Masaaki Nakayama

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi request reprint Kidney dysfunction as a risk factor for first symptomatic stroke events in a general Japanese population--the Ohasama study
    Masaaki Nakayama
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, and Ohasama Hospital, Iwate, Japan
    Nephrol Dial Transplant 22:1910-5. 2007
  2. doi request reprint Biological effects of electrolyzed water in hemodialysis
    Masaaki Nakayama
    Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Nephron Clin Pract 112:c9-15. 2009
  3. doi request reprint A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial
    Masaaki Nakayama
    Tohoku University Hospital, Department of Blood Purification, Sendai, Japan
    Nephrol Dial Transplant 25:3026-33. 2010
  4. doi request reprint Different clinical outcomes for cardiovascular events and mortality in chronic kidney disease according to underlying renal disease: the Gonryo study
    Masaaki Nakayama
    Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Clin Exp Nephrol 14:333-9. 2010
  5. ncbi request reprint Novel low Na peritoneal dialysis solutions designed to optimize Na gap of effluent: kinetics of Na and water removal
    Masaaki Nakayama
    Tohoku University Graduate School of Medicine, Sendai, Japan
    Perit Dial Int 29:528-35. 2009
  6. ncbi request reprint Fluid status and its management in Japanese peritoneal dialysis patients
    Masaaki Nakayama
    Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Perit Dial Int 26:144-9. 2006
  7. doi request reprint Polymorphonuclear leukocyte injury by methylglyoxal and hydrogen peroxide: a possible pathological role for enhanced oxidative stress in chronic kidney disease
    Masaaki Nakayama
    Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi aoba ku, Sendai 980 8574, Japan
    Nephrol Dial Transplant 23:3096-102. 2008
  8. ncbi request reprint The effect of angiotensin receptor blockade ARB on the regression of left ventricular hypertrophy in hemodialysis patients: comparison between patients with D allele and non-D allele ACE gene polymorphism
    M Nakayama
    Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Nephrol 64:358-63. 2005
  9. ncbi request reprint Radical generation by the non-enzymatic reaction of methylglyoxal and hydrogen peroxide
    Masaaki Nakayama
    Tohoku University Graduate School of Medicine, Research Division of Dialysis and Chronic Kidney Disease, Sendai, Japan
    Redox Rep 12:125-33. 2007
  10. ncbi request reprint Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water
    Masaaki Nakayama
    Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hemodial Int 11:322-7. 2007

Detail Information

Publications63

  1. ncbi request reprint Kidney dysfunction as a risk factor for first symptomatic stroke events in a general Japanese population--the Ohasama study
    Masaaki Nakayama
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, and Ohasama Hospital, Iwate, Japan
    Nephrol Dial Transplant 22:1910-5. 2007
    ..Although a high prevalence of stroke is a characteristic feature in Japanese populations, it is unclear whether CKD constitutes a risk for stroke events...
  2. doi request reprint Biological effects of electrolyzed water in hemodialysis
    Masaaki Nakayama
    Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Nephron Clin Pract 112:c9-15. 2009
    ..The present study examined the biological actions of this water on human polymorphonuclear leukocytes (PMNs), and the clinical feasibility of applying this technology to HD treatment...
  3. doi request reprint A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial
    Masaaki Nakayama
    Tohoku University Hospital, Department of Blood Purification, Sendai, Japan
    Nephrol Dial Transplant 25:3026-33. 2010
    ..Hydrogen gas (H(2)) ameliorates oxidative and inflammatory injuries to organs in animal models. We developed an HD system using a dialysis solution with high levels of dissolved H(2) and examined the clinical effects...
  4. doi request reprint Different clinical outcomes for cardiovascular events and mortality in chronic kidney disease according to underlying renal disease: the Gonryo study
    Masaaki Nakayama
    Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Clin Exp Nephrol 14:333-9. 2010
    ..Clarification of this issue is important for stratifying risk of cardiovascular disease (CVD) and death in patients before dialysis...
