Kiyotaka Nakagawa

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. doi request reprint Amyloid β-induced erythrocytic damage and its attenuation by carotenoids
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    FEBS Lett 585:1249-54. 2011
  2. ncbi request reprint Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma: application to pharmacokinetic studies
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 72:2210-3. 2008
  3. ncbi request reprint Studies targeting α-glucosidase inhibition, antiangiogenic effects, and lipid modification regulation: background, evaluation, and challenges in the development of food ingredients for therapeutic purposes
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 77:900-8. 2013
  4. ncbi request reprint Effects of co-administration of tea epigallocatechin-3-gallate (EGCG) and caffeine on absorption and metabolism of EGCG in humans
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Biosci Biotechnol Biochem 73:2014-7. 2009
  5. doi request reprint gamma-Tocotrienol reduces squalene hydroperoxide-induced inflammatory responses in HaCaT keratinocytes
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, 981 8555, Japan
    Lipids 45:833-41. 2010
  6. doi request reprint Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Br J Nutr 105:1563-71. 2011
  7. doi request reprint Phosphatidylcholine hydroperoxide promotes VEGF-induced angiogenesis in endothelial cells and rat aorta ring cultures
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Biochim Biophys Acta 1810:1205-11. 2011
  8. ncbi request reprint Amyloid β induces adhesion of erythrocytes to endothelial cells and affects endothelial viability and functionality
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 75:2030-3. 2011
  9. ncbi request reprint Distribution of tocotrienols in rats fed a rice bran tocotrienol concentrate
    Yuki Kawakami
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 71:464-71. 2007
  10. doi request reprint delta-Tocotrienol suppresses VEGF induced angiogenesis whereas alpha-tocopherol does not
    Akira Shibata
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Agric Food Chem 57:8696-704. 2009

Collaborators

Detail Information

Publications71

  1. doi request reprint Amyloid β-induced erythrocytic damage and its attenuation by carotenoids
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    FEBS Lett 585:1249-54. 2011
    ..As a preventive strategy, because the Aβ-induced RBC damage could be attenuated by treatment of RBC with xanthophylls, we suggest that xanthophylls may contribute to the prevention of AD...
  2. ncbi request reprint Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma: application to pharmacokinetic studies
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 72:2210-3. 2008
    ..We developed a method using hydrophilic interaction chromatography coupled with ion trap tandem mass spectrometry, and found that orally administered DNJ was absorbed into the blood and then excreted into the urine...
  3. ncbi request reprint Studies targeting α-glucosidase inhibition, antiangiogenic effects, and lipid modification regulation: background, evaluation, and challenges in the development of food ingredients for therapeutic purposes
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 77:900-8. 2013
    ..These studies are ongoing in our work, with an emphasis on analytical techniques...
  4. ncbi request reprint Effects of co-administration of tea epigallocatechin-3-gallate (EGCG) and caffeine on absorption and metabolism of EGCG in humans
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Biosci Biotechnol Biochem 73:2014-7. 2009
    ..These findings (modulation of plasma EGCG level by CAF) provide ideas for modulating the bioavailability of tea catechins, which can be applied to tea-related drinks and foods...
  5. doi request reprint gamma-Tocotrienol reduces squalene hydroperoxide-induced inflammatory responses in HaCaT keratinocytes
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, 981 8555, Japan
    Lipids 45:833-41. 2010
    ..These results suggest that SQ-OOH induces inflammatory responses in HaCaT, implying that SQ-OOH plays an important role in inflammatory skin disorders. As a preventive strategy, inflammation could be reduced via the use of gamma-T3...
  6. doi request reprint Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Br J Nutr 105:1563-71. 2011
    ..These results suggest that astaxanthin supplementation results in improved erythrocyte antioxidant status and decreased PLOOH levels, which may contribute to the prevention of dementia...
  7. doi request reprint Phosphatidylcholine hydroperoxide promotes VEGF-induced angiogenesis in endothelial cells and rat aorta ring cultures
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Biochim Biophys Acta 1810:1205-11. 2011
    ..The role of PCOOH in the induction of angiogenesis is unknown...
