Fuyuhiko Motoi

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi request reprint Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula after pancreaticojejunostomy
    F Motoi
    Division of Gastroenterological Surgery, Department of Surgery, Graduate School of Medicine, Tohoku University, 1 1 Seiryo machi, Aoba ku, Sendai980 8574, Japan
    Br J Surg 99:524-31. 2012
  2. ncbi request reprint Neoadjuvant chemotherapy with gemcitabine and S-1 for resectable and borderline pancreatic ductal adenocarcinoma: results from a prospective multi-institutional phase 2 trial
    Fuyuhiko Motoi
    Division of Gastroenterological Surgery, Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan
    Ann Surg Oncol 20:3794-801. 2013
  3. doi request reprint Retrospective evaluation of the influence of postoperative tumor marker status on survival and patterns of recurrence after surgery for pancreatic cancer based on RECIST guidelines
    Fuyuhiko Motoi
    Department of Surgery, Tohoku University, Sendai, Japan
    Ann Surg Oncol 18:371-9. 2011
  4. ncbi request reprint Middle pancreatectomy
    Fuyuhiko Motoi
    Division of Gastroenterological Surgery, Department of Surgery, Graduate School of Medicine, Tohoku University, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    J Hepatobiliary Pancreat Sci 19:148-51. 2012
  5. ncbi request reprint Oncolytic virotherapy as a novel strategy for pancreatic cancer
    Makoto Sunamura
    Division of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 28:326-9. 2004
  6. pmc Potential utility of eGFP-expressing NOG mice (NOG-EGFP) as a high purity cancer sampling system
    Kentaro Shima
    Division of Hepato Biliary Pancreatic Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi aoba ku, Sendai, 980 8574, Japan
    J Exp Clin Cancer Res 31:55. 2012
  7. doi request reprint Lymph nodes metastasis is a risk factor for bone metastasis from extrahepatic cholangiocarcinoma
    Yu Katayose
    Integrated Surgery and Oncology, Tohoku Unversity Graduate School of Medicine, Sendai, Japan
    Hepatogastroenterology 59:1758-60. 2012
  8. ncbi request reprint Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas
    Masaharu Ishida
    Department of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 35:348-52. 2007
  9. ncbi request reprint Clock gene mouse period2 overexpression inhibits growth of human pancreatic cancer cells and has synergistic effect with cisplatin
    Akira Oda
    Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980 8574, Japan
    Anticancer Res 29:1201-9. 2009
  10. doi request reprint An analysis of a second-line S-1 monotherapy for gemcitabine-refractory biliary tract cancer
    Yu Katayose
    Tohoku University Graduate School of Medicine, Sendai, Japan
    Hepatogastroenterology 59:691-5. 2012

Detail Information

Publications55

  1. ncbi request reprint Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula after pancreaticojejunostomy
    F Motoi
    Division of Gastroenterological Surgery, Department of Surgery, Graduate School of Medicine, Tohoku University, 1 1 Seiryo machi, Aoba ku, Sendai980 8574, Japan
    Br J Surg 99:524-31. 2012
    ..This randomized trial examined whether external stent drainage of the pancreatic duct decreases the rate of POPF after PD and subsequent pancreaticojejunostomy (PJ)...
  2. ncbi request reprint Neoadjuvant chemotherapy with gemcitabine and S-1 for resectable and borderline pancreatic ductal adenocarcinoma: results from a prospective multi-institutional phase 2 trial
    Fuyuhiko Motoi
    Division of Gastroenterological Surgery, Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan
    Ann Surg Oncol 20:3794-801. 2013
    ..First-line treatment with gemcitabine and S-1 (GS) is associated with promising antitumor activity with a high response rate. The aim of this study was to assess the feasibility and efficacy of GS in the neoadjuvant setting...
  3. doi request reprint Retrospective evaluation of the influence of postoperative tumor marker status on survival and patterns of recurrence after surgery for pancreatic cancer based on RECIST guidelines
    Fuyuhiko Motoi
    Department of Surgery, Tohoku University, Sendai, Japan
    Ann Surg Oncol 18:371-9. 2011
    ..We propose the concept of surgical RECIST based on residual tumor and TM status...
