I Nakashima

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. doi Transient increases in anti-aquaporin-4 antibody titers following rituximab treatment in neuromyelitis optica, in association with elevated serum BAFF levels
    Ichiro Nakashima
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Clin Neurosci 18:997-8. 2011
  2. ncbi Oligoclonal IgG bands in Japanese patients with multiple sclerosis. A comparative study between isoelectric focusing with IgG immunofixation and high-resolution agarose gel electrophoresis
    Ichiro Nakashima
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Neuroimmunol 159:133-6. 2005
  3. ncbi Absence of IgG1 response in the cerebrospinal fluid of relapsing neuromyelitis optica
    I Nakashima
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Neurology 62:144-6. 2004
  4. ncbi Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis
    T Misu
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Brain 130:1224-34. 2007
  5. doi Occurrence of acute large and edematous callosal lesions in neuromyelitis optica
    M Nakamura
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Mult Scler 15:695-700. 2009
  6. ncbi Therapeutic efficacy of plasma exchange in NMO-IgG-positive patients with neuromyelitis optica
    S Watanabe
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Mult Scler 13:128-32. 2007
  7. pmc Clinical and MRI features of Japanese patients with multiple sclerosis positive for NMO-IgG
    I Nakashima
    Department of Neurology, Tohoku University School of Medicine, Sendai 980 8574, Japan
    J Neurol Neurosurg Psychiatry 77:1073-5. 2006
  8. doi Intractable hiccup and nausea in neuromyelitis optica with anti-aquaporin-4 antibody: a herald of acute exacerbations
    T Takahashi
    Department of Neurology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    J Neurol Neurosurg Psychiatry 79:1075-8. 2008
  9. doi Preferential spinal central gray matter involvement in neuromyelitis optica. An MRI study
    M Nakamura
    Dept of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Japan
    J Neurol 255:163-70. 2008
  10. ncbi Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica
    T Misu
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Neurology 65:1479-82. 2005

Collaborators

Detail Information

Publications50

  1. doi Transient increases in anti-aquaporin-4 antibody titers following rituximab treatment in neuromyelitis optica, in association with elevated serum BAFF levels
    Ichiro Nakashima
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Clin Neurosci 18:997-8. 2011
    ..Although anti-AQP4 antibodies appear to decrease overall following rituximab treatment, our findings raise concern over the potential for an early BAFF-mediated worsening of patients with NMO receiving rituximab...
  2. ncbi Oligoclonal IgG bands in Japanese patients with multiple sclerosis. A comparative study between isoelectric focusing with IgG immunofixation and high-resolution agarose gel electrophoresis
    Ichiro Nakashima
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Neuroimmunol 159:133-6. 2005
    ..When OSMS was excluded, the frequency increased to 77% by IEF, whereas it remained 23% by AGE. Our study strongly suggests that IEF is highly effective for detecting OB in Japanese MS patients...
  3. ncbi Absence of IgG1 response in the cerebrospinal fluid of relapsing neuromyelitis optica
    I Nakashima
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Neurology 62:144-6. 2004
    ..The absence of the CSF IgG1 responses in the patients with RNMO may suggest less Th1 immunity and may also explain the rarity of oligoclonal IgG bands in patients with this disease...
  4. ncbi Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis
    T Misu
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Brain 130:1224-34. 2007
    ....
  5. doi Occurrence of acute large and edematous callosal lesions in neuromyelitis optica
    M Nakamura
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Mult Scler 15:695-700. 2009
    ..The corpus callosum is commonly involved in multiple sclerosis (MS), but the characteristics of callosal lesions in neuromyelitis optica (NMO) are unknown.ObjectiveTo reveal the features of callosal lesions in NMO in comparison to MS...
  6. ncbi Therapeutic efficacy of plasma exchange in NMO-IgG-positive patients with neuromyelitis optica
    S Watanabe
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Mult Scler 13:128-32. 2007
    ..PE may hasten the functional recovery from corticosteroid-resistant relapses in some NMO-IgG-positive patients with NMO...
  7. pmc Clinical and MRI features of Japanese patients with multiple sclerosis positive for NMO-IgG
    I Nakashima
    Department of Neurology, Tohoku University School of Medicine, Sendai 980 8574, Japan
    J Neurol Neurosurg Psychiatry 77:1073-5. 2006
    ..This newly discovered serum autoantibody was markedly associated with longitudinally extensive spinal cord lesions and with complete blindness, suggesting severe optic-spinal disease...