  8. ncbi request reprint Amyloid β induces adhesion of erythrocytes to endothelial cells and affects endothelial viability and functionality
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 75:2030-3. 2011
    ..These changes are likely to contribute to the pathogenesis of Alzheimer's disease...
  9. ncbi request reprint Distribution of tocotrienols in rats fed a rice bran tocotrienol concentrate
    Yuki Kawakami
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 71:464-71. 2007
    ..3 and 8.6 mg of vitamin E/kg b.w./day, respectively. Rice bran gamma-T3 was significantly distributed to the adipose tissue and increased from 1.1 to 10.2 nmol/g of adipose tissue according to the rice bran T3 intake...
  10. doi request reprint delta-Tocotrienol suppresses VEGF induced angiogenesis whereas alpha-tocopherol does not
    Akira Shibata
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Agric Food Chem 57:8696-704. 2009
    ..In summary, our results demonstrate delta-T3 has superior antiangiogenic activities to alpha-Toc, and provide insights into the different mechanisms responsible for this effect of T3 and Toc...
  11. doi request reprint Antioxidant effect of lutein towards phospholipid hydroperoxidation in human erythrocytes
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Br J Nutr 102:1280-4. 2009
    ..Therefore future biological and clinical studies will be required to evaluate the efficacy as well as safety of lutein in models of dementia with a realistic prospect of its use in human therapy...
  12. ncbi request reprint Ingestion of Chlorella reduced the oxidation of erythrocyte membrane lipids in senior Japanese subjects
    Taiki Miyazawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
    J Oleo Sci 62:873-81. 2013
    ..These reductions might contribute to maintaining the normal function of erythrocytes and prevent the development of senile dementia. ..
  13. doi request reprint Tumor anti-angiogenic effect and mechanism of action of delta-tocotrienol
    Akira Shibata
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Biochem Pharmacol 76:330-9. 2008
    ..These results suggest that T3 has potential use as a therapeutic dietary supplement for minimizing tumor angiogenesis...
  14. ncbi request reprint jacaric acid, a linolenic acid isomer with a conjugated triene system, reduces stearoyl-CoA desaturase expression in liver of mice
    Nahoko Shinohara
    Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aobaku, Sendai 981 8555, Japan
    J Oleo Sci 61:433-41. 2012
    ..Inhibition of SCD activity may have anti-obesity and anti-diabetes effects, and therefore the findings in this study suggest that JA may be effective for preventing obesity and diabetes...
  15. ncbi request reprint Ion-trap tandem mass spectrometric analysis of Amadori-glycated phosphatidylethanolamine in human plasma with or without diabetes
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Lipid Res 46:2514-24. 2005
    ..Furthermore, plasma Amadori-PE levels were positively correlated with PCOOH (a maker for oxidative stress). These results show the involvement between lipid glycation and lipid peroxidation in diabetes pathogenesis...
  16. ncbi request reprint DNA chip analysis of comprehensive food function: inhibition of angiogenesis and telomerase activity with unsaturated vitamin E, tocotrienol
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Life Science and Agriculture, Tohoku University, Sendai 981 8555, Japan
    Biofactors 21:5-10. 2004
    ..In this manner, DNA chip technology provides efficient access to genetic information regarding food function and its mechanism...
  17. ncbi request reprint Suppression of gamma-tocotrienol on UVB induced inflammation in HaCaT keratinocytes and HR-1 hairless mice via inflammatory mediators multiple signaling
    Akira Shibata
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Agric Food Chem 58:7013-20. 2010
    ..These results suggest T3 has potential use to protect against UVB-induced skin inflammation...
  18. ncbi request reprint Antiangiogenic potency of vitamin E
    Teruo Miyazawa
    Food and Biodynamic Chemistry Lab, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Ann N Y Acad Sci 1031:401-4. 2004
    ..Our findings suggest that T3 has potential as a therapeutic dietary supplement for preventing angiogenic disorders...