  5. ncbi request reprint Novel low Na peritoneal dialysis solutions designed to optimize Na gap of effluent: kinetics of Na and water removal
    Masaaki Nakayama
    Tohoku University Graduate School of Medicine, Sendai, Japan
    Perit Dial Int 29:528-35. 2009
    ..Novel low Na solutions were developed based on the concept of optimizing the Na gap of effluent to achieve better Na balance. The present study investigated Na and water removal by those solutions...
  6. ncbi request reprint Fluid status and its management in Japanese peritoneal dialysis patients
    Masaaki Nakayama
    Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Perit Dial Int 26:144-9. 2006
    ..Other means of managing fluid overload, such as drug therapy, combination (complementary) therapy with hemodialysis, and low sodium PD solution, are also explored and summarized in this article...
  7. doi request reprint Polymorphonuclear leukocyte injury by methylglyoxal and hydrogen peroxide: a possible pathological role for enhanced oxidative stress in chronic kidney disease
    Masaaki Nakayama
    Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi aoba ku, Sendai 980 8574, Japan
    Nephrol Dial Transplant 23:3096-102. 2008
    ..Thus, we tested if a high MGO of uraemic milieu could play a role in PMN injury by interaction with H(2)O(2)...
  8. ncbi request reprint The effect of angiotensin receptor blockade ARB on the regression of left ventricular hypertrophy in hemodialysis patients: comparison between patients with D allele and non-D allele ACE gene polymorphism
    M Nakayama
    Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Nephrol 64:358-63. 2005
    ..Furthermore, it has not clearly determined if ACE gene polymorphism has a possible influential effect on it. This study is conducted to clarify these issues...
  9. ncbi request reprint Radical generation by the non-enzymatic reaction of methylglyoxal and hydrogen peroxide
    Masaaki Nakayama
    Tohoku University Graduate School of Medicine, Research Division of Dialysis and Chronic Kidney Disease, Sendai, Japan
    Redox Rep 12:125-33. 2007
    ..However, the exact mechanism by which these molecules induce oxidative stress is unclear. We hypothesized that intermediate compounds, such as free radicals, are generated during the chemical reaction between H(2)O(2) and MG or GO...
  10. ncbi request reprint Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water
    Masaaki Nakayama
    Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hemodial Int 11:322-7. 2007
    ..These results appear to offer a scientific basis for supporting the clinical challenge of applying this technology to HD treatment...
  11. ncbi request reprint Association of kidney dysfunction with silent lacunar infarcts and white matter hyperintensity in the general population: the Ohasama study
    Harunori Otani
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Cerebrovasc Dis 30:43-50. 2010
    ..No previous study has investigated the association of kidney dysfunction with silent lacunar infarcts and white-matter hyperintensity (WMH) independent of ambulatory blood pressure (BP)...
  12. pmc Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats
    Xianguang Chen
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 36:361-7. 2013
    ..These results suggest that MG-induced hypertension and cardio-renal injury and increased inflammation and carbonyl and oxidative stress, which were partially preventable by an ARB...
  13. doi request reprint Masked hypertension determined by self-measured blood pressure at home and chronic kidney disease in the Japanese general population: the Ohasama study
    Hiroyuki Terawaki
    Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine and Pharmaceutical Sciences, Sendai, Japan
    Hypertens Res 31:2129-35. 2008
    ..56) and SHT (3.60) groups compared with the SNBP group (reference). MHT, like SHT, is closely related to CKD, and HBP measurement could be a useful screening strategy to detect CKD in the general population...
  14. doi request reprint Pre-hypertension as a significant predictor of chronic kidney disease in a general population: the Ohasama Study
    Atsuhiro Kanno
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Medicine and PharmaceuticalSciences, Sendai, Japan
    Nephrol Dial Transplant 27:3218-23. 2012
    ..Hypertension is associated with an increased risk of development of chronic kidney disease (CKD). However, it is unclear whether pre-hypertension is related to the incidence of CKD...