  4. ncbi request reprint Middle pancreatectomy
    Fuyuhiko Motoi
    Division of Gastroenterological Surgery, Department of Surgery, Graduate School of Medicine, Tohoku University, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    J Hepatobiliary Pancreat Sci 19:148-51. 2012
    ..This article provides indications and surgical techniques with special focus on the procedure of middle pancreatectomy...
  5. ncbi request reprint Oncolytic virotherapy as a novel strategy for pancreatic cancer
    Makoto Sunamura
    Division of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 28:326-9. 2004
    ..These results strongly suggest that AxdAdB-3 possesses a wider therapeutic potential than previously believed, given that most pancreatic cancers have abnormalities in both the TP53 and RB pathways...
  6. pmc Potential utility of eGFP-expressing NOG mice (NOG-EGFP) as a high purity cancer sampling system
    Kentaro Shima
    Division of Hepato Biliary Pancreatic Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi aoba ku, Sendai, 980 8574, Japan
    J Exp Clin Cancer Res 31:55. 2012
    ..We hypothesized that xenograft models of NOG mice expressing enhanced green fluorescent protein (eGFP), referred to as NOG-EGFP mice, may be useful for obtaining such high purity cancer cells for detailed molecular and cellular analyses...
  7. doi request reprint Lymph nodes metastasis is a risk factor for bone metastasis from extrahepatic cholangiocarcinoma
    Yu Katayose
    Integrated Surgery and Oncology, Tohoku Unversity Graduate School of Medicine, Sendai, Japan
    Hepatogastroenterology 59:1758-60. 2012
    ..Therefore, we intend to make a comparative review of the background to bone metastasis, examine a high-risk group for bone metastasis and use the data towards the improvement in quality of life...
  8. ncbi request reprint Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas
    Masaharu Ishida
    Department of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 35:348-52. 2007
    ..The purpose of this study was to determine associations between the histological types and clinicopathological features in patients with IPMN...
  9. ncbi request reprint Clock gene mouse period2 overexpression inhibits growth of human pancreatic cancer cells and has synergistic effect with cisplatin
    Akira Oda
    Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980 8574, Japan
    Anticancer Res 29:1201-9. 2009
    ....
  10. doi request reprint An analysis of a second-line S-1 monotherapy for gemcitabine-refractory biliary tract cancer
    Yu Katayose
    Tohoku University Graduate School of Medicine, Sendai, Japan
    Hepatogastroenterology 59:691-5. 2012
    ..Gemcitabine is widely used as a first-line therapy for biliary tract cancer (BTC). However, few studies have been conducted to analyze second- line therapies...
  11. doi request reprint Computed tomography reflected endocrine function of the pancreas
    Naoaki Sakata
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8574, Japan
    J Gastrointest Surg 15:525-32. 2011
    ..In this study, we examined the correlation between CT volumetry and endocrine parameters (blood glucose and HbA1c) of the pancreas...
  12. ncbi request reprint Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells
    Dan G Duda
    Division of Gastroenterological Surgery, Graduate School of Medicine, Tohoku University, 980 8574 Sendai, Japan
    Oncogene 22:6857-64. 2003
    ..ETS-1 is considered a marker for tumour invasion. Upon SMAD4 deletion, we detected high expression levels of ETS-1 in pancreatic tumour cells, suggesting the shift of the pancreatic tumour toward an invasive phenotype...
  13. doi request reprint Major hepatectomy for perihilar cholangiocarcinoma
    Michiaki Unno
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Hepatobiliary Pancreat Sci 17:463-9. 2010
    ..The aim of this study was to review the outcomes of major hepatectomy for perihilar cholangiocarcinoma...
  14. ncbi request reprint Up-regulated p27Kip1 reduces matrix metalloproteinase-9 and inhibits invasion of human breast cancer cells
    Masamichi Mizuma
    Department of Hepato Biliary Pancreatic Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Anticancer Res 28:2669-77. 2008
    ..Here, it was examined whether p27Kip1 has an inhibitory effect on cancer cell invasion and correlates with matrix metalloproteinase expression (MMPs)...