  19. doi request reprint Antiangiogenic and anticancer potential of unsaturated vitamin E (tocotrienol)
    Teruo Miyazawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Nutr Biochem 20:79-86. 2009
    ..In this work, we review the history and biological action (i.e., anticancer) of vitamin E and describe current research on the antiangiogenic effects of T3 and its mechanisms...
  20. ncbi request reprint Physiological effects and tissue distribution from large doses of tocotrienol in rats
    Akira Shibata
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Biosci Biotechnol Biochem 76:1805-8. 2012
    ..Dose-dependent T3 levels were detected in many tissues. Under the present experimental conditions, a continuous intake of the T3 concentrate would be safe in the rats as long as the T3 content was less than 0.20% of the dietary intake...
  21. doi request reprint Analysis of amadori-glycated phosphatidylethanolamine in the plasma of healthy subjects and diabetic patients by liquid chromatography-tandem mass spectrometry
    Teruo Miyazawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Ann N Y Acad Sci 1126:291-4. 2008
    ..Therefore, it is likely that pyridoxal 5'-phosphate acts as a lipid glycation inhibitor in vivo, and this may contribute to diabetes prevention...
  22. doi request reprint Sulforaphane suppresses ultraviolet B-induced inflammation in HaCaT keratinocytes and HR-1 hairless mice
    Akira Shibata
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    J Nutr Biochem 21:702-9. 2010
    ..These results suggest that SF has a potential use as a compound for protection against UVB-induced skin inflammation...
  23. pmc Amyloid β levels in human red blood cells
    Takehiro Kiko
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    PLoS ONE 7:e49620. 2012
    ..As a preventive strategy, therapeutic application of astaxanthin as an Aβ-lowering agent in RBCs could be considered as a possible anti-dementia agent...
  24. ncbi request reprint Angiogenic potency of Amadori-glycated phosphatidylethanolamine
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Ann N Y Acad Sci 1043:413-6. 2005
    ..Our results indicated for the first time that Amadori-PE would elicit vascular disease through angiogenic potency on endothelial cells, thereby playing an active part in the development and progression of diabetic microangiopathy...
  25. doi request reprint alpha-Tocopherol attenuates the cytotoxic effect of delta-tocotrienol in human colorectal adenocarcinoma cells
    Akira Shibata
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Biochem Biophys Res Commun 397:214-9. 2010
    ..These results indicate that alpha-Toc is not only less cytotoxic to cancer cells, but it also reduces the cytotoxicity of delta-T3 by inhibiting its cellular uptake...
  26. ncbi request reprint Plasma carotenoid concentrations before and after supplementation with astaxanthin in middle-aged and senior subjects
    Taiki Miyazawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
    Biosci Biotechnol Biochem 75:1856-8. 2011
    ..The plasma carotenoid concentration was significantly higher after the astaxanthin supplementation than that before in both the 1 mg/d (10 subjects) and 3 mg/d (10 subjects) groups...
  27. doi request reprint Intake of 1-deoxynojirimycin suppresses lipid accumulation through activation of the beta-oxidation system in rat liver
    Tsuyoshi Tsuduki
    Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University, Sendai, Japan
    J Agric Food Chem 57:11024-9. 2009
    ..Intake of DNJ and meDNJ did not cause hepatic dysfunction and led to a reduction of oxidative stress. These results indicate the efficacy and safety of DNJ and meDNJ...
  28. ncbi request reprint Development of a high-performance liquid chromatography-based assay for carotenoids in human red blood cells: application to clinical studies
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Anal Biochem 381:129-34. 2008
    ..3-70.2 nmol/L packed cells), and polar oxygenated carotenoids (xanthophylls) were predominant in RBCs. The HPLC-DAD-APCI/MS method would be a useful tool for clinical studies for evaluating the bioavailability of RBC carotenoids...
