurements in the Japanese general population: the Ohasama study
    Atsushi Hozawa
    Department of Public Health, Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai, Japan
    Hypertens Res 25:57-63. 2002
    ....
  95. ncbi Pulse wave velocity and the second derivative of the finger photoplethysmogram in treated hypertensive patients: their relationship and associating factors
    Junichiro Hashimoto
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai, Japan
    J Hypertens 20:2415-22. 2002
    ..To clarify the factors influencing two measures of arterial stiffness, pulse wave velocity (PWV) and the second derivative of the finger photoplethysmogram (SDPTG), and to evaluate their relationship in treated hypertensive subjects...
  96. ncbi What determines the later clinical course of patients who do not undergo colectomy at the first attack? A Japanese cohort study on ulcerative colitis
    Hisashi Shiga
    Division of Gastroenterology, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Aoba, Sendai, Japan
    Digestion 81:104-12. 2010
    ..We aimed to identify factors assessable at diagnosis or after the first induction therapy which predicted relapse or later colectomy in patients with mild to severe ulcerative colitis...
  97. ncbi Increased expression of (pro)renin receptor in the remnant kidneys of 5/6 nephrectomized rats
    Takuo Hirose
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, 6 3 Aramaki Aza Aoba, Aoba ku, Sendai 980 8578, Japan
    Regul Pept 159:93-9. 2010
    ..These findings indicate that the intra-renal (P)RR expression is increased in the remnant kidneys of 5/6 nephrectomized rats, and suggest that (P)RR may contribute to the renal injury...
  98. ncbi Determinants of the second derivative of the finger photoplethysmogram and brachial-ankle pulse-wave velocity: the Ohasama study
    Junichiro Hashimoto
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Am J Hypertens 18:477-85. 2005
    ....
  99. ncbi Increased expression of adrenomedullin 2/intermedin in rat hearts with congestive heart failure
    Takuo Hirose
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, 6 3 Aramaki Aza Aoba, Sendai 980 8578, Japan
    Eur J Heart Fail 10:840-9. 2008
    ..These findings suggest that the expression of AM2/IMD is enhanced in the failing heart, and AM2/IMD has a certain pathophysiological role in heart failure...
  100. ncbi Elevated plasma levels of immunoreactive urotensin II and its increased urinary excretion in patients with Type 2 diabetes mellitus: association with progress of diabetic nephropathy
    Kazuhito Totsune
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Miyagi 980 8578, Japan
    Peptides 25:1809-14. 2004
    ....
  101. ncbi Out-of-office blood pressure control among treated subjects
    Taku Obara
    Hypertension 49:e40-1; author reply e42. 2007