  15. doi request reprint Metabolomic profiling of uremic solutes in CKD patients
    Takafumi Toyohara
    Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 33:944-52. 2010
    ..These compounds provide diagnostic information and may be targets for therapies designed to treat the complications of CKD patients...
  16. doi request reprint Plasma alpha-oxoaldehyde levels in diabetic and nondiabetic chronic kidney disease patients
    Keisuke Nakayama
    Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Am J Nephrol 28:871-8. 2008
    ..Plasma levels of these substances are reportedly elevated in diabetes and dialysis patients, but the data on exact levels and clinical significance in chronic kidney disease (CKD) are limited...
  17. doi request reprint Increased risk of cardiovascular events and mortality among non-diabetic chronic kidney disease patients with hypertensive nephropathy: the Gonryo study
    Masaaki Nakayama
    Tohoku University Graduate School of Medicine, Center for Advanced Integrated Renal Science, Sendai, Japan
    Hypertens Res 34:1106-10. 2011
    ..HN is associated with an increased risk of CVD events and death among non-diabetic CKD patients, which highlights the clinical significance of HN...
  18. doi request reprint Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats
    Wan Jun Zhu
    Division of Nephrology, Endocrinology and Vascular Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan
    Nephrol Dial Transplant 26:2112-8. 2011
    ..We studied the biological effects of water with dissolved H(2) on ischemia-induced cardio-renal injury in a rat model of chronic kidney disease (CKD)...
  19. doi request reprint Usefulness of assessing masked and white-coat hypertension by ambulatory blood pressure monitoring for determining prevalent risk of chronic kidney disease: the Ohasama study
    Atsuhiro Kanno
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Medicine and Pharmaceutical Sciences, Aoba ku, Sendai, Japan
    Hypertens Res 33:1192-8. 2010
    ..0001), MHT (OR, 2.29; 95% CI, 1.45-3.63; P=0.0004) and WCHT (OR, 1.67; 95% CI, 1.03-2.71; P=0.0368). CKD was significantly associated with MHT and WCHT on the basis of ABP monitoring compared with SNBP in the general Japanese population...
  20. ncbi request reprint Reduction of serum antioxidative capacity during hemodialysis
    Keisuke Nakayama
    Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi aoba ku, Sendai 980 8574, Japan
    Clin Exp Nephrol 11:218-24. 2007
    ..The purpose of this study was to assess patients' oxidative status during and after HD, and to clarify the relation between oxidative status and antioxidant solutes such as uric acid (UA) and ascorbic acid (AsA)...
  21. ncbi request reprint Dialyzable uremic solutes contribute to enhanced oxidation of serum albumin in regular hemodialysis patients
    Hiroyuki Terawaki
    Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Blood Purif 25:274-9. 2007
    ..However, the in vivo redox state of HD patients, particularly after HD sessions, remains unclear. This study aimed to clarify the influence of HD on OS using the albumin redox state as a marker...
  22. doi request reprint Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure
    Susumu Ogawa
    Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Hypertension 56:471-6. 2010
    ..DG is an independent risk factor for the percentage change of ACR. MG is a predictor in type 2 diabetic patients of intima-media thickening, of increase of PWV, and of elevation of SBP...
  23. pmc Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water
    Wan Jun Zhu
    Center for Advanced and Integrated Renal Science, Tohoku University, Sendai, Japan
    Med Gas Res 3:26. 2013
    ....
  24. doi request reprint Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells
    Noriko Miyazawa
    Tohoku University Hospital, Division of Nephrology, Endocrinology and Vascular Medicine, Sendai, Miyagi, 980 8574, Japan
    Free Radic Res 44:101-7. 2010
    ..These data suggest that MGO stimulates superoxide production from mitochondria and partially stimulates nitric oxide synthase in human endothelial cells...