  29. ncbi request reprint Amadori-glycated phosphatidylethanolamine induces angiogenic differentiations in cultured human umbilical vein endothelial cells
    Jeong Ho Oak
    Food and Biodynamic Chemistry Laboratory, Graduate School of Life Science and Agriculture, Tohoku University, Sendai 981 8555, Japan
    FEBS Lett 555:419-23. 2003
    ..We also demonstrated that MMP-2 is a primary mediator of Amadori-PE-driven angiogenesis...
  30. ncbi request reprint Conjugated EPA activates mutant p53 via lipid peroxidation and induces p53-dependent apoptosis in DLD-1 colorectal adenocarcinoma human cells
    Tsuyoshi Tsuzuki
    Food and Biodynamic Chemistry Lab, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Biochim Biophys Acta 1771:20-30. 2007
    ..This is the first such gene expression analysis of the effects of CEPA, and our results confirm that CEPA induces lipid peroxidation, activates mutant p53, and causes p53-dependent apoptosis in DLD-1 cells...
  31. ncbi request reprint Occurrence of orally administered mulberry 1-deoxynojirimycin in rat plasma
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Agric Food Chem 55:8928-33. 2007
    ..The developed HILIC-MS method could be applied in determining levels of DNJ in urine and tissues, and therefore, the method would be a powerful tool for studying the metabolic fate of mulberry DNJ as well as its bioavailability...
  32. ncbi request reprint Down-regulation of telomerase activity in DLD-1 human colorectal adenocarcinoma cells by tocotrienol
    Takahiro Eitsuka
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Biochem Biophys Res Commun 348:170-5. 2006
    ..These results provide novel evidence for the first time indicating that tocotrienol acts as a potent candidate regulator of telomerase and supporting the anti-proliferative function of tocotrienol...
  33. ncbi request reprint Anti-angiogenic function of tocotrienol
    Teruo Miyazawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Asia Pac J Clin Nutr 17:253-6. 2008
    ..Anti-angiogenic mechanism of T3 mediates inhibition of growth factor induced survival, migration and angiogenesis signals. These findings suggested that T3 may have potential for preventing angiogenic disorders in humans...
  34. ncbi request reprint Aminophospholipid glycation and its inhibitor screening system: a new role of pyridoxal 5'-phosphate as the inhibitor
    Ohki Higuchi
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    J Lipid Res 47:964-74. 2006
    ....
  35. doi request reprint Amadori-glycated phosphatidylethanolamine, a potential marker for hyperglycemia, in streptozotocin-induced diabetic rats
    Phumon Sookwong
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, 981 8555, Japan
    Lipids 46:943-52. 2011
    ..Similar speculations have been made from previous human studies, but this study provides a direct evidence to support the speculations in rat study...
  36. doi request reprint Long-term intake of fish oil increases oxidative stress and decreases lifespan in senescence-accelerated mice
    Tsuyoshi Tsuduki
    Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University, Sendai, Japan
    Nutrition 27:334-7. 2011
    ..In this study, the influence of long-term ingestion of fish oil on lifespan was examined in senescence-accelerated (SAMP8) mice...
  37. doi request reprint Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo
    Nahoko Shinohara
    Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University, Japan
    Biochim Biophys Acta 1821:980-8. 2012
    ..JA also had a strong preventive antitumor effect in vivo in nude mice into which DLD-1 cells were transplanted. These results suggest that JA can be used as a dietary constituent for prevention of cancer...
  38. pmc LC-MS/MS analysis of carboxymethylated and carboxyethylated phosphatidylethanolamines in human erythrocytes and blood plasma
    Naoki Shoji
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Lipid Res 51:2445-53. 2010
    ..The presently developed LC-MS/MS method appears to be a powerful tool for understanding in vivo lipid glycation and its pathophysiological consequence...
  39. doi request reprint Tocotrienol inhibits secretion of angiogenic factors from human colorectal adenocarcinoma cells by suppressing hypoxia-inducible factor-1alpha
    Akira Shibata
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Nutr 138:2136-42. 2008
    ..Overall, our results confirmed that T3 has an inhibitory effect on angiogenic factor secretion from cancer cells and revealed the possible mechanisms, providing new information about the antiangiogenic effects of T3...