  8. doi Intractable hiccup and nausea in neuromyelitis optica with anti-aquaporin-4 antibody: a herald of acute exacerbations
    T Takahashi
    Department of Neurology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    J Neurol Neurosurg Psychiatry 79:1075-8. 2008
    ..Recent studies have strongly suggested that the pathogenesis of NMO is closely associated with anti-aquaporin-4 (AQP4) antibody. However, clinical implications of IHN and the relationship with anti-AQP4 antibody remain unknown...
  9. doi Preferential spinal central gray matter involvement in neuromyelitis optica. An MRI study
    M Nakamura
    Dept of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Japan
    J Neurol 255:163-70. 2008
    ..To delineate the MRI features that distinguish neuromyelitis optica (NMO) from multiple sclerosis (MS)...
  10. ncbi Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica
    T Misu
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Neurology 65:1479-82. 2005
    ..Like long and centrally located myelitis, a linear medullary lesion causing IHN may distinguish NMO from MS...
  11. ncbi Clinical and laboratory features of neuromyelitis optica with oligoclonal IgG bands
    M Nakamura
    Department of Neurology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8574, Japan
    Mult Scler 13:332-5. 2007
    ..Although OBs are mostly negative in NMO, which distinguishes it from multiple sclerosis (MS), they can be positive by long-standing autoimmunity, which may not be directly related to NMO...
  12. ncbi Low-dose corticosteroids reduce relapses in neuromyelitis optica: a retrospective analysis
    S Watanabe
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Mult Scler 13:968-74. 2007
    ..75). The results of the present study suggest a beneficial effect of low-dose CS monotherapy in reducing relapses in NMO...
  13. doi Pain in neuromyelitis optica and its effect on quality of life: a cross-sectional study
    Y Kanamori
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Neurology 77:652-8. 2011
    ..To assess the features of pain and its impact on the health-related quality of life (HRQOL) in neuromyelitis optica (NMO)...
  14. ncbi Significant correlation between IL-10 levels and IgG indices in the cerebrospinal fluid of patients with multiple sclerosis
    I Nakashima
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, 980 8574, Sendai, Japan
    J Neuroimmunol 111:64-7. 2000
    ..The results remained unchanged even when OS-MS patients were excluded. Our results may suggest a role of IL-10 in upregulating the intrathecal IgG synthesis in relapsing MS...
  15. ncbi Elevated plasma level of plasminogen activator inhibitor-1 (PAI-1) in patients with relapsing-remitting multiple sclerosis
    H Onodera
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 189:259-65. 1999
    ..These results suggested that PAI-1 plasma levels are associated with MS disease activity and is a good marker for MS relapse...
  16. ncbi Decrease in multiple sclerosis with acute transverse myelitis in Japan
    I Nakashima
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 188:89-94. 1999
    ..Since the genetic background of Japanese has not changed, some exogenous factors, such as food, infectious microorganisms, and chemicals in our environment, may be responsible for the change...
  17. ncbi Relevance of callosal and periventricular MRI lesions to oligoclonal bands in multiple sclerosis
    I Nakashima
    Department of Neurology, Tohoku University School of Medicine, Seiryo machi, Sendai, Japan
    Acta Neurol Scand 113:125-31. 2006
    ..To evaluate the association between callosal or periventricular lesions, and the presence of oligoclonal IgG bands (OB) or the IgG index in Japanese patients with multiple sclerosis (MS)...
  18. ncbi A comparative study of Japanese multiple sclerosis patients with and without oligoclonal IgG bands
    I Nakashima
    Department of Neurology, Tohoku University School of Medicine, Sendai 980 8574, Japan
    Mult Scler 8:459-62. 2002
    ..Our results suggest that the majority of OB-negative Japanese MS patents show either no or few brain MRI lesions or atypical brain MRI lesions...
  19. pmc Clinical and MRI study of brain stem and cerebellar involvement in Japanese patients with multiple sclerosis
    I Nakashima
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Japan
    J Neurol Neurosurg Psychiatry 67:153-7. 1999
    ..To investigate the clinical and MRI features of brain stem and cerebellar lesions in Japanese patients with multiple sclerosis...
  20. ncbi High CSF neurofilament heavy chain levels in neuromyelitis optica
    I Miyazawa
    Department of Neurology, Tohoku University School of Medicine, Seiryo machi, Aoba ku, Sendai, Japan
    Neurology 68:865-7. 2007
    ..Significantly high CSF NfHSMI35 levels (>0.73 ng/mL) were found in 6 of 24 (25%) of the patients with NMO but none of the patients with MS (0/24). This finding suggests that axonal damage is more severe in NMO than in MS...
  21. ncbi Human parvovirus B19 infection in multiple sclerosis
    I Nakashima
    Department of Neurology, Tohoku University, School of Medicine, Sendai, Japan
    Eur Neurol 42:36-40. 1999
    ..Although MS patients may be commonly infected with PVB19, our results suggest that there is no active PVB19 infection during exacerbation of MS...
