Toshio Miyata

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. pmc Early- and advanced non-enzymatic glycation in diabetic vascular complications: the search for therapeutics
    Casper G Schalkwijk
    Department of Internal Medicine, University Hospital Maastricht, P Debyelaan 25, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Amino Acids 42:1193-204. 2012
  2. doi request reprint Inhibition of advanced glycation end products (AGEs): an implicit goal in clinical medicine for the treatment of diabetic nephropathy?
    Toshio Miyata
    Center for Translational and Advanced Research, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Diabetes Res Clin Pract 82:S25-9. 2008
  3. ncbi request reprint Novel mechanisms and therapeutic options in diabetic nephropathy
    Toshio Miyata
    Center for Translational and Advanced Research, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pol Arch Med Wewn 119:261-4. 2009
  4. doi request reprint Diabetic nephropathy: a disorder of oxygen metabolism?
    Toshio Miyata
    Center for Translational and Advanced Research, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Nat Rev Nephrol 6:83-95. 2010
  5. pmc Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats
    Xianguang Chen
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 36:361-7. 2013
  6. doi request reprint Blockade of angiotensin II type-1 receptor increases salt sensitivity in Sprague-Dawley rats
    Satoshi Endo
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Tohoku University, Sendai, Japan
    Hypertens Res 32:513-9. 2009
  7. doi request reprint Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure
    Susumu Ogawa
    Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Hypertension 56:471-6. 2010
  8. doi request reprint Role of specific T-type calcium channel blocker R(-) efonidipine in the regulation of renal medullary circulation
    Chunyan Hu
    Division of Nephrology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Hypertens 30:1620-31. 2012
  9. pmc A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates
    Yuko Izuhara
    Center for Translational and Advanced Research, Tohoku University Graduate School of Medicine, Miyagi, Aoba ku, Sendai, Japan
    J Cereb Blood Flow Metab 30:904-12. 2010
  10. doi request reprint Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets
    Toshio Miyata
    United Centers for Advanced Research and Translational Medicine, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Am J Physiol Cell Physiol 300:C226-31. 2011

Collaborators

Detail Information

Publications15

  1. pmc Early- and advanced non-enzymatic glycation in diabetic vascular complications: the search for therapeutics
    Casper G Schalkwijk
    Department of Internal Medicine, University Hospital Maastricht, P Debyelaan 25, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Amino Acids 42:1193-204. 2012
    ....
  2. doi request reprint Inhibition of advanced glycation end products (AGEs): an implicit goal in clinical medicine for the treatment of diabetic nephropathy?
    Toshio Miyata
    Center for Translational and Advanced Research, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Diabetes Res Clin Pract 82:S25-9. 2008
    ..By contrast, it is almost always associated with a decreased AGE formation. AGE reduction may reflect a decreased oxidative stress as it is concomitant with a marked reduction of oxidative stress markers...
  3. ncbi request reprint Novel mechanisms and therapeutic options in diabetic nephropathy
    Toshio Miyata
    Center for Translational and Advanced Research, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pol Arch Med Wewn 119:261-4. 2009
    ..It is indeed important to acquire tools to evaluate and confirm our hypotheses and to translate experimental results into clinical practice...
  4. doi request reprint Diabetic nephropathy: a disorder of oxygen metabolism?
    Toshio Miyata
    Center for Translational and Advanced Research, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Nat Rev Nephrol 6:83-95. 2010
    ..A specific PHD1 inhibitor might, therefore, offer a novel therapy for abnormal oxygen metabolism not only in the diabetic kidney, but also in other diseases for which hypoxia is a final, common pathway...
  5. pmc Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats
    Xianguang Chen
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 36:361-7. 2013
    ..These results suggest that MG-induced hypertension and cardio-renal injury and increased inflammation and carbonyl and oxidative stress, which were partially preventable by an ARB...
  6. doi request reprint Blockade of angiotensin II type-1 receptor increases salt sensitivity in Sprague-Dawley rats
    Satoshi Endo
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Tohoku University, Sendai, Japan
    Hypertens Res 32:513-9. 2009
    ..We conclude that OLM and HCTZ could be a useful combination for reduction of blood pressure even under high salt intake without changes in urinary oxidative stress levels...
  7. doi request reprint Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure
    Susumu Ogawa
    Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Hypertension 56:471-6. 2010
    ..DG is an independent risk factor for the percentage change of ACR. MG is a predictor in type 2 diabetic patients of intima-media thickening, of increase of PWV, and of elevation of SBP...
  8. doi request reprint Role of specific T-type calcium channel blocker R(-) efonidipine in the regulation of renal medullary circulation
    Chunyan Hu
    Division of Nephrology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Hypertens 30:1620-31. 2012
    ..Studies were designed to determine the effects of a specific TCC blocker, R(-) efonidipine [R(-)EFO], on the regulation of renal circulation...
  9. pmc A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates
    Yuko Izuhara
    Center for Translational and Advanced Research, Tohoku University Graduate School of Medicine, Miyagi, Aoba ku, Sendai, Japan
    J Cereb Blood Flow Metab 30:904-12. 2010
    ..This study documents the antithrombotic benefits of a novel, more powerful, PAI-1 inhibitor in rats and, for the first time, in nonhuman primates. These effects are obtained without adverse effect on bleeding time...
  10. doi request reprint Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets
    Toshio Miyata
    United Centers for Advanced Research and Translational Medicine, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Am J Physiol Cell Physiol 300:C226-31. 2011
    ..Nrf2 activity is modulated by Kelch-like ECH-associated protein 1 (Keap1), an intracellular sensor for oxidative stress. Inhibitors of Keap 1 may prove therapeutic against oxidative tissue injury...
  11. doi request reprint A novel Sartan derivative with very low angiotensin II type 1 receptor affinity protects the kidney in type 2 diabetic rats
    Yuko Izuhara
    Center for Translational and Advanced Research, Tohoku University Graduate School of Medicine, Sendai, Japan
    Arterioscler Thromb Vasc Biol 28:1767-73. 2008
    ..Antihypertensive angiotensin II receptor blockers (ARBs) protect the kidney, at least in part, independently of blood pressure lowering. Still, the extent to which blood pressure lowering is related to renoprotection remains unclear...
  12. doi request reprint A small molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration
    Atsuhiko Ichimura
    Division of Molecular Medicine and Therapy, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Arterioscler Thromb Vasc Biol 33:935-42. 2013
    ..We rely here on a small molecule PAI-1 inhibitor (TM5275) to investigate the role of PAI-1 in Mϕ migration in the pathogenesis of renal injury...
  13. doi request reprint Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague-Dawley rats
    Qi Guo
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    J Hypertens 27:1664-71. 2009
    ..The present study was designed to investigate whether methylglyoxal could directly induce insulin resistance and salt sensitivity in Sprague-Dawley rats...
  14. doi request reprint New era for drug discovery and development in renal disease
    Toshio Miyata
    United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Nat Rev Nephrol 7:469-77. 2011
    ..In this Review, we outline the benefits of exploratory clinical trials, especially in academia, and provide an overview of the experimental tools necessary for rational drug discovery and development...
  15. doi request reprint Diabetic nephropathy: are there new and potentially promising therapies targeting oxygen biology?
    Toshio Miyata
    United Centers for Advanced Research and Translational Medicine ART, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Kidney Int 84:693-702. 2013
    ..These newer approaches targeting oxygen biology may offer new treatments not only for DN but also for several diseases in which hypoxia and/or OS is a final, common pathway. ..