  40. ncbi request reprint Conjugated eicosapentaenoic acid inhibits vascular endothelial growth factor-induced angiogenesis by suppressing the migration of human umbilical vein endothelial cells
    Tsuyoshi Tsuzuki
    Food and Biodynamic Chemistry Lab, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Nutr 137:641-6. 2007
    ..05). Our findings suggest that CEPA has potential use as a therapeutic dietary supplement for minimizing tumor angiogenesis...
  41. ncbi request reprint Chlorella is an effective dietary source of lutein for human erythrocytes
    Taiki Miyazawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
    J Oleo Sci 62:773-9. 2013
    ..Chlorella intake would be effective for improving and maintaining lutein concentrations in human erythrocytes. ..
  42. ncbi request reprint γ-Tocotrienol attenuates triglyceride through effect on lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6
    Gregor Carpentero Burdeos
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    J Nutr Sci Vitaminol (Tokyo) 59:148-51. 2013
    ..Therefore, T3 is a potential lipid-lowering compound candidate with realistic prospects for its use as a therapy for lipid-related diseases in humans...
  43. ncbi request reprint Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans
    Toshiyuki Kimura
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Agric Food Chem 55:5869-74. 2007
    ..This study suggests that the newly developed DNJ-enriched powder can be used as a dietary supplement for preventing diabetes mellitus...
  44. ncbi request reprint Optimization of 1-deoxynojirimycin extraction from mulberry leaves by using response surface methodology
    Chaluntorn Vichasilp
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 73:2684-9. 2009
    ..8%) was produced with high extraction efficiency (98%) and productivity (20%), enabling this product to be used for nutraceutical purposes...
  45. ncbi request reprint Ozonation of cholesterol in the presence of ethanol: identification of a cytotoxic ethoxyhydroperoxide molecule
    Misako Tagiri-Endo
    Food and Biodynamic Chemistry Laboratory, Graduate School of Life Science and Agriculture, Tohoku University, Sendai, Japan
    Lipids 39:259-64. 2004
    ..Hence, 7alpha-ethoxy-5-OOH is a toxic molecule of primary importance, arising during cholesterol ozonation in the presence of ethanol...
  46. doi request reprint Significance of lutein in red blood cells of Alzheimer's disease patients
    Takehiro Kiko
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    J Alzheimers Dis 28:593-600. 2012
    ..These results suggest that RBC lutein, in particular, may contribute to suppression of PLOOH accumulation in RBC of AD patients...
  47. ncbi request reprint Polyunsaturated fatty acids inhibit telomerase activity in DLD-1 human colorectal adenocarcinoma cells: a dual mechanism approach
    Takahiro Eitsuka
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Sendai 981 8555, Japan
    Biochim Biophys Acta 1737:1-10. 2005
    ..These results indicate that PUFAs can directly inhibit the enzymatic activity of telomerase as well as modulate the telomerase at the transcriptional level...
  48. ncbi request reprint In vivo angiogenesis is suppressed by unsaturated vitamin E, tocotrienol
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Nutr 137:1938-43. 2007
    ..Our findings suggest that T3 has potential as a therapeutic dietary supplement for preventing angiogenic disorders, and therefore future clinical study will be required to evaluate the efficacy and safety of T3...
  49. doi request reprint Preparation of pure lipid hydroperoxides
    Daigo Ibusuki
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Lipid Res 49:2668-77. 2008
    ..Our developed method expands the concept of the perketal method, which provides pure LOOH references. The LOOHs prepared by the perketal method would be used as "gold standards" in LOOH methodology...
  50. ncbi request reprint Oxidative stress during development of alcoholic fatty liver: therapeutic potential of cacao polyphenol
    Koichiro Suzuki
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
    Biosci Biotechnol Biochem 77:1792-4. 2013
    ..g., phospholipid peroxidation) in the development of alcoholic fatty liver (AFL), possibly in an early stage. Cacao polyphenol supplementation produced an ameliorating effect, and may help in AFL prevention. ..
