T Moriya

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi Ductal Carcinoma in situ and related lesions of the breast: recent advances in pathology practice
    Takuya Moriya
    Department of Pathology, Tohoku University Hospital, Aoba ku, Sendai 980 8574, Japan
    Breast Cancer 11:325-33. 2004
  2. ncbi Immunohistochemical analysis of Ki-67, p53, p21, and p27 in benign and malignant apocrine lesions of the breast: its correlation to histologic findings in 43 cases
    T Moriya
    Department of Pathology, Tohoku University Hospital, Sendai, Japan
    Mod Pathol 13:13-8. 2000
  3. ncbi Endocervical-like mucinous borderline tumors of the ovary: clinicopathological features and electron microscopic findings
    Takuya Moriya
    Department of Pathology, Tohoku University Hospital, Aoba ku, Sendai 980 8574, Japan
    Med Electron Microsc 36:240-6. 2003
  4. ncbi New trends of immunohistochemistry for making differential diagnosis of breast lesions
    Takuya Moriya
    Department of Pathology, Tohoku University Hospital, Aoba ku, Sendai, Japan
    Med Mol Morphol 39:8-13. 2006
  5. ncbi Pathological evaluation of sentinel lymph nodes for breast cancer
    Takuya Moriya
    Department of Pathology, Tohoku University Hospital, Sendai, Japan
    Asian J Surg 27:256-61. 2004
  6. ncbi Immunohistochemical expression of gonadotropin releasing hormone receptor in human breast carcinoma
    T Moriya
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Pathol Int 51:333-7. 2001
  7. ncbi Retinoic acid receptor and retinoid X receptor in ductal carcinoma in situ and intraductal proliferative lesions of the human breast
    N Ariga
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8575, Japan
    Jpn J Cancer Res 91:1169-76. 2000
  8. ncbi 5alpha-reductases in human breast carcinoma: possible modulator of in situ androgenic actions
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Tohoku University Hospital N A, T M, Sendai 980 8575, Japan
    J Clin Endocrinol Metab 86:2250-7. 2001
  9. ncbi Apoptosis of human endometrium mediated by perforin and granzyme B of NK cells and cytotoxic T lymphocytes
    R Konno
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 187:149-55. 1999
  10. ncbi Progesterone receptor isoforms A and B in human epithelial ovarian carcinoma: immunohistochemical and RT-PCR studies
    J Akahira
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Br J Cancer 83:1488-94. 2000

Collaborators

Detail Information

Publications130 found, 100 shown here

  1. ncbi Ductal Carcinoma in situ and related lesions of the breast: recent advances in pathology practice
    Takuya Moriya
    Department of Pathology, Tohoku University Hospital, Aoba ku, Sendai 980 8574, Japan
    Breast Cancer 11:325-33. 2004
    ..Tentatively, ADH may be treated similarly to non-comedo (low-grade) DCIS cases, according to our limited clinical experience...
  2. ncbi Immunohistochemical analysis of Ki-67, p53, p21, and p27 in benign and malignant apocrine lesions of the breast: its correlation to histologic findings in 43 cases
    T Moriya
    Department of Pathology, Tohoku University Hospital, Sendai, Japan
    Mod Pathol 13:13-8. 2000
    ..Results of these studies suggest that Ki-67 and p53 may be good markers for differentiation between benign and malignant breast apocrine lesions...
  3. ncbi Endocervical-like mucinous borderline tumors of the ovary: clinicopathological features and electron microscopic findings
    Takuya Moriya
    Department of Pathology, Tohoku University Hospital, Aoba ku, Sendai 980 8574, Japan
    Med Electron Microsc 36:240-6. 2003
    ....
  4. ncbi New trends of immunohistochemistry for making differential diagnosis of breast lesions
    Takuya Moriya
    Department of Pathology, Tohoku University Hospital, Aoba ku, Sendai, Japan
    Med Mol Morphol 39:8-13. 2006
    ..Some of the lobular carcinomas are positive for 34betaE12, but they are consistently negative for CK5/6. Comparison with histopathological findings of hematoxylin and eosin is essential to make proper diagnosis in the individual case...
  5. ncbi Pathological evaluation of sentinel lymph nodes for breast cancer
    Takuya Moriya
    Department of Pathology, Tohoku University Hospital, Sendai, Japan
    Asian J Surg 27:256-61. 2004
    ..If the SLN is positive for carcinoma metastases, both the procedure for detection and the size of the metastatic focus should be clarified on the pathological reports...
  6. ncbi Immunohistochemical expression of gonadotropin releasing hormone receptor in human breast carcinoma
    T Moriya
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Pathol Int 51:333-7. 2001
    ..Breast carcinomas positive for GnRH-R maintain some hormonal regulatory mechanisms, and GnRH actions may lead to a low proliferative rate in human breast carcinoma...