  15. doi request reprint Institutional indications for islet transplantation after total pancreatectomy
    Naoaki Sakata
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University, 1 1 Seiryo cho, Aoba ku, Sendai, Japan
    J Hepatobiliary Pancreat Surg 15:488-92. 2008
    ..This study was designed to establish institutional indications for pancreatic islet transplantation by examining patients with total pancreatectomy as candidates for islet allotransplantation...
  16. doi request reprint Bile acids repress E-cadherin through the induction of Snail and increase cancer invasiveness in human hepatobiliary carcinoma
    Koji Fukase
    Department of Surgery, Tohoku University Graduate School of Medical Science, Sendai 980 8574, Japan
    Cancer Sci 99:1785-92. 2008
    ..Inhibition of this bile acid-stimulated pathway may prove useful as an adjuvant in the therapy of hepatocellular carcinoma...
  17. ncbi request reprint Gene therapy for pancreatic cancer targeting the genomic alterations of tumor suppressor genes using replication-selective oncolytic adenovirus
    Makoto Sunamura
    Division of Gastroenterological Surgery, Tohoku University, Graduate School of Medicine, Sendai, Japan
    Hum Cell 15:138-50. 2002
    ..These results revealed thatthe AxE1AdB-UPRT/5FU system is a promising tool for intraperitoneal disseminated pancreatic cancer...
  18. doi request reprint Solid pseudopapillary neoplasms of the pancreas: an 18-year experience at a single Japanese Institution
    Takanori Morikawa
    Division of Hepato Biliary Pancreatic Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    Surg Today 43:26-32. 2013
    ..This study investigated the clinicopathological features and surgical management of solid pseudopapillary neoplasms at a single institution in Japan...
  19. ncbi request reprint Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreatoduodenectomy for cancer of Vater's papilla associated with intraductal papillary-mucinous adenoma
    Masaharu Ishida
    Department of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryocho, Aobaku, Sendai, 980 8574, Japan
    J Hepatobiliary Pancreat Surg 14:522-5. 2007
    ..These findings suggest that careful surveillance of the gastrointestinal tract and careful follow up are necessary for IPMN, because an IPMN could be associated with other gastrointestinal tract malignancies...
  20. ncbi request reprint Dilated papilla with mucin extrusion is a potential predictor of acute pancreatitis associated with intraductal papillary mucinous neoplasms of pancreas
    Tatsuo Hata
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8574, Japan
    Pancreatology 13:615-20. 2013
    ..In this study, we attempted to clarify the characteristics of IPMN associated with AP, compared to those of IPMN not associated with AP...
  21. doi request reprint Phase I trial of neoadjuvant chemoradiation with gemcitabine and surgical resection for cholangiocarcinoma patients (NACRAC study)
    Yu Katayose
    Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hepatogastroenterology 58:1866-72. 2011
    ....
  22. ncbi request reprint Clinicopathological aspects of small pancreatic cancer
    Shinichi Egawa
    Pancreatic Cancer Registry Committee, Japan Pancreas Society, Sendai, Japan
    Pancreas 28:235-40. 2004
    ..5%) had stage I disease with a median survival time of 78.2 months and a 5-year survival rate of 58.1%. Small pancreatic cancer does not necessarily mean early pancreatic cancer, and surgery alone is not sufficient to cure this disease...
  23. ncbi request reprint GCF2/LRRFIP1 promotes colorectal cancer metastasis and liver invasion through integrin-dependent RhoA activation
    Kyohei Ariake
    Division of Gastroenterological Surgery, Department of Surgery, Tohoku University, Seiryo machi, Aoba ku, Sendai, Japan
    Cancer Lett 325:99-107. 2012
    ..Altogether, our results suggest that GCF2 plays an important role in colorectal cancer metastasis by regulating RhoA-induced cell adhesion, migration, and invasion...
  24. ncbi request reprint Synchronous and metachronous extrapancreatic malignant neoplasms in patients with intraductal papillary-mucinous neoplasm of the pancreas
    Masaharu Ishida
    Department of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Pancreatology 8:577-82. 2008
    ..Recently there have been some reports on extrapancreatic malignant neoplasms (EPM) occurring in patients with IPMN. The purpose of this study was to discover the characteristic features of IPMN with EPM compared with IPMN without EPM...