  22. ncbi Linear pontine trigeminal root lesions in multiple sclerosis: clinical and magnetic resonance imaging studies in 5 cases
    I Nakashima
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Arch Neurol 58:101-4. 2001
    ..Linearly shaped lesions at the trigeminal root entry zone have been occasionally reported in single cases of MS, but, to our knowlege, the frequency and the clinical features of such patients have not been comprehensively characterized...
  23. ncbi [Multiple sclerosis--recent advances in pathogenesis and treatment]
    Yasuto Itoyama
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Sendai 980 8574, Japan
    No To Shinkei 54:5-21. 2002
  24. ncbi [Neuromyelitis optica and anti-aquaporin 4 antibody--distinct from multiple sclerosis]
    Tatsuro Misu
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Rinsho Byori 57:262-70. 2009
    ..Therefore, AQP4 antibody is indispensable in the diagnosis and treatment of NMO...
  25. ncbi Two different clinical phenotypes of Creutzfeldt-Jakob disease with a M232R substitution
    Yusei Shiga
    Department of Neurology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Neurol 254:1509-17. 2007
    ..To describe the clinical features of Creutzfeldt-Jakob disease with a substitution of arginine for methionine (M232R substitution) at codon 232 (CJD232) of the prion protein gene (PRNP)...
  26. ncbi Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre
    Toshiyuki Takahashi
    Department of Neurology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Brain 130:1235-43. 2007
    ....
  27. ncbi Successful treatment of carcinomatous meningitis with gefitinib in a patient with lung adenocarcinoma harboring a mutated EGF receptor gene
    Tatsuro Fukuhara
    Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Tohoku J Exp Med 214:359-63. 2008
    ..9 nM both before and 2 hrs after drug re-administration). Gefitinib treatment should be considered for patients with carcinomatous meningitis and lung adenocarcinoma harboring a mutated EGF gene...
  28. ncbi Two subtypes of optic-spinal form of multiple sclerosis in Japan: clinical and laboratory features
    Ichiro Nakashima
    Dept of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Neurol 254:488-92. 2007
    ..The percentage of OSMS without LESL in total OSMS has recently been increasing. The present study suggests that LESL is crucially important for distinguishing the two subtypes of OSMS...
  29. ncbi CSF chemokine levels in relapsing neuromyelitis optica and multiple sclerosis
    Koichi Narikawa
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    J Neuroimmunol 149:182-6. 2004
    ..Conversely, CCL2/MCP-1 was significantly lower in MS, but not in RNMO, than in control. CCL11/Eotaxin was not different between groups. None of the four chemokines studied was significantly different between RNMO and MS...
  30. ncbi Establishment of a new sensitive assay for anti-human aquaporin-4 antibody in neuromyelitis optica
    Toshiyuki Takahashi
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 210:307-13. 2006
    ..Thus, the newly developed anti-AQP4 antibody assay appears to have a higher sensitivity for NMO than the original NMO-IgG assay and is expected to be useful for the diagnosis of NMO...
  31. ncbi Alteration of cystatin C in the cerebrospinal fluid of multiple sclerosis
    Ichiro Nakashima
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Ann Neurol 62:197-200; discussion 205. 2007
    ..Enzyme-linked immunosorbent assay showed that the cystatin C levels tended to be lower in multiple sclerosis and NMO. Alterations of cystatin C may relate to the pathogeneses of demyelinating diseases...
  32. doi Candidate antigens specifically detected by cerebrospinal fluid-IgG in oligoclonal IgG bands-positive multiple sclerosis patients
    Masashi Nakamura
    Department of Neurology, Tohoku University School of Medicine, Aoba ku, Sendai, Japan
    Proteomics Clin Appl 1:681-7. 2007
    ..In addition, CSF-specific anti-gamma enolase IgG was found in another patient. These findings suggest that intrathecal immune responses may occur against a broad range of proteins in MS...
  33. ncbi Relapsing focal myositis: the localization detected by gallium citrate Ga 67 scintigraphy
    Tatsuro Misu
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Arch Neurol 62:1930-1. 2005
  34. ncbi Pure optic-spinal form of multiple sclerosis in Japan
    Tatsuro Misu
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Brain 125:2460-8. 2002
    ....
  35. ncbi Epitope analysis of the cerebrospinal fluid IgG in HTLV-I associated myelopathy patients using phage display method
    J Fujimori
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Neuroimmunol 152:140-6. 2004
    ..Gp46 237-243 has not been detected in previous enzyme-linked immunosorbent assay (ELISA) studies using bound longer peptides, suggesting the usefulness of the phage display method...