  7. ncbi Retinoic acid receptor and retinoid X receptor in ductal carcinoma in situ and intraductal proliferative lesions of the human breast
    N Ariga
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8575, Japan
    Jpn J Cancer Res 91:1169-76. 2000
    ....
  8. ncbi 5alpha-reductases in human breast carcinoma: possible modulator of in situ androgenic actions
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Tohoku University Hospital N A, T M, Sendai 980 8575, Japan
    J Clin Endocrinol Metab 86:2250-7. 2001
    ....
  9. ncbi Apoptosis of human endometrium mediated by perforin and granzyme B of NK cells and cytotoxic T lymphocytes
    R Konno
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 187:149-55. 1999
    ..This finding suggests that the cytotoxic granules released from EGs, which are derived from cytotoxic T lymphocytes and natural killer cells, are initiators of the apoptotic pathway that induces endometrial menstruation...
  10. ncbi Progesterone receptor isoforms A and B in human epithelial ovarian carcinoma: immunohistochemical and RT-PCR studies
    J Akahira
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Br J Cancer 83:1488-94. 2000
    ..Moreover, it is important to examine PRB LI as a prognostic factor in the cases of human epithelial ovarian carcinoma...
  11. ncbi Expression of 5alpha-reductases in human epithelial ovarian cancer: its correlation with androgen receptor status
    J I Akahira
    Department of Pathology, Tohoku University School of Medicine, Sendai 980 8574, Japan
    Jpn J Cancer Res 92:926-32. 2001
    ..The relatively wide distribution of 5alpha-reductase type 1, and its correlation to AR status in human epithelial ovarian malignancies suggest that this isozyme plays important roles in androgen metabolism and actions in these tumors...
  12. ncbi Progesterone receptor A and B isoforms in the human breast and its disorders
    N Ariga
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8575, Japan
    Jpn J Cancer Res 92:302-8. 2001
    ..These results suggest that both PRA and PRB are strongly associated with ERalpha in human breast and this relation may be disturbed in breast cancer...
  13. ncbi Estrogen inhibits cell proliferation through in situ production in human thymoma
    Hironori Ishibashi
    Department of Pathology, Tohoku University School of Medicine, Japan
    Clin Cancer Res 11:6495-504. 2005
    ..Estrogen sulfotransferase (EST), steroid sulfatase (STS), 17beta-hydroxysteroid dehydrogenase (17beta-HSD), and aromatase are considered to play important roles in hormone metabolism of estrogen-dependent tumors...
  14. ncbi Retinoid receptors in human breast carcinoma: possible modulators of in situ estrogen metabolism
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Breast Cancer Res Treat 65:31-40. 2001
    ..76-fold (p < 0.001), five days following treatment with 10 nM retinoic acid. These data suggest that retinoid receptors modulate various effects of retinoids, including estrogen metabolism in human breast carcinomas...
  15. ncbi Sex steroid hormone receptors in human thymoma
    Hironori Ishibashi
    Department of Pathology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    J Clin Endocrinol Metab 88:2309-17. 2003
    ..Results from our study suggest that estrogens may inhibit thymoma growth via ER alpha, and that ER alpha immunoreactivity may act as a prognostic factor in human thymoma...
  16. ncbi Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation
    Jun ichi Akahira
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Cancer Res 10:2687-93. 2004
    ..In this study, we examined the promoter methylation status and expression of 14-3-3 sigma and evaluated its clinical significance in epithelial ovarian cancer...
  17. ncbi Peroxisome proliferator-activated receptor gamma in human breast carcinoma: a modulator of estrogenic actions
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Endocr Relat Cancer 13:233-50. 2006
    ..These results suggest that PPARgamma is mainly expressed in well-differentiated and ER-positive breast carcinomas, and modulates estrogenic actions...
  18. ncbi Intratumoral concentration of sex steroids and expression of sex steroid-producing enzymes in ductal carcinoma in situ of human breast
    Rie Shibuya
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Endocr Relat Cancer 15:113-24. 2008
    ..Therefore, estradiol and DHT may play important roles in the development of DCIS of the human breast...
  19. ncbi PTOV1: a novel testosterone-induced atherogenic gene in human aorta
    Y Nakamura
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Pathol 209:522-31. 2006
    ....
  20. ncbi 17-beta-hydroxysteroid dehydrogenase in human breast and endometrial carcinoma. A new development in intracrinology
    H Sasano
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Oncology 59:5-12. 2000
    ..02). These results indicate that oxidation of E(2) to E(1) is dominant in endometrial carcinoma, 17 beta-HSD types 1 and 2 play an important role in the regulation of in situ estrogen production in breast and endometrial carcinoma...
  21. ncbi EBAG9/RCAS1 in human breast carcinoma: a possible factor in endocrine-immune interactions
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Br J Cancer 85:1731-7. 2001
    ..0025). This study suggests that EBAG9 is produced via ER in carcinoma cells and inhibits the intratumoural infiltration of T lymphocytes in the context of a possible endocrine-immune interaction in human breast carcinomas...