  51. doi request reprint Intake of mulberry 1-deoxynojirimycin prevents diet-induced obesity through increases in adiponectin in mice
    Tsuyoshi Tsuduki
    Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University, Sendai 981 8555, Japan
    Food Chem 139:16-23. 2013
    ..Therefore, it was suggested that DNJ promoted an increase in plasma adiponectin and activated the β-oxidation system. Overall, it was shown that DNJ prevents diet-induced obesity through an increase in adiponectin...
  52. doi request reprint Glycation of plasma lipoprotein lipid membrane and screening for lipid glycation inhibitor
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Ann N Y Acad Sci 1126:288-90. 2008
    ..Pyridoxal 5'-phosphate could easily react with PE before the glucose-PE reaction, and the PE-pyridoxal 5'-phosphate adduct was detected in human red blood cells. Pyridoxal 5'-phosphate can be used in diabetes prevention...
  53. doi request reprint Cross-fertilization for enhancing tocotrienol biosynthesis in rice plants and QTL analysis of their F2 progenies
    Phumon Sookwong
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    J Agric Food Chem 57:4620-5. 2009
    ..The results show that cross-breeding is effective in improving rice bran T3 and provides more genetic understanding on T3 biosynthesis in rice plants...
  54. ncbi request reprint Erythrocytes carotenoids after astaxanthin supplementation in middle-aged and senior Japanese subjects
    Taiki Miyazawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Japan
    J Oleo Sci 60:495-9. 2011
    ..No differences were observed in either the carotenoid compositions or the phospholipid hydroperoxide concentrations in erythrocytes after astaxanthin intake in both the 1 and 3 mg/day groups...
  55. doi request reprint Tocotrienol distribution in foods: estimation of daily tocotrienol intake of Japanese population
    Phumon Sookwong
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    J Agric Food Chem 58:3350-5. 2010
    ..The estimated daily intake of T3 appears rather low compared with the intake of tocopherol (8-10 mg/day/person as reported in the Japanese National Nutrition Survey), and additional T3 is important for its therapeutic aspects...
  56. ncbi request reprint Ion-trap tandem mass spectrometric analysis of squalene monohydroperoxide isomers in sunlight-exposed human skin
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Lipid Res 48:2779-87. 2007
    ..The LC-MS/MS method was useful for investigating the peroxidation mechanisms of SQ as well as SQ-OOH-mediated skin disorders...
  57. doi request reprint Determination of iminosugars in mulberry leaves and silkworms using hydrophilic interaction chromatography-tandem mass spectrometry
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Anal Biochem 404:217-22. 2010
    ..g., different amounts of iminosugars in mulberry leaf varieties; high DNJ and low GAL-DNJ in the silkworm body, especially in the blood) that is useful for producing iminosugar-rich products for nutraceutical purposes...
  58. ncbi request reprint 1-Deoxynojirimycin attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells
    Shuang E
    Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University, Sendai 981 8555, Japan
    Exp Gerontol 55:63-9. 2014
    ..Therefore, these results show that DNJ delays cellular senescence that is promoted under high glucose condition. ..
  59. ncbi request reprint Tandem mass spectrometry analysis of Amadori-glycated phosphatidylethanolamine in human plasma
    Teruo Miyazawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Ann N Y Acad Sci 1043:280-3. 2005
    ....
  60. doi request reprint Investigation of tocotrienol biosynthesis in rice (Oryza sativa L.)
    Kentaro Matsuzuka
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Food Chem 140:91-8. 2013
    ..The results of this study would be useful for nutraceutical purposes (e.g., development of T3-overproducing rice for the prevention of angiogenic disorders)...