  25. ncbi request reprint Transluminal replacement of displaced peritoneal catheter using a special "alpha-replacer" guidewire: effectiveness and limitations
    Hiroyuki Terawaki
    Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Perit Dial Int 27:702-6. 2007
    ..The "alpha-replacer" is a special guidewire developed specifically for TRC. This wire is usually flexible but becomes harder if coiled in the hand. Application of this unique guidewire might improve the effectiveness of TRC...
  26. doi request reprint Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague-Dawley rats
    Qi Guo
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    J Hypertens 27:1664-71. 2009
    ..The present study was designed to investigate whether methylglyoxal could directly induce insulin resistance and salt sensitivity in Sprague-Dawley rats...
  27. doi request reprint Characteristic effects of methylglyoxal and its degraded product formate on viability of human histiocytes: a possible detoxification pathway of methylglyoxal
    Kenji Koizumi
    Tohoku University Graduate School of Medicine, Division of Nephrology, Endocrinology and Vascular Medicine, Department of Blood Purification, Tohoku University Hospital, Sendai, Japan
    Biochem Biophys Res Commun 407:426-31. 2011
    ..These findings suggest that FA production by MGO degradation may play a role in attenuation of oxidative cellular injury caused by MGO. We hypothesize that FA generation pathway constitutes a detoxification system for MGO...
  28. pmc SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation
    Takafumi Toyohara
    Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan
    J Am Soc Nephrol 20:2546-55. 2009
    ..These data suggest that drugs that upregulate SLCO4C1 may have therapeutic potential for patients with CKD...
  29. doi request reprint Long-acting neuraminidase inhibitor laninamivir octanoate versus oseltamivir for treatment of influenza: A double-blind, randomized, noninferiority clinical trial
    Akira Watanabe
    Research Division for Development of Anti infective Agents, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Clin Infect Dis 51:1167-75. 2010
    ..This study evaluated the clinical efficacy of laninamivir octanoate for the treatment of adult influenza patients...
  30. ncbi request reprint Trend of westernization of etiology and clinical characteristics of heart failure patients in Japan--first report from the CHART-2 study
    Nobuyuki Shiba
    Department of Evidence based Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Circ J 75:823-33. 2011
    ..The Chronic Heart Failure Analysis and Registry in the Tohoku District 2 (CHART-2) Study was designed to elucidate characteristics and prognosis of patients at high risk for CVD progression due to AHFS...
  31. ncbi request reprint Increased secretion of adrenomedullin from cultured human astrocytes by cytokines
    K Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    J Neurochem 74:99-103. 2000
    ..The present study has shown the production and secretion of adrenomedullin by human astrocytes and increased secretion of adrenomedullin by cytokines...
  32. ncbi request reprint [Assessment of competence of predialysis chronic kidney disease stage 5 patients to make treatment decisions: preliminary report]
    Hiroyuki Terawaki
    Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine, Japan
    Nihon Jinzo Gakkai Shi 50:915-26. 2008
    ..432, p = 0.031 and r = 0.542, p = 0.014, respectively). These results suggest that the competence of predialysis CKD stage 5 patients to consent to treatment is impaired partly via an attentional deficit...
  33. ncbi request reprint Differential expression of adrenomedullin and its receptor component, receptor activity modifying protein (RAMP) 2 during hypoxia in cultured human neuroblastoma cells
    T Kitamuro
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 980-8575, Sendai, Miyagi, Japan
    Peptides 22:1795-801. 2001
    ..The decreased expression of RAMP2 and the ADM expression induction under hypoxia may constitute one mechanism of cellular adaptation to hypoxic stress...
  34. ncbi request reprint [Effect of angiotensin II receptor antagonist (losartan) on renal function, serum potassium and blood pressure in patients with advanced renal failure: differences between patients with a serum creatinine (SCr) level higher than 3 mg/dl and those with a l
    Masaaki Nakayama
    Department of Kidney and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Nihon Jinzo Gakkai Shi 44:530-6. 2002
    ..0 mg/dl and those with a lower level. The results also support the notion that patients with advanced renal dysfunction are not precluded from AIIA administration...