  22. ncbi Aromatase localization in human breast cancer tissues: possible interactions between intratumoral stromal and parenchymal cells
    Yasuhiro Miki
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Res 67:3945-54. 2007
    ....
  23. ncbi Immunolocalization of nuclear transcription factors, DAX-1 and Ad4BP/SF-1, in human common epithelial ovarian tumors: correlations with StAR and steroidogenic enzymes in epithelial ovarian carcinoma
    Manar Abd-Elaziz
    Department of Pathology, Tohoku University School of Medicine and Tohoku University Hospital, Sendai, Japan
    Int J Gynecol Pathol 24:153-63. 2005
    ..The status of intratumoral DAX-1, Ad4BP/SF-1, and StAR and steroidogenic enzymes in epithelial cells and intratumoral stromal cells of epithelial ovarian carcinoma may contribute in the progression and/or aggressiveness of these tumors...
  24. ncbi Immunohistochemical study of basaloid squamous cell carcinoma, adenoid cystic and mucoepidermoid carcinoma in the upper aerodigestive tract
    H Tsubochi
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Anticancer Res 20:1205-11. 2000
    ..In addition, decreased expression of E-cadherin and alpha-catenin proteins and increased p53 expression in BSCC may be correlated with aggressive behaviour...
  25. ncbi Uterine angiomyolipoma: case report and review of the literature
    H Yaegashi
    Department of Pathology, Mitokyodo General Hospital, Mito, Japan
    Pathol Int 51:896-901. 2001
    ..It is of particular interest that non-vascular smooth muscle cells were negative for HMB45, in contrast to renal and other extrarenal AML in which HMB45 immunoreactivity has been demonstrated in these cells...
  26. ncbi Endomyometriosis arising in the uterosacral ligament: a case report including a literature review and immunohistochemical analysis
    S Matsuzaki
    Departments of Obstetrics and Gynecology andPathology, Tohoku University School of Medicine, Sendai, Japan
    Pathol Int 50:493-6. 2000
    ..A relatively high proliferating activity was also demonstrated in these cells by Ki-67 immunostaining. These findings suggest that the mass was hormone dependent and had a relatively rapid evolution...
  27. ncbi Immunohistochemical distribution of chicken ovalbumin upstream promoter transcription factor II in human tissues
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Mol Cell Endocrinol 164:69-75. 2000
    ..The widespread expression of COUP-TFII suggests that COUP-TFII may play an important role in the function and homeostasis of various human tissues and organs...
  28. ncbi StAR and progesterone producing enzymes (3beta-hydroxysteroid dehydrogenase and cholesterol side-chain cleavage cytochromes P450) in human epithelial ovarian carcinoma: immunohistochemical and real-time PCR studies
    Manar Abd-Elaziz
    Department of Pathology, Tohoku University School of Medicine and Tohoku University Hospital, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Cancer Sci 96:232-9. 2005
    ....
  29. ncbi Immunohistochemical expression of PTEN and beta-catenin for endometrial intraepithelial neoplasia in Japanese women
    Yoshiaki Norimatsu
    Department of Pathology, Kurashiki Central Hospital, Kurashiki, Okayama 710 8672, Japan
    Ann Diagn Pathol 11:103-8. 2007
    ..The combination of PTEN-negative/beta-catenin-positive results may become the reliable marker for detecting EIN...
  30. ncbi Significance of pathological evaluation for lymphatic vessel invasion in invasive breast cancer
    Masahiro Ito
    Department of Surgical Oncology, Tohoku University School of Medicine, Sendai, Japan
    Breast Cancer 14:381-7. 2007
    ..The aim of this study is to investigate the significance of LVI in invasive breast cancers, primarily using immunohistochemical lymphatic endothelial markers...
  31. ncbi Vaginal tumors with histologic and immunocytochemical feature of gastrointestinal stromal tumor: two cases and review of the literature
    S Nagase
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int J Gynecol Cancer 17:928-33. 2007
    ..Recognition of microscopic patterns and characteristic immunohistochemical phenotype, plus genetic study, is mandatory for establishing the correct diagnosis of GIST...
  32. ncbi Conization by harmonic scalpel for cervical intraepithelial neoplasia: a clinicopathological study
    J Akahira
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Gynecol Obstet Invest 50:264-8. 2000
    ..20 mm) than with LEEP (0.30 mm; p = 0.0006). This new method produced an ideal-shaped specimen without increasing complications and thermal artifacts compared with LEEP...
  33. ncbi Primary ependymoma of the ovary: a case report and literature review
    T Takano
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int J Gynecol Cancer 15:1138-41. 2005
    ..Administration of etoposide-based chemotherapy along with cytoreductive surgery is a potential standard treatment for advanced ovarian ependymoma...