  36. ncbi [Transverse myelopathy with renovascular hypertension caused by fibromuscular dysplasia]
    M Matsuzaki
    Department of Neurology, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
    No To Shinkei 53:859-62. 2001
    ..We discussed the possibility of relationships between myelopathy, FMD, IL-8, and ANCA...
  37. ncbi [Magnetic resonance imaging for the diagnosis of multiple sclerosis]
    Ichiro Nakashima
    Department of Neurology, Tohoku University School of Medicine
    Nihon Rinsho 61:1340-6. 2003
    ..Moreover, most of Japanese MS patients without oligoclonal bands show atypical brain lesions which do not fulfill the MRI criteria for brain abnormality...
  38. ncbi [Case of Neuro-Beh├žet disease resembling bacterial meningitis]
    Masahiro Nezu
    Department of Neurology, Tohoku University School of Medicine
    Rinsho Shinkeigaku 48:750-3. 2008
    ..Serum procalcitonin was not increased. We diagnosed the recurrence of NBD retrospectively. Procalcitonin may be a useful marker for discrimination between meningitis due to NBD and septic meningitis...
  39. ncbi [New insights into the pathogenesis of neuromyelitis optica]
    Tatsuro Misu
    Departments of Neurology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Brain Nerve 62:921-31. 2010
    ..These evidences suggested the pathogenic role of AQP4 antibody with astrocytopathy in NMO. Now it is indispensable to check the AQP4 antibody,and is important to reconsider the role of astrocyte in demyelinating disorders...
  40. ncbi [A concept of neuromyelitis optica in Japan]
    Ichiro Nakashima
    Department of Neurology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Brain Nerve 62:913-9. 2010
    ..Since the discovery of NMO-IgG, various clinical and histopathological features of this condition have been recognized; in addition the concept of NMO has been established in Japan as well as in many other countries...
  41. ncbi Chemokine profile in the cerebrospinal fluid and serum of Vogt-Koyanagi-Harada disease
    Isabelle Miyazawa
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    J Neuroimmunol 158:240-4. 2005
    ..CCL11/Eotaxin was not different between groups. CSF-CCL2/MCP-1 was significantly lower in VKH than in control. The changes in VKH were essentially similar to those in multiple sclerosis, a known Th1-dominant condition...
  42. ncbi CSF-chemokines in HTLV-I-associated myelopathy: CXCL10 up-regulation and therapeutic effect of interferon-alpha
    Koichi Narikawa
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    J Neuroimmunol 159:177-82. 2005
    ..Following interferon (IFN)-alpha therapy in HAM/TSP, CCL2/MCP-1 became significantly higher than that before therapy, which may reflect a Th2 induction, while CXCL10/IP-10 remained elevated...
  43. ncbi [Pathogenesis of optic-spinal MS]
    Kazuo Fujihara
    Department of Neurology, Tohoku University School of Medicine
    Rinsho Shinkeigaku 42:1195-7. 2002
    ..These unique clinical and immunological findings probably relate to fundamental differences in the pathogeneses of OSMS and CMS and deserve further characterization...
  44. ncbi Ibudilast, a nonselective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in multiple sclerosis
    Juan Feng
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aoba ku, Sendai 980 8574, Japan
    Mult Scler 10:494-8. 2004
    ..None of the significant immunological changes were seen in healthy subjects or untreated MS patients. Ibudilast may be a promising therapy for MS and its clinical effects warrant further study...
  45. ncbi Soluble CD26 and CD30 levels in CSF and sera of patients with relapsing neuromyelitis optica
    Koichi Narikawa
    J Neurol 253:111-3. 2006
  46. ncbi [Multiple sclerosis and oligoclonal IgG bands]
    Ichiro Nakashima
    Division of Neurology, Department of Neuroscience, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    No To Shinkei 56:475-82. 2004
  47. ncbi OSMS is NMO, but not MS: proven clinically and pathologically
    Brian G Weinshenker
    Lancet Neurol 5:110-1. 2006
  48. ncbi A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis
    Vanda A Lennon
    Department of Neurology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Lancet 364:2106-12. 2004
    ..We assessed the capacity of a putative marker for neuromyelitis optica (NMO-IgG) to distinguish neuromyelitis optica and related disorders from multiple sclerosis...
  49. ncbi Complementarity-determining region 3 spectratyping analysis of the TCR repertoire in multiple sclerosis
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    J Immunol 170:4846-53. 2003
    ..2 spectratype expansion is associated with the development of MS and that TCR-based immunotherapy can be applicable to MS patients if the TCR activation pattern of each patient is determined at different stages of the disease...
  50. ncbi Successful treatment of a hypothalamic lesion in neuromyelitis optica by plasma exchange
    Shohei Watanabe
    J Neurol 254:670-1. 2007