  35. ncbi request reprint Alpha-oxoaldehydes in haemodialysis solution
    Keisuke Nakayama
    Nephrol Dial Transplant 22:2097-8. 2007
  36. ncbi request reprint Oxidative stress is enhanced in correlation with renal dysfunction: examination with the redox state of albumin
    Hiroyuki Terawaki
    Department of Nephrology and Hypertension, Tokyo Jikei University School of Medicine, Tokyo, Japan
    Kidney Int 66:1988-93. 2004
    ..Human serum albumin (HSA) is composed of human mercaptoalbumin (HMA) with cysteine residues having reducing powers, of reversibly oxidized human non-mercaptoalbumin-1 (HNA-1), and strongly oxidized human non-mercaptoalbumin-2 (HNA-2)...
  37. ncbi request reprint Significance of screening for Fabry disease among male dialysis patients
    Mayuri Ichinose
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo, 105 8461, Japan
    Clin Exp Nephrol 9:228-32. 2005
    ..In this study, we clarified the incidence of this atypical variant of Fabry disease in hemodialysis patients...
  38. ncbi request reprint Hyper-vascular change and formation of advanced glycation endproducts in the peritoneum caused by methylglyoxal and the effect of an anti-oxidant, sodium sulfite
    Masaaki Nakayama
    Division of Kidney and Hypertension, Tokyo Jikei University School of Medicine, Tokyo, Japan
    Am J Nephrol 23:390-4. 2003
    ..This study was conducted to (a) examine the acute effect of MGO on the peritoneum (including AGE formation) and (b) study the possible AGE suppressive effect of an anti-oxidant, sodium sulfite...
  39. ncbi request reprint Association between an increased surface area of peritoneal microvessels and a high peritoneal solute transport rate
    Miwako Numata
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Perit Dial Int 23:116-22. 2003
    ....
  40. ncbi request reprint Restoration of peritoneal integrity after withdrawal of peritoneal dialysis: characteristic features of the patients at risk of encapsulating peritoneal sclerosis
    Yasushi Otsuka
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishishinbashi, Tokyo 105 8461, Japan
    Clin Exp Nephrol 9:315-9. 2005
    ..Accordingly, we aimed to observe changes in peritoneal function after the stoppage of PD, and to clarify the characteristic features of the patients at risk of EPS...
  41. ncbi request reprint Combination therapy with peritoneal dialysis and hemodialysis
    Hideki Kawanishi
    Tsuchiya General Hospital, 3 30 Nakajimacho, Naka ku, Hiroshima 730 8655, Japan
    Perit Dial Int 26:150-4. 2006
  42. ncbi request reprint Risk factors for encapsulating peritoneal sclerosis in patients who have experienced peritoneal dialysis treatment
    Ryo Yamamoto
    Department of Kidney and Hypertension, The Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan
    Clin Exp Nephrol 9:148-52. 2005
    ..The present study was conducted to clarify the clinical risk factors related to the development of encapsulating peritoneal sclerosis (EPS), which is one of the most serious complications in patients undergoing peritoneal dialysis (PD)...
  43. ncbi request reprint Effect of repeated intravenous iron administration in haemodialysis patients on serum 8-hydroxy-2'-deoxyguanosine levels
    Yukio Maruyama
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 19 18 Nishi shinbashi, Minato ku, Tokyo, 105 8471, Japan
    Nephrol Dial Transplant 22:1407-12. 2007
    ..This study aims to clarify the time course of changes in serum 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of DNA oxidative injury, during a period of repeated IVIR administration in HD patients...