  34. ncbi 17Beta-hydroxysteroid dehydrogenase type 1 and type 2 in human breast carcinoma: a correlation to clinicopathological parameters
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Br J Cancer 82:518-23. 2000
    ..This study suggests that 17beta-HSD type 1 plays an important role in the regulation of in situ oestradiol production in hormone-dependent breast carcinomas...
  35. ncbi Pathological aspects of core needle biopsy for non-palpable breast lesions
    Shin Usami
    Department of Pathology, Tohoku University Hospital, Aoba-ku, Sendai 980-8574, Japan
    Breast Cancer 12:272-8. 2005
    ..Several aspects of CNB remains controversial, such as diagnosing papillary lesions by CNB, problems regarding tumor cell displacement after CNB, and management of lobular neoplasia (LN) on CNB...
  36. ncbi Progesterone receptor in non-small cell lung cancer--a potent prognostic factor and possible target for endocrine therapy
    Hironori Ishibashi
    Departments of Pathology and Molecular Medical Technology, Tohoku University School of Medicine, Sendai, Japan
    Cancer Res 65:6450-8. 2005
    ..Therefore, progesterone therapy may be clinically effective in suppressing development of progesterone receptor-positive NSCLC patients...
  37. ncbi Vasohibin-1 expression in endothelium of tumor blood vessels regulates angiogenesis
    Tomoko Hosaka
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Am J Pathol 175:430-9. 2009
    ....
  38. ncbi Aromatase in human breast carcinoma as a key regulator of intratumoral sex steroid concentrations
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Health Sciences, Sendai, Japan
    Endocr J 55:455-63. 2008
    ..Aromatase inhibitors may thus have additional antiproliferative effects through increasing local DHT concentration with estrogen deprivation...
  39. ncbi Discerning malignancy in resected adrenocortical neoplasms
    H Sasano
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryou machi, Aoba ku, Sendai, Japan 980 0872
    Endocr Pathol 12:397-406. 2001
    ....
  40. ncbi Involvement of granule-mediated apoptosis in the cyclic changes of the normal human endometrium
    T Igarashi
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 193:13-25. 2001
    ..The findings of this study suggest that granule-mediated apoptosis in endometrial glandular cells induced by NK cells expressing perforin and granzyme B may be associated with the onset of menstruation...
  41. ncbi Expression of EBAG9/RCAS1 is associated with advanced disease in human epithelial ovarian cancer
    J I Akahira
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Br J Cancer 90:2197-202. 2004
    ..In conclusion, the wide distribution of EBAG9 and its relation to advanced disease suggest that this protein may play important roles in epithelial ovarian cancer...
  42. ncbi Immunophenotypic alteration of the stromal component in minimal deviation adenocarcinoma ('adenoma malignum') and endocervical glandular hyperplasia: a study using oestrogen receptor and alpha-smooth muscle actin double immunostaining
    Y Mikami
    Department of Pathology, Jikei University Medical School, Tokyo, Japan
    Histopathology 46:130-6. 2005
    ..To define the phenotypic alteration of the stromal component in association with destructive invasion which is a crucial feature in distinguishing minimal deviation adenocarcinoma (MDA) from benign endocervical glandular lesions...
  43. ncbi Ovarian carcinoma recurring as carcinosarcoma
    S Moritani
    Department of Pathology, Shiga University of Medical Science, Ohtsu, Shiga, Japan
    Pathol Int 51:380-4. 2001
    ..These findings suggest the possible histogenesis of carcinosarcoma of the ovary as progression and clonal evolution of endometrioid adenocarcinoma...
  44. ncbi Cytogenetic abnormality 46,XX,add(21)(q11.2) in a patient with follicular dendritic cell sarcoma
    Naomi Suzuki
    Tohoku University School of Medicine, Sendai, Japan
    Cancer Genet Cytogenet 186:54-7. 2008
    ..Although this patient suffered from breast carcinoma 6 years after the onset of FDC sarcoma, the carcinoma showed different histological and phenotypic profiles...
  45. ncbi Progesterone receptor subtypes in vascular smooth muscle cells of human aorta
    Yasuhiro Nakamura
    Department of Pathology, Tohoku University School of Medicine, Seiryomachi, Sendai, Japan
    Endocr J 52:245-52. 2005
    ..PR-B was equally expressed between male and female aorta, but PR-A was more abundant in female than in male aorta. This finding demonstrated that the status of PR subtype expression was associated with the difference of genders...
  46. ncbi Utility of thin-layer preparations in the endometrial cytology: evaluation of benign endometrial lesions
    Yoshiaki Norimatsu
    Department of Pathology, Kurashiki Central Hospital, Kurashiki, Okayama 710 8602, Japan
    Ann Diagn Pathol 12:103-11. 2008
    ..Therefore, TLC preparation is a useful tool for the accurate and reliable diagnosis of normal endometrial phase and EGBD, because the preparation area is confined and identification of the target cell clumps is easy...