  25. ncbi request reprint Distal pancreatectomy (with video)
    Shinichi Egawa
    Division of Hepato Biliary Pancreatic Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo Aoba, Sendai, 980 8574, Japan
    J Hepatobiliary Pancreat Sci 19:135-40. 2012
    ..Based on the results of an international randomized trial of hand-sewn and staple closure of the pancreatic stump, the closure method of the pancreatic stump can be the surgeon's choice...
  26. ncbi request reprint Pancreatic Cancer Registry in Japan: 20 years of experience
    Seiki Matsuno
    Department of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 28:219-30. 2004
    ..To promote this effort, which requires the international comparisons and cooperation, JPS developed a computerized JPS registration system downloadable from the JPS website (http://www.kojin.or.jp/suizou/index.html)...
  27. ncbi request reprint Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer
    Hidekazu Oishi
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 39:897-903. 2010
    ..In this study, we examined the effects of the DLL4-Notch signaling on tumor angiogenesis using the neutralizing monoclonal antibodies against DLL4...
  28. pmc Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Am J Pathol 162:1807-15. 2003
    ..These results show that DUSP6 exerts apparent tumor-suppressive effects in vitro and suggest that DUSP6 is a strong candidate tumor suppressor gene at 12q22 locus...
  29. ncbi request reprint ZD1839 (IRESSA) stabilizes p27Kip1 and enhances radiosensitivity in cholangiocarcinoma cell lines
    Shinichi Yabuuchi
    Department of of Hepato Billary Pancreatic Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Anticancer Res 29:1169-80. 2009
    ..ZD1839 in combination with radiation produced a dose-dependent and synergic inhibitory effect on cellular proliferation. In conclusion, these results suggest that ZD1839 may have clinical activity against cholangiocarcinoma...
  30. ncbi request reprint [Therapeutics with replication--selective virus (RSV) for pancreatic cancer]
    Fuyuhiko Motoi
    Division of Gastroenterological Surgery, Department of Surgery, Tohoku University
    Nihon Rinsho 64:223-7. 2006
  31. doi request reprint Suppressed expression of NDRG2 correlates with poor prognosis in pancreatic cancer
    Akihiro Yamamura
    Department of Surgery, Tohoku University, Graduate School of Medicine, Sendai, Japan Department of Pathology, Tohoku University, Graduate School of Medicine, Sendai, Japan
    Biochem Biophys Res Commun 441:102-7. 2013
    ....
  32. ncbi request reprint Attenuation of phosphorylation by deoxycytidine kinase is key to acquired gemcitabine resistance in a pancreatic cancer cell line: targeted proteomic and metabolomic analyses in PK9 cells
    Ken Ohmine
    Division of Membrane Transport and Drug Targeting Department of Biochemical Pharmacology and Therapeutics Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3 Aoba, Aramaki, Aoba ku, Sendai, 980 8578, Japan
    Pharm Res 29:2006-16. 2012
    ..We aimed to clarify the mechanism of dFdC resistance in a pancreatic cancer cell line by applying a combination of targeted proteomic and metabolomic analyses...
  33. doi request reprint Segmentectomy of the liver
    Hiroshi Yoshida
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1, Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    J Hepatobiliary Pancreat Sci 19:67-71. 2012
    ..In the latter, manipulation is difficult. Therefore, ultrasonically guided segmental staining is performed by puncturing the portal branch and injecting a dye. This report described techniques for segmentectomy...
  34. doi request reprint Assessment of Frey procedures: Japanese experience
    Shinichi Egawa
    Division of Hepato Biliary Pancreatic Surgery, Tohoku University Graduate School of Medicine, Seiryo Aoba, Sendai, 980 8574, Japan
    J Hepatobiliary Pancreat Sci 17:745-51. 2010
    ..During long-term follow up, unexpected relapse in the pancreatic tail was encountered. The pattern of failure and the rationale for a new procedure to treat or prevent such relapse were investigated...