  44. ncbi request reprint [Survey on the current status of delivered informed consent for renal replacement therapy among patients with end-stage renal disease]
    Hirofumi Nakano
    Society for Senile Patients on Peritoneal Dialysis
    Nihon Jinzo Gakkai Shi 48:658-63. 2006
    ..Delivered information about RRT to ESRD patients may be biased in Japan. The findings of this study suggested that a lack of medical experience of the modality contributes to insufficient IC...
  45. ncbi request reprint Multicenter survey on hydration status and control of blood pressure in Japanese CAPD patients
    Masaaki Nakayama
    Department of Internal Medicine, Tokyo Jikei University School of Medicine, Japan
    Perit Dial Int 22:411-4. 2002
  46. ncbi request reprint Elevated oxidative stress measured as albumin redox state in continuous ambulatory peritoneal dialysis patients correlates with small uraemic solutes
    Hiroyuki Terawaki
    Nephrol Dial Transplant 22:968. 2007
  47. ncbi request reprint Peritoneal ultrafiltration and serum icodextrin concentration during dialysis with 7.5% icodextrin solution in Japanese patients
    Kazuo Ota
    Ota Medical Research Institute, Tokyo, Japan
    Perit Dial Int 23:356-61. 2003
    ..To assess the efficacy and safety of icodextrin in Japanese patients and to investigate the relationship between net ultrafiltration (UF) during the long dwell and plasma oligosaccharides...
  48. ncbi request reprint High-transport membrane is a risk factor for encapsulating peritoneal sclerosis developing after long-term continuous ambulatory peritoneal dialysis treatment
    Ryo Yamamoto
    Division of Kidney and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Adv Perit Dial 18:131-4. 2002
    ..That finding may indicate that HT state of peritoneal membrane is an early marker for EPS, and that the PET is useful to detect patients at high risk of EPS...
  49. ncbi request reprint The negative Ca(2+) balance is involved in the stimulation of PTH secretion
    Keitaro Yokoyama
    Division of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Nephron 92:86-90. 2002
    ..This suggests that low Ca(2+) dialysate may exaggerate the progression of secondary hyperparathyroidism...
  50. ncbi request reprint Clinical significance of the K/DOQI bone guidelines in Japan
    Keitaro Yokoyama
    Am J Kidney Dis 44:383-4; author reply 384. 2004
  51. ncbi request reprint Correction of CAPD catheter displacement using alpha-replacement method
    Shinya Kawamoto
    Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University Daisan Hospital, 4 11 1 Izumihonchou, Komae, Tokyo 201 8601, Japan
    Clin Exp Nephrol 9:53-7. 2005
    ..The alpha-replacement method is a nonsurgical procedure; however, the reported clinical experience has been limited. We thus reviewed our 19 cases to clarify the efficacy of this method...
  52. ncbi request reprint Fifteen cases of encapsulating peritoneal sclerosis related to peritoneal dialysis: a single-center experience in Japan
    Hiroyasu Yamamoto
    Department of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Adv Perit Dial 18:135-8. 2002
    ..3%. When EPS symptoms are not ameliorated by CS and TPN, surgical treatment should be considered. To prevent EPS, high-risk patients who have more than 72 months on CAPD and who have a high-transport peritoneum should discontinue CAPD...
  53. ncbi request reprint High iron storage levels are associated with increased DNA oxidative injury in patients on regular hemodialysis
    Kazunobu Yoshimura
    Department of Kidney and Hypertension, Tokyo Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan
    Clin Exp Nephrol 9:158-63. 2005
    ..Here, we report our investigation of the relation between iron storage and DNA oxidative injury in HD patients...
  54. ncbi request reprint Relationship between the -374T/A receptor of advanced glycation end products gene polymorphism and peritoneal solute transport status at the initiation of peritoneal dialysis
    Yukio Maruyama
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Ther Apher Dial 11:301-5. 2007
    ..03). Genetic polymorphisms of the VEGF and eNOS were not associated with initial peritoneal transport type. The RAGE polymorphism may have a considerable effect on the basal PSTR. Further studies will be needed to confirm this hypothesis...