  47. ncbi Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma
    Yasuhiro Miki
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi-ken, Japan
    Cancer Res 66:535-42. 2006
    ..These results suggest that SXR/hPXR and its target gene, such as OATP-A, may play important roles in the biology of human breast cancers...
  48. ncbi Chromogenic in situ hybridization analysis of HER-2/neu status in breast carcinoma: application in screening of patients for trastuzumab (Herceptin) therapy
    H Kumamoto
    Division of Oral Pathology, Department of Oral Medicine and Bioregulation, Tohoku University Graduate School of Dentistry, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Pathol Int 51:579-84. 2001
    ....
  49. ncbi Glomus tumors with cystic changes around the ankle
    R Tachibana
    Department of Orthopaedic Surgery, Tohoku University School of Medicine, Sendai, Japan
    Arch Orthop Trauma Surg 121:540-3. 2001
    ..Immunohistochemically, the tumor cells expressed SMA and HHF-35, indicating smooth muscle cell characters. The patient had no recurrence at 2 years after surgery...
  50. ncbi Primary invasive micropapillary carcinoma of the colon
    K Sakamoto
    Department of Pathology, Tohoku University Hospital, Sendai, Japan
    Histopathology 47:479-84. 2005
    ..IMPC has been reported in breast, urinary bladder, ureter, lung and parotid gland but not in colon. We present the clinicopathological features of three cases of primary IMPC of the colon with a review of the literature...
  51. ncbi Correlative association between circadian expression of mousePer2 gene and the proliferation of the neural stem cells
    T Moriya
    Department of Neurobiology and Behavior, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1 3 5 Sakamoto, Nagasaki, Japan
    Neuroscience 146:494-8. 2007
    ..These results suggest that mPer2 might periodically suppress the proliferation of neural stem cells...
  52. ncbi Non-functioning adrenocortical adenomas containing fat components
    T Yamada
    Department of Diagnostic Radiology, Tohoku University, School of Medicine, 1-1 Seiryo-machi Aobaku Sendai, Miyagi 980-8754, Japan
    Clin Radiol 57:1034-7. 2002
  53. ncbi Expression of estrogen-responsive finger protein (Efp) is associated with advanced disease in human epithelial ovarian cancer
    Michiko Sakuma
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Gynecol Oncol 99:664-70. 2005
    ..To understand the estrogenic action on ovarian cancer, we studied the relationships between Efp and ERs expressions and the correlations of Efp expression with clinicopathological parameters in epithelial ovarian cancer...
  54. ncbi Usefulness of immunohistochemistry for differential diagnosis between benign and malignant breast lesions
    Takuya Moriya
    Department of Pathology, Kawasaki Medical School Hospital, 577 Matsushima, Kurashiki 701 0192, Japan
    Breast Cancer 16:173-8. 2009
    ..It is important to use IHC with caution, and re-evaluation of histological findings on hematoxylin and eosin stain and clinicopathological correlation of each case is essential...
  55. ncbi Estrogen-responsive finger protein as a new potential biomarker for breast cancer
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi ken, Japan
    Clin Cancer Res 11:6148-54. 2005
    ..In this study, we examined expression of Efp in breast carcinoma tissues and correlated these findings with various clinicopathologic variables...
  56. ncbi In situ androgen producing enzymes in human prostate cancer
    Yasuhiro Nakamura
    Departments of Pathology, Tohoku University School of Medicine, Seiryo machi, Sendai, Japan
    Endocr Relat Cancer 12:101-7. 2005
    ....
  57. ncbi Bioabsorbable gelatin sheets latticed with polyglycolic acid can eliminate pericardial adhesion
    Ichiro Yoshioka
    Department of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Ann Thorac Surg 84:864-70. 2007
    ..This study was undertaken to evaluate the biomechanical property of the sheet and the preventive effect on pericardial adhesions after pericardial replacement in a canine model before its clinical applications...
  58. ncbi Sudden infant death from dilated cardiomyopathy with endocardial fibroelastosis
    Shirushi Takahashi
    Division of Forensic Medicine, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, 980 8575 Sendai, Japan
    Leg Med (Tokyo) 10:277-80. 2008
    ....
  59. ncbi Recent advances in histopathology and immunohistochemistry of adrenocortical carcinoma
    Hironobu Sasano
    Department of Pathology, Tohoku University School of Medicine and Tohoku University Hospital, Sendai, Japan
    Endocr Pathol 17:345-54. 2006
    ....
  60. ncbi In situ production of sex steroids in human breast carcinoma
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Med Mol Morphol 40:121-7. 2007
    ....