  61. pmc Aging decreases antioxidant effects and increases lipid peroxidation in the Apolipoprotein E deficient mouse
    Taro Honma
    Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University, Sendai 981 8555, Japan
    J Clin Biochem Nutr 52:234-40. 2013
    ..These results suggest that lipid peroxidation is caused by reduction of antioxidant activity with aging and that this promotes senescence and shortens lifespan in ApoE(-/-) mice...
  62. ncbi request reprint Tocotrienol attenuates triglyceride accumulation in HepG2 cells and F344 rats
    Gregor Carpentero Burdeos
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Lipids 47:471-81. 2012
    ..These results provided new information and the mechanism of the TG-lowering effect of T3. The lipid lowering effects of dietary T3 might be mediated by the reduction of TG synthesis...
  63. doi request reprint MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer's disease
    Takehiro Kiko
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    J Alzheimers Dis 39:253-9. 2014
    ..On the other hand, CSF miR-29a and miR-29b levels were significantly higher than in control subjects. Our results provide a possibility that miRNAs detected in plasma and CSF can serve as biomarkers for AD. ..
  64. ncbi request reprint A convenient method for preparation of high-purity, Amadori-glycated phosphatidylethanolamine and its prooxidant effect
    Teruo Miyazawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Ann N Y Acad Sci 1043:276-9. 2005
    ..These results indicate that Amadori-PE is a considerable risk factor that may cause membrane lipid peroxidation in the pathogenesis of diabetes and aging...
  65. doi request reprint Production of the α-glycosidase inhibitor 1-deoxynojirimycin from Bacillus species
    Shinji Onose
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Food Chem 138:516-23. 2013
    ..These findings not only lead to a further understanding of the DNJ biosynthetic pathway, but also suggest a method for microbial mass production of DNJ for therapeutic applications...
  66. ncbi request reprint Alpha-eleostearic acid (9Z11E13E-18:3) is quickly converted to conjugated linoleic acid (9Z11E-18:2) in rats
    Tsuyoshi Tsuzuki
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Nutr 134:2634-9. 2004
    ..These results indicated that alpha-ESA is converted to 9Z11E-CLA in rats by a Delta13-saturation reaction carried out by an NADPH-dependent enzyme...
  67. ncbi request reprint Dual mechanisms for telomerase inhibition in DLD-1 human colorectal adenocarcinoma cells by polyunsaturated fatty acids
    Takahiro Eitsuka
    Food and Biodynamic Chemistry Laboratory, Graduate School of Life Science and Agriculture, Tohoku University, Sendai 981 8555, Japan
    Biofactors 21:19-21. 2004
    ..Based on these observations, we suggest that PUFAs inhibit telomerase activity through dual mechanisms: direct inhibition of enzymatic activity and down regulation of hTERT, one of the telomerase components...
  68. ncbi request reprint Quantitation of tocotrienol and tocopherol in various rice brans
    Phumon Sookwong
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Agric Food Chem 55:461-6. 2007
    ..The varieties found rich in T3 could be used for nutraceutical purpose...
  69. ncbi request reprint Evaporative light-scattering analysis of sulforaphane in broccoli samples: Quality of broccoli products regarding sulforaphane contents
    Kiyotaka Nakagawa
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Agric Food Chem 54:2479-83. 2006
    ..In contrast, we found that sulforaphane could not be detected in most of broccoli products, suggesting present commercial broccoli products having low quality...
  70. ncbi request reprint Tocotrienol content in hen eggs: its fortification by supplementing the feed with rice bran scum oil
    Phumon Sookwong
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 72:3044-7. 2008
    ..3% T3) to the feed. Commercial eggs contained about 0.11 mg of T3/egg, while the T3 content was improved to 0.62 mg/egg after RBO supplementation to the feed of hens for 7 d...
  71. doi request reprint Fatty acid elongase is required for shoot development in rice
    Yukihiro Ito
    Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai 981 8555, Japan
    Plant J 66:680-8. 2011
    ..These results show that fatty acid elongase is required for formation of the outermost cell layer, and this layer is indispensable for entire shoot development in rice...