  35. doi request reprint Paclitaxel as second-line chemotherapy in patients with gemcitabine-refractory pancreatic cancer: a retrospective study
    Shimpei Maeda
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8574, Japan
    Int J Clin Oncol 16:539-45. 2011
    ..We evaluated the efficacy and feasibility of paclitaxel in patients with gemcitabine-refractory pancreatic cancer. We also evaluated the correlation between tumor marker decline and response rate...
  36. ncbi request reprint [Clinicopathological aspects of pancreatic cancer]
    Shinichi Egawa
    Dept of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Gan To Kagaku Ryoho 32:605-11. 2005
    ..Integration of the nationwide registry and pathological information will give new insights for the treatment of pancreatic cancer...
  37. pmc A GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes
    Hirotake Komatsu
    Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Tokyo, Japan Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 9:e87875. 2014
    ..PK-8 cells expressing exogenous mutated GNAS may be an ideal in vitro model of IPMN. ..
  38. doi request reprint The expression of S100A4 in human pancreatic cancer is associated with invasion
    Nobukazu Tsukamoto
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai, Japan
    Pancreas 42:1027-33. 2013
    ..Expression of S100A4 has been reported to correlate with poor prognosis in various cancers. We have investigated the role of S100A4 in pancreatic cancer tumorigenesis and its clinicopathologic significance...
  39. pmc Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue
    Tatsuyuki Takadate
    Division of Gastroenterological Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Miyagi, Japan
    Clin Proteomics 9:8. 2012
    ..abstract:..
  40. ncbi request reprint Somatostatin analog inhibits the growth of insulinoma cells by p27-mediated G1 cell cycle arrest
    Takeshi Aoki
    From the Divisions of Hepato Biliary Pancreatic Surgery, and Integrated Surgery and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan Division of International Cooperation for Disaster Medicine, International Research Institute of Disaster Science, Tohoku University, Aobaku, Sendai, Japan and Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Pancreas 43:720-9. 2014
    ..Although the somatostatin analog octreotide (OCT) has been used for uncontrollable insulinoma, the mechanism involved is still unknown. The aim of this study was to elucidate the therapeutic effect of OCT for insulinoma...
  41. ncbi request reprint Criteria for the glucagon provocative test in the diagnosis of gastrinoma
    Chikashi Shibata
    Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University School of Medicine, 1 1 Seriyo machi, Aoba ku, Sendai, 980 8574, Japan
    Surg Today 43:1281-5. 2013
    ..The glucagon provocative test is useful for the diagnosis of gastrinoma. The aim of this study was to determine the criteria for the glucagon provocative test...
  42. ncbi request reprint [Surgery for pancreatic neuroendocrine tumors]
    Chikashi Shibata
    Division of Biological Regulation and Oncology, Tohoku University School of Medicine, Sendai, Japan
    Nihon Geka Gakkai Zasshi 113:502-6. 2012
    ..The indications for total pancreatectomy should be determined individually based on the tumor status and patient age...
  43. ncbi request reprint Preoperative assessment of hilar cholangiocarcinoma by multidetector row computed tomography
    Michiaki Unno
    Division of Gastroenterological Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, 980 8574, Japan
    J Hepatobiliary Pancreat Surg 14:434-40. 2007
    ..Now that multidetector row CT (MDCT) and high-performance imaging systems are available, the diagnostic strategy for hilar cholangiocarcinoma has changed...
  44. pmc Intraoperative ultrasound examination is useful for monitoring transplanted islets: a case report
    Naoaki Sakata
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Islets 4:339-42. 2012
    ..The hyperechoic images were considered to be viable islets. Intraoperative US examination can be useful for detecting islets at transplantation in a clinical setting...
  45. doi request reprint Novel prognostic protein markers of resectable pancreatic cancer identified by coupled shotgun and targeted proteomics using formalin-fixed paraffin-embedded tissues
    Tatsuyuki Takadate
    Division of Gastroenterological Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Int J Cancer 132:1368-82. 2013
    ..The combination of shotgun proteomics verified by SRM and validated by immunohistochemistry resulted in the prognostic marker discovery that will contribute the understanding of PDAC biology and therapeutic development...