  61. ncbi Analysis of surrogate markers for target-specific therapy in breast carcinomas using archival materials
    Hironobu Sasano
    Department of Pathology, Tohoku University School of Medicine and Tohoku University Hospital, 2 1 Seiryou machi, Sendai 980 8575, Japan
    Biomed Pharmacother 61:543-7. 2007
    ....
  62. ncbi Intracrinology of estrogens and androgens in breast carcinoma
    Hironobu Sasano
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryou machi, Aoba ku, Sendai, Japan
    J Steroid Biochem Mol Biol 108:181-5. 2008
    ..However, intracrine mechanisms of androgens as well as their biological or clinical significance in the patients with breast cancer have not been fully elucidated in contrast to those in estrogens...
  63. ncbi Promoter methylation status of the Cyclin D2 gene is associated with poor prognosis in human epithelial ovarian cancer
    Michiko Sakuma
    Department of Obstetrics and Gynecology, Tohoku University, Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku Sendai, 980 8574 Japan
    Cancer Sci 98:380-6. 2007
    ..021). Our results suggest that aberrant promoter methylation of the Cyclin D2 gene is significantly associated with patient prognosis in epithelial ovarian cancer...
  64. ncbi Androgens in human breast carcinoma
    Takashi Suzuki
    Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Med Mol Morphol 43:75-81. 2010
    ..Therefore, androgenic actions may also be involved in apocrine features in breast carcinoma...
  65. ncbi Endometrial glandular and stromal breakdown, part 1: cytomorphological appearance
    Keiko Shimizu
    Department of Pathology, Saiseikai Noe Hospital, Imperial Gift Foundation Inc, Osaka, Japan
    Diagn Cytopathol 34:609-13. 2006
    ....
  66. ncbi New development in intracrinology of breast carcinoma
    Hironobu Sasano
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Breast Cancer 13:129-36. 2006
    ..Therefore, it will become very important to examine the intratumoral levels of 17beta-HSD type 1 and STS in the resected specimens of human breast carcinoma as potential targets of novel endocrine therapy in the near future...
  67. ncbi Significance of irradiation in breast-conserving treatment: comparison of local recurrence rates in irradiated and nonirradiated groups
    Takanori Ishida
    Division of Surgical Oncology, Tohoku University School of Medicine, Sendai, 980 8574, Japan
    Int J Clin Oncol 13:12-7. 2008
    ..It may also be necessary to include the patient age and margin condition as mandatory criteria for irradiation...
  68. ncbi Serum antibody against granulocyte/macrophage colony-stimulating factor and KL-6 in idiopathic pulmonary alveolar proteinosis
    Masayuki Nara
    Department of Infectious and Respiratory Diseases, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 208:349-54. 2006
    ..On the contrary, KL-6 is an excellent marker for the assessment of the clinical course of I-PAP...
  69. ncbi Analysis for localization of steroid sulfatase in human tissues
    Takashi Suzuki
    Departmen of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Methods Enzymol 400:303-16. 2005
    ....
  70. ncbi Intravenous extended liposarcoma arising from renal sinus
    Mabumi Matsushita
    Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int J Urol 14:769-70. 2007
    ..Pathological findings showed well-differentiated liposarcoma of the renal sinus. The tumor invaded to the right renal vein and the renal parenchyma...
  71. ncbi 3beta-Hydroxysteroid dehydrogenase in human aorta
    Yasuhiro Nakamura
    Department of Pathology, Tohoku University School of Medicine, Seiryo-machi, Sendai, Japan
    Endocr J 52:111-5. 2005
    ..These findings all indicated that steroidogenesis via 3beta-HSD may occur in VSMCs of human aorta, possibly related to gender differences and/or the degree of atherosclerosis...
  72. ncbi Thyroid metastasis of pulmonary adenocarcinoma
    Kouki Mori
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan
    Thyroid 15:176-7. 2005
  73. ncbi Analysis of intrapulmonary vessels and epithelial-endothelial interactions in the human developing lung
    Sumiko Maeda
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Lab Invest 82:293-301. 2002
    ..Epithelial-endothelial interactions during lung development are considered very important in the establishment of the functional blood-gas interface...
  74. ncbi Intracrine mechanism of estrogen synthesis in breast cancer
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Biomed Pharmacother 57:460-2. 2003
    ....
  75. ncbi Nuclear receptor DAX-1 in human common epithelial ovarian carcinoma: an independent prognostic factor of clinical outcome
    Manar Abd-Elaziz
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8575
    Cancer Sci 94:980-5. 2003
    ..In conclusion, DAX-1 immunoreactivity is considered to be a new independent marker of poor prognosis or adverse clinical outcome in patients with epithelial ovarian carcinoma, possibly through altering in situ steroids production...
