Affiliation: Tohoku University
Moriguchi S. Pharmacological study on Alzheimer's drugs targeting calcium/calmodulin-dependent protein kinase II. J Pharmacol Sci. 2011;117:6-11 pubmed
..In conclusion, nefiracetam enhances NMDA-receptor function through stimulation of its glycine binding site and nefiracetam-induced CaMKII activation likely contributes to improvement of cognition, learning, and memory. ..
Moriguchi S, Han F, Nakagawasai O, Tadano T, Fukunaga K. Decreased calcium/calmodulin-dependent protein kinase II and protein kinase C activities mediate impairment of hippocampal long-term potentiation in the olfactory bulbectomized mice. J Neurochem. 2006;97:22-9 pubmed
..Both decreased PKC and CaMKII activities with concomitant LTP impairment account for the learning disability observed in OBX mice. ..
Moriguchi S, Han F, Shioda N, Yamamoto Y, Nakajima T, Nakagawasai O, et al
. Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice. J Neurochem. 2009;110:170-81 pubmed publisher
Moriguchi S, Shioda N, Yamamoto Y, Fukunaga K. Platelet-activating factor-induced synaptic facilitation is associated with increased calcium/calmodulin-dependent protein kinase II, protein kinase C and extracellular signal-regulated kinase activities in the rat hippocampal CA1 region. Neuroscience. 2010;166:1158-66 pubmed publisher
..These results suggest that PAF induces synaptic facilitation through activation of CaMKII, PKC and ERK in the hippocampal CA1 region. ..
Moriguchi S, Oomura Y, Shioda N, Han F, Hori N, Aou S, et al
. Ca2+/calmodulin-dependent protein kinase II and protein kinase C activities mediate extracellular glucose-regulated hippocampal synaptic efficacy. Mol Cell Neurosci. 2011;46:101-7 pubmed publisher
..Taken together, CaMKII and PKC activation likely mediate potentiation of fEPSPs by elevated glucose levels, and CaMKII activity is also associated with LTP induction in the hippocampal CA1 region. ..