  46. ncbi request reprint Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer
    Makoto Sunamura
    Division of Gastroentrological Surgery, Tohoku University School of Medicine, Sendai, Japan
    Angiogenesis 6:15-24. 2003
    ....
  47. doi request reprint Identification of epigenetically silenced genes in human pancreatic cancer by a novel method "microarray coupled with methyl-CpG targeted transcriptional activation" (MeTA-array)
    Hideyuki Shimizu
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 411:162-7. 2011
    ..These results suggest that MeTA-array is a highly efficient method for identifying methylation-mediated transcriptionally silenced genes in human pancreatic cancer and that this method can be applied to other types of human cancer...
  48. doi request reprint How much of the pancreatic head should we resect in Frey's procedure?
    Naoaki Sakata
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai, 980 8574, Japan
    Surg Today 39:120-7. 2009
    ..We compared the functional outcome of minimized Frey's procedure with that of modified Frey's procedure to establish how deeply and widely we should cut into the head of the pancreas...
  49. ncbi request reprint Infiltration of CD40-positive tumor-associated macrophages indicates a favorable prognosis in colorectal cancer patients
    Makoto Kinouchi
    Department of Surgery, Miyagi Cancer Center, Miyagi, Japan
    Hepatogastroenterology 60:83-8. 2013
    ..We studied a series of cell surface antigens in TAMs in colorectal cancer tissues and their corresponding normal tissues using flow cytometry to find out prognostic indicators of these patients...
  50. pmc Up-regulation of MSX2 enhances the malignant phenotype and is associated with twist 1 expression in human pancreatic cancer cells
    Kennichi Satoh
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Siryo machi, Aobaku, Sendai City, Miyagi, Japan
    Am J Pathol 172:926-39. 2008
    ..These data indicate that MSX2 plays a crucial role in pancreatic cancer development by inducing changes consistent with epithelial to mesenchymal transition through enhanced expression of Twist 1...
  51. ncbi request reprint Expression of Sonic hedgehog signaling pathway correlates with the tumorigenesis of intraductal papillary mucinous neoplasm of the pancreas
    Kennichi Satoh
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Miyagi 980 8574, Japan
    Oncol Rep 19:1185-90. 2008
    ..These findings suggested that HH signaling was activated in IPMNs and contributed to tumorigenesis in these types of neoplasms...
  52. doi request reprint DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells
    Yuriko Saiki
    Department of Molecular Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Biochem Biophys Res Commun 421:98-104. 2012
    ..We found inactivating mutations in RDLD-1 and RTFK-1 and decreased expression of DCK in RMKN-28. These results indicate that the inactivation of DCK is one of the crucial mechanisms in acquisition of gemcitabine resistance...
  53. ncbi request reprint Gene therapy for pancreatic cancer based on genetic characterization of the disease
    Makoto Sunamura
    First Departments of Surgery, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8574, Japan
    J Hepatobiliary Pancreat Surg 9:32-8. 2002
    ..Furthermore, the replication-competent adenovirus is not only a strong weapon itself but it is also a useful carrier of genes that possess antitumor activities, as a virus vector specific to tumors without normal TP53 function...
  54. doi request reprint Influence of preoperative anti-cancer therapy on resectability and perioperative outcomes in patients with pancreatic cancer: Project study by the Japanese Society of Hepato-Biliary-Pancreatic Surgery
    Fuyuhiko Motoi
    Division of Gastroenterological Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    J Hepatobiliary Pancreat Sci 21:148-58. 2014
    ..Little is known about the effects of neoadjuvant therapy on outcomes in patients with pancreatic cancer. This study evaluated the effects of neoadjuvant therapy on resectability and perioperative outcomes...
  55. ncbi request reprint Gene therapy for intraperitoneally disseminated pancreatic cancers by Escherichia coli uracil phosphoribosiltransferase (UPRT) gene mediated by restricted replication-competent adenoviral vectors
    Masaru Oonuma
    First Department of Surgery, Tohoku University School of Medicine, Sendai, Japan
    Int J Cancer 102:51-9. 2002
    ..Our results showed that the AxE1AdB-UPRT/5FU system is a promising tool for intraperitoneal disseminated pancreatic cancer...