  76. ncbi Adrenal carcinoma with a signal loss on chemical shift magnetic resonance imaging
    Takayuki Yamada
    Department of Diagnostic Radiology, Tohoku University Hospital, 1 1 Seiryomachi, Aoba ku, Sendai, Miyagi 980 8574, Japan
    J Comput Assist Tomogr 27:606-8. 2003
    ..4 cm in largest diameter. It was surgically removed and diagnosed as adrenal carcinoma histopathologically. Two portions where clear cells were prominent were recognized. These areas probably contributed to the signal loss on CSI...
  77. ncbi Case report: chronic expanding hematoma in the adrenal gland with pathologic correlations
    Takayuki Yamada
    Department of Diagnostic Radiology, Tohoku University, School of Medicine, Miyati, Japan
    J Comput Assist Tomogr 27:354-6. 2003
    ..Awareness of this finding may prevent the misdiagnosis of a tumor as a neoplastic intratumoral hemorrhage...
  78. ncbi Estrogen sulfotransferase and steroid sulfatase in human breast carcinoma
    Takashi Suzuki
    Departments of Pathology, Tohoku University School of Medicine, Sendai, 980 8575, Japan
    Cancer Res 63:2762-70. 2003
    ....
  79. ncbi The correlation between the response to progestogen treatment and the expression of progesterone receptor B and 17beta-hydroxysteroid dehydrogenase type 2 in human endometrial carcinoma
    Hiroki Utsunomiya
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Clin Endocrinol (Oxf) 58:696-703. 2003
    ..However, details of the alterations of in situ oestrogen metabolism following progestogen treatment have yet to be fully elucidated...
  80. ncbi Estrogen receptors (alpha and beta) and 17beta-hydroxysteroid dehydrogenase type 1 and 2 in thyroid disorders: possible in situ estrogen synthesis and actions
    Wakako Kawabata
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Mod Pathol 16:437-44. 2003
    ....
  81. ncbi Severe acute interstitial pneumonia and gefitinib
    Akira Inoue
    Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Aobaku, Sendai, 980 8575, Toyko, Japan
    Lancet 361:137-9. 2003
    ..Physicians should be aware of the alveolar damage induced by gefitinib, especially for patients with these characteristic features...
  82. ncbi Retinoid receptors in the developing human lung
    Yuichiro Kimura
    Department of Pathology, Tohoku University School of Medicine, Tohoku University, Sendai, Japan
    Clin Sci (Lond) 103:613-21. 2002
    ..4+/-0.05-fold and 3.1+/-0.03-fold respectively; P <0.01), RAR-beta at distal sites (2.4+/-0.01-fold; P <0.05) and RAR-gamma at proximal sites (2.2+/-0.11-fold; P <0.05) were significantly higher in the fetus than in the adult...
  83. ncbi Three-dimensional reconstruction and fractal geometric analysis of serrated adenoma
    Masahiro Iwabuchi
    Department of Pathology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai 980 8574, Japan
    Jpn J Cancer Res 93:259-66. 2002
    ..These distribution patterns of the proliferative zone of SA are considered to contribute to the formation of the characteristic serrated epithelia and the complicated morphological appearance of SA...
  84. ncbi Hepatoid adenocarcinoma of the gallbladder: Case report and review of the literature
    Kazuhiro Sakamoto
    Department of Pathology, Tohoku University Hospital, Sendai, Japan
    Pathol Int 54:52-6. 2004
    ..Based on these findings, this case was diagnosed as hepatoid adenocarcinoma of the gallbladder, which is generally a vary rare neoplasm in the literature, but should be included in the differential diagnosis of a mass in the gallbladder...
  85. ncbi Gastrointestinal immunophenotype in adenocarcinomas of the uterine cervix and related glandular lesions: a possible link between lobular endocervical glandular hyperplasia/pyloric gland metaplasia and 'adenoma malignum'
    Yoshiki Mikami
    Department of Pathology, Tohoku University Graduate School of Medical Science, Sendai, Japan
    Mod Pathol 17:962-72. 2004
    ..p16INK4 immunohistochemistry appears to be a promising diagnostic tool, but pathologists should be aware of frequent negative staining in MDAs, which can be a source of erroneous diagnosis...
  86. ncbi E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis
    Yasuhiro Nakamura
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8575, Japan
    Am J Pathol 165:2019-31. 2004
    ..E4F1 is therefore considered one of the estrogen-responsive genes involving ER alpha-mediated inhibition of VSMC proliferation and may play an important role in estrogen-related atheroprotection of human aorta...
  87. ncbi Estrogen-related receptor alpha in human breast carcinoma as a potent prognostic factor
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Cancer Res 64:4670-6. 2004
    ..Results from our study suggest that ERRalpha possibly modulates the expression of ERE-containing estrogen-responsive genes, and ERRalpha immunoreactivity is a potent prognostic factor in human breast carcinoma...