  55. ncbi request reprint Quantitative assessment of the peritoneal vessel density and vasculopathy in CAPD patients
    Ali M Sherif
    Department of Kidney and Hypertension, The Jikei University School of Medicine, 3 19 18 Nishi shinbashi, Tokyo 105 8471, Japan
    Nephrol Dial Transplant 21:1675-81. 2006
    ..We present a quantitative analysis of peritoneal vascular density as well as vasculopathy grades in relation to PD duration...
  56. pmc Impact of uremia, diabetes, and peritoneal dialysis itself on the pathogenesis of peritoneal sclerosis: a quantitative study of peritoneal membrane morphology
    Kazuho Honda
    Department of Pathology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Clin J Am Soc Nephrol 3:720-8. 2008
    ..g., uremia). A quantitative method for peritoneal biopsy evaluation is required to investigate possible causative factors and severity of the peritoneal dialysis-related peritoneal alterations...
  57. ncbi request reprint Successful use of icodextrin in elderly patients on continuous ambulatory peritoneal dialysis
    Hidetomo Nakamoto
    Department of Nephrology, Tokorozawa Kidney Clinic, Saitama, Japan
    Adv Perit Dial 21:168-74. 2005
    ..From the foregoing data, we concluded that, as compared with conventional glucose solution, icodextrin has beneficial effects on ultrafiltration volume and clinical symptoms in elderly patients on CAPD...
  58. ncbi request reprint Recommendations on the management of encapsulating peritoneal sclerosis in Japan, 2005: diagnosis, predictive markers, treatment, and preventive measures
    Yoshindo Kawaguchi
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Perit Dial Int 25:S83-95. 2005
    ..Aspects covered include diagnosis, risk factors and predictive markers, treatment, and prevention, including criteria for withdrawal from peritoneal dialysis...
  59. ncbi request reprint The plasma leak-to-response hypothesis: a working hypothesis on the pathogenesis of encapsulating peritoneal sclerosis after long-term peritoneal dialysis treatment
    Masaaki Nakayama
    Department of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Perit Dial Int 25:S71-6. 2005
    ..The present article proposes a working hypothesis--the plasma leak-to-response hypothesis--that vascular alterations in the peritoneum of long-term PD patients play a crucial role in the initiation and development of EPS...
  60. ncbi request reprint [Dialysis as bridge therapy for renal transplantation: single center experience, a comparison of hemodialysis and continuous ambulatory peritoneal dialysis]
    Jun Mitome
    Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Nihon Jinzo Gakkai Shi 47:813-20. 2005
    ..Therefore, we evaluated the influence of dialytic modality on the rate of kidney transplantation and outcome in our single center...
  61. ncbi request reprint Encapsulating peritoneal sclerosis is a separate entity: Con
    Masaaki Nakayama
    Division of Kidney and Hypertension, Tokyo Jikei University School of Medicine, Tokyo, Japan
    Perit Dial Int 25:S107-9. 2005
    ..There are pitfalls in these concepts and they need be revised. This paper discusses the issue against the idea that EPS is a separate entity, supporting the idea that it has a strong connection with SS in its primary pathophysiology...
  62. ncbi request reprint [Peritoneal injury and vasculopathy in peritoneal dialysis]
    Yukio Maruyama
    Division of Kidney and Hypertension, The Jikei University School of Medicine
    Nihon Rinsho 63:430-3. 2005
  63. ncbi request reprint Plasma pteridine concentrations in patients with chronic renal failure
    Keitaro Yokoyama
    The Division of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Nephrol Dial Transplant 17:1032-6. 2002
    ..Pteridine metabolism is impaired in the uraemic state. This may affect cardiovascular function and contribute to malnutrition. We wished to clarify further the impact of impaired pteridine metabolism...