  88. ncbi Estrogen receptors in atherosclerotic human aorta: inhibition of human vascular smooth muscle cell proliferation by estrogens
    Yasuhiro Nakamura
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Mol Cell Endocrinol 219:17-26. 2004
    ..Our study also indicates that decreased levels of ER, especially ERalpha, in the female atherosclerotic neointima may be associated with progression of atherosclerotic changes...
  89. ncbi Primary vaginal adenosarcoma with sarcomatous overgrowth
    Masafumi Toyoshima
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba, Sendai 980 8574, Japan
    Gynecol Oncol 95:759-61. 2004
    ..Primary vaginal adenosarcomas are extremely rare, and typical adenosarcomas are of low malignancy. However, aggressive forms with sarcomatous overgrowth have been reported, those appear to have a poor prognosis...
  90. ncbi A case of primary mucosa-associated lymphoid tissue lymphoma of the vagina
    Kousuke Yoshinaga
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hum Pathol 35:1164-6. 2004
    ..The patient is alive and well 40 months after treatment. Because the vagina is one of the mucosa-associated tissues, MALT lymphoma, though rare, must be included in the differential diagnosis of the vaginal neoplasms...
  91. ncbi Invasive micropapillary carcinoma of the breast: clinicopathological and immunohistochemical study
    Clarissa De La Cruz
    Department of Pathology, Tohoku University Hospital, Sendai, Japan
    Pathol Int 54:90-6. 2004
    ..These results suggest that IMPCa is, at least, the same or more aggressive than lymph node positive cases of IDC-NOS. Hence, not only the high incidence of lymph node metastases but also distant, blood-borne metastases may be important...
  92. ncbi Immunohistopathological and molecular genetic features of a case in which gastrointestinal stromal tumor recurred five times
    Tsukasa Inoue
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Pathol Int 54:196-200. 2004
    ..These data indicated that 'morphologically appearing benign' tumors with lower proliferative parameters may also have the capacity of metastasis and recurrence...
  93. ncbi Successful use of anti-CD20 monoclonal antibody (rituximab) for ABO-incompatible living-related liver transplantation
    Masahiro Usuda
    Division of Advanced Surgical Science and Technology, Graduate School of Medicine, Tohoku University, Sendai, Japan
    Transplantation 79:12-6. 2005
    ..We used rituximab, which can eliminate B cells highly selectively, as an additional therapy for ABO-incompatible living-related liver transplantation...
  94. ncbi In situ production of estrogens in human breast carcinoma
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Breast Cancer 9:296-302. 2002
    ....
  95. ncbi Nuclear cyclin B1 in human breast carcinoma as a potent prognostic factor
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi ken, 980 8575, Japan
    Cancer Sci 98:644-51. 2007
    ..Nuclear cyclin B1-positive breast carcinoma is resistant to adjuvant therapy, and nuclear cyclin B1 immunoreactivity is a potent prognostic factor in breast carcinoma patients...
  96. ncbi Oncolytic viral therapy by bladder instillation using an E1A, E1B double-restricted adenovirus in an orthotopic bladder cancer model
    Hua Wang
    Division of Urology, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Urology 68:674-81. 2006
    ..To investigate the therapeutic effect of AxdAdB-3, a double-restricted oncolytic adenovirus harboring a mutant E1A and an E1B-55KD deletion, on human bladder cancer cell lines and the SCID mouse model of orthotopic bladder cancer...
  97. ncbi Systemic distribution of steroid sulfatase and estrogen sulfotransferase in human adult and fetal tissues
    Yasuhiro Miki
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8575, Japan
    J Clin Endocrinol Metab 87:5760-8. 2002
    ..We speculate that EST may play an important role in protecting peripheral tissues from possible excessive estrogenic effects...
  98. ncbi Expression of androgen receptor and 5alpha-reductases in the human normal endometrium and its disorders
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Int J Cancer 99:652-7. 2002
    ..Androgenic actions may be also regulated predominantly by serum testosterone and not by DHT in endometrial hyperplasia because of the absence of 5alpha-reductases in the site of its actions...
  99. ncbi Early growth responsive gene 3 in human breast carcinoma: a regulator of estrogen-meditated invasion and a potent prognostic factor
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Endocr Relat Cancer 14:279-92. 2007
    ..These results suggest that EGR3 plays an important role in estrogen-meditated invasion and is an independent prognostic factor in breast carcinoma...
  100. ncbi Differential expression of progesterone receptor isoforms A and B in the normal ovary, and in benign, borderline, and malignant ovarian tumors
    Jun ichi Akahira
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8574, Japan
    Jpn J Cancer Res 93:807-15. 2002
    ..These results suggest that down-regulation of PRA is associated with the development of ovarian epithelial carcinoma...
  101. ncbi 5Alpha-reductase type 1 and aromatase in breast carcinoma as regulators of in situ androgen production
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Int J Cancer 120:285-91. 2007
    ..Aromatase inhibitors may be more effective in these patients, possibly due to increasing local DHT concentration with estrogen deprivation...